Anti-Diabetic Effects of DY-101267, A Potent PPARs Agonist

Lee CH,Kim MK,Shin CY,Chae YN,Son MH,Kim JK,Min JP,Moon HS,Kim HJ,Bae MH,Kim SH,Lee JG,Lim JI 대한약학회 2004 大韓藥學會 總會 및 學術大會 Vol.2004 No.2

바르톨린선의 선양 낭포성암 1 예

김동규,이정필,김재욱,김행수,조환승,한세열,김규래 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.10

바르톨린선의 선양 낭포성암 1 예를 경험하였기에 보고하는 바이다. A patient with adenoid cystic carcinoma of Bartholins gland is reported and the literature related to this disease is reviewed. It is rare disease of which incidence is 10-15% of Bartholins gland carcinoma. Major clinical symptom is perineal pain and vulvar mass and it can be misdiagnosed as abscess or cyst. Histologically , this tumor is characterized by perineural invasion , cribriform pattern cancer cell and pseudocyst. Most acceptable treatemnt modality is radical vulvectomy but , the efficacy of inguinal femoral lymphadenectomy and postoperative adjuvant radiotherapy is controversial , yet.

Studies on Analysis and Stability of Retinol and Retinylpalmitate in Cosmetics

Kim PS,Choi SS,Kim IK,Yun MO,Son KH,Lee JP,Kim CK,Jang SJ 大韓藥學會 2000 大韓藥學會 總會 및 學術大會 Vol.2000 No.1

13-cis-Retinoic Acid 가 자궁경부암의 항암화학요법에 미치는 영향

김동규,이정필,송찬호,김영태,김재욱 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.5

1994년 1월부터 1995년 1월까지 연세대학교 의과대학 부속 세브란스병원 산부인과에서 침윤 성 편평상피 자궁경부암으로 진단되어 신보조화학요법만을 시행받은 20명의 제 1군과 신보 조화학요법과 병용하여 13-cis-Retinoic Acid를 투여받은 20명의 제2군의 환자를 대상으로 치 료효과 및 합병증을 조사하여 다음과 같은 결과를 얻었다. 1. 신보조화학요법을 시행하여 치료반응을 판정할 수 있었던 총 40예중 제 1군의 경우, 부분 관해가 6예(30%), 그리고 무반응예가 14예(70%)를 보여 임상반응율은 30%를 나타내었으며 제2군의 경우에는 완전관해가 1예(5%), 부분관해가 6예(30%) 그리고 무반응예가 13예(65%) 를 나타내어 임상반응율은 35%를 보였다. 2. 제 1군에서 신보조화학요법 전후를 SCC 항원을 측정하여 본 결과 혈중 SCC항원의 중앙 값은 각가 1.65ng/ml 0.90 ng/ml로 나타나 유의하게 감소되었으며 (p$lt;0.05), 제 2군에서도 각 각 2.90 ng/ml, 1.75 ng/ml로 나타나 통계적으로 유의한 감소를 보였다. (p$lt;0.05)그러나 제 1 군 및 제 2군의 화학요법 후 혈중 SCC항원을 비교한 결과에서는 두 군사이에 유의한 차이가 없었다. 3. 신보조화학요법으로 인한 부작용 골수억제, 위장관장애, 신 및 간독성이 있었으며 제 2 군의 경우에는 35예(59.3%)에서 경증의 피부건조증 및 구순염이 나타났으나 보존적인 치료로 회복되었다. 결론적으로 본 연구에서는 신보조화학요법만을 시행한 군보다 신화학요법과 13-cis-Retinoic Acid를 병용투여한 군에서 향상된 완전관해를 나타내었으나 국소요법후 지속적인 추적 관찰 로 치료실패율 및 무병생존율에 대한 연구 및 화학요법의 반응을 예측선별할 수 있는 연구도 필요할 것으로 사료된다. BACKGROUND : Retinoid are strong inhibitors of epithelial cancer promotion and progression in experimental carcinogenesis. Recently, therapeutic trial of retinoids have demonstrated activites in cervical cancer and precancerous lesion of cervix, Our purpose was to determine whether the administraion of 13-cis-Retinoic Acid is more effectual in the neoadjuvant chemotherapy of cervical carcinoma. METHODS : From January 1994 through January 1995, 40 patients with invasive cervical cancer were enrolled in this prospective study and divided by two groups. group 1 had neoadjuvant chemotherapy plus 13-cis-Retinoic Acid (RA) at a dosage of 1mg/kg/day for 1 month. Patients between group 1 and group 2 were similar with respect to age, parity, clinical stage, and histological subtype. Therapeutic responses were compared using Fisher`s exact test, Mann-Whitney test, and Wilcoxon signed rank test. RESULTS : RA increased the complete response rate of neoadjuvant chemotherapy from 0% in the group 1 to 5% in group 2. but difference of overall response rate between two group was not evident. The drug toxicities between group 1 and group 2 included anemia in 30.0% and 23.7%, leukopenia in 6.7% and 15.2% and hepatotoxicity in 6.7% and 6.8% respectively. More skin side effectes were seen in the patients of group 2, but these effects were mild and reversible. CONCLUSION : It would be suggested that RA plus chemotherapy may be superior chemotherapy alone in increasing the complete response rate of neoadjuvant chemotherapy forpatients with cervical cancer. The impact of such a treatment on survical needs to be futher explored.

Anti-allergic Components from the Peels of Citrus unshiu

DK Kim,KT Lee,JS Eun,OP Zee,JP Lim,SS Eum,SH Kim,TY Shin 대한약학회 1999 大韓藥學會 總會 및 學術大會 Vol.48 No.-

S-1 : Do we need total colonoscopy in patients with acute diverticulitis on computed tomography?

( Yh Choi ),( Jp Im ),( Js Kim ),( Sj Koh ),( Jw Kim ),( Kl Lee ),( Bg Kim ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Background/Aims: Although colonoscopy verification is warranted after an acute event of diverticulitis to exclude underlying malignancy, little evidence is available to support the recommendations. The aim of this study was to evaluate the yield of a colonoscopy. Methods: From January 2001 to March 2013, patients in whom acute diverticulitis was diagnosed on CT scan were matched with colonoscopy reports within 1 year from the date of CT. Results: A radiological diagnosis of acute diverticulitis was made in 443 patients. One hundred forty-nine patients underwent subsequent colonoscopy within a year from the date of CT. There were no significant differences in clinical characteristics between patients with or without colonoscopy. 12 patients (8.1%) were diagnosed with colon cancer. Conclusion: Yield of colonic malignancy in this cohort was more than that detected on screening asymptomatic average-risk individuals. Patients with diverticulitis on CT are warrants endoscopic verification.Background/Aims: Although colonoscopy verification is warranted after an acute event of diverticulitis to exclude underlying malignancy, little evidence is available to support the recommendations. The aim of this study was to evaluate the yield of a colonoscopy. Methods: From January 2001 to March 2013, patients in whom acute diverticulitis was diagnosed on CT scan were matched with colonoscopy reports within 1 year from the date of CT. Results: A radiological diagnosis of acute diverticulitis was made in 443 patients. One hundred forty-nine patients underwent subsequent colonoscopy within a year from the date of CT. There were no significant differences in clinical characteristics between patients with or without colonoscopy. 12 patients (8.1%) were diagnosed with colon cancer. Conclusion: Yield of colonic malignancy in this cohort was more than that detected on screening asymptomatic average-risk individuals. Patients with diverticulitis on CT are warrants endoscopic verification.

조산아의 원인과 예후에 관한 연구

이홍균,김복린,조용균,유태환,양종필,김은우,김재완 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.8

1992년 1월 1일부터 1993년 12월 31일까지 인제대학교 의과대학부속 상계백병원에서 분만한 총 8426건의 단태출생중에서 임신 20주이상 37주이전에 분만된 674명의 조산아를 대상으로 조사 분석한 결과 다음과 같은 결론을 얻었다. 1. 조산의 원인 중 조기파수에 의한 경우가 39.2%로 가장 많았고, 조기진통에 의한 경우는 35.0% 산모나 태아의 적응증으로 인한 경우는 25.8%였다. 2. 재태연령에 따른 조산의 분포를 보면, 35주에서는 36주에 분만된 경우가 42.7%, 31주에서 34주까지는 33.5% 30주이하인 경우는 23.9%였다. 3. 35주미만에 조기진통에 의해 조산된 22.4%중 입원당시 자궁경부의 개대가 3cm미만인 경 우는 5.8%였다. 4. 조산의 원인에 따른 신생아의 사망율은 조기진통에 의한 경우가 생아 1000명당 139명, 조 기파수에 의한 경우는 89명, 적응증에 의한 경우는 90명이었다. 5. 재태연령에 따른 생존율을 살펴보면 26주에서 27주까지는 22.8% 28주에서 30주까지는 평 균 88%의 생존율을 보여주고 있다. 6. 출생시 체중에 따른 생존율은 900gm에서 1100gm까지는 7.2% 1101-1500gm, 62.3%를 나 타내며 1501-2000 gm 까지는 76.1% 2000gm 이상인 경우는 98.4%를 나타내고 잇다. 7. 조산아의 생존율을 향상시키기 위한 최소한의 재태연령은 27주, 출생체중은 900gm이상이 되어야 할 것으로 사료된다. The preterm birth has recently one of the most important issues in obsterics. The development of neonatology has made a great contribution to the treatment fo preterm baby and decreases of neonatal mortality rate. We determined the causes and outcome of 674 cases of preterm infants delivered at Sanggye Paik Hospital from 1. 1992 to 12.31. 1993. the results were as follows; 1. When the preterm births were divided by etiology, 39.2% followed spontaneous PROM, 35% followed spotaneous preterm loabor, and 25.8% were indicated. 2. Of 674 preterm infants, 42.7% occurred at 35-36weeks, 33.5% at 31-34weeks, and 23.9% at or before 30 weeks. 3. Of 22.4% of preterm births following spotaneous onset of labor before 35 weeks gestation, 5.8% were at less than 3cm cervical dilatation. 4. The neonatal mortailiy was 139.83 per 1000 live births in spontaneous labor, 90.91 in PROM and 89.55 in indicated delivery. 5. The survival rate was 22.8% at 26-27 weeks, 60.8% at 28-30 weeks and 88% after 31 weeks. 6. The survival rate divided according to birth weight were 7.2% in 900-1000gm, 62.3% in 1101-1500gm, 76.1% in 1501-2000 gm and 98.4% over 2000gm respectively. 7. To incerease the survival rate of preterm infants, the minimal gestational age should be 27 weeks gestation and the birth weight be 900gm.

고위험 인자를 가진 침윤성 자궁경부암 환자에서 동시항암화학 방사선요법의 치료성적

박찬규,김수녕,이정필,김정연,김진영,김귀언,서창옥 대한부인종양 콜포스코피학회 1995 Journal of Gynecologic Oncology Vol.6 No.2

High risk factors(HRFs) were selected by statistically analyzing thee 386 cases of the cervical cancer treated by radiotherapy at Yonsei University Medical Center (YUMC) from 1976 to 1984. These risk factors were stage III - IV, small cell carcinoma and adenocarcinoma, stage I - II and lesion size$gt;4cm and lymph node metastasis by lymphography. To evaluate the survival of patients with at least one of these HPFs following concurrent chemotherapy and radiotherapy and to assess the toxicity of concurrent chemotherpay and radiotherapy, 171 patients were selected who had at least one of these HPFs from 1984 to 1994 YUMC. The 54 month survival was 41% with stage III - IV, the 60 month survival was 84% with stage I-II and lesion size$gt;4cm, the 60 month survival was 17% with lymph node metastasis by computed temogrphy, and the 42 month survival was 43% with small carcinoma, the 54 month survival was 72% with adenocarcinoma. Toxicity of concurrent chemoraditherapy was mild to moderate degree of leukopenia, anemia, renal toxicity, thrombocytopenia and hepatotoxicity. The study's results imply that concurrent chemororadiotherapy may be effective to the patients with stage I - II and lesion size$gt;4cm, and the number of optimal course to significantly improve prognosis while minimizing toxicity needs to be determined.

철계 복잡형상 박육주물 공정기술 개발

김성빈(S.B. Kim),임영훈(Y.H. Yim),김창덕(CD. Kim),이창섭(CS. Lee),김대업(DU. Kim),박주현(J.H. Park),이영식(YS. Lee),황재필(JP. Hwang),이정석(JS. Lee) 한국생산제조학회 2011 한국생산제조시스템학회 학술발표대회 논문집 Vol.2011 No.10

S-154 : Absolute Change in Fasting Glucose 12 month after PCI with MACE development Under Statin Therapy

( Do Kang ),( Hs Seo ),( Bg Choi ),( Cw Choi ),( Eunmi Lee ),( Jp Kim ),( Sk Lee ),( Si Lim ),( Sw Kim ),( Jo Na ),( Cu Choi ),( He Lim ),( Jw Kim ),( Ej Kim ),( S-w Rha ),( Cg Park ),( Dj Oh ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Objectives: Statins for the prevention of CVD are known to be as diabetogenic. However most clinical trials suggested that current statin therapy in moderate to high cardiovascular risk should not be changed, due to the outwheighing benefits of statins on CVD prevention. We investigated which clinical variables on treatment are most closely associated with the development of 24 month MACE (all death, any myocardial infarction and target vessel revascularization) in DES implanted patients on statin therapy. Methods: Total 299 patients undergone DES implantation with taking statins for secondary prevention were involved. Tracking the development of MACE within 24 month post-PCI, 12 month follow up clinical variables showing significant correlation to the event were evaluated. To discover whether the changes in clinical parameters over the 12 month follow up are associated with the event development, subtractions from baseline to follow up lab results and absolute value conversion of the subtractions are obtained. Variables showing significant difference between the groups were put into the multivariate analysis and into the survival curve model. Results: Fasting glucose at 12 month were significantly higher in the event group. Subtractions from baseline to 12 month follow up showed no significant differences between the groups, however, absolute change in fasting glucose revealed a significant difference. In multivariate analysis, absolute change in fasting glucose greater than 17 mg/dL/year was strongly associated with the event development. When study population was further divided into four groups by using IQR of absolute change in fasting glucose, greater absolute change during 12 month post-PCI showed a higher risk of 24 month MACE development in both multivariate analysis and survival curve models. Conclusion: The findings suggest that greater absolute change in fasting glucose during 12 month post-PCI is an independent risk factor for 24 month MACE development in DES implanted patients on statin therapy. Relative glucose control impairment described as absolute change in fasting glucose in the current study might be responsible for the development of 24 month MACE.