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김영관,소양강,박다영,김현순,전재흥,추영국,고기성,Kim, Young-Kwan,So, Yang-Kang,Park, Da-Young,Kim, Hyun-Soon,Jeon, Jae-Heung,Choo, Young-Kug,Ko, Ki-Sung 한국식물생명공학회 2010 식물생명공학회지 Vol.37 No.3
Antibodies are powerful and versatile tools to play a critical role in the diagnosis and treatment of many diseases. Their application has been enhanced significantly with the advanced recombinant DNA and heterologonous expression technologies, allowing to produce immunotherapeutic proteins with improved biofunctional properties. However, with currently available technologies, mammalian cell-based therapeutic antibody production, as an alternative for production in humans and animals, is often not plentiful for passive immunotherapeutics in treatment of many diseases. Recently, plant expression systems for therapeutic antibodies have become well-established. Thus, plants have been considered to provide an attractive alternative production system for therapeutic antibodies, as plants have several advantages such as the lack of human pathogens, and low cost of upstream production and flexible scale-up of highly valuable recombinant glycoproteins. Recent advances in modification of posttranslational processing for human-like glycosylation in transgenic plants will make it possible that plant can become a suitable protein expression system over the animal cellbased current production system. This review will discuss recent advances in plant expression technology and issues for their application to therapeutic antibody production.
정현파로 구동되는 PZT 광경로 지연기를 이용한 광 간섭 단층촬영시스템
김영관,김용평,Kim, Young-Kwan,Kim, Yong-Pyung 한국광학회 2007 한국광학회지 Vol.18 No.4
We fabricated and characterized an optical delay line for optical coherence tomography (OCT). The delay line was composed of a cylindrical piezoelectric transduce (PZT) and a single mode optical fiber. The OCT system used a duplex scanning optical delay line which was symmetrically driven in the reference and sample arms. We showed that the sinusoidal-wave was superior to a triangular-wave for driving the optical delay line for scanning depth and repeatability. 광간섭 단층촬영(OCT)용으로 원통형 압전소자(PZT)와 단일모드 광섬유를 이용한 광경로 지연기를 제작하여 정현파로 구동하고 특성을 분석하였다. 제작한 OCT 시스템은 검침단과 기준단을 대칭 구동하는 이중 광경로 지연방식을 사용하였다. 정현파 구동을 통한 PZT 광경로 지연 방식은 삼각파 구동과 비교하여 입력파형의 첨두 부분에서의 비선형현상을 제거하여 높은 반복성을 나타냄을 보였고, 삼각파 구동으로는 불가능했던 부분을 영상화 할 수 있었다.
광간섭 단층촬영(OCT)용 PZT 광경로 지연기에서의 편광모드 분산 및 열요동 보상
김영관,박성진,김용평,Kim, Young-Kwan,Park, Sung-Jin,Kim, Yong-Pyung 한국광학회 2005 한국광학회지 Vol.16 No.6
광간섭 단층촬영(OCT)용으로 원통형 압전소자(PZT)와 단일모드 광섬유를 이용한 광경로 지연기를 제작하여 그 특성을 분석하였다. 광경로 지연기에서 발생하는 편광모드 분산은 편광조절기로 조절하였고, 열요동을 2중 광경로 지연기를 구성하여 최소화하였다. 이중 광경로 지연기는 단일 광경로 지연기에 비해 2배의 측정 깊이와 속도를 구현하여 $18.6\pm0.5{\mu}m$의 해상도. 측정 깊이 1.68 mm, 측정 녹도 360.4 mm/s를 각각 얻었다. We have fabricated and characterized optical delay lines for optical coherence tomography, which is composed of cylindrical PZT(piezoelectric transducer) and single mode optical fiber. The polarization mode dispersion from the optical delay lines was compensated by the polarization controllers. By applying the duplex optical delay line, we minimized the thermal drift due to optical delay lines and obtained the scan range of 2 times that of a single optical delay line. The OCT system showed resolution of $18.6\pm0.5{\mu}m$, scanning range of 1.68mm, and scanning speed of 360.4mm/s.
시간영역 광 간섭 단층촬영 시스템의 소형 엔도스코프 제작 및 영상구현
김영관,이성헌,김용평,Kim, Young-Kwan,Lee, Sung-Hun,Kim, Yong-Pyung 한국광학회 2010 한국광학회지 Vol.21 No.5
We fabricated and characterized a compact endoscopic catheter for optical coherence tomography. The optical delay line (ODL), composed of a cylindrical piezoelectric transducer (PZT) and an optical fiber, was operated with a 1 kHz sinusoidal driving wave in the time-domain. When the ODL was driven with a sinusoidal wave function, the axial scanning speed was 6 m/s and the axial acquisition rate was 2000 line/s at a depth of about 3 mm. Endoscopic OCT images of a human finger and earhole were successfully obtained with an image rate of ten frames per second. 광 간섭 단층촬영 시스템(OCT)을 위한 소형의 광섬유 도관형 주사장치인 엔도스코프(endoscope catheter)를 제작하였다. 깊이방향 주사장치인 원통형 압전소자(PZT)를 이용한 광경로 지연기는 정현파 1 kHz로 구동하여 시간영역에서 엔도스코프 OCT 영상을 구현하였다. 정현파로 구동한 광경로 지연기의 속도는 6 m/s 이고, 깊이방향 스캐닝의 데이터 획득은 3 mm 기준에서 초당 2000 라인이다. 제작한 엔도스코프로 사람의 손가락 및 귀에 대한 초당 10프레임의 OCT 영상을 성공적으로 획득하였다.
비스테로이드성 소염제에 의한 급성 위점막손상에 있어서 Helicobacter pylori 감염증의 영향
김영관(Young Kwan Kim),김효종(Hyo Jong Kim),동석호(Seok Ho Dong),김기택(Ki Taek Kim),김희상(Hee Sang Kim),김병호(Byung Ho Kim),이정일(Jung Il Lee),장영운(Young Woon Chang),장린(Rin Chang) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.3
N/A Background/Aims: A multitude of factors are responsible for the pathogenesis of NSAID (nonsteroidal antiinflammatory drug)-induced gastropathy. Gastritis by Helicobacter pylori(H. pylori) and NSAID-induced gastropathy have several characteristics in common. H. pylori might therefore be a risk factor of NSAID-induced gastropathy. The aim of this study is to determine whether H. pylori infection influences the severity of acute NSAID-induced gastropathy. Methods: We evaluated the severity of acute mucosal injury and H. pylori status in 24 patients who had received naproxen(825 mg/day, P.O.) and ranitidine(300 mg/day, P.O.) for 14 days. NSAID-induced gastropathy was endoscopically graded separately for hemorrhages and erosions-ulcers on a scale of 0 to 4. H. pylori infection was identified by CLO test(Delta West Limited). Results: Fifteen of the 24 patients(63%) were H. pylori pisitive. There was a statistically significant difference in the severity of gastric mucosal injury between patients with and without H. pylori infection. Conclusion: The presence of H. pylori does influence the gastric mucosal injury associated with the acute administration of naproxen. (Korean J Gastroenterol 1995;27:292-299)
김영관(Kim, Young-Kwan) 역사문화학회 2017 지방사와 지방문화 Vol.20 No.2
이 논문은 475년 문주왕이 웅진으로 천도하게 된 배경을 문헌 기록을 중심으로 살펴본 것이다. 그 결과를 정리하면 다음과 같다. 웅진천도는 고구려의 공격으로 인한 한성 함락과 국왕의 참살이라는 국가적인 위기상황이 직접적인 원인이었음을 다시 확인하였다. 그리고 고구려군의 약탈과 파괴로 인해 한성이 폐허가 되어 더 이상 기능을 할 수 없었기 때문에 새로운 도읍지를 찾게 되었다고 보았다. 웅진은 한성과 지리적인 형세가 유사한 곳으로 도읍지로서의 면모를 갖추기 수월한 곳이 었다. 우선 방어에 유리한 지형이었고, 충적대지를 끼고 있어 농사에도 유리한 지역이었다. 또한 금강 수운을 이용해 대외 교류와 물자 이동 등에 편리한 교통의 요지였다. 신라와 왜 등으로부터 구원병이 왔을 때 접근하기 쉬운 곳이기도 했다. 웅진천도를 주도한 세력은 문주와 그와 함께 움직인 왕족과 중앙귀족이었다. 웅진의 재지세력들이 천도에 영향력을 행사한 것 같지는 않다. 웅진천도는 불과 한 달 만에 이루어진 것이므로 계획적인 천도였다고 볼 수는 없다. 대신에 웅진은 이미 성곽과 궁실 등 기반시설이 갖춰진 지방지배 거점이었으므로 갑작스런 결정에도 천도 후 왕도로서 기능할 수 있었다. 웅진천도는 계획된 것은 아니었지만 준비된 곳으로의 천도였다. This paper examines through the literature record the historical background for the King Munju(文周王) to move Baekje’s capital city to Ungjin(熊津) in 475 AD. The results can be briefly summarized as follows. It was re-affirmed that the national crisis of the fall of Hanseong(漢城) and the killing of the King by Goguryeo’s attack was a direct cause of moving Baekje capital to Ungjin. I think because Hanseong became ruined due to the plundering and destruction of the Goguryeo army, and Hanseong could not function anymore, Baekje searched a new city. Ungjin was an appropriate place with a facade as the capital as a place similar in geographical shape to Hanseong. It was a terrain favorable for defending, and it was also advantageous for agricultural work because it was surrounded by the alluvial ground. It was also a gist of transportation convenient for foreign exchange and material transfer, using the Geumgang(錦江) river water transportation. It was also a place that was easy to access when relief soldiers came from Silla and Japan. The forces leading Ungjin transition capital were the King Munju, the royalty and the central aristocrat who moved with him. It does not seem that the local powers of Ungjin exercised influence on the transfer. Since the capital relocation to Ungjin was held in only one month, it cannot be regarded as a planned event. Instead, Ungjin was able to function as a royal city after the sudden decision, because it was a Damno(檐魯) which was a local ruling base equipped with infrastructures such as fortress and palace. Though the relocation was not planned, it can be said to be transferred to a prepared place.