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자궁내막종의 감별진단을 위한 난소낭종 환자의 혈청 Macrophage Migration Inhibitory Factor (MIF) 농도의 진단적 유용성에 대한 연구
김만기,김유래,홍승화,박연진,지일운,정은환,김학순,Kim, Man Ki,Kim, Yu Re,Hong, Seong Hwa,Park, Yeon Jin,Ji, IL Woon,Jeong, Eun Hwan,Kim, Hak Soon 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.3
Objective: To evaluate the usefulness of serum concentrations of macrophage migration inhibitory factor (MIF) of patients with ovarian cysts for differential diagnosis of endometrioama. Method: From Jan. 2003 to Dec. 2004, preoperative serum MIF levels were assessed in 28 women with endometrioma, 32 with benign epithelial tumor, 23 with functional and simple cysts, 22 with benign mature cystic teratoma, and 25 women without ovarian tumor as control. MIF levels were determined using an ELISA (Quantikine Human MIF immunoassay, R&D Systems, Inc., USA). Results: Mean MIF levels were higher in all groups with benign tumors than control (all p<0.01), but there was no significant difference between benign tumor groups (p=0.95). There was no significant correlation between MIF levels and tumor volume, body mass index (BMI) (p=0.635, 0.674 respectively) Serum MIF level had significant correlation with count of WBC and neutrophils (p=0.008, 0.024 respectively), but had no correlation with count of lymhocytes and monocytes (p=0.688, 0.294 respectively). Conclusions: This study showed a marked increase in MIF concentrations in the peripheral blood of patients with endometrioma, but there was no significant difference with other benign tumors. Serum MIF level had significant correlation with count of WBC and neutrophils. These suggest serum MIF level has no usefulness for differential diagnosis of endometrioma from other benign ovarian cysts.
대학생의 음란물 노출력과 성태도 및 성경험간의 상관성 분석
김은만(Kim, Eun Man),유수정(Yu, Su Jeong),송미령(Song, Mi Ryeong) 기본간호학회 2013 기본간호학회지 Vol.20 No.1
Purpose: The purpose of this study was to analyze the history of exposure to obscene material, and examine sexual attitudes and intercourse experience in order to develop an effective program for university students. Method: The data were collected in May, 2012 from 385 students attending 3 universities in Korea. An independent t-test and ANOVA were used to determine the differences with regard to sexual attitudes and intercourse experience according to general characteristics and history of exposure to obscene material. Results: Sexual attitudes significantly differed according to timing of first exposure to obscene material (p<.001). Intercourse experience was significantly different according to timing of first exposure to obscene material (p=.016) and type of exposure to obscene material (p=.032). There was a negative correlation between first exposure to obscene material and sexual attitudes (p<.001), and a positive correlation between first exposure to obscene material and intercourse experience (p=.017). Conclusion: Results of this study indicate that history of exposure to obscene material should be considered as an important variable in managing the sexual health of university students.
김은만(Kim Eun Man),김금순(Kim Keum-Soon) 기본간호학회 2007 기본간호학회지 Vol.14 No.3
Purpose: This study was done to construct a quality of life (QOL) model for rectpients of a liver transplant. Method: In consideration of the main factors influencing QOL in recipient of liver transplants, a hypothetical model was constructed with 16 paths. A questionnaire was used to collect data from recipients of liver transplants who were being followed at one of 3 university hospitals. For the final analysis, there were 189 completed questionnaires and the hypothetical model was verified through covariance structure using LISREL program. Results: Overall fitness indices of hypothetical model were GFI= .99, AGFI= .97, NNFI= .96 and RMR=.020. After considering modification indices and paths that proved not to be significant and to improve model fitness, the hypothetical model was modified. In the final model, 3 paths from the hypothetical model were excluded. Overall fitness indices of the final model were GFI= .99, AGFI= .98, NNFI= .98 and RMR= .020. Eleven of fifteen paths proved to be significant. QOL was influenced by duration after transplantation, perceived health status, self-esteem, uncertainty, social support, self efficacy and depression and these variables explained 65% of the variance. Conclusion: This study presents a theoretical model for QOL for recipients of a liver transplant. Based on the results of this study and to improve QOL for recipients of a liver transplant, it is suggested that interventions to re-enforce self efficacy and self-help are needed.
세대유닛을 적용한 2차측 지역난방의 순환유량에 관한 연구
김용은(Kim Yong-Eun),박병식(Park Byung-Sik),정익희(Jung Ik-Hee),이재용(Lee Jae Yong),임용훈(Im Yong-Hoon),김혁주(Kim Hyouk-Ju),허만기(Heo Man-ki) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
2pipe system and household substation is a method to reduce the heat loss of the pipe lines and manage efficiently. In this study, the proper conditions of circulation flow to adopt household substation was suggested. The experiment was conducted to investigate the characteristics of the household substation. And then annual operation of the 2pipe system with the household substation was simulated and evaluated. To keep the hot water temperature of final users, secondary supply temperature was decided by the result of the experiment and the simulation. Under the conditions which the secondary supply temperature is 50℃ and the temperature drop is less then 3℃, the circulation flow was derived. By using 2pipe system and household substation, annual heat loss was evaluated by approximately 25% reduction against present 4 pipe system.
일차 배양 해마신경세포에서 NMDA- 및 Glutamate- 유도전류의 특성
김일만,손은익,김동원,김인홍,임만빈,송대규,박원균,배재훈,최하영,Kim, Il-Man,Son, Eun-Ik,Kim, Dong-Won,Kim, In-Hong,Yim, Man-Bin,Song, Dae-Kyu,Park, Won-Kyun,Bae, Jae-Hun,Choi, Ha-Young 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.11
Objectives : This study was performed in cultured rat hippocampal neurons to investigate the acute electrophysiological features of ionotropic glutamate receptors which act as a major excitatory neurotransmitter in mammalian brain. Method : Glutamate receptor agonists were applied into the bath solution embedding in whole-cell patch-clamp recording of single hippocampal neuron. Results : In voltage-clamped at -60mV and the presence of 1mmol $Mg^{2+}$, extracellulary applied NMDA did not induce any inward current. Both the elimination of $Mg^{2+}$ and addition of glycine in bath, however, elicited a NMDAinduced inward current. $Mg^{2+}$ block current was increased gradually in more negative potentials from -30mV, showing a negative slope in I-V plot with $Mg^{2+}$. Glutamate-induced current represented an outward rectification. A non-NMDA receptor component occupied about 40% of glutamate-induced current in the voltage range of -80mV to +60mV. Conclusion : Present study suggests that glutamate activates acutely the non-NMDA receptors which induces an inward current in the level of resting membrane potential. This makes the membrane potential increase and can activate the NMDA receptors that permit calcium influx against $Mg^{2+}$ block. At the depolarized state of neuron, there may be recovery mechanisms of membrane potential to repolarize irrespective of voltage-dependent potassium channels in the hippocampal neurons.
김일만,이창영,손은익,김동원,임만빈,김상표,Kim, Il-Man,Lee, Chang Young,Son, Eun Ik,Kim, Dong Won,Yim, Man Bin,Kim, Sang Pyo 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.3
Objective : We have currently changed treatment strategies to methotrexate(MTX)-based preirradiation chemotherapy with subsequent planned radiation for the initial therapy of primary central nervous system lymphoma (PCNSL). The aim of this study was to evaluate the results of treating PCNSL with chemotherapy plus radiotherapy (CRT) or radiotherapy(RT) alone. Method and Material : This study involved 10 females and 3 males patients with a mean age of 54.2 years. All patients underwent surgery, open(8 cases) or stereotactic biopsy(5 cases) for histological diagnosis. Eleven tumors were diffuse large B-cell lymphomas. Tumor volume change in the follow-up images and survival time were evaluated in patients treated with CRT and RT alone. In the beginning, two patients received ProMACE-Cytabom chemotherapeutic regimen, but did not complete the course and died of progressive tumor 8 and 9 months after diagnosis, respectively. One patient died at 6 months before chemotherapy. These three were excluded from the survival analysis. Five patients(RT group) completed full courses of cranial irradiation with or without boost. For the current combined modality treatment, high-dose MTXbased chemotherapy(systemic and intrathecal MTX, IV vincristine, and oral procarbazine) followed by whole brain irrdiation to 45Gy to tumor was introduced in 5 patients of CRT group. Result : A complete response was achieved in three of five who received RT only and in all of five who received CRT. All patients in CRT groups are in disease free status at a mean 23 months following therapy. The RT group patients refused any additional salvage therapy at tumor relapse and survived at mean 20 months from diagnosis. The Karnofsky performance status improved in eight of ten patients with treatment. The treatment toxicity included leukoencephalopathy in RT group and severe leukopenia, transient hepatitis, avascular necrosis of femoral head, hearing loss, and amenorrhea in CRT group, respectively. Conclusion : The combined modality therapy of MTX-based chemotherapy plus radiotherapy for PCNSL may enhance tumor response and improve patient survival. The patients who received CRT should be carefully followed up because of the higher risk of treatment-induced late neurotoxicity.