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자연산 점몰개, Squalidus multimaculatus Hosoya et Jeon의 새인두흡충, Clinostomum complanatum (Rudolphi, 1814) 감염
박명애 ( Myoung Ae Park ),서정수 ( Jung Soo Seo ),정승희 ( Sung Hee Jung ),최희정 ( Hee Jung Choi ),전은지 ( Eun Ji Jeon ),지보영 ( Bo Young Jee ),이완옥 ( Wan-ok Lee ),우승호 ( Sung Ho Woo ),이은혜 ( Eun Hye Lee ) 한국어병학회 2011 한국어병학회지 Vol.24 No.2
경상북도 영덕군의 하천에 서식하는 점몰개 spotted barbel gudgeon (Squalidus multimaculatus Hosoya et Jeon)의 근육에서 새인두흡충 Clinostomum complanatum (Rudolphi, 1814)의 피낭유충이 발견되었다. 감염된 점몰개는 "yellow grub"인 기생충의 피낭유충으로 인해 표면이 울퉁불퉁하게 보였으며, 수면위에 힘없이 유영하였고 일부 폐사한 개체도 발견되었다. 분리된 탈낭유충의 형태는 혓바닥 모양이었으며, 크기는 2.85~5.89 mm×0.8~1.99 mm였다. 어체당 1~98 개의 피낭유충을 분리하였으며 평균 감염수는 25개로 나타났다. 특히, 성어크기인 평균 7 cm 정도의 점몰개는 100% 감염되어 있었다. 본 연구는 한국의 자연수계에 서식하는 어류에서 C. complanatum 의해 질병이 발생하고 폐사가 일어난 첫 보고이다. The metacercariae of Clinostomum complanatum (Rudolphi, 1814) were isolated in the whole body muscle of wild freshwater fish, spotted barbel gudgeon (Squalidus multimaculatus Hosoya et Jeon) from the local river in Yeongdeok, Gyeongsangbuk-do, Korea. The infected fish with bumpy body surface by "yellow grub" showed erratic swimming behavior and some fish were died. The isolated excysted metacercariae were tongue shaped and 2.85~5.89 mm × 0.8~1.99 mm in size. 1~98 metacercariae were isolated in individual fish and mean infection intensity was 25. All examined adult spotted barbel gudgeon sizing 7 cm in body length were infected. This is the first report of disease outbreak and mortality caused by C. complanatum infection in wild freshwater fish in Korea.
이은실,문전옥 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.1
It is known that alcoholics have significantly lower mitochondrial aldehyde dehydrogenase (ALDH)s' activity than do normal subjects or nonalcoholics with liver disease. However, there are only few reports that explain the reasons behind this reduction of ALDHs' activities. In this study, ALDH activity is inhibited by acetaldehyde, a substrate for ALDH. However, the addition of glutathione (GSH) protected ALDH activities against the inhibitory effects of acetaldehyde in vitro. Furthermore, when GSH depletion is induced using diethyl maleate (DEM) in rats by 24% in cytosol and 43% in mitochondria, ALDH activities were also depressed by 31% and 63%, respectively compared to non-treated rats without significant reductions in other hepatic enzymes. These results suggest that ALDHs' activities are closely related to the concentration of acetaldehyde and/or cellular GSH contents. Therefore in alcoholic liver disease, increased productions of acetaldehyde and decreased contents of mitochondrial GSH may involved in the depression of ALDHs' activities.
김숙영,전은영,김귀분,서연옥 성인간호학회 2002 성인간호학회지 Vol.14 No.4
Purpose: The purpose of this study was to identify the influencing factor to self actualization in middle-aged women. Method: The subjects for this study were 191 middle-aged women selected by convenience sampling in three cities. Data collection was done using a questionnaire. The data were analyzed by using descriptive statistics. Pearson Product Moment Correlation coefficient and Stepwise Multiple Regression. Result: The results of this study were as follows: 1. The relationship between self-efficacy, social support, self esteem, motivation for achievement, parental satisfaction with children and self-actualization were found to have statistically significant positive correlations. But the relationship between depression and self-actualization were found to have statistically significant negative correlation. 2. Stepwise multiple regression analysis revealed that the most powerful predictor was social support. Social support, motivation for achievement and self esteem accounted for 38.1% of the variance in self-actualization in middle aged women. Conclusion: According to these results, it is recommended that in order to enhance self-actualization in middle-aged women, empowerment of social support, motivation for achievement and self esteem should be pursued.
Polymorphisms in Apoptosis-Related Genes and <i>TP53</i> Mutations in Non-Small Cell Lung Cancer
Bae, Eun Young,Lee, Eun Jin,Kang, Hyo-Gyoung,Lee, Shin Yup,Jin, Gwang,Lee, Won Kee,Choi, Jin Eun,Jeon, Hyo-Sung,Lim, Jeong Ok,Lee, Eung Bae,Park, Jae Yong The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.11
<P>Apoptosis plays an essential role in the elimination of mutated or transformed cells from the body. Therefore, polymorphisms of apoptosis-related genes may lead to an alteration in apoptotic capacity, thereby affecting the occurrence of <I>TP53</I> mutations in lung cancer. We investigated the relationship between potentially functional polymorphisms of apoptosis-related genes and <I>TP53</I> mutations in non-small cell lung cancer (NSCLC). Twenty-seven single nucleotide polymorphisms in 20 apoptosis-related genes were genotyped by a sequenome mass spectrometry-based genotyping assay in 173 NSCLCs and the associations with <I>TP53</I> mutations in the entire coding exons (exons 2-11), including splicing sites of the gene, were analyzed. None of the 27 polymorphisms was significantly associated with the occurrence of <I>TP53</I> mutations. This suggests that apoptosis-related genes may not play an important role in the occurrence of <I>TP53</I> mutations in lung cancer.</P>
PoulShot<SUP>?</SUP> MG-F 백신의 마이코플라즈마 감염증에 대한 산란계 농장에서의 야외 효능 평가
전은옥(Eun Ok Jeon),우창곡(Chang Gok Woo),원호근(Ho Keun Won),모인필(In Pil Mo) 韓國家禽學會 2010 韓國家禽學會誌 Vol.37 No.2
본 연구에서는 Mycoplasma gallisepticum F 주 생독 백신(PoulShot<SUP>?</SUP> MG-F)의 안전성과 효능을 평가하였다. 충청북도 진천과 경기도 안성 지역의 산란계 농장을 선정하여, 백신과 야외주 공격 접종에 따른 혈청 역가 변화, 상부 호흡기에서의 마이코플라즈마균 재분리, 조직학적 병변과 백신 접종군 및 백신 미접종군 간의 산란율 및 오파란율의 차이를 농장별로 평가하였다. 백신 접종에 의한 혈청 역가 변화는 백신 접종 후 3주부터 확인되었으며, 농장에 따라 접종 후 23주에서 31주까지 지속됨으로써 백신 항체가 오랫동안 유지되는 것을 확인할 수 있었다. 또한 상부 호흡기에서 MG-F 재분리 및 PCR에 의한 유전자 검출도 백신 접종 후 31주까지 양성이었다. 이러한 항체 및 항원의 지속적인 검출은 상부 호흡기에 MG-F 백신주의 집락 형성이 오랫동안 지속된다는 것을 의미하는 것이다. 동일한 방법으로 백신 접종군에 대한 야외주 공격접종 후 상부 호흡기에서의 백신주 집락 형성을 분석한 결과, 공격 접종 후 3주까지 백신주의 집락 형성율이 야외주보다 동등하거나 높은 것으로 확인됨으로써 야외주 공격에 대한 백신주의 방어력이 입증되었다. MG-F의 안전성과 생산성 측면에서의 효능을 야외 농장에서 검증하기 위하여 두 실험 농장에서 백신 접종군과 백신 미접종군간의 산란율 및 오파란율을 비교하였다. 그 결과, MG-F 접종에 따른 임상적 부작용과 산란율 하락은 발견되지 않았으며, 오히려 백신 접종군의 오파란율이 백신 미접종군보다 평균 1~3% 낮은 것으로 분석됨으로써 백신 접종에 의한 난질 개선 효과가 있음이 확인되었다. 따라서, PoulShot<SUP>?</SUP> MG-F 생균백신을 산란계에 접종하였을 때 임상적으로 안전하였으며, 오랜 기간 야외 감염에 방어할 수 있는 항체 형성과 상부 호흡기에서의 지속성이 확인됨으로써 마이코플라즈마 야외 감염을 효율적으로 방어할 수 있을 것으로 판단된다. Mycoplasma gallisepticum (MG) infection results in severe economic loss in the poultry industry. In the previous reports, F strain, one of the MG live vaccine strains, could protect the bird from field infection of MG strains. In this study, efficacy of PoulShot<SUP>?</SUP> MG-F vaccine againset mycoplasma gallisepticum infection was evaluated for filed application in commercial layers. Commercial layers from two different farms received with PoulShot<SUP>?</SUP> MG-F, MG-F live vaccine at 9~14 weeks of age. Serological immune response to MG vaccine, the persistency of MG vaccine strain in the upper respiratory tracts and egg production rate were evaluated in the vaccinated, contacted or nonvaccinated flocks. The serological response was first detected at 3 weeks after vaccination (WAV) and persisted for 31 WAV. The MG vaccine strains were also persisted for 31 WAV based on the reisolation and PCR detection. There was no difference between the vaccinated or non-vaccinated flocks in the egg production rate but in the abnormality rate of eggs. Based on the above results, we suggested that the PoulShot<SUP>?</SUP>, MG-F live vaccine was fully immunogenic and had characteristics of long persistence in the upper respiratory trachea which will reduce economic loss caused by MG infection in the layer farms.
전옥경(Jeon, Ok Kyung),임시은(Yim, Si Eun),정인숙,윤은영(Yun, Eun Young),김미현(Kim, Mi Hyun),박윤선(Park, Yun Sun),이수란(Lee, Su Ran) 대한종양간호학회 2010 Asian Oncology Nursing Vol.10 No.2
Purpose: This survey was aimed to examine the current dietary restrictions practices for neutropenic patients among hospitals with 500 and more beds. Methods: Self-administered questionnaires were sent to 100 head or charge nurses of oncology or hemato-oncology wards by mail during October 2009, and 51 questionnaires were returned. The data were analyzed with descriptive statistics using SPSS (win version 12.0). Results: Of the hospitals surveyed, 47.1% (n=24) had guidelines on the dietary restrictions, and 80.4% (n=41) placed patients with neutropenia on restricted diets. The major decisional criteria of the dietary restriction was absolute neutrophil count (30.5%) and cooking status (29.2%). The most commonly restricted foods were raw fish or fresh meat (98.0%), uncooked intestine (98.0%), raw eggs (98.0%), draught beer (96.1%), and fresh fruits or vegetables (86.3%). Conclusion: The results showed variation in pattern of dietary restrictions and lower rate of guideline among hospitals, so that the need for the standard dietary restriction guideline is high. However, the role of diet in the development of infection in neutropenic patients is still unclear, which makes it difficult to establish dietary restriction guideline. Therefore, additional research are required to identify the relationship between dietary factors and infections. 본 연구는 의료기관별 호중구감소환자를 위한 식이제한 실태를 파악하기 위해 실시되었다. 연구결과 대부분의 기관에서호중구감소환자식이를 적용하였으며, 조리되지 않은 식품에대해 낮은 허용률을 보였다. 그러나 식이제한적용 및 해제 시기, 식이제한/섭취 허용기준, 식품군별 제한여부 등에서 차이가 있었으며, 지침을 가지고 있는 경우도 반이하로 낮은 수준이었다. 식이제한지침이 다양하고 일관성이 없는 경우 환자나 간호사에게 혼돈이 될 수 있으며, 부적절한 식이제한으로 환자에게 부정적인 영향을 줄 수 있어 표준화된 식이제한지침에 대한개발요구는 높다. 그러나, 아직 식이제한과 감염발생과의 관계가 명확하지 않아 표준화된 식이제한지침개발에 어려움이 있음을 감안하여, 관련 연구가 좀 더 활발히 진행되어야 할 것이다