初等學生의 그래프 能力과 論理的 思考力 科學探究能力 및 科學에 관한 態度와의 관계

최영재,고영신,이재희 서울교육대학교 과학교육연구소 2001 科學과 數學敎育 論文集 Vol.27 No.-

중심성 분석을 이용한 2018년 판보로 국제 에어쇼 참가업체 기술동향 분석

황재교(Jae Gyo Hwang),박재우(Jae Woo Park),고용신(Yong-Sin Ko),이창범(Changbum Lee),황재식(Jae Sik Hwang) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.8

본 연구에서는 전 세계 3대 에어쇼 중의 하나인 “FIA(Farnborough International Airshow, 판보로 국제 에어쇼)”의 참여기관/업체를 대상으로 네트워크 분석을 활용하여 항공우주분야 기술동향을 분석하였다. 판보로 국제 에어쇼는 전 세계 주요 항공관련 민간 및 방산 업체와 각국 정부 및 군 관계자가 참여하여 항공우주산업분야에 대한 최신 기술을 선보이는 중요한 행사로서, 2018 FIA에서는 총 112개 국가에서 1,500여 업체(기관)가 참여하였다. 본 연구에서는, 항공우주분야 기술관련 45개 국가, 1,108개 업체를 대상으로 223개의 기술 분류 카테고리를 통해 네트워크 분석 중 하나인 키워드 기반의 중심성 분석을 수행하였다. 분석결과, 전 세계적 우주항공 분야의 핵심기술은 "Machining"으로 조사되었다. 하지만 지역(국가) 별로 분류되는 핵심기술은 다소 다른 경향을 보여주고 있었는데, 유럽(EU)과 영국의 경우 “Machining", 아시아의 경우 ”Aircraft Components", 미국의 경우 “Engine Components/controls"가 식별되었다. 우리나라의 경우에는 관련 기관/업체 수의 부족으로 뚜렷한 중심 기술이 식별되지 않았다. 본 연구의 결과가 우주항공분야 기술기획 및 연구 방향성 제시를 위한 참고자료로서 활용 될 수 있으며, 또한 국내 관련 업체의 수출 진흥을 위한 국외 주요 기술 분야를 제시하는데 유용하게 활용되리라 기대한다. The purpose of this research was to introduce a network analysis method for analyzing technology trends in the aerospace industry at the Farnborough International Airshow (FIA), one of the world"s three major airshows. Civil and defense companies and government and military officials from 112 countries and 1,500 agencies convened at FIA 2018 to share and explore recent trends in the aerospace industry. We studied aerospace technologies from 45 countries, 1,108 exhibiters, and 223 technology categories via centrality analysis. The results from the network analysis showed that machining is the center of aerospace technology. However, there were quite different tendencies, depending on the region and country. The centers of aerospace technology are machining in Europe and the United Kingdom, aircraft components in Asia, and engine components/controls in the United States. In Korea, no one key technology was recognized, due to the country"s small attendance. We hope this research will be conducive to aerospace technology-and-research planning, and that it will be an appropriate tool to help domestic manufacturers boost their exports.

서울 서초동 지역의 산성비에 대한 조사

고영신,최영재,최홍관 서울교육대학교 과학교육연구소 1996 科學과 數學敎育 論文集 Vol.22 No.-

The Effects of Green Tea Extracts (Polyphenon E, EGCG) in Human Papilloma Virus Positive Cervical Lesion

( Ko Hyun Sun ),( Huh Seung Won ),( Bae Su Mi ),( Son Seung Ae ),( Chung Jae Eun ),( Dong Kun Jin ),( In Su Peter Lee ),( Jeong Im Sin ),( Joon Mo Lee ),( Sung Eun Namkoong ),( Woong Shick Ahn ) 대한산부인과학회 2003 대한산부인과학회 학술대회 Vol.89 No.-

mtDNA cytochrome b에 기초한 한국흑우의 계통유전학적 분석

Jae-Hwan Kim(김재환),Mi Jung Byun(변미정),Myung-Jick Kim(김명직),Sang Won Suh(서상원),Young-Sin Kim(김영신),Yeoung-Gyu Ko(고응규),Sung Woo Kim(김성우),Kyoung-Sub Jung(정경섭),Dong-Hun Kim(김동훈),Seong-Bok Choi(최성복) 한국생명과학회 2013 생명과학회지 Vol.23 No.1

본 연구는 mtDNA cytochrome b(Cyt b) 유전자 서열을 토대로 한국흑우의 유전적 다양성 및 계통유전학적 위치를 파악하기 위하여 실시하였다. 한국흑우 38두로부터 결정된 mtDNA Cyt b유전자 전체서열 내에서 염기삽입 및 결실 없이 1개의 silent mutation이 동정되었다. 또한 2개의 haplotype으로 분류되었고, 염기변이율 및 haplotype 다양성지수에 기초한 한국흑우의 유전적 다양성은 기존에 보고된 중국 품종에 비해 낮게 나타났다. 한국, 일본, 중국에 분포하고 있는 12품종 101개 서열을 수집하여 한국흑우와의 유연관계를 확인하였다. 한국흑우에서 분류된 2개의 haplotype은 모두 B. taurus계열에 포함되었으며, 한우, 일본흑우, Yanbian, Zaosheng 등 4개 품종과 하나의 그룹을 형성하였다. 또한 품종별 D xy유전거리 산출 결과, 한국흑우는 한우 및 일본흑우에 비해서 중국의 Yanbian, Zaosheng 품종과 더 가까운 유연관계를 보였다. 본 연구의 결과는 가축유전자원으로서 한국흑우의 보존 및 유전적 특성 구명을 위한 중요한 자료로 활용이 가능할 것으로 사료된다. The purpose of this study was to identify genetic polymorphisms of the mitochondrial cytochrome b (mtDNA cyt b) gene in Korean black (KB) cattle breed and to analyze the genetic relationship between the KB and other breeds. We determined the complete sequence of the mtDNA cyt bgene in 38 KB cattle. We also analyzed their genetic diversity, and phylogenetic analysis was performed by comparison with Korean cattle (KC, called Hanwoo) and breeds from China and Japan. A nucleotide substitution was detected in the KB cattle, and two haplotypes were defined. In the neighbor-joining (NJ) tree, the haplotypes of KB were located in Bos taurus lineage with those of KC, Japanese black (JB), Yanbian and Zaosheng breeds. However, the haplotypes of Chinese breeds, excluding Yanbian and Zaosheng, were separated into B. taurusand B. indicus lineages. In the NJ tree of breeds based on D xygenetic distances, Chinese breeds mixed with B. taurus and B. indicus lineages were located between B. indicus and B. taurus lineages. KB was contained within B. taurus lineage and was determined to be genetically more closely related to two Chinese (Yanbian and Zaosheng) breeds than to KC and JB. The haplotype distribution and the results of the phylogenetic analysis suggest that KB and KC have genetic differences in their mtDNA cyt b gene sequences.

Partially Covered Metal Stents May Not Prolong Stent Patency Compared to Uncovered Stents in Unresectable Malignant Distal Biliary Obstruction

( Jae Yun Kim ),( Gyu Bong Ko ),( Tae Hoon Lee ),( Sang-heum Park ),( Yun Nah Lee ),( Young Sin Cho ),( Yunho Jung ),( Il-kwun Chung ),( Hyun Jong Choi ),( Sang-woo Cha ),( Jong Ho Moon ),( Young Deok 대한간학회 2017 Gut and Liver Vol.11 No.3

Background/Aims: Controversy still exists regarding the benefits of covered self-expandable metal stents (SEMSs) compared to uncovered SEMSs. We aimed to compare the patency and stent-related adverse events of partially covered SEMSs (PC-SEMSs) and uncovered SEMSs in unresectable malignant distal biliary obstruction. Methods: A total of 134 patients who received a PC-SEMS or uncovered SEMS for palliation of unresectable malignant distal biliary obstruction were reviewed retrospectively. The main outcome measures were stent patency, stent-related adverse events, and overall survival. Results: The median stent patency was 118 days (range, 3 to 802 days) with PC-SEMSs and 105 days (range, 2 to 485 days) with uncovered SEMSs (p=0.718). The overall endoscopic revision rate due to stent dysfunction was 36.6% (26/71) with PC-SEMSs and 36.5% (23/63) with uncovered SEMSs (p=0.589). Tumor ingrowth was more frequent with uncovered SEMSs (4.2% vs 19.1%, p=0.013), but migration was more frequent with PC-SEMSs (11.2% vs 1.5%, p=0.04). The incidence of stent-related adverse events was 2.8% (2/71) with PC-SEMSs and 9.5% (6/63) with uncovered SEMSs (p=0.224). The median overall survival was 166 days with PC-SEMSs and 168 days with uncovered SEMSs (p=0.189). Conclusions: Compared to uncovered SEMSs, PC-SEMSs did not prolong stent patency in unresectable malignant distal biliary obstruction. Stent migration was more frequent with PC-SEMSs. However, tumor ingrowth was less frequent with PC-SEMSs compared to uncovered SEMSs. (Gut Liver 2017;11:440-446)

의약품중 잔류유기용매 시험법 확립에 관한 연구

고용석,강찬순,최보경,김혜수,홍정희,최명신,김상현,장성재,김길수 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

Headspace-GC(딘5-GC)를 이용하여 ICH 잔류웅매 가이드라인 class 1, 2에 속하는 28종의 잔류유기웅매 분석방법을 연군한 결과 SPB-5, BB-WAX column을 동시 이용하여 각각을 확인, 정량할 수 있었다.또한 염의 참가효과, 평형시간,평형온도가 headspace분석에 미치는 영향을 검토한 결과 평형 시간 30분,평형온도 85℃,Na₂SO₄Ig을 첨가하여 시험할 때 최적 부넉조건을 나타내었다. 회수율은 1,1-achloroethene(68.3%)를 제외하고 90.9 ~ 114.5%로 패체적으로 양호하였다. 따로 HS-GCJECD, DB-524 column을 이용하여 9종의 잔류유기용매에 대하여 각각의 검랸선을 작성하고 검출한계를 구하였다. 실제 의약품 원료 10종및 제제 5종에 적용시킨 결과 모두 불검출되었으며 본 시험법은 의약품중의 잔류유기용매 분석에 적용할 수 있는 방법이라고 판단된다. The headspace-fC/FID(HS -GC/FID) method was performed for test method developnlent of residu;31 organic solvents in pfrarmaceuticals. Using SPB-S and BB-WAXcolumn, 28 kinds of solvents iri ICH residual sof)·ents guidetine class 1, 2 couBd be individuallt-identified and quantitated. The foIBowing residoal soIYents were not detected by the headspaceinjection condition : N,N-Cmethylacetamide, N,N-dimeth)rlformamide, ethyfeneglycol, formamide,2-methoryethanot, N-rnethylpyrrolidone, suBforane. The effects of the addition of salts,equilibration time, and equilibration temperature on headspace analt·sis were invesugated. Theoptimum conditions weiFe obtained with addtion of Ifa2s04 19 as a salt, simultaneously. thetime and temperature of equitibration were 30min and 8i'f, respectivety. The recovery havefound between 90.9 and 114.5% except 1,1-dichloroethene(fi8.3%). Using DB-624 column &HS-GC/:ECD method, 9 kinds of residual solvents could be individually identified andfuantitated. This HS-GC method can be applied to test the residua3 organic solvent in thepharmaceuticals.

S-75 Two cases of Neurofibromatosis Type 1 Associated GISTs and Characteristics of the 18 Korean Cases

( Jae Sin Lee ),( Kang Won Cho ),( Eu Won Ko ),( Hyung Joon Cho ),( Yeon Ho Joo ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Nerufibromatosis type 1 (NF1) is a cancer predisposition syndrome characterized by cafe-au lait spots and cutaneous neurofibromas. Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal tract tumor that occurs in NF1 patients. To date, there are a few reports with the result, NF1 associated GISTs have unique clinicopathologic and genotypic characteristics. They tend to occur in the small intestine at a younger age, have multiple lesions with good prognosis. They have positive CD 117 (KIT) expression in immunohistochemical staining but neither KIT or PDGFRA genes are mutated in majority of cases. Here we report two cases of small intestinal GISTs that occurred in patients with NF1. In the first case, a 55 years old woman had small bowel segmental resection for bleeding of abdomnial masses, that were identified as multiple GISTs. In the second case, a 48 years old woman had laparotomy for rupture of a abdominal mass, that was identified as a GIST. We also review related literature and find 18 Korean cases of NF1 associated GISTs. We compared them with foreign cases to find distict features of Korean cases. This report shows that there are no distinct features of Korean cases except presenting symptom.

Influence of the Duration of Diabetes on the Outcome of a Diabetes Self-Management Education Program

Ko, Seung-Hyun,Park, Sin-Ae,Cho, Jae-Hyoung,Ko, Sun-Hye,Shin, Kyung-Mi,Lee, Seung-Hwan,Song, Ki-Ho,Park, Yong-Moon,Ahn, Yu-Bae Korean Diabetes Association 2012 Diabetes and Metabolism Journal Vol.36 No.3

<P><B>Background</B></P><P>Diabetes education and lifestyle modification are critical components in controlling blood glucose levels of people with type 2 diabetes. Until now, available data on the effectiveness of education with respect to the duration of diabetes are limited. We investigated whether adherence to lifestyle behavior modification prompted by diabetes education was influenced by the duration of diabetes.</P><P><B>Methods</B></P><P>Two hundred and twenty-five people with type 2 diabetes were recruited for an intensive, collaborative, group-based diabetes education program with annual reinforcement. We divided the patients into two groups based on the duration of their diabetes prior to the education program (≤1 year [≤1Y] vs. ≥3 years [≥3Y]). Dietary habits, physical activity, and the frequency of blood glucose self-monitoring were evaluated with a questionnaire prior to education and at the follow-up endpoint.</P><P><B>Results</B></P><P>The mean follow-up period was 32.2 months. The mean hemoglobin A1c (A1C) value was significantly lower in the ≤1Y group. Self-care behaviors, measured by scores for dietary habits (<I>P</I>=0.004) and physical activity (<I>P</I><0.001), were higher at the endpoint in the ≤1Y group than in the ≥3Y group. Logistic regression analysis revealed that a longer diabetes duration before education was significantly associated with mean A1C levels greater than or equal to 7.0% (53 mmol/mol).</P><P><B>Conclusion</B></P><P>Diabetes duration influenced the effectiveness of diabetes education on lifestyle behavior modification and glycemic control. More-intense, regular, and sustained reinforcement with encouragement may be required for individuals with longstanding type 2 diabetes.</P>

성형 장치에 따른 PSA 소성 경량골재의 품질

문경주,고대형,김재신,소양섭 대한건축학회 2000 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.20 No.2

The purpose of this study is to evaluate the qualities of the lightweight aggregate which is made by two kinds of the extrusion type and disk type pelletizer. The surface of the aggregate made by the disk type is also coated with AI₂O₃, and fly ash with the view to manufacturing the light-weight aggregate that specific gravity is lower than 1.0. As the result of test, it was possible to make light-weight aggregate that specific gravity was ranged about 0.6 to 1.4. Also, it's qualities are suitable as lightweight aggregates for non structural or structural concrete.