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박히준,이제현,김수영,심범상,구헌종,강전모,최일환,이재동,김남재,이지숙,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
Objective : The use of herbal therapy is becoming an increasingly attractive approach for the treatment of various inflammatory disorders. The Alpiniae officinari Rhizoma is popular in Aisa as a traditional herbal medicine. Alpiniae officinari Rhizoma is a species of the ginger family(Zingiberacease). Method : This study was performed to investigate the anti-inflammatory effect of Alpiniae officinari Rhizoma extract by the methods of "carrageenan induced paw edema" and "Lipopolysaccharide-induced inflammatory mediators in mouse macrophage RAW 264.7 cells". Result : We suggest that Alpiniae officinari Rhizoma extract decreased paw volume induced by plantar injection of carrageenan. Also Alpiniae officinari Rhizoma extract inhibited nitric oxide, prostaglandin E₂production and induced nitric oxide synthase, cyclooxygenase-2 protein expression in Mouse macrophage RAW 264.7 cells stimulated with lipopolysaccharide. Conclusion : This study shows that Alpiniae officinari Rhizoma extract seems to have anti-inflammatory effect by inhibition of nitric oxide, prostaglandin E_(2) production and nitric oxide synthase, cyclooxygenase-2 protein expression.
박히준,이지숙,이재동,김남재,표지희,강전모,최일환,김수영,심범상,이제헌,임사비나 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-
Objectives : Cinnamomi Ramulus (CR), the young twing of Cinnamomi loureirii nees, has been used for treating symptoms related to pain. rheumatic arthritis and inflammation in Korean herb medicine. This study was carried out to investigate the anti-inflammatory effect of CR in vivo and in vitro. Methods : Extracts of CR were prepared and the chemical components of the extracts were examined by gas chromatography-mass spectrometry (GC-MS). The extracts were administrated to the rat paw edema model induced by carrageenan to evaluate the anti-inflammatory effect of CR. The expressions of nitric oxide (NO). prostaglandin E2(PGE2), inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 were also quantified in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages to survey the effect of CR in vitro. The main components were cinnamaldechyde and coumarin. Results : We examined the anti-inflammatory activity of the 80% ethanol extract of Cinnamomi Ramulus in vivo by using carrageenan-induced rat paw edema model. Maximum inhibition of 54.9% was noted at the dose of 1000㎎/㎏ after 2 hours of drug administration in carrageenan-induced rat paw edema and this showed a potent anti-inflammatory effect. Conclusions : The results showed that Cinnamomi Ramulus suppressed dose-dependently LPS-induced NO production in RAW 264.7 macrophages and also decreased iNOS protein expression. Cinnamomi Ramulus also showed a significant inhibitory effect in LPS-induced PGE2 production and COX-2 expression.
( Dong Mo Je ),( Yong Han Paik ),( Geum Youn Gwak ),( Moon Seok Choi ),( Joon Hyeok Lee ),( Kwang Cheol Koh ),( Seung Woon Paik ),( Byung Chul Yoo ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.3
Background/Aims: To investigate the efficacy and longterm outcome of esophageal variceal ligation (EVL) plus propranolol in comparison with propranolol alone for the primary prophylaxis of esophageal variceal bleeding. Methods: A total of 504 patients were retrospectively enrolled in this study. 330 patients were in propranolol group (Gr1) and 174 patients were in EVL plus propranolol group (Gr2). The endpoints of this study were esophageal variceal bleeding and mortality. Association analyses were performed to evaluate bleeding and mortality between Gr1 and Gr2. Results: EVL was more applied in patients with high risk, such as large-sized varices (F2 or F3) or positive red color signs. Total 38 patients had bleeds, 32 in Gr1 and 6 in Gr2. The cumulative probability of bleeding at 120 months was 13% in Gr1 versus 4% in Gr2 (P=0.04). The predictive factors of variceal bleeding were red color signs (OR 2.962, P=0.007) and the method of propranolol plus EVL (OR 0.160, P=0.000). 20 patients died in Gr1 and 12 in Gr2. Mortality rates are similar in the two groups compared, 6.7% in Gr1 and 6.9% in Gr2. The cumulative probability of mortality at 120 months was not significantly different in the two groups (7% in Gr1, 12% in Gr2, P=0.798). The prognostic factors for mortality were age over 50 (OR 5.496, P=0.002), Child-Pugh class B (OR 3.979, P=0.001), and Child-Pugh class C (OR 10.861, P=0.000). Conclusions: EVL plus propranolol is more effective than propranolol alone in the prevention of the first variceal bleeding in patients with liver cirrhosis. (Clin Mol Hepatol 2014;20:283-290)
Je-Hyeok Yu,Min-Heon Yun,Seon-Mo Yang,Dong-Seop Kim,Young-Ho Yun,Kyung-Ho Ma,Eun-Ho Son,Sok-Young Lee,Hong-Sig Kim,Sun-Hee Woo 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Breeding and cultivation techniques are being treated very severely regarding ecological and physiological development in buckwheat. This study was conducted to focus on the diversity occurring in the cultivated and tartary buckwheat and provide an overview of the characteristics and genetic resources activities. Morphological results showed that the height of common buckwheat ranges from 82-90cm, common buckwheat induced by 200Gy ranges from 52-75cm, common buckwheat induced by 300Gy ranges from 43-56cm, common buckwheat induced by 400Gy ranges from 33-60cm whereas the tartary buckwheat hight ranges from 65-87cm, and while it exposed to various radiation (200Gy, 300Gy and 400Gy), the obtained height ranges from 73-92cm, 55-80cm and 60-75cm respectively. However, the stems from the both cultivar are hollow and that’s why, the plant is very prone to lodging. The leaf color of common buckwheat was green, 200Gray, 300Gy 400Gy common buckwheat light green and green, whereas the tartary buckwheat green and bottle-green, 200Gray 300Gy 400Gy tatary buckwheat bottle-green, common buckwheat (control, 200Gy, 300Gy, 400Gy) stem color is light green and pink, flower color is white, tartary buckwheat (control, 200Gy, 300Gy, 400Gy) flower color is light green. The stem color from tartary buckwheat showed (200Gy, 300Gy, 400Gy) light green and light red color. The results revealed that the two buckwheat cultivars showed diversified characteristics.
정상기능 갑상선 결절 환자에서 갑상선 유두암의 의미 있는 예측인자로서 혈청 갑상선 자극호르몬의 역할
김동선(Dong-Sun Kim),문신제(Shin-Je Moon),이창범(Chang-Bum Lee),홍상모(Sang-Mo Hong),이유화(Yu-Hwa Lee),박정환(Jung-Hwan Park),최웅환(Woong-Hwan Choi),안유헌(You-Hern Ahn),박용수(Yong-Soo Park) 대한두경부종양학회 2011 대한두경부 종양학회지 Vol.27 No.2
Background and Objectives:Distinguishing benign from malignant lesion in thyroid noddex is important but clinically difficult. FNAB is the first investigation of choice. However, cytologic results are often indeter-minable. In those cases, additional molecular biologic tests are helpful. If serologic tests are available to predict malignancy, it can be useful to fortify accurate diagnosis. We analyzed whether TSH or FreeT4 level could be used as a predictor of malignancy. Materials and Methods:From January 2008 to March 2009, 540 patients received one of thyroidectomy in a single center. We only included 167 patients from 18 to 65 years old without cardiopulmonary or renal disorders. All the patients were in euthyroid state and took no medications, which affect the thyroid function. We reviewed charts retrospectively to find out differences in TSH level and FreeT4 level between the benign and malignant groups. Results:In this study, all the patients with malignancy had the papil-lary cancer. In benign group, average TSH level came out to be 1.48mU/L, whereas the average TSH level of malignant group was 1.98 mU/L. Moreover, the higher the cancer stage was, the higher the TSH level was. Al-though we have adjusted factors that can affect TSH level(age, sex, race, goiter type), we still received the same result. The risk of malignant cancer increased in proportion with TSH level within the normal range. In free T4 level, there was no difference between benign and malignant group. Conclusion:We propose that TSH level can play a role as one of the predictors for thyroid cancer. However, there is limitation because all the patients with malignancy in this study have papillary cancer. Thus, we can apply this result only in papillary cancer, and we need more study for other types of thyroid cancer.
Case Reports : Acute Generalized Exanthematous Pustulosis Caused by Diltiazem
( Hyun Je Kim ),( Kyu Dong Jung ),( Kyung Tae Lee ),( Ji Yeon Byun ),( Dong Youn Lee ),( Joo Heung Lee ),( Jun Mo Yang ),( Eil Soo Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.23 No.1
Acute generalized exanthematous pustulosis is clinically characterized by fever, pruritus and an acute pustular eruption. It can be described as having an abrupt onset and then spontaneous resolution occurs shortly after the start of symptoms, and there is usually only a single episode. Most cases have been triggered by the ingestion of drugs. Diltiazem hydrochloride is a calcium channel blocker that is commonly used for treating hypertension and angina. This drug was found to be the responsible agent in our current patient. There have been 9 such case reports in the English medical literature, yet this is the first such report in the Korean medical literature. We present the case of a 51-year-old male who experienced an acute generalized exanthematous pustulosis due to diltiazem hydrochloride and we review the relevant literature. (Ann Dermatol 23(1) 108~110, 2011)
유역단위 농업용수 연계 물수지 분석 모델 개발 및 적용
윤동현 ( Dong-hyun Yoon ),남원호 ( Won-ho Nam ),정석제 ( Seok-je Jeong ),고보성 ( Bo-sung Koh ),김경모 ( Kyung-mo Kim ),김상우 ( Sang-woo Kim ),박진현 ( Jin-hyeon Park ) 한국농공학회 2023 한국농공학회 학술대회초록집 Vol.2023 No.0
통합물관리 정책에 따른 농어촌용수 이용 효율화, 농어촌용수구역 단위의 농업용수 물수지 분석 등 농업용수의 정량화·과학적 관리에 대한 중요성이 증가하고 있다. 농업용수는 내리흘림식 개수로 방식의 용수 공급과 경험적인 용수 배분 체계로 공급 효율이 48%에 불과하며, 기초자료가 부족하여 농업용수의 수요량, 공급량, 회귀량 등과 같은 정량적 용수량 추정에 한계점이 있다. 농업용수의 물수지 분석은 국가물관리기본계획, 농어촌용수이용합리화계획 등 물관련 법정 계획 수립시 수행되고 있다. 각 계획은 목적에 맞는 물수지 분석 모델을 활용하고 있으나, 농업용수 분석시 방법론적 측면에서의 한계점이 있다. 국가물관리기본계획의 경우 저수지와 하천시설의 수요처를 구분하지 않아 분석 결과가 현장의 물공급 실태와 차이가 있으며, 순물소모량 개념의 일률적인 회귀율 반영으로 물수지 분석 전반의 왜곡이 발생하고 있다. 또한, 농어촌용수이용합리화계획의 경우 하천용수량을 고려하지 않고 단일 저수지 대상의 물수지 분석만 수행하며, 하천 연계, 시설물 간 연계를 반영하지 못하고 있다. 본 연구에서는 이러한 기존 물수지 분석의 한계를 보완하고 실제 현장을 반영할 수 있는 유역 단위의 연계 물수지 분석 방법을 제시하고자 한다. 안성천 중권역을 대상으로 저수지, 양수장, 취입보 등 수리시설물의 공간 자료를 구축하여 농업수리시설물의 상하류 관계를 정의하고, 이에 따른 물수지 분석과 하천 흐름에 기반한 소유역 단위의 하천 물수지 분석을 수행하였다. 본 연구의 결과물은 향후 국가 물수급 표준모델(K-MODSIM)과의 연계, 농어촌용수이용합리화계획의 농업용수 유역단위로 물수지 분석이 가능한 표준모델로 활용될 수 있을 것으로 기대된다.