[박송이 신작시] 입덧 외 2편

박송이 천년의시작 2018 (계간)시작 Vol.17 No.3

Oocyte에서 p63에 의해 활성화되어 세포사멸을 일으키는 target gene들에 대한 연구

박송이 이화여자대학교 스크랜튼대학 스크랜튼학부 2012 ATE Vol.2 No.-

HepG2 세포에서 커큐민의 mTOR와 COX-2 경로 억제를 통한 Apoptosis 조절

박송이,정다운,김영민,박옥진 대한암예방학회 2011 Journal of cancer prevention Vol.16 No.2

Curcumin, a phytochemical claimed to be an effective cancer preventive effect, possibly through apoptosis. This study approached to address the mechanism for inducing apoptosis and the consequences of the treatment on the important signals of cancer cell control-mTOR (phospho-mammalian target of rapamycin) and COX-2 (cyclooxygenase-2). In curcumin-treated HepG2 hepatocarcinoma cells, the inhibition of cancer cell proliferation and the induction of apoptosis were observed. In order to explore the relationship between the decrement of p-mTOR and COX-2 expression induced by curcumin and the observed the inhibition of cell growth and the induction of apoptosis, the HepG2 cancer cells were treated with mTOR inhibitor rapamycin and COX-2 inhibitor, celecoxib respectively or in combination with curcumin. The greater decreased cell proliferation and the increased apoptosis were noticeable in the combination treatments of rapamycin and curcumin or celecoxib and curcumin. The depressed expressions of both mTOR and COX-2 were observed under the treatment of rapamycin alone or in combination of curcumin and rapamycin. However, the treatment of celecoxib alone was not resulted in the decreased mTOR expression even though the combined treatment of curcumin and celecoxib decreased COX-2 as well as mTOR. These results suggest that curcumin deareases cell proliferation and induces apoptosis by inhibiting p-mTOR and COX-2, and the inhibition of mTOR can modulate the expression of COX-2but the inhibition of COX-2 may not influence mTOR. (Cancer Prev Res 16, 118-125, 2011)

Dy₂O₃, DyF₃ 분말 첨가에 따른 Nd-Fe-B 소결자석의 미세구조와 자기적 특성 변화의 상관관계 연구

박송이,김태훈,이성래,남궁석,장태석 한국자기학회 2011 한국자기학회 학술연구발표회 논문개요집 Vol.2011 No.6

Control of AMP-activated Protein Kinase, Akt, and mTOR in EGCG-treated HT-29 Colon Cancer Cells

박송이,Yun-Kyoung Lee,김영민,박옥진,신장인 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.1

Suppressing the mammalian target of rapamycin (mTOR) pathway has emerged as an attractive method for controlling cancer growth and preventing cancers. Epigallocatechin-3-gallate (EGCG) is a well-known chemopreventive polyphenol, and its effects on AMP-activated protein kinase (AMPK) activation were previously reported. In this study the regulatory mechanisms of EGCG on mTOR and Akt, 2 cancer survival signals, and the interrelationships among mTORC1, Akt, and AMPK were examined. It was found that the suppression of mTORC1by EGCG requires signals from AMPK, however, the inhibition of Akt with EGCG seems to be AMPK independent. Further, there was no clear indication of Akt as an upstream regulator of mTOR in EGCG treated HT-29 colon cancer cells.

옥상

박송이 고요아침 2023 열린시학 Vol.28 No.1

Clinical performance of medical students in Korea in a whole-task emergency station in the objective structured clinical examination with a standardized patient complaining of palpitations

박송이,공현희,김민정,윤유상,이상화,임선주,서지현 한국보건의료인국가시험원 2020 보건의료교육평가 Vol.17 No.-

This study assessed the clinical performance of 150 third-year medicalstudents in Busan, Korea in a whole-task emergency objective structured clinical examination station that simulated a patient with palpitations visiting the emergency department. The examination was conducted from November 25 to 27, 2019. Clinical performance was assessed as the number and percentage of students who performed history-taking (HT), a physical examination (PE), an electrocardiography (ECG) study, patient education (Ed), and clinical reasoning (CR), which were items on the checklist. It was found that 18.0% of students checked the patient’s pulse, 51.3% completed an ECG study, and 57.9% explained the results to the patient. A sizable proportion (38.0%) of students did not even attempt an ECG study. In a whole-task emergency station, students showed good performance on HT and CR, but unsatisfactory results for PE, ECG study, and Ed. Clinical skills educational programs for subjected student should focus more on PE, timely diagnostic tests, and sufficient Ed.

소아 뇌척수액 검사 시 진정제 및 진통제 사용 : 응급의학과와 소아청소년과 전공의의 경험 및 태도 조사

박송이,서준석,김도균 대한응급의학회 2010 大韓應急醫學會誌 Vol.21 No.1

Purpose: The purpose of this study was to compare the patterns of clinical practice in procedural sedation and analgesia (PSA) during lumbar puncture (LP) between the emergency medicine residents (ER) and the pediatric residents (PR), and to evaluate factors that impeded decisions to use sedation and analgesia during LP. Methods: The survey was sent to ER and PR in a tertiary referral hospital. The survey inquired about clinical practice patterns, experience of PSA training, current administration of PSA during LP and factors that influence PSA use. Results: Sixteen ER and nineteen PR completed the survey. PR were more confident in LP skill than ER. ER used topical analgesic cream and injectable lidocaine more frequently than PR. The most influential factor in PR administering systemic sedative was the concern of respiratory compromise. PR reported less training opportunities during residency than ER. Conclusion: Both ER and PR under-administered sedation and analgesia for LP in pediatric patients. ER were administering more injectable lidocaine and topical analgesic cream for LP in children compared to PR. In spite of the increased ER training opportunities, there are rooms for improvement in the practice of sedation and analgesia.

3D 프린팅 된 서베이드 금관과 금속 프레임워크를 이용한 양악 가철성 의치 수복 증례

박송이,박상원,박찬,장우형,윤귀덕 대한치과보철학회 2023 대한치과보철학회지 Vol.61 No.2

Computer-aided design–computer-aided manufacturing technology has been widely used in the manufacture of fixed prostheses including implants, but in the case of removable dentures, the analog method is still being used due to the errors such as a lack of fusion and over-fusion in selective laser meting process. With the recent development of CAD software, virtual surveying and framework design are made possible, and the designed file can be manufactured by milling or 3D printing. It replace the analog method of waxing and denture curing process and also can reduce the production time and cost. Therefore, this case is reported because good clinical results were obtained by digitally surveying on CAD software to produce a surveyed metal restoration and framework on maxillary and mandibular removable dentures. 임플란트를 비롯한 고정성 보철물 제작에 있어서 Computer-aided design-computer-aided manufacturing 기술이 많이 사용되어 왔지만 가철성 의치의 경우 Selective laser melting 방식의 레이저 분말의 융합과정에서 오차가 생기면 융착 부족이나 과융합 등의 오차가 발생하여 정밀도를 크게 손상시킬 수 있어 여전히 기존의 아날로그 방식의 제조법을 사용하고 있다. 최근 CAD 소프트웨어의 발달로 가상의 서베잉과 프레임워크의 디자인이 가능해지고 이렇게 디자인된 형태를 밀링이나 3D 프린팅과 같은 방식으로 제작할 수 있게 되면서 전통적인 의치제작 방식 중 납형 제작이나 온성과 같은 과정을 대체할 수 있게 되었고, 제작 소요되는 시간과 비용을 줄일 수 있다. 따라서 본 증례는 CAD 소프트웨어 상에서 디지털 서베잉을 시행하여 서베이드 금속도재관을 제작하고 금속 프레임워크를 디자인하여 이를 3D 프린팅 하는 디지털 방식의 상하악 가철성 의치를 제작하여 좋은 임상 결과를 얻었기에 보고하는 바이다.

다지표 잠재성장모형에서 요인동일성과 요인척도 설정의 문제: 모형 적합도와 모수 추정값에 미치는 영향

박송이,장승민 한국심리학회 2018 한국심리학회지 일반 Vol.37 No.1

The multiple-indicator latent growth model (MI-LGM) is a second-order confirmatory factor model that analyzes latent trajectories of a factor measured by multiple indicators over time. Although MI-LGM can test the factorial invariance of indicators and estimate trajectories of a latent variable controlling measurement error, model fit and parameter estimates of the model may vary depending on factor scaling methods. The purpose of this study is to investigate how factor scaling methods, given a specified level of factorial invariance, change the meaning of the factor mean and thus affects the model fit and parameter estimates of MI-LGM. The authors first explored how factorial invariance and factor scaling affect the definition of factor means and the model fit in longitudinal factor analysis models. Next, they showed that constraining the sum of the indicator’ intercepts to zero creates a clear definition of the factor mean and the constraint provides consistent results and interpretation of the means of growth factors in the MI-LGM even under the weak factorial invariance. An analysis of actual panel data then illustrated such characteristics of the MI-LGM. Finally, the authors discussed the importance of factorial invariance and factor scaling in the analysis of mean and covariance structure models and that of using the strong factorial invariance when modeling the MI-LGM. 다지표 잠재성장모형(LGM)은 여러 관측변수에 의해 측정되는 요인의 시간에 따른 변화 궤적을 2차 요인모형을 이용하여 분석하는 모형이다. 다지표 LGM은 여러 가지 장점에도 불구하고 요인척도법에 따라 모형 적합도와 모수 추정값이 달라지는 문제를 가지고 있다. 본 연구는 다지표 LGM에서 요인동일성의 수준과 요인척도의 설정 방식에 따라 요인 평균의 의미가어떻게 달라지는지를 규명하고, 요인척도의 설정이 다지표 LGM의 모형 적합도와 모수 추정값에 어떻게 영향을 미치는지를 확인하였다. 먼저 종단 요인분석 모형에서 요인동일성 제약과 요인척도법에 따라 요인 평균이 어떻게 정의되는지와 모형 적합도가 어떻게 달라지는지논의하였다. 또한 절편의 합을 0으로 제약하는 설정이 요인 평균을 어떻게 정의하는지 밝히고, 이러한 제약이 약한 요인동일성을 가정한 다지표 LGM의 성장 요인 평균에 대해 일관적인 분석 결과와 해석을 제공한다는 것을 제시하였다. 이어서 패널 자료를 이용한 실제 자료의 분석을 통해 이와 같은 다지표 LGM의 특징을 예시하였다. 끝으로 평균공분산구조 모형의분석에서 요인동일성과 요인척도 설정의 중요성과 다지표 LGM에서 강한 요인동일성 모형을사용하는 것의 중요성에 대해 논의하였다.