http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Javier Vázquez-Bourgon,Ignacio Mata,Roberto Roiz-Santiáñez,Rosa Ayesa-Arriola,Paula Suárez Pinilla,Diana Tordesillas-Gutiérrez,José Luis Vázquez-Barquero,Benedicto Crespo-Facorro 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.2
Objective DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis. Methods Two hundred and thirteen Caucasian drug-naïve patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects. Results Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers. Conclusion DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.
José Daniel Barquero-Cabrero,Arnulfo Luévanos-Rojas,Sandra López-Chavarría,Manuel Medina-Elizondo,Francisco Velázquez-Santillán,Ricardo Sandoval-Rivas 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.6
This paper presents a model of the elastic curve for rectangular beams with straight haunches under uniformly distributed load and moments in the ends considering the bending and shear deformations (Timoshenko Theory) to obtain the deflections and rotations on the beam, which is the main part of this research. The traditional model of the elastic curve for rectangular beams under uniformly distributed load considers only the bending deformations (Euler-Bernoulli Theory). Also, a comparison is made between the proposed and traditional model of simply supported beams with respect to the rotations in two supports and the maximum deflection of the beam. Also, another comparison is made for beams fixed at both ends with respect to the moments and reactions in the support A, and the maximum deflection of the beam. Results show that the proposed model is greater for simply supported beams in the maximum deflection and the traditional model is greater for beams fixed at both ends in the maximum deflection. Then, the proposed model is more appropriate and safe with respect the traditional model for structural analysis, because the shear forces and bending moments are present in any type of structure and the bending and shear deformations appear.
Javier Vá,zquez-Bourgon,Ignacio Mata,Roberto Roiz-Santiá,ñ,ez,Rosa Ayesa-Arriola,Paula Suá,rez Pinilla,Diana Tordesillas-Gutié,rrez,José,Luis Vá,zquez-Barquero,Benedicto Cr 대한신경정신의학회 2004 PSYCHIATRY INVESTIGATION Vol.1 No.2
Objective-DISC1 gene is one of the main candidate genes for schizophrenia since it has been associated to the illness in several populations. Moreover, variations in several DISC1 polymorphisms, and in particular Ser704Cys SNP, have been associated in schizophrenic patients to structural and functional modifications in two brain areas (pre-frontal cortex and hippocampus) that play a central role in the genesis of psychotic symptoms. This study tested the association between Ser704Cys DISC1 polymorphism and the clinical onset of psychosis. Methods-Two hundred and thirteen Caucasian drug-naïve patients experiencing a first episode of non-affective psychosis were genotyped for rs821616 (Ser704Cys) SNP of the DISC1 gene. The clinical severity of the illness was assessed using SAPS and SANS scales. Other clinical and socio-demographic variables were recorded to rule out possible confounding effects. Results-Patients homozygous for the Ser allele of the Ser704Cys DISC1 SNP had significantly (p<0.05) higher rates at the positive symptoms dimension (SAPS-SANS scales) and hallucinations item, compared to Cys carriers. Conclusion-DISC1 gene variations may modulate the clinical severity of the psychosis at the onset of the disorder.