생식주기에 따른 자성 생쥐의 생식기관의 Matrix Metalloproteinase의 단백질 발현

김문영,이기원,김해권,김문규,조동제,Kim, Moon-Young,Lee, Ki-Won,Kim, Hae-Kwon,Kim, Moon-Kyoo,Cho, Dong-Jae 대한생식의학회 1998 Clinical and Experimental Reproductive Medicine Vol.25 No.2

Protein expression patterns of matrix metalloproteinases (MMPs) were examined in mouse reproductive organs during estrous cycle. Estrous cycle was classified into diestrus, proestrus, estrus or metestus and MMP expression was analyzed by zymography using gelatin as a substrate. Uterine fluid (UF) obtained both at diestrus and proestrus exhibited 4 major MMPs including 106kDa, 64kDa, 62kDa and 59kDa gelatinases. However, in UF at estrus, the gelatinolytic activity of 64kDa MMP disappeared and that of 106kDa and 62kDa MMPs dramatically decreased. At metestrus, 64kDa MMP activity reappeared and 106kDa and 62kDa MMP exhibited increased activities such that the band intensity of 106kDa was comparable to that in UF at diestrus. Gelatinolytic activity of 59kDa MMP was not changed throughout the cycle. Both ovarian and oviductal tissue homogenate revealed 4 MMPs which corresponded to the 4 MMPs of UF. However, unlike UF MMPs, gelatinolytic activity of these MMPs did not show distinct changes throughout the cycle. Either an inhibitor of MMP, 1,10-phenanthroline, or a metal chelator, EDTA, abolished the appearance of the above MMP activities in gelatinated gel whereas a serine proteinase inhibitor, phcnylmethylsulfonyl fluoride, failed to inhibit the appearance of MMP activities, proving that gelatinolytic activity of the above reproductive tissues were due to the enzymatic activity of MMP. When gclatinolytic activity of mouse serum was examined, it revealed 5 MMPs (131kDa, 106kDa, 89kDa, 64kDa and 62kDa bands) and one gelatinase (84kDa) band. From these results, it is concluded that the protein expression of MMPs of mouse reproductive organs, particularly uterus, is temporally regulated during estrous cycle and uterine 106kDa, 64kDa and 62kDa MMPs are suggested to play an important role in cyclic tissue remodeling of mouse uterus.

슬라이딩을 허용하는 다절점 케이블요소

김문영,이준석,한만엽,김성보,김낙경,Kim, Moon Young,Lee, Jun Seok,Han, Man Yop,Kim, Sung Bo,Kim, Nak Kyung 한국강구조학회 2005 韓國鋼構造學會 論文集 Vol.17 No.4

다양한 케이블지지 시스템에 적용이 가능한 슬라이딩을 허용하는 다절점 케이블-트러스 요소를 개발한다. 먼저 일반적인 2절점 케이블-트러스 요소에 대한 유한요소 정식화 과정을 요약하고, 이를 토대로 여러 절점에 연결되어 장력은 동일하지만 절점에서 슬라이딩이 가능한 다절점 케이블-트러스 요소의 탄성강도행렬을 유도한다. 개발된 케이블-트러스 요소를 검증하기 위하여, 케이블 장력을 부정정력으로 선택하고 적합조건을 이용하여 장력을 산정하는 방법(유연도법)을 제시하고 두 방법에 의한 장력 값을 비교한다. 또한 상용 유한요소 해석프로그램의 2절점 트러스요소를 사용한 해석결과와도 비교, 분석한다. A multi-noded cable element allowing sliding at its nodes without frictions was introduced in this paper, and its elastic stiffness matrix was derived. A two-node truss element was briefly summarized and extended to multi-node, cable-truss elements that keep their tension constant but are connected without frictions through several nodes. The element elastic stiffness matrix of the multi-node,cable-truss elements was consistently derived. The steel wales pre-stressed externally in the IPS system were chosen as numerical examples and analyzed under various loading conditions. The cable tensions calculated using the present element were compared with the results of the flexibility method and those using the two-node truss element, respectively.

휨 및 비틀림 거동 및 전단변형 효과를 고려한 차량-현수교의 동적 상호작용 해석

김문영,임명훈,권순덕,김호경,김남일,Kim Moon-Young,Lim Myoung-Hun,Kwon Soon-Duck,Kim Ho-Kyung,Kim Nam-Il 한국전산구조공학회 2005 한국전산구조공학회논문집 Vol.18 No.4

본 저자의 이전연구(김문영 등, 2004)에서는 2차원 차량 모형과 전단변형 및 회전관성 효과가 고려된 현수교요소와의 상호작용을 고려한 2차원 수직응답에 대한 동적해석을 수행하였다. 본 연구에서는 전단변형 효과와 편심차량의 효과를 알아보는데 목적을 두었다. 이를 위하여 전단변형 및 회전관성 효과가 고려된 3차원 현수교의 수직, 비틂에 대한 고유진동수와 모드형상, 그리고 교량-차량 에너지로부터 라그랑지안식을 이용하여 상호작용을 고려할 수 있는 3차원 운동방정식을 유도한다. 이후 모드중칩법을 이용하여 유도된 운동방정식을 Newmark method를 사용하여 동적해석을 수행한다. 마지막으로 본 연구에서 제시한 이론을 따라 수치해석예제를 수행하여 차량의 동적거동을 분석한다. In the previous study(Kim 등, 2004), the finite element method was used for the vortical vibration analysis of suspension bridge with the effects of the shear deformation and the rotary inertia under moving load considering the bridge-vehicle interaction. The purpose of this study is to investigate the effect of an eccentric vehicle and shear deformation. So we firstly performs the eigenvalue analysis for the free vortical and the torsional vibration of suspension bridges using FEM analysis. Next the equations of motion considering interaction between suspension bridges and vehicles/trains are derived using the mode superposition method. And then dynamic analysis was performed using the Newmark method. Finally through the numerical examples, the dynamic responses of bridges are investigated according to the proposed procedure.

박벽보의 응력해석을 위한 단면상수의 자동산정

김문영,최명수,장영,김남일,Kim, Moon Young,Choi, Myeong Su,Chang, Young,Kim, Nam Il 한국강구조학회 2002 韓國鋼構造學會 論文集 Vol.14 No.1

박벽보의 응력해석을 위한 단면상수 값들을 자동적으로 산정하는 알고리즘을 개발한다. 사용자의 편의를 위해서 최소한의 단면정보만으로 복잡한 폐단면 및 개단면에 대하여 단면상수를 자동적으로 산정할 뿐만 아니라 보이론에 의하여 계산된 단면력에 대하여 대응하는 수직응력 또는 전단응력분포의 자동계산이 가능하다. 본 이론 및 프로그램의 타당성을 검증하기 위하여 기존의 논문결과와 비교하여 타당성을 입증한다. An efficient algorithm automatically determining cross sectional properties of thin-walled beams is developed using the minimum information about geometry of the cross section. This scheme is applied to automatic calculation of normal and shear stress distribution corresponding to stress resultants as well as sectional constants for complex open and closed thin-walled sections. Numerical examples evaluating section constants and stress distributions is presented and compared with the available reference's results.

편심축하중을 받는 비대칭 박벽보의 엄밀한 동적강도행렬

김문영,윤희택,Kim, Moon Young,Yun, Hee Taek 한국강구조학회 2001 韓國鋼構造學會 論文集 Vol.13 No.6

비대칭단면을 갖는 박벽 직선보의 3차원 자유진동해석을 수행하기 위하여 엄밀한 요소강도행렬을 유도한다. 단면이 균일한 비대칭 박벽 탄성보에 대하여 운동방정식, 힘-변위 관계식을 유도하고 엄밀한 동적강도행렬을 수치적으로 산정하는 방법을 제시한다. 14개의 변위파라미터를 도입하여 고차의 연립미분방정식을 1차 연립미분방정식으로 바꾸고, 비대칭행렬을 갖는 선형 고유치문제의 해를 복소수영역에서 구한다. 이를 이용하여 절점변위에 대한 처짐함수을 엄밀히 구하고, 재단력-변위 관계식을 이용하여 엄밀한 동적요소강도행렬을 산정한다. 본 방법의 타당성을 보이기 위하여 비대칭 박벽보의 고유진동수를 계산하고, 해석해, 혹은 3차 Hermitian 다항식을 사용한 보요소 및 ABAQUS를 사용한 유한요소 해석결과와 비교한다. Derivation procedures of exact dynamic stiffness matrices of thin-walled straight beams subjected to eccentrically axial forces are rigorously presented for the spatial free vibration analysis. An exact dynamic stiffness matrix is established from governing equations for a uniform beam element with nonsymmetric thin-walled cross section. First this numerical technique is accomplished via a generalized linear eigenvalue problem by introducing 14 displacement parameters and a system of linear algebraic equations with complex matrices. Thus, the displacement functions of displacement parameters are exactly derived and finally exact stiffness matrices are determined using element force-displacement relationships. The natural frequencies of nonsymmetric thin-walled straight beams are evaluated and compared with analytical solutions or results by thin-walled beam element using the cubic Hermitian polynomials and ABAQU's shell elements in order to demonstrate the validity of this study.

전단변형(剪斷變形)을 고려(考慮)한 평면(平面)뼈대 구조물(構造物)의 기하적(幾何的)인 비선형(非線形) 해석(解析)

김문영,장승필,Kim, Moon Young,Chang, Sung Pil 대한토목학회 1990 대한토목학회논문집 Vol.10 No.1

본(本) 논문(論文)에서는 전단변형(剪斷變形) 효과(效果)가 고려되는 평면(平面)뼈대 구조물(構造物)의 기하적(幾何的)인 비선형(非線形) 해석(解析)을 수행하기 위한 두 가지 방법 즉, 유한분절법(有限分節法)과 유한요소법(有限要素法)을 제시한다. 유한분절법(有限分節法)의 경우에는 평형방정식(平衡方程式)을 직접(直接) 적분(積分)하므로써 엄밀(嚴密)한 접선강도(接線剛度) 매트릭스가 유되되는 반면에 유한요소법(有限要素法)의 경우에는 전단변형(剪斷變形)을 고려하는 Hermitian 다항식(多項式)을 형상함수(形狀函數)로 사용하므로써 탄성(彈性) 및 기하적(幾何的)인 강도(剛度)매트릭스가 산정된다. 선택된 예제(例題)들을 해석(解析)한 결과들과 다른 문헌(文獻)의 결과들을 비교, 검토하므로써 본(本) 논문(論文)에서 제시된 이론(理論)의 정당성(正當性)을 입증(立證)한다. Two beam/column elements in order to analyze the geometric nonlinear plane framed structures including the effects of transverse shear deformation and bending stretching coupling are developed. In the case of the first element (finite segment method), tangent stiffness matrix are derived by directly integrating the equilibrium equations whereas in the case of the second element (finite element method) elastic and geometric stiffness matrices are calculated by using the hermitian polynomials including shear deformation effect as the shape function. Both elements possess the usual six degree of freedoms. Numerical results are presented for the selected test problems which demonstrate that both elements represent reliable and highly accurate tools.

전단변형(剪斷變形)을 고려(考慮)한 공간(空間) 뼈대구조(構造)의 기하학적(幾何學的)인 비선형(非線形) 해석(解析)

김문영,Kim, Moon Young 대한토목학회 1993 대한토목학회논문집 Vol.13 No.4

In order to present the geometrically nonlinear F.E. formulation of space frames, two beam/column elements including the effects of transverse shear deformation and bending stretching coupling are developed. In the case of the first element (Finite segment method), the tangent stiffness matrices are derived by directly integrating the equilibrium equations, whereas in the case of the second element (Finite element method) elastic and geometric stiffness matrices are calculated by using the hermitian polynomials including shear deformation effect as the shape function. Both elements possess the usual twelve degrees of freedom. Also, the bowing function including shear deformation effects is obtained in order to account for the effect of shortening of member chord length due to the bending and torsional behavior. Numerical results are presented for the selected test problems which demonstrate that both elements represent reliable and highly accurate tools. 전단변형(剪斷變形) 효과(效果)가 고려되는 공간(空間)뼈대 구조(構造)의 기하학적(幾何學的)인 비선형(非線形) 해석(解析)을 수행하기 위한 두 가지 방법 즉, 유한분절법(有限分節法)과 유한요소법(有限要素法)을 제시한다. 유한분절법(有限分節法)의 경우에는 평형방정식(平衡方程式)을 직접(直接) 적분(積分)하므로써 휨과 비틂거동(擧動)에 대한 엄밀(嚴密)한 접선강도(接線剛度) 매트릭스가 유도되는 반면에 유한요소법(有限要素法)의 경우에는 전단변형(剪斷變形)을 고려하는 Hermitian 다항식(多項式)을 형상함수(形狀函數)로 사용하므로써 탄성(彈性) 및 기하적(幾何的)인 강도(剛度)매트릭스가 산정된다. 또한 축방향력(軸方向力)이 영(零)인 경우에 휨 및 비틂거동으로 인한 부재양단의 길이변화를 보정하는 Bowing 함수와 불평형하중의 산정방법을 제시한다. 선택된 예제(例題)들을 해석(解析)한 결과들과 다른 문헌(文獻)의 결과들을 비교, 검토하므로써 본(本) 논문(論文)에서 제시된 이론(理論)의 정당성(正當性)을 입증(立證)한다.

광물공생(鑛物共生)의 개념(槪念)에 대(對)한 문제점(問題點)과 광맥광상(鑛脈鑛床)의 macrostructure -특(特)히 일본(日本) 대고광산(大谷鑛山)의 광맥광상(鑛脈鑛床)에 대(對)한 macrostructure-

김문영,나카무라 다케시,Kim, Moon Young,Nakamura, Takeshi 대한자원환경지질학회 1986 자원환경지질 Vol.19 No.no.spc

Concepts on mineral association, mineral paragenesis, and mineralization stage relating to macrostructures of vein filling in ore veins are briefly discussed. As an example of plutonic ore vein, macrostructures of vein filling of plutonic tungsten-tin-copper vein at the Ohtani mine, Kyoto Prefecture, Japan, one of representatives of plutonic tungsten-tin vein related genetically to acidic magmatism of late Cretaceous in the Inner zone of Southwest Japan, are examined. Based on macrostructures of vein filling, three major mineralization stages, are distinguished by major tectonic breaks. Sequence of mineralization, characteristic features of each mineralization stage, and variations of filling temperature and salinity ranges of fluid inclusions in minerals from stage I to stage III are summarized.

통영광산산(統營鑛山産) 섬아연석(閃亞鉛石)의 화학조성(化學組成)

김문영,신홍자,Kim, Moon Young,Shin, Hong Ja 대한자원환경지질학회 1989 자원환경지질 Vol.22 No.2

The Tongyoung deposits are epithermal gold and silver bearing quartz-rhodochrosite vein type deposits of late Cretaceous. They occurs in the andesite and tuff breccia member called Gyeongsang basin. Four mineralizations can be distinguished at the mine based on macrostructures. From earlist stage to lastest stage they are: stage I, base-metal quartz vein; stage II, rhodochrosite vein (IIA) and Pb-Zn vein (IIB); stage III, barren quartz vein; stage IV, calcite-ankeritic rhodochrosite veins. Gold and silver mineralizations occur predominantly in the stage I and IIB. Electrum is closely associated with galena, sphalerite and pyrite, and has chemical compositions of 50.98-64.05 atom % Ag. Sphalerite contains 2.09-5.05 mol % FeS and 0.34-2.01 mol % MnS in the stage I, and 2.01-3.41 mol % FeS and 0.21-2.80 mol % MnS in the stage IIB. The FeS and MnS contents are in general correlated, and shows a characteristic zonal arrangement of electrum. It reveals rhat FeS contents of sphalerite which precipitated before electrum, gradually decreases in a grain during its deposition ranging from about 3.3 to 2 mol %. It may be considered from the above data that an increase of $fs_2$ caused by the oxidation of ore forming fluid is more important that the decrease of temperature.

대곡(大谷) W-Sn-Cu 광상(鑛床)의 열수변질작용(熱水變質作用)

김문영,Kim, Moon Young 대한자원환경지질학회 1988 자원환경지질 Vol.21 No.3

The ore deposit of the Ohtani mine is one of repesentatives of plutonic tungsten-tin veins related genetically to acidic magmatism of Late Cretaceous in the Inner zone of Southwest Japan. Based on macrostructures of vein filling on the order of ore body, three major mineralization stages, called stage I, stage II, and stage ill from earliest to latest, are distinguished by major tectonic breaks. The alteration zories are characterized by specific mineral associations in pseudomorphs after biotite. The alteration zones can be divided into two parts, i. e. a chlorite zone and a muscovite zone, each repesenting mineralogical and chemical changes produced by the hydrothermal alteration. The chloritic alteration took place at the beginning of mineralization, and muscovite alteration in additions to chloritic alteration took place at stage II and ill. The alteration zones are considered to be formed by either of two alteration mechanism. 1) The zones are formed by reaction of the rock with successive flows of solution of different composition and different stage. 2) The zones are formed contemporaneously as the solution move outward. Reaction between the solution and the wall-rock results in a continuous change in solution chemistry. The migration of the successive replacement of the fresh zone$\rightarrow$the chlorite zone$\rightarrow$the muscovite zone may have transgressed slowly veinward, leaving metasomatic borders between the different zones.