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      • KCI등재

        A case of encephalitis in a juvenile rheumatoid arthritis patient treated with etanercept

        권아름,박은정,김기환,김동수 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.2

        Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine involved in the pathophysiology of juvenile rheumatoid arthritis. Etanercept is an effective inhibitor of TNF-α and has shown a beneficial effect in patients with JRA. However, the most important cause of concern related to etanercept administration is infection. We report a case of encephalitis in a JRA patient receiving long-term treatment with etanercept. The patient was a 4-year-old boy with refractory JRA, and he received etanercept subcutaneously at a dose of 0.4 mg kg-1 day-1 twice a week for 14 months, along with non-steroidal anti-inflammatory drugs, methotrexate, oral steroids, and sulfasalazine. The patient presented with sudden fever, headache, vomiting, a generalized tonic seizure, and changes in mental status. We suspected a central nervous system infection, and simultaneously administered antibiotics, an antiviral agent, and steroids. After 2 days of hospitalization, his mental function returned to normal, and he showed no further seizure-like movements. Brain magnetic resonance imaging scan of the patient showed a multifocal cortical lesion on both sides of the temporoparietooccipital lobe, which indicated encephalitis. Although we were unable to identify the causative organism of encephalitis, we think that the encephalitis may be attributed to infection, and the use of etanercept may have increased the risk of severe infection. Therefore, etanercept was discontinued and the patient recovered shortly after. To the best of our knowledge, this is the first case of encephalitis in a juvenile rheumatoid arthritis patient treated with etanercept.

      • KCI등재후보

        Chinese speakers perceptibility of the Korean voiceless obstruents

        권아름 한국언어연구학회 2014 언어학연구 Vol.19 No.3

        One characteristic of Korean consonants is that there are three distinctive voiceless sounds in the stop category. Since Chinese has two-way contrast stop consonants while Korean has three-way contrast stop consonants, it was anticipated that the Chinese group selected for the experiment would demonstrate particular difficulties in learning a foreign language with a different system of contrast consonants. This paper suggests factors in two aspects as major factors in distinguishing the three-way contrast in the Korean voiceless obstruents. The first aspect is speech production, including VOT (Voice Onset Time) and F0 (fundamental frequency). The second aspect is speech perception, including the factor of the pronunciation of Korean learners. Generalizing from the results of Perception Test 1 and 2, adult learners of a foreign language seem to exhibit a correlation between articulation and auditory perception. Perception Test 3 shows how both Korean and Chinese participants can use F0 and VOT values as the major factors in distinguishing three-way contrast stop consonants in Korean.

      • 지황 단경기 생산을 위한 적정 정식시기

        권아름,김수동,성봉재,김선익,지무근,이가순,김현호 한국약용작물학회 2018 한국약용작물학술대회 발표집 Vol.2018 No.10

        Background : Rehmannia glutinosa L. that is a perennial plant belonging to the family Scrophulariaceae is one of the most popular local income crops. Recently, the cultivation area of Chungnam (2017) accounts for 50.5% (106 ha) of the whole country. In July and August, which is the off-season at the highest price of R, glutinosa L. This experiment was carried out to develop early harvest cultivation technology for the improve farm income. Methods and Results : In order to investigate the growth characteristic and yield of R, glutinosa L. by using the rhizome of 'Tokang' were transplanted four times at intervals of 10 days from mid-March to mid-April 2017 and 2018. Growth characteristics of the above and under ground part were investigated by 3 repetitions for 10 ea harvested in mid-July. Regression analysis was performed on the relationship between the planting time and fresh root weight. The highest emergence rate was 88.7% in the mid-March, and the highest above ground part growth was observed in the plant height, leaf number, leaf length, leaf width, and fresh leaves weight. The number of days to flowering tended to be shortened to 60, 53, 52, and 49 days from the mid-March to the mid-April. The growth of underground part was also highest in mid-March and the total root weight per 10 a was also 1,127.4 ㎏ in mid-March. The faster the planting time, the higher the yield. The results of the linear regression on the roots weight according to the planting time showed that there was a negative correlation relation between the planting time, the marketable roots weight, rhizome weight and total roots weight. Conclusion : The total roots weight improved by 80% in the mid-March than mid-April. Therefore, mid-March is considered optimal planting time for off-season production of R. glutinosa L.

      • KCI등재

        WRF-Chem 모델과 결합된 CFD 모델을 활용한 도시 지역의 일산화탄소 확산 연구

        권아름,박수진,강건,김재진 대한원격탐사학회 2020 大韓遠隔探査學會誌 Vol.36 No.5

        본 연구에서는 CFD 모델을 WRF-Chem 모델과 결합(WRF-CFD 모델)하였고, 서울 영등포구에 소재한건물 밀집 지역에서 흐름과 일산화탄소(carbon monoxide, CO) 분포 특성을 조사하였다. 이를 위하여, 자동기상관측소에서 측정한 풍속, 풍향과 도시대기측정소에서 측정한 CO 농도를 이용하여 수치 모의 결과를 검증하였다. AWS 510 지점에서는 남풍과 남서풍 계열 바람이 측정되었고, 야간 시간 보다는 주간 시간에 높은 풍속이 측정되었다. WRF-Chem 모델은 주로 동남동풍에서 서남서풍 계열의 바람을 수치 모의하였고, 측정 풍속을과대 모의하였다. WRF-CFD 모델이 수치 모의한 풍향은 WRF-Chem 모델 풍향에 대한 의존도가 높았고, 측정풍속을 상대적으로 잘 수치 모의하였다. 통계적 검증 지수에 대한 목표 값과 추천 범위를 고려하였을 때, WRFCFD 모델이 WRF-Chem 모델에 비해 측정 풍속을 통계적으로 더 현실적으로 수치 모의하였다. WRF-Chem 모델은 측정 CO 농도를 크게 과소 모의하였고, WRF-CFD 모델은 CO 농도 예측을 개선하였다. 통계적 검증 결과를 종합한 결과, WRF-CFD 모델은 도시 지역에 복잡하게 분포한 건물과 이동 오염원을 고려함으로써 CO 농도예측 성능을 개선하였다. 5월 22일 04시에는 AQMS가 위치한 지역에는 하강류가 존재하고, 상층으로부터 비교적 낮은 농도의 CO가 유입되면서 주변 지역에 비해 낮은 농도가 수치 모의되었다. 5월 22일 15시에는 AQMS 측정 지점에 약한 상승류가 형성되었고, 이에 따라 주변보다 다소 높은 CO 농도가 나타났다. WRF-CFD 모델은 상승류에 의해 도로의 이동 오염원으로부터 배출된 CO를 AQMS 측정 고도까지 수송하여, 결과적으로, 측정 CO 농도를 잘 재현한 것으로 판단된다. 5월 22일 18시 사례는 CO 배출량 증가, 상승류 발생 지역 증가, 풍속증가로 인한 지면 근처의 난류운동에너지 생성 증가에 따른 난류 확산 증가 등으로 인해 전체적으로 높은 CO 농도가 수치 모의되었다. AQMS 지점에서는 하강류가 수치 모의되었지만, 풍상측에 형성된 고농도의 CO 밴드로 인해WRF-CFD 모델은 측정 CO 농도를 과대 모의하였다. We coupled a CFD model to the WRF-Chem model (WRF-CFD model) and investigated the characteristics of flows and carbon monoxide (CO) distributions in a building-congested district. We validated the simulated results against the measured wind speeds, wind directions, and CO concentrations. The WRF-Chem model simulated the winds from southwesterly to southeasterly, overestimating the measured wind speeds. The statistical validation showed that the WRF-CFD model simulated the measured wind speeds more realistically than the WRF-Chem model. The WRF-Chem model significantly underestimated the measured CO concentrations, and the WRF-CFD model improved the CO concentration prediction. Based on the statistical validation results, the WRF-CFD model improved the performance in predicting the CO concentrations by taking complicatedly distributed buildings and mobiles sources of CO into account. At 04 KST on May 22, there was a downdraft around the AQMS, and airflow with a relatively low CO concentration was advected from the upper layer. Resultantly, the CO concentration was lower at the AQMS than the surrounding area. At 15 KST on May 22, there was an updraft around the AQMS. This resulted in a slightly higher CO concentration than the surroundings. The WRF-CFD model transported CO emitted from the mobile sources to the AQMS measurement altitude, well reproducing the measured CO concentration. At 18 KST on May 22, the WRF-CFD model simulated high CO concentrations because of high CO emission, broad updraft area, and an increase in turbulent diffusion cause by wind-shear increase near the ground.

      • KCI등재후보

        1형 당뇨병 환자에서 생리주기 이상

        권아름,채현욱,김호성,김덕희 대한소아내분비학회 2009 Annals of Pediatirc Endocrinology & Metabolism Vol.14 No.2

        Purpose:This study compares the prevalence of pubertal menstrual disorders in type 1 diabetes mellitus (DM) patients with that in normal subjects. Methods:A questionnaire was used to obtain data on pubertal development and menstrual history from 43 type 1 DM patients, who were diagnosed at the pediatrics department of Severance Children’s Hospital, Yonsei University, and 56 normal control subjects. We evaluated the estrogen levels in all type 1 DM patients. Results:The age at onset of puberty did not significantly differ between the 2 groups. However, the prevalence of oligomenorrhea in type 1 DM patients (21.21%) was significantly higher than that in the control group (2.08%; P˂0.05). In addition, the incidence of amenorrhea in type 1 DM patients (20.59%) was significantly higher than that in the control group (2.08%; P˂0.05 ). Pubertal development in type 1 DM patients was delayed due to elevated levels of glycosylated hemoglobin (HbA1c). The delay (9 months) in pubertal development in the patients diagnosed with type 1 DM at prepubertal ages was shorter than that (14.8 months) in the patients diagnosed with type 1 DM at postpubertal age (P˂0.05). The level of LH, FSH were higher and E2 level was lower in DM patients compared to control group, especially in diabetics with amenorrhea (P˂0.05). Conclusion:We observed a high frequency of delayed pubertal development and menstruation irregularities in patients who were diagnosed with type 1 DM at the prepubertal age or in type 1 DM patients with high levels of HbA1c. This finding can be attributed to the decreased plasma levels of E2 or due to the decreased E2 activity in patients with type 1 DM. Further evaluation of hormonal changes in type 1 DM patients is essential. 목 적:최근 1형 당뇨 여아에게서 사춘기 발달이 늦거나, 생리 이상의 빈도가 높다는 연구 결과가 있었다. 본 연구에서는 한국에서 사춘기 연령의 1형 당뇨 여아에서 정상 사춘기 여아와 비교하였을 때 사춘기 지연 및 생리 이상의 빈도에 차이가 있는지 알아보고, 그 원인을 규명하고자 한다. 방 법:2006년 이후 연세대학교 세브란스 어린이병원 소아청소년과에서, 1형 당뇨병으로 진단받은 만 10세에서 17세 사이의 여아 43명을 대상으로 하였고, 정상 대조군은 같은 연령의 만성 기저 질환이 없는 정상 여아 56명을 선정하였다. 모든 대상자의 신장 및 몸무게를 측정하고, 생리 주기 및 기간, 생리 불순 및 무월경 여부 등에 대해 설문조사를 하였으며, 당뇨 환자에게는 혈당 조절 정도와 에스트로겐의 농도를 측정하였다. 결 과:당뇨환자와 정상 대조군의 평균 연령의 유의한 차이는 없었다. 당뇨 환자와 정상 대조군 사이에 사춘기 발달 시기의 유의한 차이는 없었으나, 희발 생리는 1형 당뇨 환자와 정상 대조군에서 각각 21.21%, 2.08% 로 당뇨 환아에서 더 높았고, 무월경은 1형 당뇨 환자에서 20.59%로 정상 대조군 2.08% 에 비해 높았다. 1형 당뇨 환자 중, 당화혈색소가 높을수록 사춘기가 지연되는 경향을 보였고, 사춘기 시작 이전에 당뇨가 발병한 경우 유방 발달 시기는 사춘기 시작 이후에 발병한 군보다 약 9개월, 초경 시기는 약 14.8개월 가량 늦었다. 당뇨 환자에서 LH 및 FSH의 농도는 정상 사춘기 여아에 비해 증가되었고, 이는 무월경이 있을수록 더욱 높았다. 또한 당뇨 환자에서 혈중 E2의 농도는 정상 사춘기 여아에 비해 의미 있게 낮았고, 무월경이 있을 경우에는 더 낮았다. 결 론:본 연구에서는 사춘기 시기 당뇨 여아에서 사춘기 이전에 당뇨가 발병했을 경우, 당화혈색소가 높을수록 사춘기 발달이 늦어지고 생리 불순이 많았으며, 이는 혈중 E2농도 저하나 작용 기전 저하 때문으로 생각되며, 그 기전에 대해 추후 연구가 필요하다.

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