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김민경,이인환,신애숙,김나희,김혜미,심소라,나병조,조승연,박성욱,정우상,문상관,박정미,고창남,조기호,김영석,배형섭,Kim, Min-kyung,Lee, ln-whan,Shin, Ae-sook,Kim, Na-hee,Kim, Hye-mi,Shim, So-ra,Na, Byung-Jo,Cho, Seung-yeon,Park, Seong-uk,Jung, Woo Sang 대한중풍순환신경학회 2010 대한중풍.순환신경학회지 Vol.11 No.1
Object : This study was conducted as part of the national project to standardize stroke diagnosis in Korean medicine. In this study, we aimed to evaluate the characteristics of acute stroke between heat pattern group and cold pattern group. Methods : We recruited stroke patients from 5 universities(Kyung-Hee University oriental medical center, Kyung-Hee University East-West Neo medical center, Kyungwon university lncheon oriental medical center, Kyungwon university Songpa oriental medical center and DongGuk university llsan oriental medical center) from April, 2007 until February, 2010. We diagnosed them and selected 463 heat pattern patients and 182 cold pattern patients. Results : We find that the risk factor of smoking, alcohol, diet(prefer to meat) are more associated with the heat pattern group. On the other hand, inflammation history in recent 3 months and diet(prefer to sea food) are more associated with the cold pattern group. RBC, Hg, Hct, TG, CK and Cl are more related to the heat pattern group. CPT, total cholesterol and HDL are more related to the cold pattern group. Tae-eum type takes high distribution of the heat pattern group, and So-eum type takes high distribution of the cold pattern group. Conclusions : This study provides evidence that the heat pattern group have more risk factor than the cold pattern group.
Jo, Eun-Jung,Song, Woo-Jung,Kim, Tae-Wan,Park, Heung-Woo,Chang, Yoon-Seok,Kim, Tae-Bum,Kim, Sang-Heon,Hur, Gyu-Young,Lee, Jae-Hyung,Yoon, Ho-Joo,Park, Hae-Sim,Cho, Nam-Ho,Moon, Hee-Bom,Min, Kyung-Up,C The Korean Academy of Asthma, Allergy and Clinical 2014 Allergy, Asthma & Immunology Research Vol.6 No.6
<P><B>Purpose</B></P><P>Exhaled nitric oxide (NO) is a useful non-invasive biomarker for asthma diagnosis; however, the literature suggests that exhaled NO levels may be affected by demographic factors. The present analysis investigated determinant factors that present exhaled NO reference levels for Korean elderly adults.</P><P><B>Methods</B></P><P>For reference levels, we analyzed the baseline data of healthy adult participants in the Ansung cohort. The fraction of exhaled NO (FeNO) was measured by NIOX MINO®. The characterization of the subjects was performed through structured questionnaires, spirometry, and methacholine challenge tests. To validate the diagnostic utility of the determined reference levels, asthma patients were recruited from medical institutions for FeNO measurement.</P><P><B>Results</B></P><P>A total of 570 healthy subjects were analyzed (mean age, 59.9±12.3; male, 37.0%) for reference levels. FeNO levels significantly correlated with weight, height, body mass index, atopy, or forced expiratory volume in 1 second % predicted by simple linear regression analysis. Multiple linear regression analysis identified gender as an independent determinant for FeNO levels; subsequently, the reference values for FeNO were 18.2±10.6 ppb (5th to 95th percentile, 6.0 to 37.4 ppb) for males and 12.1±6.9 ppb (5th to 95th percentile, 2.5 to 27.0 ppb) for females. The diagnostic utility of FeNO reference levels was validated by receiver operating curve analysis (area under curve, 0.900 for males and 0.885 for females) for diagnosing asthma. The optimal cutoff values for the prediction of asthma were 30.5 ppb for males and 20.5 ppb for females.</P><P><B>Conclusions</B></P><P>The current analysis presented reference ranges and the diagnostic utility of FeNO levels for asthma in Korean elderly adults.</P>
Differential Benefit of Statin 2ndary Prevention of AMI according to level of TG and HDL cholesterol
( Sang Woo Jeong ),( Wan Kim ),( Sun Ho Hwang ),( Won Yu Kang ),( Sang Cheol Cho ),( Kyung Hwan Kim ),( Gyu Ik Lee ),( Young Eun Jo ),( Myung Ho Jeong ),( Young Keum Ahn ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Background: The benefit of statin in acute myocardial infarction (MI) was well established. However, there were few studies about the differential efficacy of statin according to the baseline level of triglyceride and high-density lipoprotein (HDL)-cholesterol. Objective: To address the efficacy of statin in secondary prevention of MI according to the level of triglyceride and HDL-cholesterol on admission. Methods: The 36580 acute MI patients were enrolled from November 2005 to August 2012. Total patients were divided according to level of triglyceride and HDL cholesterol on admission and evaluated the efficacy of statin in patients with no lipid component of metabolic syndrome (Group A; n=15,461) (HDL cholesterol ≥40 mg/dL & triglyceride <150 mg/dL) and both components of metabolic syndrome (Group B; n=4,399)(HDL<0.001). However, the efficacy of statin was not prominent in Group B (HR=0.987; 95% CI; 0.708-1.376; p=0.939). After propensity matching, the survival analysis revealed that statin therapy reduced the risk of MACE in group A (HR=0.752, 95% CI; 0.609-0.929, p=0.008). This result was mainly due to reduction of cardiac death (HR=0.628, 95% CI; 0.420-0.938, p=0.023). Multivariate analysis revealed that use of statin contributed independently to improvement of clinical outcome in only Group A (HR=0.692, CI; 0.543-0.882, p=0.003). Conclusions: The long-term benefit ofstatin was not prominent in acute MI patients with lipid profiles of metabolic syndrome. Therefore, different lipid-lowering strategy is necessary in patients with low HDL and high triglyceride.
Sung-Yoon Jo,Kyung-Sook Bang 한국아동간호학회 2023 Child Health Nursing Research Vol.29 No.3
Purpose: This study aimed to identify clinical characteristics of South Korean pediatric inflammatory bowel disease (IBD) in a children's hospital over the past 5 years, with a specific focus on comparing the features observed between Crohn's disease (CD) and ulcerative colitis (UC). Additionally, it aimed to examine the nursing diagnoses given to patients. Methods: This retrospective study analyzed the medical records of Korean pediatric patients under 18 years of age who were diagnosed with IBD and hospitalized at a children's hospital in Seoul, South Korea, from January 2017 to December 2021. Results: The number of pediatric patients diagnosed with IBD steadily increased. This finding was particularly prominent for CD patients, the majority of whom were male. Pediatric patients with CD had significantly higher rates of abdominal pain and perianal lesions, while pediatric patients with UC had a higher rate of bloody stool. Laboratory findings indicated that CD patients had higher levels of inflammatory markers and lower albumin levels than UC patients. The nursing diagnoses given during hospitalization mostly related to safety and protection, physical comfort, and gastrointestinal function. Conclusion: This study provides insights into Korean pediatric IBD patients, enabling early detection and the development of nursing intervention strategies. From a comprehensive perspective, nursing care should not only address patients' physical needs but also their psychosocial needs.
( Sang Muk Hwang ),( Ji Hyun Yang ),( Sang Kyung Jo ),( Myung Seok Lee ),( Sang Hoon Park ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Acute kidney injury (AKI) is the most frequent and devastating complication in cirrhotic patients. Emerging evidences suggest that novel biomarkers could predict AKI earlier than conventional markers and better predict prognosis in these patients. To determine the incidence and prognosis of AKI in acutely decompensated cirrhotic patients and also test whether plasma cystatinc C, urine neutrophil gelatinase associated lipocalin (NGAL) or tissue inhibitor of metalloproteinase-2 (TIMP-2), insulin like growth factor 7 (IGFBP7) could predict the development of AKI and prognosis. Methods: This is a single center prospective observational study conducted between May 2015 and Dec. 2017 with acutely decompensated cirrhotic patients. AKI was defined by KDIGO (Kidney Disease Improving Global Outcomes) criteria and urine and plasma samples were collected at the time of admission. Performances of novel biomarkers as well as various functional, clinical parameters were compared. Results: Of 111 patients, 45 (40.5%) developed AKI during hospitalization and these patients showed significantly higher mortality (25% vs. 46.5%, P=0.02). Although initial BUN and serum creatinine were not different, plasma cystatin C and urine NGAL at the time of admission were significantly increased in patients who developed AKI and also death. Plasma cystatin C and urine NGAL were independently associated with the development of AKI after adjusting for clinical variables including age, co-morbidity and Child-Pugh score. [plasma cystatin C, odds ratio (OR) 2.09; 95% confidence interval (CI), 1.01- 4.35), urine NGAL, OR 1.04, CI 1.01-1.05]. Although these biomarkers failed to predict mortality independent of clinical variables, urine NGAL significantly improved the accuracy of MELD in predicting mortality. Conclusions: Novel biomarkers including plasma cystatin C or urine NGAL might be useful in earlier diagnosis of AKI and also in predicting mortality in acutely decompensated cirrhotic patients.