Data-driven design strategy in fused filament fabrication: status and opportunities

Zhang Yongjie,Moon Seung Ki 한국CDE학회 2021 Journal of computational design and engineering Vol.8 No.2

The advent of additive manufacturing (AM) has brought about radically new ways of designing and manufacturing of end-use parts and components, by exploiting freedom of design. Due to the unique manufacturing process of AM, both design and process parameters can strongly influence the part properties, thereby enlarging the possible design space. Thus, finding the optimal combination of embodiment design and process parameters can be challenging. A structured and systematic approach is required to effectively search the enlarged design space, to truly exploit the advantages of AM. Due to lowered costs in computing and data collection in the recent years, data-driven strategies have become a viable tool in characterization of process, and researches have starting to exploit data-driven strategies in the design domain. In this paper, a state-of-the-art data-driven design strategy for fused filament fabrication (FFF) is presented. The need for data-driven strategies is explored and discussed from design and process domain, demonstrating the value of such a strategy in designing an FFF part. A comprehensive review of the literature is performed and the research gaps and opportunities are analysed and discussed. The paper concludes with a proposed data-driven framework that addresses the identified research gaps. The proposed framework encompasses knowledge management and concurrent optimization of embodiment design and process parameters to derive optimal FFF part design. Contribution of this paper is twofold: A review of the state-of-the-art is presented, and a framework to achieve optimal FFF part design is proposed.

Intelligent Matching Assembly: System Design Based on Reuse of Ultra-Difference Parts

Yongjie Zhang,Kang Cao,Zhiqiang Cai,Xinwen Wang,Wei Jin 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.7

As the industrial digitalization has been recently leaping forward, high-efficiency production processes emerge, and assembly integration technologies are being progressively developed. For high-tech industries (e.g., aerospace manufacturing), however, unprecedented challenges are imposed on the conventional assembly manufacturing process technology. To be specific, the shallow digitizing and intelligent technologies fail to satisfy the rising requirements for efficiency, pass rates and cost; in particular, the way to down-regulate the unqualified rate and assembly cost of parts production remains unclear. In the present study, an intelligent matching assembly system was designed for reapplying out-of-tolerance parts. In addition, the concept of the mating base is proposed. Next, the fi t relation between parts is quantified by employing the functional expression of dimension data, and such a relation is characterized as a function constraint with a variable of dimension. Moreover, the designed intelligent matching system was introduced into the existing assembly process to reemploy a number of unqualified parts and determine the matching parts most suitable for the original unqualified parts. On that basis, the most suitable parts are enabled to be involved in the assembly activities, as an attempt to satisfy the design requirements. To efficiently find the optimal matching scheme in the database of the unqualified parts and most effectively employ the unqualified parts, a set of optimal matching algorithms are proposed, thereby significantly down-regulating the production cost. Lastly, Monte Carlo method was adopted to simulate the actual production data, and the optimal matching scheme determined by the intelligent matching system was analyzed and assessed, which verified the effectiveness and practicability of the system.

The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts

( Yongjie Xu ),( Rui Li ),( Kaili Zhang ),( Wei Wu ),( Suying Wang ),( Pengpeng Zhang ),( Haixia Xu ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.7

HnRNPK is a multifunctional protein that participates in chromatin remodeling, transcription, RNA splicing, mRNA stability and translation. Here, we uncovered the function of hnRNPK in regulating the proliferation and differentiation of myoblasts. hnRNPK was mutated in the C2C12 myoblast cell line using the CRISPR/Cas9 system. A decreased proliferation rate was observed in hnRNPK-mutated cells, suggesting an impaired proliferation phenotype. Furthermore, increased G2/M phase, decreased S phase and increased sub-G1 phase cells were detected in the hnRNPK-mutated cell lines. The expression analysis of key cell cycle regulators indicated mRNA of Cyclin A2 was significantly increased in the mutant myoblasts compared to the control cells, while Cyclin B1, Cdc25b and Cdc25c were decreased sharply. In addition to the myoblast proliferation defect, the mutant cells exhibited defect in myotube formation. The myotube formation marker, myosin heavy chain (MHC), was decreased sharply in hnRNPK-mutated cells compared to control myoblasts during differentiation. The deficiency in hnRNPK also resulted in the repression of Myog expression, a key myogenic regulator during differentiation. Together, our data demonstrate that hnRNPK is required for myoblast proliferation and differentiation and may be an essential regulator of myoblast function. [BMB Reports 2018; 51(7): 350-355]

Separation of valuable metals from mixed cathode materials of spent lithium-ion batteries by single-stage extraction

Yongjie Li,Qiang Fu,Hongyun Qin,Kun Yang,Junnan Lv,Qicheng Zhang,Zhang Hui,Feng Liu,Xia Chen,Ming Wang 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.10

With the intensity of resource scarcities and environmental problems, the disposal and recovery of spent lithium-ion batteries, especially recovery of valuable metals, becomes vital. In this work, a method of co-extracting nickel, cobalt, manganese and being separated from lithium by single-stage solvent extraction is proposed. The extraction and separation process of D2EHPA was studied. The effects of extractant concentration, saponification percentage, extraction time and O:A on the extraction efficiency of D2EHPA were systematically studied. Nearly 100% manganese, 94% cobalt and about 90% nickel were co-extracted and separated from lithium using D2EHPA in kerosene by single-stage extraction. The maximum value of separation factors (Ni/Li, Co/Li and Mn/Li) was 13.03, 23.42 and 1904.24. The mathematical model of extraction of four ions was developed by combination of Levenberg-Marquardt method and Universal Global Optimization method. The proposed extraction model accurately fits the experimental data and helps to predict the extraction efficiency of each metal under the corresponding conditions.

Glabridin Liposome Ameliorating UVB-Induced Erythema and Lethery Skin by Suppressing Inflammatory Cytokine Production

( Chijian Zhang ),( Yongjie Lu ),( Yong Ai ),( Xian Xu ),( Siyang Zhu ),( Bing Zhang ),( Minghui Tang ),( Lanyue Zhang ),( Tinggang He ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.4

Glabridin, a compound of the flavonoid, has shown outstanding skin-whitening and anti-aging properties, but its water insolubility limits its wide application. Therefore, glabridin liposome (GL) has been developed to improve its poor bioavailability, while there are few studies to evaluate its amelioration of UVB- induced photoaging. This study is performed to investigate the amelioration of GL against UVB- induced cutaneous photoaging. The prepared GL has a spheroidal morphology with an average diameter of 200 nm. The GL shows lower cytotoxicity than glabridin, but it has a more effective role in inhibition of melanin. Moreover, the application of GL can effectively relieve UV radiation induced erythema and leathery skin, associated with the down-regulated expression of inflammatory cytokines (TNF-α, IL-6 and IL-10). Taken together, these results demonstrate that GL has potentials as topical therapeutic agents against UVB radiation induced skin damage through inhibiting inflammation.

Synthesis and Characterization of a Novel Preceramic Polymer for SiBNC Ceramic Fibers

Chenyu Zhang,Yong Liu,Yongjie Cui,Minqiang Jiang,Keqing Han,Hui Zhang,Muhuo Yu 한국섬유공학회 2018 Fibers and polymers Vol.19 No.5

A new approach for the synthesis of polymer precursor for quaternary SiBNC fibers is presented. The inexpensive, commercially available reactants n-propylamine (C3H7NH2), trichlorosilane (SiHCl3) and boron trichloride (BCl3) were used in a simple one-step reaction. The reaction mainly involved the co-polymerization between Si-Cl, B-Cl and N-CH2CH2CH3 with C3H7NH2 evaporation. Characterization of synthesized polymer was performed by FT-IR and NMR. The polymer has a relatively linear-chain chemical structure, and could be easily converted into flexible green fibers by melt-spun with diameter of 24 μm. After pyrolysis process at 1000 oC under nitrogen atmosphere, SiBNC ceramic fibers were obtained with a diameter of about 19 μm. Those fibers showed average tensile strength of 1.05 GPa and it remained in the amorphous state up to 1600 oC, which made them as the promising candidates for reinforcements in ceramic matrix composites for hightemperature application.

국내 넷플릭스 이용자 규모 및 만족도 영향 요인 분석: 2018~2021 넷플릭스앱 빅데이터를 중심으로

장용걸(Yongjie Zhang),비립(Li Fei),박찬욱(Chanwook Park) 한국콘텐츠학회 2023 한국콘텐츠학회논문지 Vol.23 No.1

CHE 주입방법과 기판 순바이어스를 이용한 새로운 고온 전자 주입방법의 프로그램 효율성 비교에 관한 연구

장영걸(Yongjie Zhang),안호명(Ho-Myoung An),김희동(Hee-Dong Kim),김태근(T. G. Kim) 大韓電子工學會 2010 電子工學會論文誌-SD (Semiconductor and devices) Vol.47 No.1

본 논문에서는, SONOS 소자에서의 일반적인 CHE(Channel Hot Electron) 주입 방법과 기판 순바이어스를 이용한 새로운 전자 주입 방법의 프로그램 효율성에 대해 직접 비교하였다. 기존의 CHE 주입 방법과 비교해서, 새로운 전자 주입 방법은 낮은 구동전압, 빠른 프로그램 속도 등의 특성을 포함하여 높은 프로그램효율을 보였으며, 또한 드레인 영역에서의 순방향 읽기와 역방향 읽기의 문턱전압 차이가 1 V 가량 발생한다는 점에서 국소 주입 동작이 가능함을 확인하였다. 이렇게 제안된 전자주입 방법은 차세대 나노 크기 멀티-비트 SONOS 소자의 동작에 매우 유용하게 사용될 것으로 기대된다. In this paper, we directly compare the program efficiency of conventional channel hot electron (CHE) injection methods and a novel hot electron injection methods using substrate forward biases in our silicon-oxide-nitride-oxide-silicon (SONOS) cell. Compared with conventional CHE injection methods, the proposed injection method showed improved program efficiency including faster program operation at lower bias voltages as well as localized trapping features for multi-bit operation with a threshold voltage difference of 1 V at between the forward and reverse read. This program method is expected to be useful and widely applied for future nano-scale multi-bit SONOS memories.

Ligustrazine attenuates inflammation and oxidative stress in a rat model of arthritis via the Sirt1/NF-jB and Nrf-2/HO-1 pathways

Yongji Li,Zaihua Zhu,Ting Zhang,Yan Zhou 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.9

Inflammation responses and oxidative stress areclosely involved in the pathogenesis of arthritis. Ligustrazine(Lig), a natural four methyl which is isolated fromChinese herb ligusticum chuanxiong hort, has been provedsignificantly anti-inflammation and anti-oxidative stresseffects. The present study aimed to evaluate the effect ofLig on inflammation and oxidative stress in Freund’scomplete adjuvant (FCA)-induced arthritis in rats. Thetreatment of Lig significantly decreased the hind-pawvolume change and alleviated the histopathological changesin sections of rat paws induced by arthritis. Lig alsoreduced the serum levels of pro-inflammatory cytokines(interleukin [IL]-6, IL-1 beta, and tumor necrosis factoralpha),increased the activity of superoxide dismutase(SOD) and reduced the concentration of malondialdehyde(MDA). Besides that, the protein expressions of the sirtuin1 (Sirt1)/nuclear factor kappa B (NF-jB) and nuclearfactor (erythroid-derived 2)-like-2 factor (Nrf-2)/hemeoxygenase (HO)-1 pathways determined by western boltfurther confirmed that Lig effectively inhibited the Sirt1/NF-jB pathway and activated the Nrf-2/HO-1 pathway. Taken together, our results suggest Lig has therapeuticpotential for arthritis, which might be via the regulation ofSirt1/NF-jB and Nrf-2/HO-1 pathways.

Small gas adsorption on Co–N4 porphyrin-like CNT for sensor exploitation: a first-principles study

Zhang Xuanning,Wang Yongjie,Wang Zhenhua,Ma Shouxiao 한국탄소학회 2020 Carbon Letters Vol.30 No.2

Using frst-principles theory, we investigated the adsorption performance of CoN4-CNT towards six small gases including NO, O2, H2, H2S, NH3, and CH4, for exploiting its potential application for chemical gas sensors. The frontier molecular orbital theory was conducted to help understand the conductivity change of the proposed material at the presence of gas molecules. The desorption behavior of gas molecules from CoN4-CNT surface at ambient temperature was analyzed as well to determine its suitability for sensing application. Results show that CoN4-CNT is a promising material for O2 and NH3 sensing due to their desirable adsorption and desorption behaviors while not appropriate for sensing NO due to the poor desorption ability and for sensing CH4 and H2 given the poor adsorption behavior. Our calculation would provide a frst insight into the CoN4-embedded efect on the structural and electronic properties of single-walled CNT, and shed light on the application of CoN4-CNT towards sensing of small gases.