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공성민 ( Sung Min Kong ),김광민 ( Kwang Min Kim ),이재진 ( Jae Jin Lee ),홍웅표 ( Woong Pyo Hong ),최익성 ( Ik Sung Choi ),정계화 ( Kye Hwa Jeong ),권병수 ( Byung Soo Kwan ),이동규 ( Dong Gyu Lee ) 대한췌담도학회 2016 대한췌담도학회지 Vol.21 No.3
간내 육종양 담관암은 간내 담관암의 비교적 드문 변이형으로 간내 증식 및 전이 혈관 침범 등이 흔해 예후가 불량하다고 알려져 있다. 따라서 완치를 위해서는 조기진단과 적극적인 치료가 무엇보다 중요하다. 본 저자들은 영상학적 검사와 간생검을 하였지만 임상 진단이 불충분하였던 간 병변을 수술 후 병리조직검사를 통해 간내 육종양 담관암으로 확진한 증례를 경험하였기에 보고한다. 기존에 보고되었던 증례들과 달리, 초기 병기로 확인되어 비교적 좋은 예후가 기대되는 바이다. Sarcomatoid transformation of intrahepatic cholangiocarcinoma is rarely found but usually has very poor prognosis due to the lack of effective approaches for early detection and its aggressive nature. We report a case of this tumor type, in a 60-year-old man who was referred to our hospital for further evaluation of screeningdetected, asymptomatic hepatic lesion. Clinical diagnosis was elusive despite performance of different imaging modalities and a transcutaneous liver biopsy. Pathology of the surgically resected tumor demonstrated intrahepatic sarcomatoid cholangiocarcinoma. In our case, tumor cells expressed strong immunoreactivity to both cytokeratin-19 and vimentin. We assume the relatively good prognosis of this patient would be expected because surgery played a critical role at an early stage of the tumor. Korean J Pancreas Biliary Tract 2016;21(3):174-179
신이식 환자에서 자발적으로 발생한 저구연산뇨증 연관성 요관 결석로
나정구,공성민,이동규,김성민,장윤정,김성록,이유지 이화여자대학교 의과학연구소 2015 EMJ (Ewha medical journal) Vol.38 No.3
Urolithiasis is an uncommon complication in renal transplantation. We report a case of hypocitraturia-related ureteral steinstrasse which was spontaneously formed in a renal transplant recipient. The patient who underwent renal transplantation was admitted with acute pyelonephritis. Hydronephrosis in the transplanted kidney and multiple stones (steinstrasse) in the distal ureter were incidentally found on computed tomography scanning. After a failed attempt of ureteroscopic removal of stones, the patient underwent open ureterolithotomy and ureteroureterostomy. On stone analysis, carbonate apatite was confirmed. Urinary citric acid levels were decreased to 127.6 mg/day. Potassium citrate was administered to prevent stone recurrence by increasing urinary citrate excretion. No recurrence of stones was shown six months later. Urolithiasis in renal transplant recipients requires a high index of suspicion. Hypocitraturia can increase the risk for urolithiasis. Rapid recognition by careful surveillance, prompt removal of stones, and precautionary efforts to prevent recurrence are needed.
S-30 Clinical significance of heat shock protein 90α expression in gastric cancer
이동규,공성민,이정원,이현수,오지은,조대현,이현욱,이은희,김광민 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background and Aims: Heat shock protein 90 (HSP90), which possesses two major isoforms, α and β, plays essential roles in protection against stressful conditions and in the re-establishment of cellular homeostasis. We investigated the clinical significance of HSP90α and HSP90β expression in patients with gastric cancer (GC). Methods: HSP90α and HSP90β expression were examined immunohistochemically in surgical specimens obtained from 186 GC patients. The correlations between their expression status and clinicopathological parameters, along with patient survival, were analyzed. Results: The frequency of larger tumor size (maximum diameter ≥ 4 cm) and more prominent tumor invasion (≥ pT3) was 73.4% and 68.8% higher in the high intensity HSP90α expression group than in the low intensity group, respectively (p=0.001 and p=0.001, respectively). High HSP90α expression was also significantly associated with lymphatic invasion, lymph node metastasis, and advanced stage (TNM stage ≥ III) disease (p=0.047, p=0.046 and p=0.004, respectively). Patients with high HSP90α expression demonstrated significantly worse survival than did those with low HSP90α expression (p=0.047). In contrast, survival did not differ significantly according to the intensity of HSP90β expression. Conclusions: Our results show that HSP90α overexpression may be associated with disease progression and poorer survival in patients with GC. HSP90α could constitute a feasible biomarker for the prognosis of GC.
흉추 가동성(mobility) 운동을 접목한 통합적 운동프로그램이 통증 및 기능장애, 흉추후만각, 기능적 움직임에 미치는 영향
강해주(Kang, Hae-Joo),공성민(Kong, Sung-Min),정혜진(Jung, Hye-Jin),김범수(Kim, Bum-Soo) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.6
The purpose of this study was to investigate to demonstrate its effectiveness of integrated thoracic exercise program in thoracic kyphosis. The subjects were 14 female college students who were selected with the thoracic kyphosis angle greater than 40 degrees. We were evaluated. that body composition, pain and functional disability questionnaire, thoracic angle of spine alignment, functional movement assessment (FMS). They exercised 3 times a week and each session took about 60 minutes which Consists of an integrated program of thoracic movement was a self-myofascial relaxation exercise with foam roller to prepare, conduct was the main exercise thoracic mobility and strength training exercises, Cool down was a stretch. The results was as follow: Thoracic exercise program for improving posture for 8 weeks was performed before and after the exercise intervention, thoracic, thoracic kyphosis angle reduction(p<.05) and improvement in functional movement(p<.001), have a good effect on subjective pain and physical function(p<.05) showed.