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1
A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis

Javier Vázquez-Bourgon,Ignacio Mata,Roberto Roiz-Santiáñez,Rosa Ayesa-Arriola,Paula Suárez Pinilla,Diana Tordesillas-Gutiérrez,José Luis Vázquez-Barquero,Benedicto Crespo-Facorro 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2
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Objective DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis. Methods Two hundred and thirteen Caucasian drug-naïve patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects. Results Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers. Conclusion DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.
2
A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis

Javier Vá,zquez-Bourgon,Ignacio Mata,Roberto Roiz-Santiá,ñ,ez,Rosa Ayesa-Arriola,Paula Suá,rez Pinilla,Diana Tordesillas-Gutié,rrez,José,Luis Vá,zquez-Barquero,Benedicto Cr 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2
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Objective-DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis. Methods-Two hundred and thirteen Caucasian drug-naïve patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects. Results-Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers. Conclusion-DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.
3
THE UNAM-KIAS CATALOG OF ISOLATED GALAXIES

Herná,ndez-Toledo, H. M.,Vá,zquez-Mata, J. A.,Martí,nez-Vá,zquez, L. A.,Choi, Yun-Young,Park, Changbom American Institute of Physics 2010 The Astronomical journal Vol.139 No.6
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A new catalog of isolated galaxies from the Sloan Digital Sky Survey Data Release 5 (SDSS DR5) is presented. A total of 1520 isolated galaxies were found in 1.4 sr of sky. The selection criteria in this UNAM-KIAS catalog are a variation on the criteria developed by Karachentseva, including full redshift information. Through an image processing pipeline that takes advantage of the high-resolution (~0<img entity='farcs' SRC='http://ej.iop.org/icons/Entities/farcs.gif' ALT='farcs' ALIGN='BOTTOM' />4 pixel–1) and high dynamic range of the SDSS images, a uniform g-band morphological classification for all these galaxies is presented. We identify 80% (Sa-Sm) spirals (50% later than Sbc types) on one hand, and a scarce population of early-type E (6.5%) and S0 (8%) galaxies amounting to 14.5% on the other hand. This magnitude-limited catalog is ~80% complete at 16.5, 15.6, 15.2, 14.6, and 14.4 mag in the ugriz bands, respectively. Some representative physical properties including SDSS magnitudes and color distributions, color-color diagrams, absolute magnitude-color, and concentration-color diagrams as a function of morphological type are presented. The UNAM-KIAS Morphological Atlas is also released along with this paper. For each galaxy of a type later than Sa, a mosaic is presented that includes (1) a g-band logarithmic image, (2) a g-band filtered-enhanced image where a Gaussian kernel of various sizes was applied, and (3) a red giant branch color image from the SDSS database. For E/S0/Sa galaxies, in addition to the images in (1), (2), and (3), plots of r-band surface brightness and geometric profiles (ellipticity ε, position angle PA, and A4/B4 coefficients of the Fourier series expansions of deviations of a pure ellipse) are provided. The size of the sample, the redshift completeness, the availability of high-quality multicolor photometric data and detailed morphological and spectroscopic information make the UNAM-KIAS catalog of isolated galaxies a suitable sample to address important issues such as (1) comparative studies of environmental effects, (2) constraining the currently competing scenarios of galaxy formation and evolution, (3) the nature and evolution of elliptical and spiral galaxies in the field, (4) the spectral properties of a statistically significant number of isolated galaxies and their evolution as a function of redshift, and (5) the fraction of active galactic nuclei in isolated environments, among other important topics. The optimization and estimation of new structural parameters as well as important information to complement existing ones in other wavelengths is being carried out.