신경계 중환자실 환자의 벤지다민 용액 (Benzydamine hydrochloride solution)의 구강간호 효과

반효정,김경희,곽연희 한국웰니스학회 2020 한국웰니스학회지 Vol.15 No.3

This study was designed as a non-equivalent control group pretest-posttest to investigate whether there are differences between two oral care solution on participants' halitosis, hydrogen exponent and oral status. 28 subjects in the experimental group using benzydamine hydrochloride solution and 29 subjects in the control group using 0.1% chlorhexidine received oral care three time/day for 5 days. Data collected were analyzed with chi-squared test, Fisher’s exact test, t-test, and ANCOVA using SPSS 25.0 software. The results showed halitosis of experimental group to which benzydamine hydrochloride solution was applied reduced more, showing statistically significant difference(F=19.42, p<.001). Hydrogen exponent of experimental group increased more, showing statistically significant difference(F=4.73, p=.034). There were no significant differences between the two groups for tongue(F=0.45, p=.502), oral mucosa(F=1.92 p=.168), gum(F=1.31, p=.257), and teeth(F=1.63, p=.207). This study showed that oral care using benzydamine hydrochloride solution partially effectively used to improve the oral health of neurological ICU patients. 본 연구는 신경계 중환자실 환자를 대상으로 벤지다민과 0.1% 클로르헥시딘 구강간호 용액을 이용하여 구강간호를 실시한 후, 구강 내 구취, 산도, 구강 상태에 미치는 효과를 확인한 비동등성 대조군 전ㆍ후 실험연구이다. 벤지다민을 이용한 실험군 28명과 0.1% 클로르헥시딘을 이용한 대조군 29명에게 1일 3회, 5일간 구강간호를 적용하였다. SPSS 25.0 프로그램을 이용하여 chi-squared test와 Fisher’s exact test, t-test, 및 ANCOVA을 실시하였다. 연구결과, 벤지다민이 0.1% 클로르헥시딘보다 구취(F = 19.42, p <.001)와 구강 내 산도(F = 4.73, p = .034)에 효과적인 것으로 나타났다. 벤지다민과 0.1% 클로르헥시딘 이용한 구강간호 전후, 혀(F = 0.45, p = .502), 구강점막(F = 1.92, p = .168), 잇몸(F = 1.31, p = .257)과 치아(F=1.63, p=.207)를 포함한 구강상태 점수에서는 통계적으로 유의한 차이는 없었다. 벤지다민을 이용한 구강간호가 신경계 중환자실 환자의 구강건강 증진에 부분적으로 효과가 있음을 확인하였다.

유전지표를 활용한 사상체질 분류모델

반효정,이시우,진희정,Ban, Hyo-Jeong,Lee, Siwoo,Jin, Hee-Jeong 사상체질의학회 2020 사상체질의학회지 Vol.32 No.2

Objectives Genome-wide association studies(GWAS) is a useful method to identify genetic associations for various phenotypes. The purpose of this study was to develop predictive models for Sasang constitution types using genetic factors. Methods The genotypes of the 1,999 subjects was performed using Axiom Precision Medicine Research Array (PMRA) by Life Technologies. All participants were prescribed Sasang Constitution-specific herbal remedies for the treatment, and showed improvement of original symptoms as confirmed by Korean medicine doctor. The genotypes were imputed by using the IMPUTE program. Association analysis was conducted using a logistic regression model to discover Single Nucleotide Polymorphism (SNP), adjusting for age, sex, and BMI. Results & Conclusions We developed models to predict Korean medicine constitution types using identified genectic factors and sex, age, BMI using Random Forest (RF), Support Vector Machine (SVM), and Neural Network (NN). Each maximum Area Under the Curve (AUC) of Teaeum, Soeum, Soyang is 0.894, 0.868, 0.767, respectively. Each AUC of the models increased by 6~17% more than that of models except for genetic factors. By developing the predictive models, we confirmed usefulness of genetic factors related with types. It demonstrates a mechanism for more accurate prediction through genetic factors related with type.

퍼머넌트 웨이브 시술시 포공영 헤어미스트 전처리에 따른 모발보호효과

반효정 ( Hyo Jeong Ban ),고경숙 ( Kyoung Sook Ko ) 한국미용학회 2015 한국미용학회지 Vol.21 No.5

Recently, various studies are being conducted using natural materials and this study manufactured and applied hair mist using Taraxaci Herba extract to hair. In order to verify the effect of manufactured Taraxaci Herba hair mist, this study experimented by classifying objects into C1 which only applied permanent wave to virgin hair, C2 which preprocessed hair mist base before applying permanent wave and C3 which preprocessed Taraxaci Herba hair mist before applying permanent wave. As permanent wave solutions, first, thioglycollic acid was used as reducing agent and, second, sodium bromate was used as oxidizing agent. As the result of measurement on wave efficiency, the efficiency of C3 proved the highest while that of C1turned out to be lowest. As the result of measurement of tensile strength and degree of hair damage using Methylene blue dying method and of observation on cuticle and structure of minute hair, degree of hair damage of C1 proved to be the most severe. Given that hair mist base did not reduce damage to a remarkable extent when compared with Taraxaci Herba hair mist, antioxydant function of Taraxaci Herba extract is presumed to have reduced the damage of the hair. Therefore, it was confirmed that preprocessing of Taraxaci Herba hair mist at the time of permanent hair treatment can provide elastic curl while maintaining healthy state of hair.

적하수오 추출물 크림의 SD-rat 두피손상 완화 및 안전성 검사

반효정 ( Hyo Jeong Ban ),고경숙 ( Kyoung Sook Ko ) 한국미용학회 2012 한국미용학회지 Vol.18 No.6

Oxidized hairdyes which are frequently used in dyeing cause abnormal scalp and contact dermatitis. And they even do hair loss in severe cases. Pleuropterus multflorus extract cream was used to relieve damaged scalp due to frequent use of oxidized hairdyes. First, the result which carried out the cytotoxicity test (mtt-assay) to check the safety of Pleuropterus multflorus extract has found that there is no cytotoxicity on concentration of less than 100 ?g/mL. The result which observed the effect by applying polygonum multiflorum extract cream which was made based on them three times per week to the SD-rat back part that caused scalp damage as the oxidized hairdye is as follow: We applied Pleuropterus multflorus cream to SD-rat whose scalp was damaged by oxidized hairdye. In contrary to control group, erythema and edema appeared in first 2~4 weeks which completely alleviated in week 6~8. We also conducted a patch test on 20 people to investigate allergic reaction of Pleuropterus multflorus cream. As a result, P.I.I was 0.072, which is equivalent to non-irritation reaction, thus proving rare existence of skin irritation. Therefore, the study confirmed safety of Pleuropterus multflorus cream and alleviation effect on scalp damage through basic level test.

오가피 메탄올 추출물의 기능성 화장품 소재 가능성 연구

반효정 ( Hyo Jeong Ban ),김미연 ( Mi Yeon Kim ),고경숙 ( Kyoung Sook Ko ) 대한미용문화예술학회 2013 대한미용문화예술학회지 Vol.2 No.2

With the recent well-being craze and the growing preference for organic foods, various plant resources with functional effects such as antioxidant, antibacterial, anti-inflammatory, and whitening properties are being developed, in order to produce a functional, natural cosmetic material for cosmetics. The present researcher studied Acanthopanax sessiliflorus seeman as a material for functional cosmetics and came up with the following findings. The extraction yield of Acanthopanax sessiliflorus seeman methanol was found to be 6.95%. The total flavonoid content was found to be 3.393 ± 5.48 ㎎(TAE)/g. In the DPPH radical scavenging activity measurement, the scavenging activity was over 91.49% at a concentration of over 0.25%, which was on the same level as BHT, an existing antioxidant. Measurements of the cytotoxicity of the NIH/3T3 cell revealed that there was no cytotoxicity but the growth of the cell increases proportionally according to the treatment concentration. After the scavenging activity was measured for the nitrite by causing a reaction in pH of 1.2, it was found that there was similar scavenging activity to that of BHT, as with the scavenging activity of the DPPH radical. Concerning Staphylococus aureus and staphylococcus epidermidis, when the antibacterial ability of the Acanthopanax sessiliflorus seeman methanol extract was measured, it was found that the clear zone increased proportionally according to the increase in the concentration of the extract. From this, it was confirmed that antibacterial activity is dependent on the concentration. From the aforementioned research findings, the Acanthopanax sessiliflorus seeman methanol extract is deemed to have potential as a functional cosmetic material with antioxidant, anti-inflammatory and antibacterial properties.

적하수오 메탄올 추출물의 항산화 활성

반효정 ( Hyo Jeong Ban ),고경숙 ( Kyoung Sook Ko ) 대한미용문화예술학회 2012 대한미용문화예술학회지 Vol.1 No.1

The present experiments were carried out to develop new antioxidants from methanol extract of Polygoni mulitiflori Radix concerning total polyphenol and flavonoid content, scavenging activities on DPPH and ABTS radicals, SOD-like activities. Methanol extracts from Polygoni mulitiflori Radix showed higher level of total polyphenol content, and the flavonoid content was the highest. And showed higher level of scavenging activities on DPPH and ABTS. However, methanol extracts from Polygoni mulitiflori Radix showed SOD-like radical activity was the low.

요추 추간판 탈출증 환자의 보존적 치료결과와 흡연의 상관성에 대한 임상적 고찰

반효정(Hyo-Jung Bahn),김석(Seok Kim),윤현석(Hyun-Seok Yoon),김한겸(Han-Kyum Kim),김선민(Sun-Min Kim),김지용(Jee-Yong Kim),김태헌(Tae-Hun Kim),박병윤(Byoung-Yoon Park) 척추신경추나의학회 2010 척추신경추나의학회지 Vol.5 No.2

Objectives : To investigate the association between cigarette smoking and clinical outcomes of conservative treatment for lumbar herniated disc. Methods : We reviewed 74 male patients with lumbar herniated disc who were hospitalized at the Jaseng Oriental Medicine Hospital. 74 patients were divided into 2 groups(smokers, non-smokers) and we measured age, ODI score, SF-36 score, VAS. Results : Between smokers and non-smokers, statically significant differences were found in clinical symptoms on the time of 6 months later, effective scores of treatments, value of ODI and value of VAS on the time of 6 months later. And in these values of measurements, non-smokers were higher than those of smokers. Conclusion : These results suggest that possibility of the association between cigarette smoking and clinical outcomes of conservative treatment for lumbar herniated disc.

黃芩이 척수압박손상 흰쥐의 척수신경세포 자연사에 미치는 영향

반효정 ( Hyo Jung Bahn ),조종진 ( Jong Jin Jo ),김범회 ( Bum Hoi Kim ),박성하 ( Seong Ha Park ),신정원 ( Jung Won Shin ),김성준 ( Seong Joon Kim ),손낙원 ( Nak Won Sohn ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.4

Objectives: This study was performed to evaluate the effects of Scutellariae Radix(SR) water-extract on the tissue and neuronal apoptosis of the spinal cord injury(SCI). Methods: SCI was induced by mechanical contusion following laminectomy of 10th thoracic vertebra in Sprague-Dawley rats. SR was orally given once a day for 7 days after SCI. Neuronal apoptosis was examined with terminal deoxynucleotidyl transferase-mediated dUTPnick-end labeling(TUNEL) assay. Bax (Bcl-2-asociated X protein), Bcl-2(B-cell blastoma 2), c-Fos(FBJ osteosarcoma oncogene) expressions were examined using immuno-histochemistry. Individual TUNEL and immuno-labeled cells expressing Bax, Bcl-2 and c-Fos were counted on the same level in peri-damaged region and in ventral horn. Results: 1. SR significantly reduced number of TUNEL labeled apoptotic cells induced by the spinal cord contusion injury. 2. SR significantly reduced Bax positive cells expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury. 3. SR strengthened Bcl-2 expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury. 4. SR reduced c-Fos expression on the motor neuron in the ventral horn induced by the spinal cord contusion injury. Conclusions: These results suggest that SR plays an inhibitory role against neuronal apoptosis and has significant effects for locomotor dysfunction induced by SCI.

염색 시술 시 포공영 샴푸 처리에 따른 모발 손상도 및 색상도 변화 연구

반효정(Hyo-Jeong Ban),고경숙(Kyoung-Sook Ko) 한국인체미용예술학회 2015 한국인체미용예술학회지 Vol.16 No.4

This study aimed to produce a shampoo with using extract of Taraxacum Herba and to develop hair care products. For this, changes in the degree of hair damage and hair color were observed by washing dyed hair with an oxidized hair dye to verify the efficacy of the Taraxacum Herba shampoo. For accurate verification, a comparative analysis was conducted using various shampoos on the market. After dyeing test hair with the oxidized hair dye, they were washed with each shampoo. The shampoos manufactured by ‘A’ were divided into regular shampoo, color care shampoo, conditioning shampoo and Taraxacum Herba shampoo and comparatively analyzed. In terms of tensile strength, the hair washed with the Taraxacum Herba shampoo was the greatest, followed by the conditioning shampoo, color care shampoo and regular shampoo. According to the analysis of hair components, in terms of sulfur contents, hair washed with the Taraxacum Herba shampoo was the highest, followed by the conditioning shampoo, color care shampoo and regular shampoo. In terms of hair damage measured using the MB dye method, hair washed with the Taraxacum Herba shampoo was the weakest, followed by the conditioning shampoo, color care shampoo and regular shampoo. In terms of the degree of hair color in which L* values were comparatively analyzed, hair washed with the regular shampoo was the brightest, followed by the conditioning shampoo. The color care shampoo and Taraxacum Herba shampoo were less bright, relatively. The said results found that when the Taraxacum Herba shampoo was used after hair dyeing, hair damage and loss of hair color were minimized. Therefore, it was shown that the Taraxacum Herba shampoo has a positive effect on dyeing properties as well.

시스테인 펌제 시술시 포공영 헤어미스트 전처리가 모발에 미치는 영향

반효정 ( Hyo Jeong Ban ),김은영 ( Eun Young Kim ),고경숙 ( Kyoung Sook Ko ) 대한미용문화예술학회 2015 대한미용문화예술학회지 Vol.4 No.1

This study verified the degree of hair injury prevention effect of hair mist manufactured with Taraxaci Herba when it is applied as pre treatment agent at the time of permanent wave treatment with cysteine composition. In order to verify the effect of Taraxaci Herba hair mist, this study conducted experiments by classifying them into C1 in which only permanent wave was treated on virgin hair, C2 in which pre treatment with hair mist base was followed by permanent wave treatment and C3 in which pre treatment with Taraxaci Herba hair mist was followed by permanent wave treatment. As major ingredients of permanent wave composition, cysteine was used for 1st composition and sodium bromated was used for 2nd composition. As the result of measurement of hair thickness, C3``s hair was the thickest while C1``s hair was the thinnest, and as the result of measurement on the degree of hair damage with observation on minute structures of cuticles and Methylene blue dyeing method, C3``s damage was the lightest while C1``s hair damage was the most severe. Judging from the fact that hair mist base does not greatly reduce the damage when compared with Taraxaci Herba hair mist, it was confirmed that hair mist base only helps useful ingredients of Taraxaci Herba effectively penetrate into the inside of hair but does not have other independent functions. Therefore, it was verified that pre treatment with Taraxaci Herba hair mist at the time of permanent wave helps maintain healthy hair.