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방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계
정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2
Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.
정상적인 부모에서 산전초음파로 진단된 Holt-Oram 증후군 1 예
이용희,이정건,이정노,이숙환,최안나,지은경,권태희,조주연,정창조,계정웅 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.11
Holt-Oram Syndrome is an autosomal dominant disorder characterized by the association of upper-limb abnormalities and congenital heart disease. A woman with no family history of genetic disease underwent antenatal sonography at 27 weeks' menstrual age to screen for fetal anomalies. Ultrasonography revealed abnormalities in the upper limbs. The limb abnormalities included abscence of bilateral thumbs and radius: the left humus was short. Pregnancy termination was performed. The postnatal chromosomal analysis revealed a normal 46XX karyotype and the autopsy finding confirmed the Holt-Oram syndrome. We report a case of Holt-Oram Syndrome in fetus with unaffected parents with brief of the literatures.
Lee, Do-Yeon,Jeon, Gye Sun,Shim, Yu-mi,Seong, Seung-Yong,Lee, Kwang-Woo,Sung, Jung-Joon The Korean Society for Brain and Neural Science 2015 Experimental Neurobiology Vol.24 No.3
<P>Amyotrophic lateral sclerosis (ALS) is a fatal neurological disorder characterized by selective degeneration of motor neurons. Mutant superoxide dismutase 1 (SOD1) is often found as aggregates in the cytoplasm in motor neurons of various mouse models and familial ALS patients. The interplay between motor neurons and astrocytes is crucial for disease outcome, but the mechanisms underlying this phenomenon remain unknown. In this study, we investigated whether transient transfection with wild-type and mutant-type SOD1 may lead to amplification of mutant SOD1-mediated toxicity in cortical neurons and astrocytes derived from wild-type and mutant-type (human G93A-SOD1) mice. In transgenic mice expressing either wild- or mutant-type SOD1, we found that green fluorescent protein (GFP)-wtSOD1 was present in the cytoplasm and nuclei of wild-type cortical neurons and astrocytes, whereas GFP-mutant SOD1 was mainly cytoplasmic in wild- and mutant-type cortical neurons and astrocytes. These findings indicate that intracellular propagation of misfolding of GFP-wt or mtSOD1 are possible mediators of toxic processes involved in initiating mislocalization and aggregation. Here, we provide evidence that cytoplasmic aggregates induce apoptosis in G93A-SOD1 mouse cortical neurons and astrocytes and that the toxicity of mutant SOD1 in astrocytes is similar to the pathological effects of ALS on neurons <I>in vitro</I>. Collectively, our results indicate that mtSOD1 probably interacts with wtSOD1 via an unknown mechanism to produce augmented toxicity and may influence aggregate formation and apoptosis.</P>
이계원(Gye Won Lee),이주연(Ju Yeon Lee),조영호(Young Ho Cho) 한국생물공학회 2010 KSBB Journal Vol.25 No.1
본 연구에서는 가래나무 추출물의 항산화 효과와 티로시나제 활성 저해, 멜라닌 생성 및 티로시나제 합성 억제 효과를 측정하고 이 추출물을 함유하는 제품의 임상시험을 실시하여 미백 화장품 소재로서의 개발 가능성을 관찰하였다. 가래나무 추출물은 농도 의존적으로 DPPH radical 과 초산소 음이온 라디칼을 소거하였고, SC50 값은 각각 20 μg/mL 및 25 μg/mL 이었다. B16/BL6 멜라노마 세포를 이용하여 세포내 티로시나제 활성, 멜라닌 생성 및 티로시나제 합성 억제 효과를 측정한 결과 농도 의존적으로 티로시나제의 활성 및 멜라닌생성을 억제하였으며, 티로시나제 단백질의 합성도 감소시켰다. 또한, 임상시험을 통하여 가래나무 추출물을 함유한 화장품이 대조 제품에 비해 통계적으로 유의한 피부 미백 효과가 있음을 확인하였다. 이상의 결과를 종합해 볼 때 가래나무 추출물은 색소침착 방지와 개선에 효과있는 새로운 미백 원료로 개발할 수 있을 것으로 사료된다. Juglans mandshurica belongs to the family Juglandaceae is known to contain a wide range of pharmacological activities including anti-cancer, anti-inflammation, astringent, and anti-human immunodeficiency virus-type 1 (HIV-1). Melanogenesis refers to the biosynthesis of melanin pigment in melanocytes. In this study, to investigate the whitening activity of the extracts from Juglans mandshurica, we measured effects on a tyrosinase activity, a melanogenesis, and a tyrosinase synthesis in the B16/BL6 melanoma cells and an antioxidant activity. The extracts significantly scavenged a 1,1-diphenyl-2-picrylhydrazyl (DPPH) and a superoxide anion radicals in a dose-dependent manner with a SC50 value of 20 μg/mL and 25 μg/mL, respectively. Also, the tyrosinase activity and melanogenesis were significantly inhibited by the extracts. Furthermore, the synthesis of tyrosinase protein was ignificantly decreased by the extracts in enzyme-linked immunosorbent assay. Double blind study on the clinical efficacy of a cream containing 2% of the extracts showed that the extracts have a significant skin whitening effect. Therefore, this study demonstrates that the extracts from Juglans mandshurica may be useful as a potential agent for skin whitening.
Kwak, Gye-Hoon,Lee, Kun-Hong,Hong, Sang Yeon,Seo, Seong Deok,Lee, Ju Dong,Lee, Bo Ram,Sum, Amadeu K. American Chemical Society 2018 Journal of chemical and engineering data Vol.63 No.6
<P>We present pure CH<SUB>4</SUB> and CH<SUB>4</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> mixed hydrate phase equilibria formed from a mixture of NaCl (10 wt %) and monoethylene glycol (MEG, 10 and 30 wt %) solutions. As expected for thermodynamic inhibitors, the mixture of salt and glycol causes the hydrate phase equilibrium boundary to shift to lower temperatures and higher pressures, and on increasing the MEG concentration, the hydrate stable region shifted more. The measured experimental data are also compared with a thermodynamic model recently developed, named the Hu-Lee-Sum correlation, showing that the data match well with the predictions. The experimental data were used to calculate the enthalpy of hydrate dissociation. The enthalpies of CH<SUB>4</SUB> hydrates in the mixture of 10 wt % NaCl brine and 10 or 30 wt % MEG were found to be ∼58.7 and 54.63 kJ/mol, respectively, corresponding to structure I hydrates, whereas for the CH<SUB>4</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> (91.98:8.02 mol %) mixed gas system, the enthalpies of dissociation were found to be ∼101.10 kJ/mol (10 wt % NaCl + 10 wt % MEG) and 95.34 kJ/mol (10 wt % NaCl + 30 wt % MEG), confirming the mixed hydrates formed structure II. We also performed Raman analysis for CH<SUB>4</SUB> hydrates and CH<SUB>4</SUB>/C<SUB>3</SUB>H<SUB>8</SUB> mixed hydrates in the NaCl and MEG system and investigated their spectroscopic behavior and hydrate structure.</P> [FIG OMISSION]</BR>
증 례 : 담낭담관염 및 방광염으로 발현한 과호산구증가증후군
이계연 ( Gye Yeon Lee ),김선형 ( Sun Hyung Kim ),이승연 ( Seung Youn Lee ),박형도 ( Hyung Do Park ),장홍석 ( Hong Suk Chang ),고동희 ( Dong Hee Koh ),이진 ( Jin Lee ),최영희 ( Young Hee Choi ) 대한췌담도학회 2015 대한췌담도학회지 Vol.20 No.4
호산구성 담낭염은 비교적 드문 질환으로 다른 일반적인 원인의 담낭염과 비교하여 증상, 검사실 소견 및 이학적 검사에 있어 차이가 없어, 주로는 수술 후 진단하게 된다. 한편, 호산구성 방광염은 호산구성 담낭염과 마찬가지로 드물게 발생하며 이 역시 조직학적 진단을 통해서만 확진된다. 본 저자들은 우상복부통증으로 내원하여 급성 담낭담관염으로 담낭절제술 시행 후 호산구성 담낭염이 진단된 환자에서, 수술 후에도 경도의 말초혈액 호산구증가증의 지속과 만성 하부 요로 증상으로 인해 경요로방광조직검사 후 호산구성 방광염의 병발을 국내 최초로 확인하였고, 과호산구증가증후군으로 발현한 호산구성 담낭담관염 및 방광염 진단하에, 이에 대해 스테로이드 투약을 통해 증상 및 말초혈액 호산구증가증의 소실을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Eosinophilic cholangiopathy is a rare disease characterized by dense transmural eosinophilic infiltration of the gallbladder and bile duct. It’s clinical and laboratory manifestations are not different from those of other causes of cholangiopathy, and the diagnosis is usually made based on pathologic findings after cholecystectomy. Moreover, the occurrence of eosinophilic cystitis accompanied by cholangiopathy is extremely rare. We report a rare case of hypereosinophilic syndrome manifested as eosinophilic cholangiopathy accompanied with eosinophilic cystitis, for the first time in Korea, in a 49-year-old woman who presented with persistent right upper quadrant pain. After performing imaging study to validate the diagnosis of acute acalculous cholecystitis and cholangitis, an urgent cholecystectomy was performed. Pathologic examination of the excised gallbladder was consistent with eosinophilic cholecystitis. The patient underwent bladder biopsy because there was persistant irritative voiding symptoms combined with constant mild peripheral eosinophilia even after cholecystectomy, and the pathologic findings revealed eosinophilic cystitis. Symptoms and peripheral eosinophilia were improved after steroid therapy for an indicated period.