중년기 남성의 피로대처에 관한 주관성

윤은자,류은정,전미영,황윤영 성인간호학회 2002 성인간호학회지 Vol.14 No.4

Poupose: The purpose of this study is to identify factors that affect coping with fatigue in middle-aged men according to Q-methodology and to provide basic strategies for health promotion. Method; 25 subjects in Seoul, Incheon, Chung-buk classified 24 selected Q-statements in to 9 points standard. The collected data were analyzed by using a QUNAL pc program. Result; Principal component analysis identified 3 types of coping with fatigue among middle-aged Korean men. 1st Type : Coping with fatigue through various kinds of game, using alcohol, smoking cigarette other than rest and sleep. 2nd Type : Coping with fatigue through rest and sleep, taking medicine or food which helps relieving fatigue. 3rd Type : coping with fatigue through acitivities such as sports or trip other than sleep. Conclusion: We have found how Korean middle-aged men cope against fatigue through this research. To setup and apply different nursing intervention on each type based on this result is needed.

고속 다중 파장망을 위한 효율적인 채널 예약 프로토콜

李湖淑,李東垠,金永川 全北大學校 1996 論文集 Vol.41 No.-

In the high speed multi-wavelength networks, signal propagation delay time is much larger than the transmission time of data packet. So retransmission overhead due to destination conflict or control packet collision is one factor of performance degradation. An efficient WDMA protocol with a collision avoidance mechanism is proposed for high speed optical networks. It can be applied to the WDM single-hop network with a passive star topology. In proposed protocol, each node has source queues and routing table to store routing information. This architecture makes it possible to avoid any kind of collision when a node reserves the channel to transmit a data packet. High system thoughput and channel utilization can be achieved by proposed protocol since there are no discarded packets caused by any collision at transmission time. The performance of proposed is evaluated in terms of throughput and delay with variations in offered load. Simulation results show that the proposed protocol has superior performance to conventional protocols under nonuniform as well as uniform traffic.

광양만 유역 퇴적토 중의 다환방향족탄화수소류

정흥호,정호승,김은영,조환익,황주찬,최상원 한국환경과학회 2004 한국환경과학회지 Vol.13 No.6

Polycyclic aromatic hydrocarbons(PAHs) in sediments of Kwangyang bay on Korea, have been investigated by gas chromatography-mass spectrometery (GC/MS). The average content of total PAHs in all samples was 2,211ppb, and the range was from 36 to 22,699pph. The higher concentrations were found in sediment sampled near Kwangyang iron processing plant, Taeindo. The resulting distributions of PAHs according to the number of aromatic ring and molecular ratios of specific aromatic compounds (phenanthrene, anthracene, fluoranthene and pyrene) have been discussed in terms of sample location, origin of the organic matter. Four, five and six rings of PAHs were mainly found near to Kwangyang iron processing plant, and three and four rings near to Yeosu chemical kombinat. This result typically indicated the local characteristics, depending on the origin of PAHs.

일 간호대학의 지역사회 방문간호사업 사례

강윤숙,최양자,고영애,전시자,조갑출,이옥철,주혜경,신기수,안은숙 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

LC, Acute : PE-115 ; Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis

( Young Eun Chon ),( Eun Hee Choi ),( Ki Jun Song ),( Jun Yong Park ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Sang Hoon Ahn ),( Seung Up Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Transient elastography (TE), a noninvasivetool that measures liver stiffness, has been evaluated in meta- analyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC).However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB. Methods: Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study. Result: A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857-0.860), 0.887 (95% CI, 0.886-0.887), and 0.929 (95% CI, 0.928-0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1-11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1-9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3-17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%. Conclusion: TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.

HC, Acute : PE-115 ; Performance of transient elastography for the staging of liver fibrosis in patients with chronic hepatitis B: a meta-analysis

( Young Eun Chon ),( Eun Hee Choi ),( Ki Jun Song ),( Jun Yong Park ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Sang Hoon Ahn ),( Seung Up Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: Transient elastography (TE), a noninvasivetool that measures liver stiffness, has been evaluated in metaanalyses for effectiveness in assessing liver fibrosis in European populations with chronic hepatitis C (CHC).However, these data cannot be extrapolated to populations in Asian countries, where chronic hepatitis B (CHB) is more prevalent. In this study, we performed a meta-analysis to assess the overall performance of TE for assessing liver fibrosis in patients with CHB. Methods: Studies from the literature and international conference abstracts which enrolled only patients with CHB or performed a subgroup analysis of such patients were enrolled. Combined effects were calculated using area under the receiver operating characteristic curves (AUROC) and diagnostic accuracy values of each study. Result: A total of 18 studies comprising 2,772 patients were analyzed. The mean AUROCs for the diagnosis of significant fibrosis (F2), severe fibrosis (F3), and cirrhosis (F4) were 0.859 (95% confidence interval [CI], 0.857?0.860), 0.887 (95% CI, 0.886?0.887), and 0.929 (95% CI, 0.928?0.929), respectively. The estimated cutoff for F2 was 7.9 (range, 6.1?11.8) kPa, with a sensitivity of 74.3% and specificity of 78.3%. For F3, the cutoff value was determined to be 8.8 (range, 8.1?9.7) kPa, with a sensitivity of 74.0% and specificity of 63.8%. The cutoff value for F4 was 11.7 (range, 7.3?17.5) kPa, with a sensitivity of 84.6% and specificity of 81.5%. Conclusion: TE can be performed with good diagnostic accuracy for quantifying liver fibrosis in patients with CHB.

HBV : PO-03 ; Partial virological response to adefovir add-on lamivudine rescue therapy in patients with lamivudine-resistant chronic hepatitis B

( Young Eun Chon ),( Jun Yong Park ),( Sang Hoon Ahn ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Ara Choi ),( Seung Up Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background: In patients with lamivudine (LAM)-resistant chronic hepatitis B (CHB) receiving adefovir (ADV) add-on LAM rescue therapy, insufficient viral suppression or the appearance of additional ADV resistance has remained unresolved. This study determined the partial virological response (PVR) criteria to predict a virological response (VR) at week 96 in these patients. Methods: Between January 2000 and December 2007, 96 patients with LAM-resistant CHB, who received ADV add-on LAM rescue therapy for more than 2 years, were analyzed. For predicting VR at week 96, the area under the receiver operating characteristic curve values at different time points were compared to establish the optimal time point, and the maximal Youden index was calculated to determine the optimal cutoff HBV DNA level. Results: Fifty (52.1%) patients achieved VR at 2 years after ADV add-on LAM rescue therapy. The optimal PVR criteria were determined to be HBV DNA 500 IU/mL (3.40 log10 copies/mL, 2500 copies/mL) at week 48. Forty-four (45.8%) patients who met the established optimal PVR criteria showed a significantly higher risk for detectable HBV DNA levels at week 96 than those with a favorable VR (HBV DNA < 500 IU/mL) at week 48 (odds ratio, 4.2; 95% confidence interval, 3.2-5.4). Conclusions: This study suggested optimal PVR criteria in patients with LAM-resistant CHB receiving ADV add-on LAM rescue therapy. Modification of the antiviral agent regimen should be considered if serum HBV DNA level exceeds 500 IU/mL at week 48.

HBV : O-001 ; An observational, multicenter, cohort study evaluating the antiviral efficacy, safety, and tolerability in Korean patients with chronic hepatitis B (CHB) receiving pegylated Interferon-alpha 2a (Pegasys®): TRACES STUDY

( Young Eun Chon ),( Dong Joon Kim ),( Sang Gyune Kim ),( In Hee Kim ),( Si Hyun Bae ),( Seong Gyu Hwang ),( Jeong Heo ),( Jeong Won Jang ),( Byung Seok Lee ),( Hyung Joon Kim ),( Dae Won Jun ),( Gang 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: Until today, there is currently no data available on the efficacy, safety, and tolerability of pegylated interferon alfa 2a (PEG-IFNa-2a) in Korean patients with chronic hepatitis B (CHB), who are known to have mostly HBV genotype C. Methods: We collected data from 18 institutes of 451 Korean patients with CHB who were treated with PEG-IFNa-2a as a first line therapy (370 patients with HBeAg positive and 81 with HBeAg negative). Treatment responses at the end of treatment (ET) and at 6 months post-treatment (PT6) were compared between patients treated for 24 weeks vs. 48 weeks, and adverse events were evaluated. Results: In HBeAg-positive patients, the patients who had received PEG-IFNa-2a for 48 weeks than 24 weeks achieved significantly higher virological response (HBV DNA < 2,000 IU/mL) (48 vs. 24 weeks at ET, 44.4% vs. 27.2%, p = 0.005; at PT6, 46.7% vs. 17.2%, p=0.001). Complete virological response (HBV DNA < 60 IU/mL) at ET was also achieved in more patients with a longer treatment (48 vs. 24 weeks 22.0% vs. 13.0%, p=0.005). HBeAg seroconversion rate at ET was 18.1% with 48 weeks treatment, which is significantly higher than 10.1% (p=0.012) with 24 weeks treatment. This finding was continued to PT6 (23.7% vs. 17.2%, p = 0.028). The rate of ALT normalization was increased from 61.4% at ET to 76.8% at PT6 on 48 weeks-treatment. HBsAg seroconversion was not common (48 vs. 24 weeks at ET, 0.4% vs. 0%; at PT6, 0.8% vs. 0%). In HBeAg-negative patients, virologic response at ET was higher than that in HBeAg-positive patients following 48 weeks treatment (serum HBV DNA< 60 and < 2,000 IU/mL; 60.8% and 87.8%, respectively). HBsAg seroconversion was 1.4% at ET and it was maintained at PT6. Adverse events were typical of those associated with PEG-IFNa-2a. Conclusion: In Korean CHB patients, PEG-IFNa-2a showed substantial treatment response and good tolerability. In patients with HBeAg-positive CHB, the longer treatment of PEG-IFNa-2a (48 weeks rather than 24 weeks) was more efficacious with similar safety profiles.

Hepatocellular carcinoma statistics in South Korea

( Young Eun Chon ),( Soung Won Jeong ),( Dae Won Jun ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3

Hepatocellular carcinoma incidence is decreasing in Korea but increasing in the very elderly

Young Eun Chon,Seong Yong Park,Han Pyo Hong,Donghee Son,Jonghyun Lee,Eileen Yoon,Soon Sun Kim,Sang Bong Ahn,Soung Won Jeong,Dae Won Jun 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.1

Background/Aims: A comprehensive analysis of trends in the incidence of hepatocellular carcinoma (HCC) is important for planning public health initiatives. We aimed to analyze the trends in HCC incidence in South Korea over 10 years and to predict the incidence for the year 2028. Methods: Data from patients with newly diagnosed HCC between 2008 and 2018 were obtained from Korean National Health Insurance Service database. Age-standardized incidence rates (ASRs) were calculated to compare HCC incidence. A poisson regression model was used to predict the future incidence of HCC. Results: The average crude incidence rate (CR) was 22.4 per 100,000 person-years, and the average ASR was 17.6 per 100,000 person-years between 2008 and 2018. The CR (from 23.9 to 21.2 per 100,000 person-years) and ASR (from 21.9 to 14.3 per 100,000 person-years) of HCC incidence decreased during the past ten years in all age groups, except in the elderly. The ASR of patients aged ≥80 years increased significantly (from 70.0 to 160.2/100,000 person-years; average annual percent change, +9.00%; P<0.001). The estimated CR (17.9 per 100,000 person-years) and ASR (9.7 per 100,000 person-years) of HCC incidence in 2028 was declined, but the number of HCC patients aged ≥80 years in 2028 will be quadruple greater than the number of HCC patients in 2008 (from 521 to 2,055), comprising 21.3% of all HCC patients in 2028. Conclusions: The ASRs of HCC in Korea have gradually declined over the past 10 years, but the number, CR, and ASR are increasing in patients aged ≥80 years.