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김진상,채수완,조규박,Kim Jin-Sang,Chae Soo-Wan,Cho Kyu-Park The Korean Society of Pharmacology 1995 대한약리학잡지 Vol.31 No.1
갑상선 기능 항진증 심장에서의 ${\beta}-adrenoceptor$의 역할은 잘 알려져 있으나 ${\alpha}-adrenoceptor$에 대해서는 알려져 있지 않은 바, 저자 등은 갑상선 기능 항진증 기니픽 심장의 유두근에서 일반 미세 전극과 이온-선택적 미세 전극을 이용하여 세포내 $Na^+$과 $H^+$ 활성도에 대한 phenylephrine의 영향을 연구하였다. Phenylephrine ($10^{-5}$ 또는 $3{\times}10^{-5}M$)에 의한 ${\alpha}_1-adrenoceptor$ 자극은 다양한 활동전위의 변동, 수축기 막전위의 과분극 ($1.5{\pm}0.1mM$), 세포내 활성도 증가 ($0.4{\pm}0.15mM$), 현저한 수축력 증가 ($220{\pm}15%$) 그리고 세포내 pH의 증가 ($0.06{\pm}0.002\;unit$)를 일으켰고, 이와 같은 변동이 prazosin과 atenolol에 의해 차단되었다. 그래서 이들 효과가 ${\alpha}_1-adrenoceptor$를 경유함을 알 수 있었고, 역시, 세포내 $Na^+$ 활성도와 수축력 증가 효과가 $Na^{+}-H^{+}$ 교환기 억제제인 ethylisopropylamiloride로 차단됨으로 보아 ${\alpha}_1-adrenoceptor$ 자극은 $Na^{+}-H^{+}$ 교환기를 자극하여 세포내 $a^{i}_{Na}$와 pH를 증가시킴을 시사한다. 이는 ${\alpha}_1-adrenoceptor$ 자극에 의한 세포내 $Na^+$감소와 초기 수축력 감소 효과를 나타내는 정상 기니픽 심장과는 매우 다른 결과로 갑상선 기능 항진증 심장에서 ${\alpha}_1-adrenoceptor$는 매우 중요한 기능을 갖고 있음을 의미한다. The roles of ${\beta}-adrenoceptor$ were well known in hyperthyroidal heart, but not with ${\alpha}-adrenoceptor$. So we studied the effects of phenylephrine on membrane potential, intracellular sodium activity ($a^{i}_{Na}$), twitch force, and intracellular pH ($pH_i$) by continuous intracellular recordings with ion-selective and conventional microelectrodes in the papillary muscles of hyperthyroid guinea pig heart. ${\alpha}_1-adrenoceptor$ stimulation by phenylephrine (10^{-5}\;or\;3{\times}10^{-5}M$) produced the following changes: variable changes in action potential duration, a hyperpolarization ($1.5{\pm}0.1mM$) of the diastolic membrane potential, an increase in $a^{i}_{Na}\;(0.4{\pm}0.15mM)$, a stronger positive inotropic effect ($220{\pm}15%$), an increase in $pH_i\;(0.06{\pm}0.002\;unit)$. These changes were flocked by prazosin and atenolol. This indicated that the changes in membrane potential, $a^{i}_{Na}$ twitch force, and $pH_i$ are mediated by a stimulation of the ${\alpha}_1-adrenoceptor$. Ethylisopropylamiloride ($10^{-5}$) also blocked the increase in $a^{i}_{Na}$ and twitch force. On the other hand, strophanthidin, tetrodotoxin, $Cs^+$ or verapamil did not block the increase in $a^{i}_{Na}$ and twitch force. Thus, it was suggested that ${\alpha}_1-adrenoceptor$ stimulation increased $a^{i}_{Na}\;and\;pH_i$ by stimulation of $Na^{+}-H^{+}$ exchange, thereby allowing intracellular alkalinization and $a^{i}_{Na}$ increase. These results were very different from euthyroidal heart which showed ${\alpha}_1-adrenoceptor$-induced decrease in $a^{i}_{Na}$ and initial negative inotropic effect. From the above results, it was concluded that ${\alpha}_1-adrenoceptor$ had a important role in hyperthy-roidal heart.
김진상,Kim, Jinsang- 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.11A
The edge and contour information are very much appreciated by the human visual systems and are responsible for our perceptions and recognitions. Therefore, if edge information is integrated during extracting video objects, we can generate boundaries of oects closer to human visual systems for multimedia applications such as interaction between video objects, object-based coding, and representation. Most of object extraction methods are difficult to implement real-time systems due to their iterative and complex arithmetic operations. In this paper, we propose a VLSI architecture integrating edge information to extract video objects for precisely located object boundaries. The proposed architecture can be easily implemented into hardware due to simple arithmetic operations. Also, it can be applied to real-time object extraction for object-oriented multimedia applications. 에지나 윤곽 정보는 인간의 시각 시스템에 의하여 가장 잘 인식되며 객체의 인식과 지각에 사용되는 중요한 정보이다. 그러므로 비디오내의 객체간의 상호작용, 객체기반 코딩과 표현과 같은 응용을 위하여, 비디오객체의 추출과정에 에지정보를 적용하면 인간의 시각 시스템과 근접한 객체 경계를 얻을 수 있다. 대부분의 객체추출 방식은 연산량이 많고 반복적인 연산을 수행하므로 실시간 처리가 어렵다. 본 논문에서는 비디오객체 분할 과정에 에지 정보를 적용하여 정확한 객체 경계를 추출하는 VLSI 구조를 제안한다. 제안된 하드웨어 구조는 연산방식이 간단하므로 하드웨어로 쉽게 구현될 수 있으며, 제안된 VLSI 하드웨어 구조를 이용하면 객체기반 멀티미디어 응용을 위하여 실시간으로 비디오객체를 분할할 수 있다.
김진상,신양규 한국자료분석학회 2008 Journal of the Korean Data Analysis Society Vol.10 No.2
We apply a sequential minimal optimization method to business questionnaire data for finding the most cost effective set of spots in the `above-the-line(ATL)' marketing. The resulting set of important spots can be used in many ATL marketing activities to promote companies' brand/image, specific products and services. Our method has been tested to various kinds of questionnaire data about cellular phones, TVs, supermarkets and auto- mobiles for its generality. One of the main findings of this paper is supervised learning can solve an optimal regression problem efficiently by using a sequential minimal optimization method. The other interesting result is a data filter to make a training data set's sheer size. Finally, not the least, our study is a real application that is used in decision-making system at a leading company in Korea.
金鎭相 啓明大學校 産業技術硏究所 1983 産業技術硏究所 論文報告集 Vol.4 No.-
In this paper, the method of the partial separation for Hangeul consonants and vowels and the recognition of Hangeul characters are proposed. Geometrical feature points are extracted from a handwritten Hangeul character image, and the direction of a stroke started from a feature point is quantized. From the basic stroke description, basic units, join units, and blocks are constructed. A block is the unit of Hangeul character recognition, and it can be used in the recognition of the types of Hangeul consonants and vowels on the basis of the inclusion, the up-down, and the right-left relation. An approach based on the U-tree is adapted to generate a unique code from each Hangeul character. It is shown that this method is available for the classification and discrimination of handwritten Hangeul characters.
金鎭相 啓明大學校 産業技術硏究所 1991 産業技術硏究所 論文報告集 Vol.14 No.1
The notion of common knowledge and belief plays and important role in such disciplines as artificial intelligence, economics, and politics. We investigate a formalization of common belief in first-order logic. Use of mutual belief, which is a variation of common belief is applied to construct a simple model for processing speech acts. The sketched system is under developing in Prolog.