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대시호탕(大柴胡湯)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響)
박선동,윤병국,Park, Seon-Dong,Yun, Byeong-Guk 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1
The purpose of this study was to reseach the effect of Daesihotang and its component groups on diabetes, free radical and antioxidative defense system in alloxan-induced diabetic rats. The experimental group was divided into three groups: Daesihotang (DS), Soyangyak (DS1), Yangmyungyak (DS2). The results were obtained as follows: The level of glucose, triglyceride, total cholesterol, creatinine in serum were considerablely reduced by Daesihotang. And the level of HDL cholesterol, albumin, total protein in serum were increased by Daesihotang significantly. And the level of BUN has some decreased, but with no significancy. In the study of Daesihotang on free radical scavenging effect in vitro, it has shown that Daesihotang and its components group have significant suppressing effect on peroxidation of linoleic acid on concentration. And in other experiments as scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system and inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2-Fe^{2+}$ system, Daesihatang have some activity, but with no significancy. In the study of Daesihotang on antioxidative defense system in vivo, the activity of GOT and GPT in serum were significantly increased; and the amounts of lipid peroxide in serum was reduced significantly but in liver no significancy. In hepatic catalase activity, Daesihotang has showed significant effect. In the level of hepatic glutathione, Daesihotang increased the amount of glutathione significantly. And in the activity of glutathione-s-transferase, Daesihotang has decreasing effect but has no significancy. These result suggest that Daesihotang has strong effect on diabetes and it is useful to prevent diabetes, but has less effect on peroxidative damage by free radical.
박선동,문진영 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1
Sihosamultang has been used in treatment for puerperal fever, liver disease in traditional medicine. The present study was carried out to evaluate the antioxidant effects of Sihosamultang methnol extract(SME) in vitro. The inhibitory effect of SME on lipid peroxidation was examined in the linoleic acid autoxidation system. In this test, SME significantly inhibited the time course of the lipid peroxidation. And SME showed about 77% scavenging effect on DPPH radical, also exhibited about 89% inhibitory effect on lipid peroxide formation induced by hydroxyl radical derived from H₂O₂-Fe^2+ in the rat liver homogenate. And SME dose-dependently inhibited superoxide generation from xanthine-xanthine oxidase system. In addition, SME protected the hepatic cell death induced by tert-butyl hydroperoxide. These data indicated that SME might play a protective role against oxidative injury by free radicals.
deegree를 이용한 국토공간영상정보 국가 표준파일포맷(NIX)의 OGC 표준 프로토콜 지원 방안 연구
박선동(SeonDong Park) 대한공간정보학회 2009 한국지형공간정보학회 학술대회 Vol.2009 No.9
본 논문은 현재 국토지리정보원에서 국토공간영상정보 국가표준파일포맷(NIX)를 사용하여 기존에 촬영된 항공사진을 DB화하여 보관하고 있으며 인터넷을 통하여 항공영상의 확인 및 교부 서비스를 수행하고 있다. 그러나 이러한 서비스는 OGC등에서 권장하고 있는 웹 매핑 표준을 지원하지 않고 있음으로 인해, 기타 웹서비스와의 연계등의 매우 불리하다. 또한 NIX의 경우 새로운 영상 포맷을 정의한 것으로 기존의 웹서비스에서 직접적으로 사용하는 것은 거의 불가능하다. 따라서 OGC에서 정의한 웹 표준을 지원함으로써 다른 웹 서비스와의 연계를 수행할 수 있는 방안을 강구하고 Open Source 웹 맵 서버를 사용하여 데이저 제공자 부분에 NIX를 지원할 수 있도록 개발함으로써 NIX 포맷을 일반적인 영상포맷으로 변환하지 않고 서비스 수행이 가능하다.