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F-number matching method in light field microscopy using an elastic micro lens array
Kim, Jonghyun,Jeong, Youngmo,Kim, Hyungjin,Lee, Chang-Kun,Lee, Byeongmoon,Hong, Jisoo,Kim, Youngmin,Hong, Yongtaek,Lee, Sin-Doo,Lee, Byoungho OPTICAL SOCIETY OF AMERICA 2016 Optics letters Vol.41 No.12
<P>In light field microscopy (LFM), the F-number of the micro lens array (MLA) should be matched with the image-side F-number of the objective lens to utilize full resolution of an image sensor. We propose a new F-number matching method that can be applied to multiple objective lenses by using an elastic MLA. We fabricate an elastic MLA with polydimethylsiloxane (PDMS) using a micro contact printing method and address the strain for the F-number variation. The strain response is analyzed, and the LFM system with the elastic MLA is demonstrated. Our proposed system can increase the F-number up to 27.3% and can be applied to multiple objective lenses. (C) 2016 Optical Society of America</P>
이정기(JungKi Lee),용기중(GeeJoong Yong),이종현(JongHyun Lee),이광범(KwangBum Lee),홍윤석(YunSeog Hong),이현우(HyunWoo Lee),정혁(Hyuk Jung),임종순(JongSoon Lim) 한국자동차공학회 2005 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2005 No.11_3
The effective use of vehicle have a energy savings and a reduction of greenhouse emission cause for a greenhouse effect. For the high cost of fuel and the effectuation of The Kyoto Protocol, we should achieve the vehicle Fuel economy and CO₂ emission test according to the variable vehicle weight and should announce the effectiveness that fuel economy and CO₂ emission depend on the driving method and circumstance to the driver.
Automated Evaluation of Upper-Limb Motor Function Impairment Using Fugl-Meyer Assessment
Lee, Seunghee,Lee, Yang-Soo,Kim, Jonghyun IEEE 2018 IEEE transactions on neural systems and rehabilita Vol.26 No.1
<P>The Fugl-Meyer assessment (FMA) is the most popular instrument for evaluating upper extremity motor function in stroke patients. However, it is a labor-intensive and time-consuming method. This paper proposes a novel automated FMA system to overcome these limitations of the FMA. For automation, we used Kinect v2 and force sensing resistor sensors owing to their convenient installation as compared with body-worn sensors. Based on the linguistic guideline of the FMA, a rule-based binary logic classification algorithm was developed to assign FMA scores using the extracted features obtained from the sensors. The algorithm is appropriate for clinical use, because it is not based on machine learning, which requires additional learning processes with a large amount of clinical data. The proposed system was able to automate 79% of the FMA tests because of optimized sensor selection and the classification algorithm. In clinical trials conducted with nine stroke patients, the proposed system exhibited high scoring accuracy (92%) and time efficiency (85% reduction in clinicians’ required time).</P>
Single-molecule views of MutS on mismatched DNA
Lee, Jong-Bong,Cho, Won-Ki,Park, Jonghyun,Jeon, Yongmoon,Kim, Daehyung,Lee, Seung Hwan,Fishel, Richard Elsevier 2014 DNA repair Vol.20 No.-
<P><B>Abstract</B></P> <P>Base-pair mismatches that occur during DNA replication or recombination can reduce genetic stability or conversely increase genetic diversity. The genetics and biophysical mechanism of mismatch repair (MMR) has been extensively studied since its discovery nearly 50 years ago. MMR is a strand-specific excision-resynthesis reaction that is initiated by MutS homolog (MSH) binding to the mismatched nucleotides. The MSH mismatch-binding signal is then transmitted to the immediate downstream MutL homolog (MLH/PMS) MMR components and ultimately to a distant strand scission site where excision begins. The mechanism of signal transmission has been controversial for decades. We have utilized single molecule Forster Resonance Energy Transfer (smFRET), Fluorescence Tracking (smFT) and Polarization Total Internal Reflection Fluorescence (smP-TIRF) to examine the interactions and dynamic behaviors of single <I>Thermus aquaticus</I> MutS (TaqMutS) particles on mismatched DNA. We determined that TaqMutS forms an incipient clamp to search for a mismatch in ∼1s intervals by 1-dimensional (1D) thermal fluctuation-driven rotational diffusion while in continuous contact with the helical duplex DNA. When MutS encounters a mismatch it lingers for ∼3s to exchange bound ADP for ATP (ADP→ATP exchange). ATP binding by TaqMutS induces an extremely stable clamp conformation (∼10min) that slides off the mismatch and moves along the adjacent duplex DNA driven simply by 1D thermal diffusion. The ATP-bound sliding clamps rotate freely while in discontinuous contact with the DNA. The visualization of a train of MSH proteins suggests that dissociation of ATP-bound sliding clamps from the mismatch permits multiple mismatch-dependent loading events. These direct observations have provided critical clues into understanding the molecular mechanism of MSH proteins during MMR.</P>
Modeling and Analysis of Through-Silicon Via (TSV) Noise Coupling and Suppression Using a Guard Ring
Jonghyun Cho,Eakhwan Song,Kihyun Yoon,Jun So Pak,Joohee Kim,Woojin Lee,Taigon Song,Kiyeong Kim,Junho Lee,Hyungdong Lee,Kunwoo Park,Seungtaek Yang,Minsuk Suh,Kwangyoo Byun,Joungho Kim IEEE 2011 IEEE transactions on components, packaging, and ma Vol.1 No.2
<P>In three-dimensional integrated circuit (3D-IC) systems that use through-silicon via (TSV) technology, a significant design consideration is the coupling noise to or from a TSV. It is important to estimate the TSV noise transfer function and manage the noise-tolerance budget in the design of a reliable 3D-IC system. In this paper, a TSV noise coupling model is proposed based on a three-dimensional transmission line matrix method (3D-TLM). Using the proposed TSV noise coupling model, the noise transfer functions from TSV to TSV and TSV to the active circuit can be precisely estimated in complicated 3D structures, including TSVs, active circuits, and shielding structures such as guard rings. To validate the proposed model, a test vehicle was fabricated using the Hynix via-last TSV process. The proposed model was successfully verified by frequency- and time-domain measurements. Additionally, a noise isolation technique in 3D-IC using a guard ring structure is proposed. The proposed noise isolation technique was also experimentally demonstrated; it provided -17 dB and -10dB of noise isolation between the TSV and an active circuit at 100 MHz and 1 GHz, respectively.</P>
Poly(A) RNA and Paip2 act as allosteric regulators of poly(A)-binding protein
Lee, Seung Hwan,Oh, Jungsic,Park, Jonghyun,Paek, Ki Young,Rho, Sangchul,Jang, Sung Key,Lee, Jong–,Bong Oxford University Press 2014 Nucleic acids research Vol.42 No.4
<P>When bound to the 3′ poly(A) tail of mRNA, poly(A)-binding protein (PABP) modulates mRNA translation and stability through its association with various proteins. By visualizing individual PABP molecules in real time, we found that PABP, containing four RNA recognition motifs (RRMs), adopts a conformation on poly(A) binding in which RRM1 is in proximity to RRM4. This conformational change is due to the bending of the region between RRM2 and RRM3. PABP-interacting protein 2 actively disrupts the bent structure of PABP to the extended structure, resulting in the inhibition of PABP-poly(A) binding. These results suggest that the changes in the configuration of PABP induced by interactions with various effector molecules, such as poly(A) and PABP-interacting protein 2, play pivotal roles in its function.</P>