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공기업 수명주기 분류변수 도출을 위한 기초연구 : 준시장형 SOC 공기업을 대상으로
박동선,신완선 한국산업경영시스템학회 2014 한국산업경영시스템학회지 Vol.37 No.4
The enterprise life cycle derived from the product life cycle consists of introduction, growth, maturity and decline. The enterprise tries to reach the growth stage early and stay at the maturity stage stably through expanding its businesses and investing for the new technology. The public enterprise is not different but its life cycle is more prone to be affected by the national development and policy. A typical example can be found in the case of the quasi market SOC public enterprise which spends massive amount of fund to provide social infrastructure. After the fulfillment of its mandated mission it is exposed to the pressure of a merger or a closure usually because large portion of the debt is directly linked to the national financial stability and credit ratings. This research is focused on the variables that influence the life cycle of the quasi market SOC public Enterprise for its future competitiveness is in connection with its normalization, advancement and rationalization. In this respect, categorical variables system centering on public characteristics and profitability drew eight categorical variables such as policy outcomes, public benefit, finance and business values etc.
박동선,Park, Dong-Seon 한국정보처리학회 1997 정보처리학회논문지 Vol.4 No.2
본 논문에서는 클래스내부와 클래스간의를 확정하게 제어할 수 있는 랜덤 프로세스 모델을 제어하는 프리세스 내부의 파라메다들을 변화시키며, 프로세스간의 통계적인 차이와 랜덤 잡음을 변화시켜 학습을 위한 패턴들을 생성한다. 이 랜덤 프로세스 모델에서 생성된 패턴들을 이용하여 역전파알고리즘으로 학습된 다단 신경망의 성능 성능을 평가한다. 평가 실험결과는 패턴 분류문제에서 일반화된 통계적인 거리가 분류문제의 난이도에 대한 좋은 예측기가 되는 것을 보여 준다. 또한 본 논문에서는 다단신경망의 성능과 베이스패턴분류기의 성능을 비교하기 위하여 베이스분류기의 이론적인 성능분석과 모의실험을 통한 평가를 하였다. 다단신경망의 분류성능이 이론적인 성능과 실헝치와 매우 근사하며 그 두 성능 중간에 위치함을 발견하였다. We describe a random prcess model that prvides sets of patterms whth prcisely contrlolled within-class varia-bility and between-class distinctions.We used these pattems in a simulation study wity the back-propagation netwoek to chracterize its perfotmance as we varied the process-controlling parameters,the statistical differences between the processes,and the random noise on the patterns.Our results indicated that grneralized statistical difference between the processes genrating the patterns provided a good predictor of the difficulty of the clssi-fication problem. Also we analyzed the performance of the Bayes classifier whith the maximum-likeihood cri-terion and we compared the performance of the neural network to that of the Bayes classifier.We found that the performance of neural network was intermediate between that of the simulated and theoretical Bayes classifier.
A Dunnione Compound MB12662 Improves Cisplatin-Induced Tissue Injury and Emesis
박동선,조인근,장자영,곽태환,유상구,전정희,최흔경,주성수,김옥진,김윤배 한국응용약물학회 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.5
The present study was aimed to investigate the effects of MB12662, a synthetic dunnione compound, on cisplatin-induced vomiting reflexes and intestinal, renal, immune system, and hematopoietic toxicities in ferrets and mice, respectively. Male ICR mice were orally administered MB12662 (5, 10, 25 or 50 mg/kg) for 10 days, during which intraperitoneally challenged with cisplatin (3.5 mg/kg) from day 4 to 7, and sacrificed on day 10 for the pathological examination. Male ferrets were orally administered MB12662 (25, 50 or 100 mg/kg) for 7 days, subcutaneously challenged with cisplatin (5 mg/kg), and monitored for vomiting reflexes and survival of the animals. Four-day injection of cisplatin (3.5 mg/kg) to mice caused body weight loss and degeneration and atrophy of intestinal villi, reducing villi/crypt ratio to a half level of control animals. Cisplatin also induced renal and hepatic toxicities, and depletion of splenocytes and bone marrow progenitor cells. The systemic toxicities including decreased villi/crypt ratio, immune system atrophy, splenocyte depletion, and decreased cellularity in bone marrow were improved by MB12662. Cisplatin (5 mg/kg) induced retching and emetic responses of ferrets, which were remarkably attenuated by MB12662 in a dose-dependent manner. All the ferrets pretreated with MB12662 survived the challenge of cisplatin, in comparison with 40% mortality in vehicle-treated animals, and blood parameters of nephrotoxicity and hepatotoxicity were markedly recovered. It is expected that MB12662 could be a candidate for the body protection against burden, including emesis, of chemotherapeutic agents.
A Case of Acute Colonic Diverticulitis as a Complication of Colonoscopy
박동선,박지원,김성열,장길수,홍은영,안정선,김소연,백일현,김종혁,박충기 대한장연구학회 2013 Intestinal Research Vol.11 No.2
Colonoscopy is a good diagnostic tool and facilitates treatment of various colonic diseases. Nevertheless, it can induce many serious complications such as perforation and hemorrhage. Diverticulitis has also been reported as a serious complication of colonoscopy, with an incidence ranging from 0.04% to 0.08%. A 44-year-old male with chronic hepatitis B was presented with general weakness, myalgia, and febrile sensation. After admission for evaluation, pneumonia detected in the left upper and lower lobe and treated. We performed colonoscopy for screening and found multiple colonic diverticula in the right side of the colon. After 48 hours, the patient complained of abdominal pain and febrile sensation. Physical examination revealed tender-ness in the right side of the abdomen. Abdomen-pelvis computed tomography showed bowel wall thickening of the cecum and ascending colon and multiple inflamed diverticula at the cecum with pericolic fat infiltration and fluid collection. We diagnosed the patient with acute diverticulitis after colonoscopy. Thereafter, he was treated with bowel rest and broad-spectrum intrave-nous antibiotics, and recovered. With a review of the relevant literature, we report a case of acute colonic diverticulitis as a com-plication of colonoscopy. (Intest Res 2013;11:146-148)
신부전 환자에서 치료 내시경술 후 발생한 십이지장 벽내 혈종과 혈복강 1예
박동선,신운건,김민관,이정아,허경미,김학양 대한소화기내시경학회 2007 Clinical Endoscopy Vol.34 No.5
Duodenal intramural hematoma is mostly caused by blunt abdominal trauma. It is also less commonly reported as a complication of anticoagulation therapy or as a blood dyscrasia, and as a complication of diagnostic/ therapeutic endoscopy. The presentation of these patients is abdominal pain, vomiting, fever and hematochezia, and this is rarely accompanied with intestinal obstruction, severe pancreatitis and acute peritonitis as its complications. The diagnosis is made clear by performing abdominal ultrasonography and abdominal computed tomography. We reported here on one case of intramural duodenal hematoma and hemoperitoneum after performing endoscopic hemostasis in a chronic renal failure patient who was on maintenance hemodialysis. (Korean J Gastrointest Endosc 2007;34:269-273) 십이지장 벽내 혈종의 원인은 복부에 외상이 가해졌을 때 가장 흔하며 혈액 응고 장애 환자나 항응고제 사용 환자 그리고 내시경적 치료 후에 드물게 발생할 수 있다. 십이지장 벽내 혈종의 증상은 복통, 구토, 발열, 혈변 등이 있고 장폐색이나 복막염, 췌장염 등의 합병증을 동반하기도 한다. 진단은 전산화 단층 촬영 및 복부 초음파 등으로 하며 장폐색이나 복막염의 합병증이 없고 환자의 전신 상태가 양호한 경우 보존적 치료만으로 대부분 회복된다. 저자들은 토혈을 주소로 내원한 말기 신부전 환자에서 십이지장 궤양의 내시경적 지혈술 후 발생한 십이지장 벽내 혈종과 혈복강이 보존적 치료로 호전된 1예를 경험하였기에 문헌 고찰과 함께 보고한다.