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만성 바이러스성 간염에서 수상세포, HLA-DR 및 CD8+림프구의 역할 : 면역조직화학적 연구 An Immunohistochemical Study
최상욱,김성수,양진모,선희식,한남익,이창돈,정규원,안병민,조돈현 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.4
Backgrounds/Aims: This study focuses on the pathogenesis of inflammatory reaction and cell necrosis in patients with chronic viral hepatitis and examines the possible effects of follicular dendritic cells, HLA-DR and CD8+ presenting lymphocytes by analyzing their expression and the histological activity index (HAI) in liver tissues. Methods: Liver biopsy specimens were obtained from 59 patients with chronic hepatitis B and from 26 patients with chronic hepatitis C. The expressions of dendritic cells, HLA-DR and CD8+ presenting lymphocytes were determined by immunohistochemical stain. Results: The incidence of lymphoid follicle and/or lymphoid aggregates in portal tracts of the liver was higher in chronic hepatitis C than it was in chronic hepatitis B (84.6% vs. 15.3%, p=0.000). Follicular dendritic cells were exclusively expressed within lymphoid follicles and/or lymphocyte aggregates in portal areas. HLA-DR restricted cells were mainly observed in portal and periportal areas as well as in the area of piecemeal necrosis. CD8+ lymphocytes were diffusely expressed in portal and periportal areas and within intralobular parenchymal sinusoids. The expression of dendritic cell and HLA-DR was more frequently observed in moderate chronic hepatitis than in mild chronic hepatitis. While that of CD8+ lymphocyte expression was more frequent in severe chronic hepatitis with a high HAI score. Conclusions: The follicular dendritic cells may trap viral antigens in intraportal lymphoid follicle and present them to HLA-DR and CD8+ presenting lymphocytes. It is suggested that the associated expression of dendritic cells, HLA-DR and CD8+ presenting lymphocytes in liver tissues may play one of the biological role in immune injury in chronic viral hepatitis.(Korean J hepatol 2000;6;448-455)
이은희,안대현,박두호,양동헌,안병민,황성하,이동수,이강문,이영중,장영이 대한소화기학회 2000 대한소화기학회지 Vol.36 No.5
As the pancreas and the spleen lie adjacently, complication in spleen may occur during the course of acute or chronic pancreatitis. Intrasplenic pseudocyst is one of the complications which may occur. These complications are spontaneous rupture, bleeding, secondary infection (abscess) and splenic infarction. Intrasplenic pseudocyst is the most common complication. Diagnosis can be usually made under emergency conditions and is mainly based on ultrasonogram, computed tomography (CT), selective arteriogram, endoscopic retrograde cholangiopancreatography (ERCP) and ultrasono-or computed tomography-guided needle aspiration of fluid collection in the left upper quadrant. We experienced a 48-year-old man complaining of supraumbilical pain. He was diagnosed as having intrasplenic pseudocyst associated with chronic pancreatitis, which was confirmed by ultrasonography of abdomen, abdominal CT, ERCP and ultrasono-guided aspiration. After external catheter drainage was performed intrasplenic pseudocyst was regressed, but still remained. Thus, distal pancreatectomy and splenectomy were performed. We report this case with a review of literature.
이은희,정인식,박두호,안병민,이동수,한석원,이강문 대한소화기학회 2000 대한소화기학회지 Vol.36 No.6
Backgroud/Aims: Apoptosis is necessary to appropriately delete cells during organ development, and serves as a protector against malignant transformation by removing damaged or mutated cells. Recently, Bcl-x has been cloned as a bcl-2-related gene. In human, the Bcl-x gene encodes 2 proteins, a long form (Bcl-xL) and a short form (Bcl-xS), through an alternative splicing mechanism. The Bcl-xL protein inhibits apoptosis as effectively as Bcl-2 protein. The aim of this study was to investigate the immunohistochemical expression of Bcl-xL protein in the gastric adenoma and gastric adenocarcinoma. Methods: Immunohistochemical staining using monoclonal Bcl-xL antibody was performed on paraffin-embeded specimens obtained from 23 gastric adenomas and 43 gastric adenomcarcinomas. Results: When compared to the intensity observed in adjacent normal mucosal epithelial cells, immunostaining of Bcl-xL was observed in 22 of 23 (96%) adenomas, all of 13 (100%) early adenocarcinomas, and 19 of 30 (63.3%) advanced adenocarcinomas. In gastric adenocarcinoma, Bcl-xL expression was observed in 24 of 28 (85.7%) intestinal type-adenocarcinomas and 8 of 15 (53.3%) diffuse type-adenocarcinomas. No correlation was observed between Bcl-xL expression and tumor stage. Conclusions: The Bcl-xL expression would be involved in the early phase of gastric carcinogenesis, but not in tumor progression.