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문형배,이영규,김홍곤,김삼봉,한원철 대한부인종양 콜포스코피학회 1994 Journal of Gynecologic Oncology Vol.5 No.2
Massive ovarian deema is a tate condition. It is a benign enlargement of the ovary caused by accumulation of fluid, which is thought to result from intermittent partial torsion of the ovarian pedicle. Histologically, the ovaries were characterized by diffuse edema of medulla and inner cortex. Two cases of massive ovanan edema are reported with brief review of the literatures.
문형배,이정균 圓光大學校 醫科學硏究所 1993 圓光醫科學 Vol.9 No.1-2
This study was aimed at examining the culture incidence and histological findings of the malignant tumors on the collagen gel in vitro. The malignant tumors of the experimental anima(malignant fibrous histiocytoma of the rat, malignant melanoma of the mice) and human malignant tumors(lung, stomach, breast, cervix, lymphoma, colon, hepatoma) were cultured on the collagen gel which was soaked by RPMI-1640 with 10% fetal calf serum in the humidified 5% CO_2 incubator. The cultured tumor tissues were examined by the light microscope or inverted microscope under the unstained condition and by use of H & E stain or histochemical stain(PAS, alcian blue-pH 2.5). 1. The culture incidence was 80% (8/10) in the malignant tumors of the experimental animal and 50% (15/30) in the human malignant tumors. 2. The malignant cells were attached to the adjacent collagen matrix and histological pattern of the cultured cells were nearly same as original tumor tissue. 3. There were same morphological findings and histochemical reactions between original tumor cells and cultured cells ; melanin pigments in the malignant melanoma and PAS or alcian blue reactions in the gastric adenocarcinoma or ductal carcinoma of the breast.
HBx형질전환 생쥐에서 발생한 간세포암종에서 H-ras 및 c-myc의 발현에 관한 연구
문형배,소병준,김학철,윤기중,한원철,조향정,유대열,정영진 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2
<연구목적> HBx형질전환 생쥐에서 발생한 간세포암종의 발암과정에 종양유전자(H-rgs, c-myc)의 발현 정도를 조사하고자 하였다. <연구방법> 정상생쥐 12마리(4-18개월) 및 HBx 형질전환 생쥐 44마리(4-18개월)를 대상으로 포르말린에 고정하고 파라핀에 포매한 간 조직을 이용하여 면역조직화학적염색을 실시하였다. 실험군은 정상 부위, 이형성 부위 및 종양 부위로 구분하였으며, 종양 부위는 소결절성병변 부위와 간세 포암종 부위로 구분하였고, 이형성병변 부위는 이형성병변만 발견되는 부위, 소결절성병변과 동반된 이형성병변 부위 및 간세포암종과 동반된 이형성병변 부위로 구분하였다. <연구결과> H-rgs의 발현은 정상 간조직에 비하여 이형성병변 부위(P<0.05) 및 종양 부위(P<0.01)에서 증가하였으며, 소결절성병변 부위과 간세포암종 부위 사이에서는 간세포암종 부위에서 증가된 경향이었으나 통계학적으로 유의한 차이가 없었으며, 각 이형성병변 부위 사이에서도 유의한 차이는 없었다. c-myc의 발현은 정상 간조직 및 이형성병변 부위에 비해 종양 부위에서 증가하였으며(P<0.001), 소결절성병변 부위와 간세포암종 부위에서는 비슷하였고, 각 이형성병변부위 사이에서도 비슷하였다. <결론> HBx형질전환 생쥐에서 발생하는 간세포암종의 발생에 H-rgs는 이형성 변화를 일으키는 시기에 관여하며, c-myc은 이형성병변에서 암으로 이행하는 시기에 관여할 것으로 생각한다. Background: This experiment was designed for the expression of H-ras and c-myc in hepatocarcinogenesis of the HBx transgenic mice. Methods: Immunohistochemical stains in the paraffin embedded tissue of the liver were used for the detection of H-ras and c-myc in the 12 normal mice and 44 HBx transgenic mice of the 4-18 month old. Results: Expression of the H-ras was significantly increased in the dysplastic area (P<0.05) and tumor area (P<0.01) than in the normal liver. But there were no differences of H-ras expression between areas of microscopically identified hepatocellular carcinoma (MI-HCC) and grossly identified hepatocellular carcinoma (GI-HCC) and dysplastic areas among the only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Expression of the c-myc was significantly increased in the tumor area (P<0.001) than in the normal liver and dysplastic area. But there were no differences of c-myc expression between areas of MI-HCC and GI-HCC, and dysplastic areas among only dysplastic areas, dysplastic areas with MI-HCC and GI-HCC. Conclusions: Our study suggests that H-ras is related to the dysplastic change and c-myc is related to the neoplastic change in the hepatocarcinogenesis of the HBx transgenic mice.
면역조직화학법에 의한 자궁경부암 및 자궁경부 상피내종양의 p53 단백검출
문형배,김기석,김흥곤,이희섭,홍기연,민부기,최기욱 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.1
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. p53 gene aberrations are common in human malignancies, and recent studies suggest that in cervical carcinoma p53 function is inactivated either by complex formation with human papilloma virus (HPV) E6 product or by gene mutation. To study the expression of p53 gene in the cervical cancer and cervical intraepithebal neoplasia, immunohistochemistry for the p53 protein was done in the 47 cases of squamous cell carcinoma, 6 cases of adenocarcinoma and 32 cases of cervical intraepithelial neoplasia. 1. The p53 protein was detected in the 31% of cervical intraepithelial neoplasia (10/32 cases). 2. The p53 protein was detected in the 55% of invasive cervical cancer (29/53 cases). 3. By the histologic type of cervical cancer, the p53 protein was detected in the 57% of squamous cell carcinoma (27/47 cases) and 33% of(2/6 cases) adenocarcinoma. The p53 protein wes more frequently detected in the squamous cell carcinoma than in the adenocarcinoma. 4. By the staging in cervical cancer, the p53 protein was detected in the 31% of stage 0, 50% of Stage Ia, 50% of stage I b, 75% of IIa and 50% of stage IIb.
문형배,김홍곤,신무철,김삼봉,윤기중 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.11
경화성 간질종양은 난소의 간질 세포에서 기원하는 섬유종, 난포막 세포종, 리포이드 세포종과 임상적 및 병리학적으로 뚜렷이 구분이 되는 소견을 보이는 비교적 희귀한 양성종양이다. 저자들은 원광대학교 의과대학 부속병원에서 경화성 간질종양 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Sclerosing stromal tumor is a rare tumor of ovary. The sclerosing stromal tumor differs from the fibroma, thecoma and lipoid ceil tumor both clinically and pathologically. We had experienced a case of sclerosing stromal tumor of the ovary. We present this case with a brief review of literatures.