miR-19a Promotes Cell Growth and Tumorigenesis through Targeting SOCS1 in Gastric Cancer

Qin, Shuang,Ai, Fang,Ji, Wei-Fang,Rao, Wang,Zhang, He-Cheng,Yao, Wen-Jian Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Accumulating evidence has shown that microRNAs are involved in cancer development and progression. However, it remains unknown about the potential role of miR-19a in the pathogenesis of gastric cancer. Here, we report that suppressor of cytokine signaling 1 (SOCS1) is a novel target of miR-19a in gastric cancer cells and that miR-19a expression is inversely correlated with SOCS1 expression in gastric cancer cells and a subset of gastric cancer tissues. Ectopic expression of miR-19a dramatically promoted proliferation and tumorigenicity of gastric cancer cells both in vitro and in vivo. Moreover, we showed that silencing of SOCS1 promoted cell growth and colony formation resembling that of miR-19a overexpression, whereas re-introduction of SOCS1 (without the 3'-UTR) attenuated the pro-tumorigenic functions. Taken together, our findings suggest that the SOCS1 gene is a direct target of miR-19a, which functions as an oncogenic miRNA in gastric cancer by repressing the expression of tumor suppressor SOCS1.

Tea seed saponin(TSS) improve lipid metabolism and oxidative stress in high fat diet(HFD)-induced obese mice

Shuang Liu,Huishan Qin,Yanmin Su,Jiali Li,Wenjing Cao,Wen He,Zhen Zeng,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

To investigate the effect of TSS on lipid metabolism and oxidative stress in HFD mice. The body weight and food intake were observed. The serum SOD, MDA, GSH, TC, TG, HDL-C, LDL-C were determined by kits. Western Blotting was used to detect the levels of PPAR-γ, AMPK, SIRT1 and PGC-1α. TSS treatment reduced the body weight, Lee"s index and fat organ indices of mice in the HFD group. Compared with the control(CON) group, the serum TC, TG and LDL-C in the HFD group were increased, Administrated with TSS can improve abnormal blood lipid levels. Compared with the CON group, the serum SOD level in HFD group was significantly reduced(P<0.05), and MDA level was increased; while the levels of serum MDA in the TSS group decreased and SOD level increased. The pathological sections showed that TSS could improve the degree of hepatic steatosis. TSS also increased the levels of PPAR-γ, AMPK, SIRT1 and PGC-1α, and the effect of the high-dose group was the most significant. TSS can reduce body weight and fat accumulation, improve lipid metabolism disorder and oxidative stress caused by HFD.

Modeling and Vibration Control of a Coupled FloatingWind Turbine System

Shuang Zhang,Hui Qin,Xiuyu He,Wei He 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

This paper presents the dynamic modeling and vibration control design of a floating wind turbine system. Two flexible mooring lines attached to a flexible wind turbine tower (taut-moored floating spar) are used to represent the dynamics of system. The wind turbine tower is modeled as an Euler-Bernoulli beam, and the mooring lines are modeled as two strings. The control laws are designed to suppress vibrations of both wind turbine tower and the mooring lines. Based on the construction of a physically motivated Lyapunov function, the bounded stability is proved with the proposed control. Numerical examples illustrate the performance of the control system.

RBC Parameters in Thalassemia and Normal Pregnancy

Zhang Qin,Xiao Shuang 한국간호과학회 2023 한국간호과학회 학술대회 Vol.2023 No.11

The Specific Case Analysis of Biomineralization Induced by Sulfate Reducing Bacteria

( Hongwei Liu ),( Shuang Qin ),( Chaoyang Fu ),( Fei Xiao ),( Deli Wang ),( Xia Han ),( Tianli Wang ),( Hongfang Liu ) 한국부식방식학회(구 한국부식학회) 2017 Corrosion Science and Technology Vol.16 No.6

The effects of sulfate reducing bacteria (SRB) on the corrosion and scaling of the Q235 carbon steel has been investigated in the simulated sewage water and oil field gathering pipelines production water, using scanning electron microscopy (SEM), energy dispersive x-ray spectrometry (EDS), and three-dimensional stereoscopic microscope. Results indicated that the concentration of SRB reached the maximum value on the ninth day in simulated sewage water with a large amount of scaling on the surface of specimen. In oil field gathering pipelines, a large amount of scaling and mineralization of mineral salts and thick deposition of extracellular polymeric substance (EPS) layers were also observed on the surface of specimen. The thickness of biofilm was about 245 μm within 30 days. After adding microbicides, the thickness of corrosion products film was only up to 48 - 106 μm within 30 days, suggesting that SRB could induce biomineralization. Under-deposit corrosion morphology was uniform in the absence of microbicides while local corrosion was observed in the presence of microbicides.

Design of Active Frequency Selective Surfaces for the RCS Reduction

Guo hui Yang,Shuang Ma,Er chao Wang,Yuemei Qin,Xuemai Gu 보안공학연구지원센터 2013 International Journal of Security and Its Applicat Vol.7 No.5

Efficient Traffic Engineering for 5G Core and Backhaul Networks

Gang Wang,Gang Feng,Shuang Qin,Ruihan Wen 한국통신학회 2017 Journal of communications and networks Vol.19 No.1

The next generation mobile networks (5G) should beefficient and elastic to accommodate numerous and diverse ser-vices. By explicitly assigning bandwidth to service flows, trafficengineering (TE) is effective to improve network efficiency andelasticity. Unfortunately, existing mobile network TE schemes aremostly focused on core network only, which is inadequate for effi-cient end-to-end traffic delivery in mobile networks. In this paper,we propose a TE framework that incorporates the data gateway(D-GW) selection and exploits the topology and traffic informa-tion of both core and backhaul networks for SDN-based 5G net-works. With ideal flow to D-GW association (IFDA) strategy, weformulate the TE problem as a multicommodity flow problem toachieve network load balancing. Considering the cooperation sig-nalling between D-GWs, we propose multiple BSs to one D-GWassociation (MBODA) and multiple flows to one D-GW associa-tion (MFODA) strategy, and formulate the corresponding TE prob-lems as mixed integer linear programs (MILPs) which are NP-hard. To efficiently solve the IFDA-TE problem, we design an im-proved version of fully polynomial time approximation scheme (i-FPTAS). Moreover, we propose a heuristic method and an LP re-laxation method that both use i-FPTAS to solve the MBODA-TEand MFODA-TE problems respectively. Numerical results showthat i-FPTAS achieves close-optimal solution with significantlylower computational complexity, compared with FPTAS, and theperformance of MFODA-TE is very close to that of the IFDA-TE,while there is a small performance degradation for MBODA-TE asthe cost of computational efficiency.

Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments

Yuanyun Wei,Yaqi Gong,Shuang Wei,Yonglin Chen,Jian Cui,Xiang Lin,Yueqiu Yu,Hongxia Yan,Hui Qin,Lan Yi 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8

Sometimes, people can be exposed to moderateor high doses of radiation accidentally or through the environment. Radiation can cause great harm to several systemswithin organisms, especially the hematopoietic system. Severaltypes of drugs protect the hematopoietic system againstradiation damage in diff erent ways. They can be classifi edas “synthetic drugs” and “natural compounds.” Their cellularmechanisms to protect organisms from radiation damageinclude free radical-scavenging, anti-oxidation, reducinggenotoxicity and apoptosis, and alleviating suppression ofthe bone marrow. These topics have been reviewed to providenew ideas for the development and research of drugsalleviating radiation-induced damage to the hematopoieticsystem.

Effect of Interface on Mechanical Properties and Stamping Formability of Ti/Al Multilayered Composites

Miao Cao,Hui‑Qin Chen,Kun‐Kun Deng,Xing‑Wang Duan,Shuang Liu,Xin Che,Fei Li 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.5

Ti/Al multilayered composites (LMCs) with 3-layers, 5-layers and 7-layers were prepared by hot‐pressing and hot‐rolling. Theeffects of the interface on the mechanical properties and stamping formability of LMCs were revealed. The results indicatethat the TiAl3phases at the interface thicken gradually with the increase of layers. As the layers of LMCs increases, boththe grain size and the basal texture strength of Ti decrease, and Ti possesses a higher Schmid factors (SF) and more uniformSF distribution, which promotes the overall coordinated deformation of LMCs. The elongation (EL) of LMCs graduallyincreases at the expense of the strength with the increase of layers. The stress–strain transfer across the interface, the releaseof residual stress through interfacial microcracks, and the improvement of the interfacial metallurgical bonding strengthare all conducive to the coordinated deformation between Ti and Al layers, thus the strength of LMCs decreases and theEL enhances. Both the yield strength ratio (σs/σb) and plastic strain ratio (r) decrease, while the strain-hardening exponent(n) increases with the increase of layers of LMCs, which are beneficial to improve the stamping formability of LMCs. Thenumber of interface increases with the increase of layers, which hinders crack propagation. Moreover, the microcracks areeasily induced by the brittle TiAl3phase at the interface, and the main cracks deflect obviously and release part energy inthe form of secondary microcracks, thus delaying the failure of LMCs and improving their stamping formability.

Content Distribution for 5G Systems Based on Distributed Cloud Service Network Architecture

( Lirong Jiang ),( Gang Feng ),( Shuang Qin ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.11

Future mobile communications face enormous challenges as traditional voice services are replaced with increasing mobile multimedia and data services. To address the vast data traffic volume and the requirement of user Quality of Experience (QoE) in the next generation mobile networks, it is imperative to develop efficient content distribution technique, aiming at significantly reducing redundant data transmissions and improving content delivery performance. On the other hand, in recent years cloud computing as a promising new content-centric paradigm is exploited to fulfil the multimedia requirements by provisioning data and computing resources on demand. In this paper, we propose a cooperative caching framework which implements State based Content Distribution (SCD) algorithm for future mobile networks. In our proposed framework, cloud service providers deploy a plurality of cloudlets in the network forming a Distributed Cloud Service Network (DCSN), and pre-allocate content services in local cloudlets to avoid redundant content transmissions. We use content popularity and content state which is determined by content requests, editorial updates and new arrivals to formulate a content distribution optimization model. Data contents are deployed in local cloudlets according to the optimal solution to achieve the lowest average content delivery latency. We use simulation experiments to validate the effectiveness of our proposed framework. Numerical results show that the proposed framework can significantly improve content cache hit rate, reduce content delivery latency and outbound traffic volume in comparison with known existing caching strategies.