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Cortex Mori Extract Induces Cancer Cell Apoptosis Through Inhibition of Microtubule Assembly
Hwang, Pyoung-Han,Nam, Sang-Yun,Yi, Ho-Keun,Lee, Jung-Chang,Kim, Jae-Cheol,Song, Chang-Ho,Park, Jin-Woo,Lee, Dae-Yeol,Kim, Jung-Soo The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.2
The water extract from the root bark of Cortex Mori (CM, Morus alba L.: Sangbaikpi), a mulberry tree, has been known in Chinese traditional medicine to have antiphlogistic, diuretic, and expectorant properties. In this study, the cytotoxicity of CM against tumor cells and its mechanism was examined . CM exhibited cytotoxic activity on K-562, B38O human leukemia cells and B16 mouse melanoma cells at concentrations of > 1 mg/ml. A DNA fragmentation, PARP cleavage, and nuclear condensation assay showed that those cells exposed to CM underwent apoptosis. The water extract of Scutellarie Radix (SR) was used as a negative control and showed no cytotoxicity in those cells. The flow cytometric profiles of the CM-treated cells were also indicative of apoptosis. However, they did not appear to exert the G1 arrest, which is observed in other tubulin inhibitor agents such as vincristine, taxol. The protein-binding test using Biacore and a microtubule assembly-disassembly assay provided evidence showing that CM bound to the tubulins resulting in 3 markets inhibition of the assembly, but not the disassembly of microtubules. The possible nonspecific effect of the CM extract could be excluded due to the results using SR, which did not affect the assembly process. Overall, the water extract of CM induces apoptosis of tumor cells by inhibiting microtubule assembly.
Primary Polydipsia in Children: Two Case Reports
Hwang, Nu Ri,Kim, Min Sun,Kim, Soon Chul,Lee, Dae-Yeol Korean Society of Pediatric Nephrology 2018 Childhood kidney diseases Vol.22 No.2
Primary polydipsia (PP) is marked by an increase in thirst, and most often presents in patients with psychiatric illnesses. Although uncommon in children, we experienced cases of PP in a 15-month-old boy and a 5-year-old girl. Both were admitted to the hospital with symptoms of polydipsia and polyuria that appeared 1-3 months before admission. Brain magnetic resonance imaging in both patients was normal. A water restriction test was performed after hospitalization and showed normal results. The symptoms improved after the parents were instructed to implement water-intake restriction for 2 weeks. Our report provides useful information for the treatment of PP in children.
클러스터 기반 구조의 PCS 에서 호 처리 프로토콜의 설계 및 구현
이대욱(Dae-Wook Lee),박선영(Sun-Young Park),황성호(Sung-Ho Hwang),이원열(Won-Yeol Lee),한기준(Ki-Jun Han),김명철(Myung-Chul Kim) 한국정보과학회 1997 정보과학회 컴퓨팅의 실제 논문지 Vol.3 No.6
본 논문은 클러스터 기반 구조의 분산 ATM 망에서 PCS를 위한 호 처리 프로토콜을 설계하고 구현하였다. 호 처리 절차의 설계를 위해 시스템의 배경이 되는 분산 처리 환경과 호 처리 과정을 분석하여 분석 모델을 제시하였는데 이는 시스템에서 필요한 요소들을 오브젝트 개념을 이용하여 모델링하고, 시스템 오브젝트들 간에 주고 받는 시그널의 흐름을 동적으로 모델링함으로써 이루어졌다. 전체 시스템을 몇 개의 논리적인 블럭 단위로 나누고 각 블럭에 속하는 오브젝트들과 이 오브젝트간에 주고 받을 시그널을 정의하였고 각 오브젝트별로 시그널의 교환으로 인한 구체적인 내부 상태의 천이와 속성을 정의하였다. 이렇게 설계한 호 처리 기법을 시뮬레이션을 통해 오류를 수정하고 보완함으로써 설계한 호 처리 프로토콜이 이상 없이 동작함을 검증하였다. 프로토콜의 효율적인 구현을 위해 OMT(Object Modeling Technique), SDL(Specification and Design Language)과 MSC(Message Sequence Chart)를 이용하였다. In this paper, we designed and implemented a call processing protocol for PCS on the distributed cluster-based ATM network. For design of the call processing protocol, we set up a model for the distributed environment and the call processing procedure through object modeling of the system components and dynamic modeling of the signals between the system objects. We divided the system into the several logical blocks and defined the objects within each block and the signals transmitted among those objects. We also defined states of each object and state transitions caused by lots of signal exchange. We verified the correctness of the designed protocol by correcting the error and modified the protocol through the simulation. For the efficient implementation of the protocol, we use the OMT(Object Modeling Technique), SDL(Specification and Design Language) and MSC(Message Sequence Chart).