한방 이화주의 미백 및 피부 주름 개선 효과

이상진(Sang-Jin Lee),권이영(Yi-Young Kwon),조성원(Sung-Won Cho),권희숙(Hee-Suk Kwon),신우창(Woo-Chang Shin) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4

본 연구에서는 한방이화주의 피부 생리기능 활성을 알아보기 위해 70% EtOH 추출물의 피부 미백, 주름 개선 및 항염증 효과를 조사하였다. HEE은 tyrosinase 활성 억제 및 tyrosine을 기질로 melanin이 형성되는 pathway에 관여하는 주요한 인자인 TRP-1과 TRP-2를 저해하는 작용 기전을 통해 피부 색소침착의 주요 원인 물질인 melanin 생합성을 농도 의존적으로 저해하는 것을 확인하였다. HEE은 피부진피 내 피부 탄력을 유지하는 elastin을 분해하는 효소인 elastase의 활성을 저해하였고, 피부의 keratinocyte가 생성분비하는 MMP-2와 MMP-9의 단백질 발현과 proteolytic 활성을 억제하여 노화에 따른 피부 주름 생성 억제할 수 있는 가능성을 확인하였다. 또한 세포 독성 없이 LPS에 의해 유도된 염증 반응을 50% 저해하는 HEE의 농도(IC50)는 24.9 μg/mL이며, 50 μg/mL 농도로 처리하였을 때 염증 반응 저해 효과가 70%로 높은 효과를 가지는 것을 확인하였다. 이상의 결과를 종합하면 HEE의 피부 미백, 주름 개선 및 항염증에 우수한 효과를 나타내고 있으므로 기능성 화장품의 주요한 소재로 이용 가치가 높을 것으로 사료된다. Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)- induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

유해화학물질 운송 파이프의 안정성 진단 센서 개발을 위한 기초연구

신상희(Shin, Sang_Hee) 대한토목학회 2019 대한토목학회 학술대회 Vol.2019 No.10

녹차 음용이 알루미늄을 투여한 흰쥐의 혈청 효소 활성도에 미치는 영향

신미경,한성희,한경조 동아시아식생활학회 1996 동아시아식생활학회지 Vol.6 No.2

This study was performed to investigate the effects of green tea activities in rats with administration of aluminum in drinking green tea. Male Sprague Daweley rats were divided into five groups consisting of the control, aqueous green tea at the level of 1.5%, a aquous green tea(1.5%) and aluminum sulfate solution 500ppm, before the 2 weeks administration by aquous green tea(1.5%) and after the 2 weeks aluminum sulfate solution 500ppm, aluminum sulfate solution 500ppm. After 4weeks of feeding, serum enzymes activities were measured for experimental rats, and analyzed the activities of alanine amino trans aminase(ALT), asparate amino transminase(AST), lactate dehydrogenase(LDH) cholinesterase(ChE). Comparing to control group, Alanine amino trans aminase(ALT) was decreased in aqueous green tea administrated group and increased significantly administration by aluminum sulfate solution 500ppm group. Alanine amino trans aminase(ALT) was decreased administration by aqueous green tea group and increased addition to aluminum sulfate solution 500ppm group as compared to control group. Lactate dehydrogenase(LDH) was increased compared to control group by experimental group and increased significantly administration by aluminum sulfate solution 500ppm. Cholinesterase(ChE) activity was decreased compared to control group by experimental group.

유기농업에서의 작물의 양분관리

안난희, 신재훈, 옥정훈, 이상민, 김석철, 사동민 忠北大學校 農業科學硏究所 2016 農業科學硏究 Vol.32 No.2

Soil fertility is fundamental in determining the productivity of all farming systems and is most�ﾠ�ﾠ commonly defined in terms of the ability of the soil to supply nutrients to crops. Organic farming systems rely on the management of soil organic matter to enhance the chemical, biological and physical properties of the soil, in order to optimize crop production. Organic agriculture excludes the use of chemical nitrogen fertilizers, instead requiring a balance between supply and demand nutrients through the use of organic matter. Nutrient management is one of the main challenges facing organic farming. The short term challenge is supplying sufficient nutrients to crops at the correct point in their development to achieve economically viable yield, while in the long term, the difficulty is to balance nutrient inputs and runoffs to avoid nutrient rundown or environmental pollution. This paper reviews information from the literature to investigate strategies of managing nutrients by supplying organic matter in organic agriculture during the major phases of crop growth.

분자내 고리화반응에 의한 <Benz-[f]-Indole>-4,9-Dione 유도체 합성

신상희,서명은 梨花女子大學校 藥學硏究所 1991 藥學硏究論文集 Vol.- No.1

Compound of the structure of <benz-[f]-indole>-4.9-dione are known to have an antibacterial activity against Gram-positive bacteria. New kinds of 2-amino-<benz-[f]-indole>-4.9-diones are prepared via intramolecular cyclization. 2-Chloro-3-(α-cyano-α-ethoxycarbonyl-methyl)-1.4-naphthoquinone was reacted with some alkylamines (methylamine, ethylamine, ethanolamine, isopropylamine, cyclohexylamine, benzylamine) to yield 2-amino-3-ethoxycarbonyl-N-alcyl-<benz-[f]-indole>-4.9-diones.

생분해성 플라스틱이 포함된 유기성 생활 쓰레기의 퇴비화

신창호,김영진,이상일,장상희,조무환,신부영 영남대학교 환경문제연구소 2000 環境硏究 Vol.19 No.2

준 생산용 퇴비화 장치를 이용하여 생분해성 플라스틱을 포함하는 유기성 도시생활쓰레기기의 퇴비화를 연구하였다. 유기성 도시생활쓰레기는 실제 도시생활쓰레기 구성비에서 무기물을 제외한 유기성 물질만의 비로 만들어 사용하였다. 유기성 도시생활쓰레기를 구성하는 각각의 물질에 대한 생분해도를 ISO법으로 측정하였고, 퇴비의 화학적 물리적 특성도 조사하였다. 구성 물질에 대한 생분해도 결과에서, 생분해성 고분자를 포함한 각 물질들은 퇴비화에 충분한 생분해도를 나타내는 것으로 밝혀졌다. 또한, 유기성 도시 생활쓰레기로부터 비독성의 퇴비를 얻을 수 있음을 알았다. The composting study of organic municipal solid waste containing biodegradable plastic was performed by using pilot scale composting apparatus. The organic municipal solid waste(OMSW) was artificially prepared for composting. The composition of artificial OMSW was the same as that of real municipal solid waste excluding inorganic waste. The biodegradability of individual component of OMSW was studied according to the ISO method. The chemical and physical characteristics were also observed. Biodegradability study revealed that every component of OMSW including biodegradable plastic had sufficient degradability for real composting. And it was found that non-toxic compost could be produced from OMSW containing biodegradable plastic.

筋骨格系 領域에서 Thermography의 臨床的 活用에 對한 考察

신현택,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

근골격계 질환은 임상에서 가장 흔하게 접할 수 있는 대상의 하나로 그 진단과 평가가 매우 중요하며 여러 가지 진단기기와 평가방법이 이용되고 있다. Thermography는 기존의 진단기기와 달리 질병의 기능적인 측면을 평가할 수 있다는 점과 통증과 같은 주관적인 표현을 어느정도 객관화할 수 있다는 점에서 임상적 가치가 고려되고 있다. 본 연구는 최근 국내외의 임상 논문을 대상으로 근골격계 영역에서 Thermography의 활용 동향을 고찰하여 진단적 가치를 확인하고자 하였다. Thermography는 척추신경병증, 근막동통증후군, 말초신경병증, 반사성 교감신경 이영양증, 레이노증후군, 악관절 장애 및 일부 기타 질환에서 적용되었으며, 대부분의 질환에서 보조적인 진단기기로 활용가치가 있었다. 특히, 질병의 경과 관찰과 약물 및 기타 처치에 대한 효과 판정에 유용하였으며, 레이노 증후군 및 반사성 교감신경 이영양증과 같은 질병에서는 일차적인 진단기기로도 활용이 가능하였다. 향후 근골격계 영역에서 Thermography의 보다 폭넓은 적용을 위해서는 질환에 따른 적절한 촬영방법의 개발 및 결과 판독에 대한 객관성 확보가 있어야 할 것이다. The purpose of this study is to assess the usefulness of thermography in patients with musculoskeletal disease. Thermography is noninvasive, easy to reading, objective and physiologic instrument by measuring and imaging infrared energy emitted from skin surface. Thermography can show the skin temperature changes in various conditions of the body with musculoskeletal disease. This literature review was done for the usefulness of thermography in diagnosing musculoskeletal disease. In conclusion, thermography was adapted in radiculopathy, MPS, peripheral neuropathy, RSD, Raynaud's phenomen, TMJ dysfunction, etc. It was useful as a secondary diagnostic method in those diseases, also possible as a primary diagnostic method in RSD, Raynaud's phenomen. And, it might be reliable tool for estimating disease procedure and consequence after treatment. But, the objectivity of the reading and the development of the operating method are required for further adaptation in musculoskeletal disease.

간호사의 목표관리[MBO]에 대한 인식과 간호조직의 유효성

신을숙,안성희 대한간호행정학회 2008 간호행정학회지 Vol.14 No.3

Purpose: It is a descriptive study to analyze correlation between the perception of management by objectives(MBO) and organizational effectiveness among clinical nurses. Methods: The subjects were 315 nurses at two hospitals (A and B) of C university, who have had more than 3.5 years of nursing experience. The survey instrument included two major concepts, Perception of MBO (29 items) and organizational effectiveness, which has three sub-concepts, job satisfaction (18 items), organizational commitment (12 items), and motivation (20 items). The data analyses included t-test, ANOVA, Scheffe' test, Pearson's correlation coefficients, and Stepwise multiple regression. Result: The mean score of the perception of MBO was 3.13 out of 5. In organizational effectiveness, job satisfaction was 3.09, organizational commitment 3.25, and motivation 3.38. The perception of MBO had significantly positive correlation with job satisfaction(r=.71), organizational commitment(r=.65) and motivation(r=.61). The perception of MBO explained 50.4%, 42.4%, and 37.1% for job satisfaction, organizational commitment, and motivation respectively. Conclusions: The results show that the MBO affected the organizational effectiveness, and the MBO serves as a useful system to improve the organizational effectiveness in a nursing department.

Bowling 투구 動作分析

신성휴,위승두,손명성,구희성 조선대학교 스포츠과학연구소 1998 스포츠科學硏究 Vol.9 No.-

The Purpose of this study is the provide basic data for bowlers by analyzing the kinematical variables of throwing motion to the male pro bowler using 3-dimensional image analysis method. This researcher took the pictures with a video camera, analyzed them using the Kwon 3D program. 1×4×2m control object installed to get a 3 dimensional space coordinates. Results were as follows. 1. It was indicated that the trunk angle did not change left and right. Back and forth from stance to release motions of three subjects, and the average angle of trunk angle at the stance and that at the tabular side were 19.5˚ and 14.6˚ respectively, which showed they did not deviated from well-known range of forward direction, 15-20˚ and lateral direction 10-15˚. Also the trunk angle of release motion was average 17.1˚ for thalamus side, 41.3˚ for tabular side. 2. It was indicated that the knee angle repeated the increase and decrease to a small degree from the first to the fourth phase, the average angle of left knee at the release motion, the sixth phase was 110.8˚, which was higher than generally known 90˚.

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1