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김장연,김영조,엄인웅,이동근,이재은 大韓顎顔面成形再建外科學會 1993 Maxillofacial Plastic Reconstructive Surgery Vol.15 No.3
Many surgeons are on the point of bone excision and reconstruction of the bone defects by autograft. xenograft, and allograft in the treatment fo begin and malignant tumors of bone. Of all type of bone grafts, we received the autograft as the best ideal bone graft. Of autogenic bone graft, replantation of excised autogenic bone for reconstructiong the bone defects has been the ideal method until now, but early bone healing reponses and tumor cell devitalization after replantation of excised autogenic bone have not been identified for clinical applications. So, to evaluate bone healing response after replantation in rabbit's calvarial bone, we divided the experimental group into three groups. Group 1 is a fresh autogenous bone group. Group 2 is a deep frozen group. Group 3 is freeze-dried demineralized group. Obtained result were as followed: 1. Inflammatory cell infiltration appeared at I week and disappeared at 4 weeks in all experimental group, Especially, severe inflammatory cell infiltration showed in fresh autogenous bone group at 2 weeks, Especially, severe inflammatory cell infitration showed n fresh autogenous bone group at 2 week Group 3 is the least showing group on the point of inflammatory cell infiltration. 2. Osteoblastic activity evenly increased upto 4 weeks and maintained to 6 weeks and decreased after this period, especially osteoblastic activity in group 2 is less than group 1 and group 3. We can't discriminate between osteoblastic activity of group 1 and that of group 3. 3. In new bone formation, group 3 was more active than any other groups at early stage, but there were little differences among three experimental groups at later state. 4. Bone resorption around the grafted bone slightly appeared at 1 week and disappeared at 4 weeks in all experimental groups. We can find the more bone resorption in group 2 at 2 weeks than any other groups. We could suggest, as appears from our results, that freeze-dried deminiralized bone graft is the useful bone graft in the clinical applications of excised autogenic bone.
( Jae Il Chung ),( Nayoung Kim ),( Min Sik Um ),( Kyung Phil Kang ),( Donghun Lee ),( Jong Chun Na ),( Eun Sil Lee ),( Yeon Mu Chung ),( Ji Yeon Won ),( Kwang Ho Lee ),( Tek Man Nam ),( Jung Hun Lee ) 대한소화기기능성질환·운동학회 2010 Gut and Liver Vol.4 No.1
Background/Aims: Colonoscopy training programs and the minimal experience with colonoscopy required to be considered technically competent are not well established. The aim of this study was to determine the colonoscopy learning curves and factors associated with this difficult procedure at a single center. Methods: A total of 3,243 colonoscopies were performed by 12 first-year gastroenterology fellows, and various clinical factors were assessed prospectively for 22 months. Acquisition of competence (success rate) was evaluated based on two objective criteria: (i) the adjusted completion rate (>90%) and (ii) cecal intubation time (<20 minutes). Results: The overall success rate in reaching the cecum in less than 20 minutes was 72.8%. The cecal intubation time was 9.34±4.13 minutes (mean±SD). Trainees` skill at performing cecal intubation in <20 minutes reached the requisite standard of competence after 200 procedures. Cecal intubation time decreased significantly from 11.3 to 9.4 minutes after 100 procedures and improved continuously thereafter. Female patients and advanced patient age (over 60 years) were associated with prolonged cecal intubation time (>20 minutes). Surgery of the uterus and ovaries was significantly correlated with delayed cecal intubation time, but not after sufficient colonoscopy experience. Conclusions: The minimum number of procedures to reach technical competence was 200. The cecal intubation time was longer in female and older patients. (Gut Liver 2010;4:31-35)
엄아영(Um A Young),오경은(Kyung Eun Oh),신윤재(Yoon Jae Shin),강병길(Byung Kil Kang) 한국디자인문화학회 2014 한국디자인문화학회지 Vol.20 No.4
재난은 예방이 최선이나, 이상기후, 도시화 등으로 인해 예측할 수 없는 크고 작은 재난이 발생하고 있음이 현실이며, 다양한 재난으로 인해 주거지를 잃은 이재민들 또한 매년 예외 없이 발생하고 있다. 이에, 본 연구의 목적은 일차적 재난피해로 기존 거주지를 잃은 이재민들이 응급 대피환경인 임시수용시설에서 인간다운 생활을 하고, 갑작스러운 생활환경변화로 인한 정서불안 등 2차 피해를 최소화할 수 있는 생활 방안을 디자인적 관점에서 제시하는 데 있다. 연구의 방법으로는 첫째, 이재민 임시수용시설 관련교육 참여와 국제적 인도주의 관련 문헌조사를 통한이재민 거주환경의 이해를 도모하였고, 둘째, 국내외이재민 생활환경 사례분석과 세월호 침몰사고 실종자가족 임시수용시설 현장조사를 통하여, ‘인간존엄성’을 최우선 과제로 하는 국제 인도주의 원칙에 근거한 국내 이재민 생활 속 해결과제를 도출하였다. 셋째, 전문가인터뷰를 통해 해결과제의 타당성을 검증하였고,각 과제에 적합한 디자인 접근방향을 제시하였다. 본 연구의 결과로, 이재민 임시수용시설 내 생활 속에서 발생하는 문제점들을 크게 ‘생활’, ‘관리’, ‘위생’세 가지 분야로 구분하고, 이를 해결하기 위한 최적의 디자인 접근방법을 역시 세 가지로 다음과 같이 도출하였다. 첫째, 이재민들의 ‘생활’ 관련 문제점들은 일상생활 지원을 위해 커뮤니티 활동의 필수요소들을 구성하는 ‘공간디자인’ 접근방법으로, 둘째, 정보 및물품의 ‘관리’에 대한 문제들은, 효율적 커뮤니케이션을 지원하는 ‘시각디자인’의 접근으로, 마지막으로 ‘위생’관련 문제들은 의료활동과 위생관리를 용이하도록 하는 기능과 재질 선정을 포함한 ‘제품디자인’적 접근이다. 이재민들이 무사히 기존 주거지로 복귀할 때까지 임시적으로 수용시설에서 생활하면서, 인간다운 삶을 보장받을 수 있도록 대비하는 공공의 배려를 느끼며,안전하고 쾌적하게 생활하도록 기여함에 있어 디자인이 중점적인 역할을 수행할 수 있는 방안을 제시하는 데 이 연구의 궁극적인 의의가 있다. 더불어, ‘안전하고 안심할 수 있는 임시생활’이라는 사회문제 속에서 디자인의 역할과 책임을 찾고자 하는데 또 다른 의미를 두고자 한다. Prevention is the best method of addressing the possibility of disaster. Disasters, small and large, occur in an unpredictable fashion, and some of them are associated with abnormal climate conditions or urbanization. Every year, many people lose their homes to natural disasters. The purpose of this study is to find a way to help the victims of disaster live a decent life in temporary facilities and minimize any secondary damage caused by the feeling of unease resulting from sudden changes in their living environment. This study also intends to determine the role of design in disaster victims’ life and living conditions in connection with the current emphasis on the social role of design. The study was carried out as follows: First, we attended educational sessions associated with temporary accommodation facilities for disaster victims and conducted a survey of literature concerning international humanitarianism to get a clearer idea of the difficulties faced by the victims of disasters. Second, we strove to determine which problems needed to be resolved with regard to domestic victims based on humanitarian principles that put human dignity first, based on an onsite survey of the temporary accommodation facilities provided for the families of the victims of the Sewol disaster, and on an analysis of the living environment of disaster victims both in and out of the country. Third, we held interviews with experts to determine whether our approach was adequate and proposed design-related approaches suited to the task. This study divided the problems associated with life in temporary accommodation facilities into three categories: those associated with daily activities; those associated with information and necessary goods; and those related with medical services and hygiene. We devised the following optimal design-related approaches: 1) a human behavior-centered indoor space design that considers the need for privacy; 2) an integrated proposal concerning service design and visual information design for the efficient management of information and goods; 3) and a proposal for a desirable direction of goods design, including a function for facilitating medical service provision and hygiene management. The significance of this study lies in the proposal of solutions in which design plays a central role in helping disaster victims to live as dignified human beings in temporary facilities until they can return to their homes with public care.
Polyethylene glycol plus ascorbic acid for bowel preparation in chronic kidney disease
Lee, Jae Min,Keum, Bora,Yoo, In Kyung,Kim, Seung Han,Choi, Hyuk Soon,Kim, Eun Sun,Seo, Yeon Seok,Jeen, Yoon Tae,Chun, Hoon Jai,Lee, Hong Sik,Um, Soon Ho,Kim, Chang Duck,Kim, Myung Gyu,Jo, Sang Kyung Williams & Wilkins Co 2016 Medicine Vol.95 No.36
<P>The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease.We retrospectively reviewed prospectively collected data on colonoscopy in patients with impaired renal function. Patients were divided into 2 groups: 2 L polyethylene glycol plus ascorbic acid (n = 61) and 4 L polyethylene glycol (n = 80). The safety of the 2 groups was compared by assessing the differences in laboratory findings before and after bowel cleansing.The laboratory findings were not significantly different before and after the administration of 2 L polyethylene glycol plus ascorbic acid or 4 L polyethylene glycol. In both groups, the estimated glomerular filtration rate was not influenced by the administration of the bowel-cleansing agent. Patients' reports on tolerance and acceptability were better in the 2 L polyethylene glycol plus ascorbic acid group than in the 4 L polyethylene glycol group.The 2 L polyethylene glycol plus ascorbic acid solution is a safe choice for bowel preparation before colonoscopy in patients with impaired renal function.</P>
ALLIUM TUBEROSUM IMPROVES HEPATIC STEATOSIS VIA INHIBITION OF HISTONE ACETYLATION
Shin, Eun Ju,Choi, Hyo-Kyoung,Hur, Haeng Jeon,Park, Jae Ho,Sung, Mi Jeong,Lee, Ae sin,Hur, Jin-Young,Kim, Myung Sunny,Um, Soo-Jong,Hwang, Jin-Taek NEW CENTURY HEALTH PUBLISHERS 2017 Current topics in nutraceutical research Vol.15 No.1
Hong, Eun-Hee,Song, Jie-Young,Lee, Su-Jae,Park, In-Chul,Um, Hong-Duck,Park, Jong Kuk,Lee, Kee-Ho,Nam, Seon Young,Hwang, Sang-Gu unknown 2014 IUBMB LIFE Vol.66 No.2
<P>Although low-dose radiation (LDR) regulates a wide range of biological processes, limited information is available on the effects of LDR on the chondrocyte phenotype. Here, we found that LDR, at doses of 0.5–2 centiGray (cGy), inhibited interleukin (IL)-1β-induced chondrocyte destruction without causing side effects, such as cell death and senescence. IL-1β treatment induced an increase in the expression of α-, β-, and γ-catenin proteins in chondrocytes via Akt signaling, thereby promoting dedifferentiation through catenin-dependent suppression of Sox-9 transcription factor expression and induction of inflammation through activation of the NF-κB pathway. Notably, LDR blocked cartilage disorders by inhibiting IL-1β-induced catenin signaling and subsequent catenin-dependent suppression of the Sox-9 pathway and activation of the NF-κB pathway, without directly altering catenin expression. LDR also inhibited chondrocyte destruction through the catenin pathway induced by epidermal growth factor, phorbol 12-myristate 13-acetate, and retinoic acid. Collectively, these results identify the molecular mechanisms by which LDR suppresses pathophysiological processes and establish LDR as a potentially valuable therapeutic tool for patients with cytokine- or soluble factors-mediated cartilage disorders.</P>