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Chun, Jiyeon,Kwon, Dae-Young,Kim, Jong Sang,Kim, Jeong-Hwan John Wiley Sons, Ltd. 2008 Journal of the science of food and agriculture Vol.88 No.10
<P>BACKGROUND: Soy yoghurts containing enhanced bioactive isoflavone aglycones were prepared from combinations of yellow (YS) and black soymilk (BS) (YS:BS = 100:0, 70:30, 50:50 and 0:100, v/v) by fermentation with Streptococcus infantarius 12 and Weisellia sp. 4 at 37 °C for 10 h. Sensory properties of the bioactive soy yoghurts were investigated. Furthermore, other characteristics including the contents of isoflavones, viable cell numbers, pH, colour and DPPH radical scavenging activity were investigated.</P><P>RESULTS: One hundred percent YS yoghurt showed the highest scores of all sensory attributes while 100% BS yoghurt was the lowest for colour and smoothness. The overall acceptability scores were 5.9 and 5.2 for 100% YS and 100% BS yoghurts, respectively (9-point scale). The L-values of soy yoghurts decreased as the percentage BS increased, indicating darkening of soy yoghurts. The contents of bioactive isoflavone aglycones (daidzein and genistein) in soy yoghurts remarkably increased (>1300 mg kg<SUP>−1</SUP>) by fermentation. Viable cell numbers and pH of soy yoghurts ranged from 8.4 × 10<SUP>8</SUP> to 9.6 × 10<SUP>8</SUP> CFU g<SUP>−1</SUP> and 4.43 to 4.54, respectively. DPPH radical scavenging activity significantly increased as the percentage BS increased (P < 0.05).</P><P>CONCLUSION: One hundred percent YS yoghurt was better for overall sensory properties while 100% BS yogurt was more bioactive in terms of the isoflavone aglycone contents and DPPH radical scavenging activity compared to other yoghurts. Copyright © 2008 Society of Chemical Industry</P>
Park Jiyeon,Kim Dong-Moung,Lee Jin-Ok,Park Hyeon-Chun,Ryu Brian Y.,Kim Ju Han,Lee Sug Hyung,Chung Yeun-Jun 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Despite growing evidence of the relevance of alternative splicing (AS) to cancer development and progression, the biological implications of AS for tumor behaviors, including papillary thyroid cancer (PTC), remain elusive. With the aim of further understanding the molecular and histological subtypes of PTC, we in this study explored whether AS events might act as new molecular determinants. For this purpose, AS profiles were analyzed in RNA-sequencing data from The Cancer Genome Atlas (TCGA) and from a Korean patient dataset. A total of 23 distinct exon-skipping (ES) events that correlated significantly with PTC oncogenic activity and differentiation scores were identified. The two top-ranked ES events, NUMA1_17515 in exon 18 of NUMA1 and TUBB3_38175 in exon 6 of TUBB3, showed high correlations with oncogenic activities and discriminated histological and molecular subtypes of PTC. Furthermore, two novel intron-retention (IR) events for TUBB3 were uncovered. All ES and IR events for the TUBB3 gene were predicted to induce nonsense-mediated mRNA decay. The relative abundances of intron reads in the PTC dataset from TCGA showed IR levels to differ significantly among PTC subtypes, possibly reflecting their different tumor behaviors. This study provides a landscape of AS changes among PTC subtypes and identified two significant AS events, NUMA1_17515 and TUBB3_38175, as potential AS biomarkers for PTC subclassification and characterization. The AS events identified in this study may be involved in the development of phenotypic differences underlying the functional characteristics and histological differentiation of PTCs.