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강정우,Md Akil Hossain,박해철,김용상,이광직,박성원 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.2
It is crucial to optimize the dose of fluoroquinolones to avoid antibiotic resistance and to attain clinical success. We undertook this study to optimize the dose of enrofl xacin against Salmonella enterica subsp. enterica serovar Enteritidis (S. Enteritidis) in chicken by assessingits pharmacokinetic/pharmacodynamic (PK/PD) indices. The antibacterial activities of enrofl xacin against S. Enteritidis were evaluated. After administering 10 mg/kg body weight (b.w.) of enrofl xacin to broiler chickens of both sexes by intravenous (IV) and peroral (PO) routes, blood samples were drawn at different intervals and enrofl xacin concentrationsin plasma were determined. PK/PD indices were calculated by integrating the PK and PD data. The elimination half-lives (T1/2), time required to reach peak concentration (Tmax), peak concentration (Cmax), and area under curve (AUC) after administering enrofl xacin by PO and IV routes were 25.84 ± 1.40 h, 0.65 ± 0.12 h, 3.82 ± 0.59 µg/mL, and 20.84 ± 5.0 µg·h/mL, and 12.84 ± 1.4 h, 0.22 ± 0.1 h, 6.74 ± 0.03 µg/mL, and 21.13 ± 0.9 µg.h/mL, respectively. The bioavailability of enrofl xacin was 98.6% ± 8.9% after PO administration. The MICs of enrofl xacin were 0.0625–1 µg/mL against S. Enteritidis strains, and the MIC50 was 0.50 µg/ mL. The Cmax/MIC50 were 7.64 ± 0.2 and 13.48 ± 0.7 and the 24 h AUC/MIC50 were 41.68 ± 0.1 and42.26 ± 0.3 after administering the drug through PO and IV routes, respectively. The data in this study indicate that the application of 50 mg/kg b.w. of enrofl xacin to chicken through PO and IV routes with a dosing interval of 24 h can effectively cure S. Enteritidis infection, indicating the need for a 5-fold increase in the recommended dosage of enrofl xacin in chicken.
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PbO · B_(2)O_(3)· AI_(2)O_(3) 유리계의 굴절률에 관한 연구
강정우 濟州大學校 師範大學 科學敎育硏究所 1984 科學敎育 Vol.1 No.-
The refractive indices in the PbOㆍ B_(2)O_(3)ㆍA1_(2)O_(3) glass system have been measured by the Liquid Immerson method under the Leitz-Orthohxpd Pola-rizing microscope as function of the PbO composition. The refractive idex is increasing in proportion to the PbO camposition without any connection with A1_(2)O_(3), ccmposition. However, it does not increase above 45 mol, % PbO composition. The reason is that amount of Pb ion acts as the glass modifier under the 45mol, %PbO in the PbOㆍB_(2)O_(3)ㆍA1_(2)O_(3) glass system, and that parts of Pb ion become the formation a tom of glass acts as the glass former with the above 45 mol, % PbOㆍB_(2)O_(3)ㆍA1_(2)O_(3) glass system.
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강정우,김성용,장윤영,배범한,장윤석 한국지하수토양환경학회 2002 지하수토양환경 Vol.7 No.1
본 연구는 제강분진/${H_2}{O_2}$ 시스템을 이용한 매립지 침출수의 화학적 산화처리 효과를 알아보고자 하였다. 먼저 회분식 실험을 통해 산화촉매로서의 제강분진의 활용 가능성을 확인하였으며, 반응의 주요 변수인 pH, 제강분진과 과산화수소의 주입농도, 그리고 과산화수소의 분할주입 등의 조건변화에 따른 매립지 침출수의 처리효율과 최적 반응조건을 알아보았다. 최적 ${H_2}{O_2}$와 제강분진의 주입조건인 20g/L dust +2,000mg/L ${H_2}{O_2}$에서 반응시간 60분내에 초기 TOC 농도(250mg/L)의 75%가 제거되었으며, 이 때 ${H_2}{O_2}$/dust 시스템의 최적 반응 pH는 3-4였다. 철염을 반응촉매로 사용하는 펜톤산화반응과 비교하였을 때, 제강분진을 반응촉매로 사용하는 경우가 반응성과 경제성에서 더 유리한 것으로 나타났다. This study attempts to elucidate the possibility of treating landfill leachate by steelers' dust/${H_2}{O_2}$ system in a well-mixed batch reactor. Experiments were conducted to investigate the effects of operating variables such as pH, dust and ${H_2}{O_2}$ dosages and ${H_2}{O_2}$ injection method on the treatment efficiency, Contaminant concentrations were identified by TOC (Total Organic Carbon) analyzer. Experimental observations showed the possibility of steelers' dust as a catalytic reagent in the ${H_2}{O_2}$/dust system. The batch experiments showed that the optimal $H_2O$$_2$ and dust dosage, 20g/L dust. 2,000mg/L ${H_2}{O_2}$ removed about 75% of initial TOC concentration (250mg/1) within 60 min. And the TOC removal in the ${H_2}{O_2}$/dust system effectively proceeded only within a limited pH range of 3-4. The stealers' dust-catalyzed oxidative treatment of landfill leachate was more efficient compared with the $FeSO_2$catalyzed system (Fenton oxidation) for the removal rate and the cost.
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강정우,김정찬,조필자,조정희,김승민,선우일남 대한신경과학회 2004 대한신경과학회지 Vol.22 No.5
Leigh syndrome (LS) is a genetically and clinically heterogeneous disorder caused by metabolic defects affecting lactate/pyruvate metabolism. The consequence of the metabolic defects are decreased amounts of APT and basic cell energy productions of the nervous system. In LS, several mutations have been reported in both the nuclear and the mitochondrial genome. Here, we report a 26-year-old woman clinically diagnosed with LS having characteristic brain MR and MRS abnormalities but without known definite pathogenetic mitochondrial DNA mutations.
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강정우,정진우,이은영,김성원 대한 소아알레르기 호흡기학회 2009 Allergy Asthma & Respiratory Disease Vol.19 No.4
Purpose : We attempted to investigate clinical characteristics of children with severe atopic dermatitis. Methods : A total of 204 children diagnosed with Atopic dermatitis at the Pediatric Allergy Respiratory Center in Busan St. Mary's Medical Center from June 2006 to June 2008 were enrolled in this study. Cases were divided into 3 groups according to SCORAD index: severe, moderate and mild groups. We collected birth, environment, and allergic family history, and tested serum IgE, total eosinophil count, specific IgE, ECP (Eosinophil Cationic Protein) and the SCORAD index between the 3 groups. Results : Of the 204 patients, 100 (49.02%) were included in the severe group, 51 (25.0%) in the moderate group, and 53 (25.98%) in the mild group. There were no differences in serum total IgE, serum total eosinophil counts and ECP between the severe and moderate groups. Serum total IgE, serum total eosinophil counts and ECP were relatively higher in the severe group than mild group. Food allergen sensitization rate was relatively higher in the infantile severe group than in the childhood severe group, while inhalant allergen sensitization rate was relatively higher in the childhood severe group than in the infantile severe group. There was no correlation between serum total IgE, serum total eosinophil counts, ECP and the number of sensitized allergens relative to SCORAD index in the severe group. Conclusion : Serum IgE, total eosinophil count, specific IgE and ECP may be specific indicators of children with severe atopic dermatitis. Further studies are needed to determine a clear distinction between severe and moderate atopic dermatitis patients. 목 적 : 중증의 소아아토피피부염 환자에 대한 임상양상의 연구를 통해 중증의 소아아토피피부염 환자의 특징을 파악하고자 하였다. 방 법 : 2006년 6월부터 2008년 6월까지 부산 성모병원 소아청소년과 알레르기클리닉에 내원한 204명의 아토피피부염 환자를 대상으로 하였다. 아토피피부염의 중증도는 SCORAD점수에 의거하여 임상적 중증도를 평가하였으며, SCORAD 점수가 15점 미만인 경우를 경증, 15점 이상이고 40점 이하인 경우를 중등증, 40점 초과를 중증으로 구분하였다. 그리고 대상자의 생활환경, 가족력을 조사하고, 혈청 총 IgE, 총 호산구수, ECP, 특이 IgE (유럽집먼지진드기, 아메리카집먼지진드기, 계란, 우유, 메밀, 땅콩, 대두)에 대한 검사를 실시하였다. 결 과 : 204명의 대상자 중 중증군은 100명(49.02%), 중등증군은 51명(25.0%), 경증군은 53명(25.98%)이었다. 중증군과 중등증군 간에 총 IgE, 총 호산구수, ECP농도의 비교에서는 유의한 차이가 없었고, 중증군과 경증군 간의 총 IgE, 총 호산구수, ECP농도의 비교에 있어서는 중증군이 경증군보다 유의하게 높았다. 그리고 중증의 영아 연령군이 중증의 소아 연령군보다 식품 알레르겐에 감작된 수에서 유의하게 많았고, 흡입 알레르겐에 감작된 수에 있어서는 중증의 소아 연령군이 중증의 영아 연령군보다 유의하게 많았다. 중증군에서 SCORAD 점수와 총 IgE, 총 호산구수, ECP, 감작된 알레르겐의 개수와는 유의한 상관관계가 없었다. 그리고 중증의 소아 아토피피부염 환자에서는 피부병변이 광범위하고 심해서 입원한 경우가 가장 많았다. 결 론 : 총 IgE, 총 호산구, ECP, 특이 IgE는 중증의 소아 아토피피부염 환자의 임상적 특징을 반영하고 있으나, 중등증의 소아 아토피피부염 환자와의 차이에 관해서는 추가적인 광범위한 연구가 필요하다고 생각된다.
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