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원자력발전소 PSI/ISI 데이터 관리를 위한 지능형 데이터베이스 프로그램 개발(제2보)
박은수,박익근,엄병국,이종포,한치현 한국비파괴검사학회 2000 한국비파괴검사학회지 Vol.20 No.3
제 1보에서 Windows 환경 하에서 PSI/ISI 데이터의 효율적 관리 및 다원적평가와 분석이 가능한 고리 원전 PSI/ISI 데이터베이스 구축과 프로그램 개발(IDPIN)에 대해 소개하였다. 제 2보에서는 월성 원자력발전소 PSI/ISI 자료 관리를 위한 지능형 데이터베이스 프로그램(WS-IDPIN)을 개발하였다. 이 프로그램에는 월성 원전 PSI/ISI 관련 자료 분석 기능, PSI/ISI UT 검사 보고서 양식의 표준화와 전산 시스템화, PSI/ISI 비파괴검사 결과의 통계적 신뢰도 평가 프로그램(depth and length sizing performance 등) 등을 개발하여 원전 PSI/ISI 데이터 관리 전문가시스템(expert system)화에 한 단계 접근하였다. In a previous paper, we have discussed the intelligent Windows 95-based data management program(IDPIN) which was developed for (effective) and efficient management of large amounts of pre-/in-service inspection(PSI/ISI) data of Kori nuclear power plants. The IDPIN program enables the prompt extraction of previously conducted PSI/ISI conditions and results so that the time-consuming data management, painstaking data processing and analysis of the past are avoided. In this study, the intelligent Windows based data management program(WS-IDPIN) has been developed as an effective data management of PSI/ISI data for the Wolsong nuclear power plants. The WS-IDPIN program includes the modules of comprehensive management and analysis of PSI/ISI results, statistical reliability assessment program of PSI/ISI results(depth and length sizing performance etc), standardization of UT report form and computerization of UT results. In addition, the program can be further developed as a unique PSI/ISI data management expert system which can be part of the PSI/ISI total support system for Korean nuclear power plants.
WinDS3000<sup>TM</sup> 시스템의 블레이드 개발 및 시험
이상일(Lee, Sang-Il),이경우(Lee, Kyeong-Woo),주완돈(Joo, Wan-Don),이기학(Lee, Ki-Hak),박종포(Park, Jong-Po) 한국신재생에너지학회 2009 한국신재생에너지학회 학술대회논문집 Vol.2009 No.11
A new blade has been developed to apply to Doosan 3MW offshore wind turbine named as WinDS3000TM. The 3MW blade has been designed by the concept of slim external shape and optimized structure. High-performance glass fiber reinforced epoxy composites were used as the main material of the blade. The blade was manufactured using vacuum infusion process in order to increase the fiber volume fraction and to reduce micro-porosities. The blade has successfully passed the full-scale blade static test for certification. During the test, micro-failure signal and strain change of the blade were measured using acoustic emission sensors and strain gages. The blade has robust structure and weighs lighter compared to conventional blade since the new blade was designed by optimization process. The 3MW blade will be commercially applied to WinDS3000^{TM} in 2010.
양막과 콜라겐을 이용한 생체 적합 드레싱 소재 개발 및 백서 창상치유 실험
안강민(Kang-Min Ahn),이지호(Ji-Ho Lee),이의룡(Ui-Lyong Lee),이종호(Jong-Ho Lee),이종원(Jong-Won Lee),김성포(Sung-Po Kim),양은경(Eun-Kyung Yang),김기호(Ki-Ho Kim) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.3
Purpose of study: Partial thickness skin graft is the golden standard regimen for full-thickness skin defect caused by burn or trauma. However, in case of extensive burns of more than 50% of total body surface area, the donor site is not sufficient to cover all defects. As a second choice, allograft, xenograft and synthetic materials have been used to treat skin defect. Among them the amniotic membrane(AM) was used as a biological dressing for centuries because of its potential for wound healing. In this study, quantification of EGF in AM and effect of AM-collagen complex on full thickness skin defects was examined. Materials & Methods: The concentration of EGF in fresh, deep frozen and freeze-dried AM was evaluated by ELISA. EGF-R immunostaining was performed in freeze-dried AM. SD rats weighing 250~300g was used for wound healing experiment. Three full thickness skin defects(28mm diameter) were made on dorsal surface of SD rat. The control group was covered by Vaselin gauze and AM-collagen complex and Terudermis was grafted in two other defects. Healing area, Cinamon’s score were evaluated before biopsy. Grafted sites were retrieved at 3 days, 1 week, 2 weeks and 4 weeks after operation. H & E and Factor VIII immunohistochemical stain was performed to evaluate the microscopic adhesion and structural integrity and microvessel formation. Results: 1. EGF concentration of fresh, deep frozen and freeze-dried AM showed similar level and EGF-R was stained in epithelial layer of freeze-dried AM. 2. At 4 weeks after grafting, the healing area of AM-collagen and Terudermis group was 99.29±0.71% and 99.19±0.77 of original size. However, that of control group was 24.88±2.90. 3. The Cinamon’s score of AM-Collagen and Terudermis group at 4 weeks was 15.6±1.26 and 14.6±3.13 and that of control group was 3.7±0.95. Significant difference was observed among control and experimental groups(p〈0.05). 4. Histologic examination revealed that AM protected leukocyte infiltration and epithelial migration was nearly completed at 4 weeks. Terudermis group showed mild neutrophil infiltration until 2 weeks and completion of epithelization at 4 weeks. Control group showed massive leukocyte infiltration until 4 weeks. 5. Microvessels were increased sharply at 1 week and control group at 1 and 4 week showed significant differences with Terudermis group of same interval(p〈0.05) but no differences were found with AM group(p〈0.05). Conclusion: EGF and EGF-R were well preserved in freeze-dried AM. AM attached to collagen acted as excellent biologic dressing which had similar effect with Terudermis. AM showed anti-inflammatory action and healing was completed at 4 weeks after full-thickness skin defect.
경기도내에서 분리한 캠필로박터 제주니균의 유전적특성 및 항생제내성 연구
허은선,박포현,김종화,손종성,윤희정,이예은,최연숙,윤미혜,이정복,Hur, Eun-Seon,Park, Po-Hyun,Kim, Jong-Hwa,Son, Jong-Sung,Yun, Hee-Jeong,Lee, Yea-Eun,Choi, Yun-Sook,Yoon, Mi-Hye,Lee, Jong-Bok 한국미생물학회 2013 미생물학회지 Vol.49 No.3
Campylobacter jejuni는 사람에서 매우 중요한 식중독 원인균의 하나이며, 2010년 경기도내 병원을 내원한 설사 환자와 4번의 식중독 outbreak에서 42균주를 분리하였다. 본 연구에서는 분리된 C. jejuni 42균주의 유전적 특성과 혈청형, 항균제 내성율을 분석하였다. hipO 종특이 유전자(100%), cdtB 독소 유전자(100%)가 검출되었고, gyrA 돌연변이 유전자(95.2%)가 PCR 실험결과 검출되었다. gyrA 돌연변이 유전자는 ciprofloxacin 내성과 연관이 깊으며, 디스크 확산법에 의해 실험한 결과 gyrA 돌연변이 유전자가 검출된 40균주(95.2%)에서 실제 ciprofloxacin에 대해 내성을 보였다. 분리된 42균주 C. jejuni에 대한 gyrA 유전자의 염기서열을 분석한 결과 ciprofloxacin에 내성을 가진 40균주에서 아미노산 서열이 ACA (트레오닌)에서 ATA (이소루신)으로 돌연변이 되어있음을 확인하였다. 하지만 대체 치료제인 erythromycin과 azithromycin에 대해서는 97.6% (41균주) 감수성을 보였다. 또한 C. jejuni의 혈청형을 분석한 결과 4가지 타입으로 분류되었는데, HS2(B), HS3(C), HS4(D), HS19(O)로 확인되었다. 도내에서 분리한 C. jejuni 42균주의 유전형을 rep-PCR과 PFGE로 확인한 결과 PFGE에 의해서는 12 cluster, rep-PCR에 의해서는 11 cluster의 유전형으로 구분되었다. Campylobacter jejuni is one of important food-borne pathogens causing human gastroenteritis. We isolated 42 strains of C. jejuni from diarrhea patients and 4 food-poisoning outbreaks in 2010, Gyeonggi-do. In this study, 42 strains were tested for genetic characteristics, the serotype distribution and antimicrobial resistant rate. The presence of hipO (100%), cdtB (100%), and mutated gyrA (95.2%) genes was detected in C. jejuni by polymerase chain reaction (PCR). Detection of mutated gyrA gene correlated with ciprofloxacin resistance. Forty isolates had mutated gyrA gene and were actually resistant to ciprofloxacin. Furthermore, comparing the gyrA DNA sequence data, ciprofloxacin-resistant isolates had a mutation of the DNA sequence from ACA (threonine) to ATA (isoleucine). But 41 strains (97.6%) of patient isolates were susceptible to erythromycin and azithromycin. A total of 35.7% among 42 C. jejuni isolates were identified into 4 different serotypes. The serotype distribution of C. jejuni strains were shown to be HS2(B), HS3(C), HS4(D), HS19(O). To investigate the genotypes of C. jejuni isolated in Gyeonggi province, repetitive sequence polymerase chain reaction (rep-PCR) analysis and SmaI-digested pulsed-filed gel electrophoresis (PFGE) profile analysis were performed. From the PFGE analysis of 42 C. jejuni strains, 12 clusters of PFGE profile were obtained. On the other hand, 11 clusters of rep-PCR profile were obtained from 42 strains of C. jejuni.