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      • KCI등재SCOPUS
      • SCOPUSKCI등재

        내시경적 역행성 담췌관조영술 후의 발열에 대한 연구 - 위험인자와 예방적 항생제 사용 효과 분석 -

        서승오(Seong O Seo),천재희(Jae Hee Chun),상균(Sang Kyun Kim),진(Jin Kim),장유현(Yoo Hyun Chang),용태(Yong Tae Kim),윤용범(Yong Bum Yoon),정룡(Chung Yong Kim) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3

        Background/Aims : Fever and cholangitis can be serious complications after endoscopic retrograde cholangiopancreatography (ERCP). The risk factors of these complications and the efficacy of prophylactic antibiotics are not clearly verified yet. In this study, we investigated the frequency, risk factors, pathogens of the fever after ERCP, and evaluated the effect of prophylactic antibiotics. Methods : Retrospective analysis was performed on 674 patients who underwent ERCP between 1996 and 1999. Results : Fever after ERCP occurred in 68 of 674 cases (10.1%). Twenty-six kinds of bacteria were isolated in 23 of 68 febrile cases (33.8%). Fever occurred more frequently in patients (33.4%) in whom therapeutic ERCP failed to remove common bile duct (CBD) stones or to drain obstructed bile duct than in patients (7.3%) with effective drainage (p<0.001). Therapeutic procedure after ERCP caused fever more frequently (16.7%) than diagnostic ERCP only (4.2%)(p=0.03). Moreover, fever was also developed frequently after endoscopic retrograde biliary drainage (ERBD). Prophylactic administration of more than 2 kinds of antibiotics can reduce the rate of fever occurrence after ERCP. Conclusions : Therapeutic ERCP procedures especially after ERBD or unsuccessful biliary drainage were the high risk factors for fever after ERCP. Prophylactic antibiotic treatment using more than two kinds of antibiotics can reduce the incidence of the fever after ERCP. (Kor J Gastroenterol 2000;36:390 - 397)

      • KCI등재
      • KCI등재

        청소년의 자아존중감이 자살생각에 미치는 영향

        한솔(Han-sol Kim),염동문(Dong-mun Yeum),장유미(Yu-mi Jang) 충남대학교 사회과학연구소 2019 사회과학연구 Vol.30 No.1

        The purpose of this study was to examine the types of interpersonal stress among adolescents through the potential profile, to examine the influence of each type and characteristics, and to examine the role of interpersonal stress in the relationship between self - esteem and suicidal ideation. The subjects of this study included 3,331 high school students from the ‘2013 Child and Adolescent Mental Health Survey’ conducted by the Korea Youth Policy Institute. Study findings were as follows. First, subjects who answered low levels of stress on questionnaires were classified as the low stress type, and moderate stress type included students who answered moderate levels on the questionnaire. Intrafamilial stress type was defined as featuring high stress levels concerning questions on relationship with parents, brothers and sisters. Extrafamilial stress type was characterized a high stress levels with questions on relationship with friends, members of the opposite sex, seniors, juniors, and teachers. Second, a characteristic variable having an effect between types was checked by carrying out multinomial logistic regression analysis. Third, with regard to testing the interpersonal stress mediation effect, the low stress, moderate stress and intrafamilial stress types produced a partial mediation effect. In addition, the test showed that extrafamilial stress type had a full mediation effect. Based on this, the implications and limitations of this study as well as directions for follow-up studies were provided.

      • KCI등재

        브라질 상파울루 시의 배출량 규제 정책과 대기오염물질 변화 연구

        장유운(Jang, Yu Woon),이강웅(Lee, Gangwoong),이태형(Lee, Taehyoung),영성(Ghim, Young Sung),정환(Kim, Jeonghwan),병곤(Kim, Byung-Gon) 한국외국어대학교 중남미연구소 2018 중남미연구 Vol.37 No.2

        본 연구는 상파울루 시의 대기질 저감정책에 따른 대기질의 변화를 연구하였다. 상파울루 시는 차량에서 배출되는 오염물질을 규제하기 위하여 PROCONVE (Programa de controle de emissões veiculares)라는 배출량 제어 정책을 시행하고 있다. PROCONVE 정책을 수행하면서 차량에 의해 대기로 배출되는 일산화탄소(CO)와 질소산화물(NOx) 감축량에 따라 대기중 CO와 NOx 성분도 감소하였다. 그러나 미세먼지(PM10)는 차량 이외에도 산업시설과 2차 에어로졸 생성으로 발생할 수 있어서, PM10의 정책 감축 효과는 대기 중 PM10의 33% 인 것으로 평가되었다. 상파울루 시에서 NOx와 CO 그리고 PM10의 시간 변화는 멕시코시티와 산티아고 시의 출퇴근시간에 증가하는 특성과 달리 새벽에도 고농도로 분포하였다. 상파울루 시에서는 정책적으로 PROCONVE의 차량 오염물질 배출량을 제어함으로 1차 대기오염물질 감소와 함께 광화학 오염물질인 지표면 오존(O₃) 감소에도 기여하였다. This study investigated the change of air quality in Sao Paulo, Brazil, which has implemented an emissions control policy called PROCONVE (Programa de controle de emissões veiculares) to regulate pollutants emitted from vehicles. Through PROCONVE, the quantitative decrease of atmospheric carbon monoxide (CO) and nitrogen oxide (NOx) components matched the reduction level of both components emitted by vehicles. However, PM10 emission sources, in addition to vehicle emissions, also include industrial facilities and secondary aerosols, which caused the decrease of PM10 emissions from vehicles only to contribute 33% of the reduction in atmospheric PM10 concentration. Diurnal variation of NOx, CO, and PM10 concentration in Sao Paulo was high at dawn, unlike the increase shown during the rush hours in Mexico City and Santiago. In Sao Paulo, regulation of pollutant emissions through PROCONVE has contributed to the decrease of primary air pollutants as well as the reduction of surface photochemical ozone (O₃).

      • KCI등재

        최신 IMO 전략계획 분석을 통한 대응 역량 강화 방안연구

        찬란(Chan-Ran Kim),장유락(You-Rak Jang),이윤철(Yun-Cheol Lee) 한국해사법학회 2017 해사법연구 Vol.29 No.3

        The IMO establishes internationally agreed rules and standards to ensure maritime safety and security and protect marine environment. It solidly achieves its role such as having over 172 member states representing over 99% of world tonnage and establishing numerous convention with high ratification so far. However, IMO is consistently expected to revise or establish convention due to an expansion of world trading and development of technology and some issues arose from a compliance of existing conventions. Therefore, Organization establishes and implements specific method to enhance an efficiency of the organization with a relatively limited internal organization and budget despite of wide scope of their missions and challenging situation. This specific method is consists of strategic directions and strategic plan representing trend, development and challenge for 6 years and output for 2 years to achieve 6 years plan efficiently. An adopted strategic plan is a base of all of organization s activities and IMO only works within strategic plan so that Strategic plan is a good guideline to prospect next step of IMO. Especially, in the middle of a big change of regulating and standardizing new international regulations and rules arising from the 4th revolution, which shifted a paradigm that regulation transforms industry and create new industry such as E-Navigation and development of high-efficiency and Eco-friendly technology and autonomous vessel, a submission of proposal for outputs by member states become more important. If a proposal which was developed and submitted on a basis of fully-understanding of Strategic plan, same direction with IMO and a strength of their shipping industry, it is possible to lead to economic benefits and reputation and greater influence in a shipping industry. Therefore, an analysis on application of the strategic plan and the high-level action plan of the organization A.1099(29) and newly adopted strategy, planning and reform, report of the working group on the development of a new strategic framework and on how other member states coping with IMO and its response structure was carried out and in this respect, I suggest that firstly, research activity based on IMO s TDC by maritime industry and all related research center, secondly, re-organization of maritime affairs and safety policy bureau in Korea Ministry of Oceans and Fisheries, thirdly, formation of regional or political union as a possible and suitable agenda to be developed and a plan for enhancing capability of respond to IMO with Korea shipping·shipbuilding industry s strength. In result, it will be possible to carry out a duty as a one of member of A group council and the IMO Secretary-General s country for the international maritime safety and marine environmental protection. Also, it will strengthen the competitiveness of the domestic maritime industries by leading an establishment of new technological rules, including maritime, shipbuilding 국제해사기구는 해상 인명 안전, 해상 보안 및 해양 오염 방지를 위하여 전세계적으로 준용될 수 있는 규칙과 기준 제정을 목적으로 현재까지 전체 선복량의 99%에 해당하는 172개국이 회원으로 가입하고 있으며, 비준율이 높은 다 수의 협약을 제정함으로서 그 역할을 견고히 해내고 있다. 하지만, 세계 무역및 기술의 발달로 새로운 도전과제에 직면하는 상황과 발효 중인 협약의 준수로 파생되는 순·역기능으로 인하여 IMO는 협약의 개정 또는 새로운 협약 제정이 지속적으로 요구 되고 있다. 이처럼 기구의 광범위한 담당분야와 새로운 도전과제와는 상대적으로 한정적인 내부 조직과 예산으로 효율적인 기구 운영을위하여 IMO만의 운영상 전략계획을 수립하고 시행 중이다. 기구의 궁극적인목적을 달성하고자 6년 간격으로 채택되는 ‘전략계획’은 동향·기술 개발과 도전과제를 식별하여 이를 반영한 전략 방향과 전략 계획으로 구성되며 6년단위의 과제를 효율적으로 수행하기 위한 2년 단위의 과제로 구성되어 있다. 채택된전략계획은 IMO가 수행하는 모든 활동과 예산 편성의 기초가 되므로 전략계획은 향후 IMO의 활동을 예측 할 수 있는 좋은 지침이라 할 수 있다. 제4차 혁명으로 시작된 새로운 규제로 신산업이 창출하는 패러다임의 전환과 친환경·고효율 기술 개발, 무인화 선박 개발에 따른 새로운 규정 및 국제 표준화 작업 속에서 회원국의 의제 문서는 더욱 중요해졌다. 따라서 회원국은 기 구의 전략계획을 정확히 이해하고 IMO 활동방향과 동일한 의제 문서를 개발하여야 하며, 제출된 의제가 채택 될 경우 해사안전과 해양환경 보호라는 일차적목표와 자국 해운·조선 산업의 이익 강화라는 이차적 목표를 동시에 달성하게될 것이다. 따라서 이 연구에서는 IMO가 제시한 기존의 전략계획과 상위급 활동계획의적용에 관한 지침과 새롭게 개정된 2018∼2023 전략계획과 동향·발전 및 개발사항과 과제에 대해 철저하게 분석하고, 우리나라 해운 산업의 강점을 바탕으로 개발할 수 있는 의제 및 영향력 강화 방안에 대해 고찰하고자 한다. 다른 회원국가의 IMO 대응체계 연구를 통하여 우리나라 IMO 대응 역량을강화하기 위한 방안으로 첫째, 모든 소속기간, 단체, 연구기관의 정책연구는IMO 동향·기술 개발과 도전과제를 바탕으로 수행, 둘째, 해양수산부의 해사안 전국의 업무 재편, 셋째, 지역적·정책적 협력 체제를 구축을 제안한다. 전략적인 의제 개발과 대응체계 개선으로 우리나라는 IMO 사무총장을 배출하고 A 그룹 이사국으로 국제사회에 해양 안전과 해상안전을 위한 의무를 다하고, 해운·조선·선원을 모두 갖춘 나라로서 새롭게 변화하는 기술규칙을 선제 적으로 주도하고 시장을 선점함으로써 국내산업의 경쟁력을 강화하여야 할 것이다.

      • SCOPUSKCI등재

        K-ras 변이가 있는 췌장암세포주에서 Mitogen Activated Protein Kinase와 PI 3-kinase가 세포증식에 미치는 역할

        류지곤(Ji Kon Ryu),진(Jin Kim),장유현(Yoo Hyun Chang),이우진(Woo Jin Lee),용태(Yong Tae Kim),윤용범(Yong Bum Yoon),정룡(Chung Yong Kim) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3

        Background/Aims: K-ras mutation is considered to be important for the development and proliferation of pancreatic cancer. After activation of Ras protein, several cytoplasmic protein kinases, such as the mitogen activated protein kinase (MAPK) signaling cascade and PI 3-kinase, are sequentially stimulated. The aim of this study was to examine the role of MAPK and PI 3-kinase on cellular proliferation of pancreatic cancer cell lines with K-ras mutation. Methods: MiaPaCa-2 and Panc-1 cell lines were cultured and stimulated with growth factors such as fetal bovine serum (FBS) and epidermal growth factor (EGF). The cell proliferation was measured by 3H thymidine incorporation assay. MAPK/extracellular signal regulated kinase (ERK) activating kinase (MEK) inhibitor (PD098059) or PI 3- kinase inhibitor (wortmannin) was added in media and their effects on proliferation were examined. The activity of ERK was measured by immunoblotting assay. Results: FBS stimulated cell proliferation dose-dependently in both cell lines but EGF did not. PD098059 blocked dose-dependently the cell proliferation but wortmannin did not. The activities of ERK were increased by both FBS and EGF and blocked only by PD098059. Conclusions: MAPK kinase signal transduction pathway from MEK to ERK plays an important role in the stimulation of proliferation in pancreatic cancer cell lines with K-ras mutation. (Kor J Gastroenterol 2000;36:372 - 382)

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