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( Gyeol Seong ),( Dong Hyun Sinn ),( Wonseok Kang ),( Geum-youn Gwak ),( Yong-han Paik ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Hepatitis e antigen-positive patients with high serum hepatitis B virus (HBV) DNA but normal alanine aminotransferase (ALT) are presumed in immune-tolerant phase, and their risk of developing complication is still debatable. Recent guideline suggested to use ALT levels, liver biopsy, elastography or liver fibrosis biomarker (eg, FIB-4) to stratify risk of complication for patients presumed in immune-tolerant phase. Methods: We analyzed of 651 HBeAg positive patients with high serum HBV DNA levels (=7 log IU/mL) but normal or mildly elevated ALT levels (<80 U/L), age more than 18 years (male = 404) who were monitored for at least 1 year from 1998 to 2006. Normal ALT was defined as 35 U/L for men and 25 U/ L for women. The risk of developing hepatocellular carcinoma (HCC) was assessed. Results: During a median 11.2 years of follow-up (range: 1.1- 18.0 years), 42 patients (6.5%) developed HCC. Age, sex, ALT and FIB-4 levels were independent factors associated with HCC development. Those with mildly elevated ALT levels showed significantly higher risk of developing HCC than normal ALT levels (3.4% vs. 9.4% at 10 years for normal ALT vs. mildly elevated ALT, P=0.001). Among patients with normal ALT level (n = 301), FIB-4 level was independent factor associated with HCC development (hazard ratio 2.35; 95% confidence interval 1.54-3.58, P<0.001). Among 301 patients with normal ALT levels, 51 patients (16.9%) had FIB-4 = 1.453. The HCC risk at 10 years was significantly higher for those with high FIB-4 levels (1.3% vs. 13.6% for FIB-4 <1.453 vs. =1.453, P<0.001). Conclusions: Among patients presumed in immune tolerant phase, HCC risk was generally low but was not null. Among patients with normal ALT levels, some showed high FIB-4 levels, and their risk of developing HCC was high. Our data indicate that FIB-4 can be an useful non-invasive marker for stratifying HCC risk among patients presumed in immune tolerant phase, and those with high FIB-4 levels warrants close attention.
회복환경을 위한 물리적 환경요소에 관한 연구 - 주의회복이론을 중심으로 -
조성결(Cho, Seong-Gyeol),임호균(Lim, Ho-Kyun) 대한건축학회 2023 대한건축학회 학술발표대회 논문집 Vol.43 No.2
The purpose of this study is to analyze and identify physical environmental factors that can enhance restorative experiences. While most previous research has focused on healthcare environments, this paper explores the physical environmental factors that can be applied in different types of public spaces, such as cultural spaces, libraries, museums, and more. The literature review was based on Attention Restoration Theory and 12 existing studies focusing on elements within the built and natural environment that have a restorative effect on human beings. As a result, natural elements, accessibility (wayfinding), natural lighting, color, and noise were considered influential factors for creating healing environments. Future research should investigate their actual effects in real-world settings.
Kim, Seong Yun,Jang, Han Gyeol,Yang, Cheol-Min,Yang, B.J. Elsevier 2018 Composites science and technology Vol.155 No.-
<P><B>Abstract</B></P> <P>The importance of the thermal conductivity of engineering plastics reinforced with nanofillers is increasing in various industries, and the need for a model with which to make reliable predictions continues. We propose a micromechanics-based multiscale model that considers multi-shaped nanofillers to predict the thermal conductivity of composites. The distribution of each phase is assumed to be probabilistically distributed, and the Kapitza resistance at the interface between the filler and matrix was calculated by means of a molecular dynamics simulation. A polybutylene terephthalate (PBT) composite system embedded with multi-walled carbon nanotubes (MWCNTs) was used in a specific simulation. Composites containing MWCNTs of different lengths were also fabricated to obtain appropriate experimental results for the verification of the proposed model. Fourier-transform infrared (FT-IR) spectroscopy, Raman spectroscopy, and field-emission scanning microscopy (FE-SEM) were carried out to confirm that the selected materials could suitably be compared. Finally, the proposed model was applied to the finite element method to examine the heat flux of the composites according to the constitutive properties, and their results were compared to the experimental results.</P>
Role of Th2 cytokines on the onset of asthma induced by <i>meta</i>‐xylene in mice
Hong, Seong‐,Gyeol,Hwang, Yun‐,Ho,Mun, Seul‐,Ki,Kim, Su‐,Jin,Jang, Ho‐,Yeol,Kim, Hangun,Paik, Man‐,Jeong,Yee, Sung‐,Tae John Wiley Sons, Inc. 2019 Environmental toxicology Vol.34 No.10
<P><B>Abstract</B></P><P><I>meta</I>‐Xylene (<I>m</I>‐xylene) is one of three isomers of xylene, which is widely used as a solvent and detergent in various industries and medical technology. Exposure to volatile organic compounds, such as <I>m</I>‐xylene, causes pulmonary inflammation and airway inflammation, thereby contributing to the onset of asthma. Exposure to <I>m</I>‐xylene increases acute wheezing and intensity of asthma symptom. However, the mechanism of the onset of asthma by <I>m</I>‐xylene has not been studied yet. C57BL/6 mice were sensitized and challenged by <I>m</I>‐xylene at 100 or 300 mg/kg. The mice were then sacrificed after the last challenge. Exposure to <I>m</I>‐xylene increased the total number of inflammatory cells and the production of interleukin (IL)‐4, IL‐5, IL‐13, and immunoglobulin E related to the Th2 immune response. In contrast, the production of interferon‐γ related to the Th1 immune response was decreased. In addition, the airway resistance increased according to the airway hyper‐responsiveness measurements. Finally, a histological analysis revealed infiltration of inflammatory cells, mucus production, and lung fibrosis. These results suggest that <I>m</I>‐xylene is a potential risk factor for asthma and the onset of asthma is caused by TH2 cytokines.</P>
일부 만 30세 이상 성인에서 구강건조증 관련요인 분석
한해성 ( Hae Seong Han ),권다애 ( Da Ae Kwon ),김리나 ( Ri Na Kim ),김유나 ( Yu Na Kim ),이결희 ( Gyeol Hui Lee ),이나람 ( Na Ram Lee ),이다정 ( Da Jeong Lee ),이승희 ( Seung Hui Lee ),최준선 ( Jun Seon Choi ) 한국치위생과학회 2013 치위생과학회지 Vol.13 No.1
The aim of this study was to analyze factors related to xerostomia in adults aged 30 years and over. The data were analyzed using the t-test, one-way ANOVA and multiple linear regression analysis in the SPSS version 12.0 program. The results were as follow. 1. The respondents who were older than 51 years old, unemployed and had less than 3 million won of average monthly income were more aware of xerostomia (p<0.05). 2. The respondents who answered poor and moderate for their general and oral health and the group with duplicate medication and comorbidity were more aware of xerostomia (p<0.05). 3. The respondents that had problems in chewing, communication, ordinary activities and complained of pain? discomfort and suffered from anxiety depression were more aware of xerostomia (p<0.001). 4. The respondents that answered frequent dryness on their skin, eyes, lips, and nasal mucosa were more aware of xerostomia (p<0.001). 5. Xerostomia showed highest correlation with quality of life (b=0.436) followed by the number of medications (b=0.239), sense of entire body dryness (b=0.200), feeling of hopelessness (b=0.160) and number of oral mucosa disease symptoms (b=0.099) (p<0.05). According to the results of the study, xerostomia may cause deterioration in quality of life. Thus, it is advised to improve the patient management system among dental professions to prevent various complications caused by xerostomia and conduct regular health education on the cause and management method of xerostomia.
Jang, Han Gyeol,Yang, Beomjoo,Khil, Myung-Seob,Kim, Seong Yun,Kim, Jaewoo Elsevier 2019 Composites Applied science and manufacturing Vol.125 No.-
<P><B>Abstract</B></P> <P>In spite of active studies on multi-walled carbon nanotube (MWCNT)-incorporated polymer, MWCNTs of different thickness and lengths have been employed. Here, the effects of MWCNT morphology, specifically its length, on the mechanical, thermal, and electrical properties of MWCNT/polymer composites were examined in comparison with theoretical modeling. Field-emission scanning electron microscopy and micro-computed tomography observations revealed that short MWCNTs were dispersed more uniformly than long MWCNTs in a polyamide 6 (PA6) polymer. Correlation of this result with the tensile performance revealed that at low MWCNT concentrations the long-MWCNT/PA6 composite showed superior tensile properties since the effect of length was dominant. However, at high MWCNT concentrations, the short-MWCNT/PA6 showed superior tensile properties to the long-MWCNT/PA6 due to the better dispersion of the former. The thermal conductivity gradually improved with increasing MWCNT concentration, showing larger improvement for the long-MWCNT/PA6, while the electrical conductivity reached percolation threshold at 1 wt% for both MWCNTs.</P>