인체 체액내 황색포도상구균의 증식과 철 획득 기전

신성희,이강길,이명희,양남웅,임용,김진호 대한감염학회 2000 감염 Vol.32 No.5

녹차의 주성분인 에피갈로카테킨 갈레이트의 정맥주사후 흰쥐에서의 약물속도론 연구

임재수,황성주,지웅길,김동출 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-

The pharmcacokinetic study of epigallocatechin gallate was performed following iv bolus administration in Sprague-Dawley rats. The values of systemic clearance (CL) were 68±5 and 27±1 ml/min/kg following iv bolus administration of 1 mg and 5 mg EGCG, respectively. The values of volume of distribution at steady state were 380 and 835 ml/kg body weight after iv bolus administration 1mg and 5mg EGCG, respectively. The decrease in the value of CL and the increase of Vss as a function of dose suggest saturable pharmacokinetics of EGCG in rats.

결함 허용성과 부하 균등화를 위한 프로세스 스케쥴러 연구

임종규,박영진,최길성,김한웅 안성산업대학교 1993 論文集 Vol.25 No.-

A Process Scheduler is designed for load balancing under normal state and for load redistribution under failure in a fail-soft distributed system. The proposed load redistribution algorithm is that if any soft-fault occurs in the local nodes, all the processes in the queue of the failed processor and all incoming processes the failed processor are automatically rescheduled by a certain policy in which we determine to buffer them in the current node or to transfer them to another underloaded node considering criticality and service time of the fault. The proposed load balancing algorthm enhances Soh's model(ESM). Our algorithm eliminates the problems of conventional algorithm which has load tables in each processor. This model provided us with several advantages such as reliability, availability and fault-tolerance.

실험실 벤치로부터 임상적용까지 : 부갑상선호르몬 PTH

임승길 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.3

Neural Oscillator를 이용한 강인한 피치추적에 관한 연구

임성길,김형호 대불대학교 2002 論文集 Vol.8 No.1

This Paper treats on the Method for robust pitch tracking on neural oscillator. We used the method which was modified LEGION(Locally Exitator Globally Inhibitory Oscillator Network) algorithm for neural oscillator. The proposed pitch tracking method was evaluated on a man and woman's clean voice which was recoded in the lab and news reporter's voice which has noice signal.

흰쥐에서 녹차카테킨류의 간추출율의 평가

임재수,황성주,지웅길,김동출 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

To investigate the role of liver in the elimination of green tea catechins, the hepatic extraction ratio of epigallocatechin gallate, epigallocatechin, and epicatechin gallate was investigated following intraduodenal administration of green tea catechin extracts in Sprague-Dawley rats. The plasma concentrations of the catechins in portal and systemic circulations were determined simultaneously in the same rat to evaluate the hepatic extraction ratio. The values of hepatic extraction ratio of epigallocatechin gallate, epicatechin gallate, and epicatechin were 0.54, 0.28, and 0.51, respectively. Therefore, it is suggested that the hepatic clearance plays a major role in the elimination of epigallocatechin gallate and epicatechin.

분리장소에 따른 황색포도구균의 항생제 내성

임용,이강길,신성희 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.1

본 연구의 결과를 요약하면 다음과 같다. 1. 임상 분리주 총 70주의 황색 포도구균의 9가지 항생제에 대한 내성율을 조사한 결과, OXAC 내성율 즉 MRSA 분리율은 54.3%이었다. PCV에는 92.9%의 균주가 내성을 보인 반면, SXT 5.7%의 내성율을 보여서 좋은 항균효과를 보였으며, VM에는 모든 실험균주가 감수성을 보였다. 2. 임상 분리주 중 87%(61주)에 해당되는 균주가 2가지 이상의 항생제에 다제내성을 보였다. 3. 대상균주를 환자 분리주(56주), 의료인 분리주(7주), 병원환경 분리주(7주)로 나누어 각 항생제의 내성율을 비교한 결과 통계적 차이를 보이지 않았으나 CLM, SXT 등의 항생제는 환자 분리주에서 보다 병원환경 분리주에서 더욱 높은 내성율을 보였다. 4. 환자 분리주를 외래환자 분리주(16주)와 입원환자분리주(40주)로 나누어 항생제 내성율을 비교한 결과, SXT와 VM을 제외한 모든 항생제에서 통계학적으로 의미 있는 차이를 보였다(p<05). 즉 외래환자 분리주는 기타 환자 분리주에 비해 항생제에 대해 매우 높은 감수성을 보였다. 또한 OXAC에 전부 감수성이 있는 MSSA이었다. 이상과 같은 결과를 토대로 환자 분리주, 의료인 분리주, 병원환경 분리주에서 항생제에 대한 내성율에 큰 차이를 보이지 않고 비슷한 내성율을 보인 점은 이러한 비교군 간의 황색 포도구균 감염의 연쇄고리가 있음을 알 수 있으며 외래환자 분리주가 입원환자 분리주에 비해 항생제 감수성이 높은 것은 외래 환자들의 감염원이 병원내에 있지 않고 자연환경이나 건강인의 피부나 비강에서 비롯된 것이었기 때문으로 생각해 볼 수 있다. Objectives: Staphylococcus aureus showing multi-drug resistance is one of the major human pathogens causing nosocomial infection. The aim of this study is to investigate the difference of antimicrobial resistance according to the isolation sites and to offer the latest information of antimicrobial chemotherapy and reappraisal. Materials and Methods: We isolated and identified seventy stains of S. aureus from community hospitals and the isolated strains were classified according to the isolation sites. Disk diffusion test was used for the determination of antibiotic resistance. Results: The obtained results were as the follows. (1) Methicillin-resistant S. aureus was 54.3% of the total seventy strains. 92.9% were susceptible against sulphamethoxazole and trimethoprim and 100% against vancomycin. (2) When the total isolates were divided into the three groups including the isolates from patients (56 strains), those from doctors and nurses (7 strains) and those from a hospital environment (7 strains), there was a slight, but not significant difference in the resistance ratio against the tested antimicrobial agents. (3) There was a striking difference in the resistance ratio between the isolates obtained from the outpatient department (OPD, 16 strains) and those from the hospitalized patients (40 strains). Isolates obtained from OPD showed a higher susceptibility than those from the hospitalized patients (p<0.05) and all the isolates obtained from OPD proved MSSA (methicillin-susceptible S. aureus). Conclusion: Taken together, these findings suggest that there is an intimate circuit for bacterial transmission among the three groups. The higher susceptibility in the isolates from OPD suggests that they may be less frequently exposed to antimicrobial agents and originated from either a natural environment or the nares of normal persons but not from the hospital environments.

개심술후 정신의학적 합병증

임기영,조범구,민성길,이홍식,유계준 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

Pre-and post operative psychiatric evaluations were done using semi-structured interview with Hamilton scales for anxiety and depression in 57 open heart surgery receipients to assess post-operative psychiatric complications. Conspicuous post-operative psychiatric complications were observed in 16 (23%) of 57 patients after open heart surgery. Postcardiotomy delirium occurred in seven patients; acute psychotic reaction with paranoid ideation in one; and neurotic reaction in eight. Factors that tended to influence postoperative psychiatric complications were older age, unempolyment, previous medical/psychiatric history, and high level of preoperative anxiety. By analysis of the preoperative psychiatric evaluation, patients could be largely divided in 3 groups; anxiety group, denial group, and adjusted group. Excessive anxiety and massive denial seemed to be signficant in the postoperative psychiatric compliactions. With these findings, the author's impression was that the consultation psychiatrist should give comprehensive psychiatric evaluation and psychiatric preparation in pre-and post-open heart surgery for the possible prevention of postopertive psychiatric complications.

노안수술후 각막형태검사 변화

박근성,고길환,김용선,이재림,민병무,최시환 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

We prospectively analyzed the corneal topography of 26 eyes in 26 patients who had undergone scleral expansion for correcting presbyopia. We examined 26 eyes of 26 patients which were devided into 2 groups (mean age: 51 years, range 40-60 years) according to type of scleral expansion band, with computerized corneal topographic analysis system. Preoperatively and 5 times postoperatively (1day, 1week, 2weeks, 1month, 2months), quantitative descriptors of corneal topograpgy such as Sim K (simulated keratometry value), SRI(surface regularity index), and SAI(surface asymmetry index) were measured at each visit. The mean follow-up period was 43 days. Sim K of the operative eyes ranged from 0 to 2.5 (mean, 0.93) before operation, and mean 2.24 at postoperative 1 day in group Ⅰ. In group Ⅱ, Sim K was mean 2.20 at postoperative 1 day and decreased thereafter. SRI was from 0.54 to 1.39 and SAI was from 0.09 to 0.45 before operation. After operation, mean SAI was maximum at postoperative 2 week and mean SRI was maximum at postoperative 1 day and decreased thereafter. After two months, it became minimum. This study demonstrates that quantitative topographic change after scleral expansion for correcting presbyopia were great during first 1 week after surgery but this change diminished thereafter. Further long studies are in progress to evaluate the long term effects of this procedure.

農藥과 環境과의 關係 : 農藥使用量 推移 및 農藥販賣商에 關하여 Agricultural chemical use and status of agricultural chemical dealers

金吉雄,林鍾聲 경북대학교 1981 새마을 硏究論叢 Vol.1 No.-

In order to understand the interrelationship of agricultural chemical consumption with environment, the preliminary study was conducted to evaluate consumption of the agricultural chemicals in Korea and the present status of agricultural chemical dealers in Daegu city, emphasizing specially on qualification and academic background. The agricultural chemicals consumed in 1975 was 8,618.8 ton(a.i) and increased upto 14,454.2 ton(a.i.) in 1979, showing approximately an increase of 1.7 times during five years period. The academic background of managers working in the agricultural chemical dealers was mostly high school graduates and only 5.7% of them was agricultural college graduates in Daegu city as of December, 1981.