Brain Topological Correlates of Motor Performance Changes After Repetitive Transcranial Magnetic Stimulation

Park, Chang-hyun,Chang, Won Hyuk,Yoo, Woo-Kyoung,Shin, Yong-Il,Kim, Sung Tae,Kim, Yun-Hee Mary Ann Liebert 2014 Brain connectivity Vol.4 No.4

<P>Repetitive transcranial magnetic stimulation (rTMS) influences the brain temporally beyond the stimulation period and spatially beyond the stimulation site. Application of rTMS over the primary motor cortex (M1) has been shown to lead to plastic changes in interregional connectivity over the motor system as well as alterations in motor performance. With a sequential combination of rTMS over the M1 and functional magnetic resonance imaging (fMRI), we sought changes in the topology of brain networks and specifically the association of brain topological changes with motor performance changes. In a sham-controlled parallel group experimental design, real or sham rTMS was administered to each of the 15 healthy subjects without prior motor-related dysfunctions, over the right M1 at a high frequency of 10 Hz. Before and after the intervention, fMRI data were acquired during a sequential finger motor task using the left, nondominant hand. Changes in the topology of brain networks were assessed in terms of global and local efficiency, which measures the efficiency in transporting information at global and local scales, respectively, provided by graph-theoretical analysis. Greater motor performance changes toward improvements after real rTMS were shown in individuals who exhibited more increases in global efficiency and more decreases in local efficiency. The enhancement of motor performance after rTMS is supposed to be associated with brain topological changes, such that global information exchange is facilitated, while local information exchange is restricted.</P>

Factors associated with inflammatory change of epidermal cyst

( Jisang Yun ),( Kyung-nam Bae ),( Jin-hwa Son ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byungsoo Kim ),( Moon-bum Kim ),( Kihyuk Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1

Background: Epidermal cysts (EC) are the most common tumors found on the skin and accompanying inflammation is also frequent. However, the predictors for inflammatory change have not been investigated yet. Objectives: This study was performed to investigate the difference between inflamed and uninflamed epidermal cysts, and to assess associated factors for inflammatory change. Methods: We analyzed the biopsy-proven 1723 epidermal cysts (515 inflamed and 1208 uninflamed) at two tertiary hospitals from 2011 to 2021. Results: The proportion of inflamed epidermal cysts (IEC) and uninflamed epidermal cyst (UIEC) were 29.9 % and 70.1 %, respectively. Inflammatory change was less frequently observed on the face (25.5 %) than the other sites (32.1 %) (p=0.0046). The anatomic location with the highest rate of inflammatory change was back (40.8 %, p=0.0004). Mean duration of inflammatory change from UIEC to IEC on the face was shorter than the other sites (12.5 months vs 17.9 months, respectively, p= 0.0473). On ultrasonography, long axis of IEC (20.7mm) was generally longer than that of UIEC (15.7mm) (p=0.0218). Moreover, Inflammatory change was more frequent on the EC with punctum compared to those without punctum (35.3 % vs 30.3 %, P=0.0471). Conclusion: Based on the location, size and presence of punctum, decision on the optimal treatment strategies can be established when encountering patients with EC.

FC 2-8 : Factors associated with inflammatory change of epidermal cyst

( Jisang Yun ),( Kyung-nam Bae ),( Jin-hwa Son ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byungsoo Kim ),( Moon-bum Kim ),( Kihyuk Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-

Background: Epidermal cysts (EC) are the most common tumors found on the skin and accompanying inflammation is also frequent. However, the predictors for inflammatory change have not been investigated yet. Objectives: This study was performed to investigate the difference between inflamed and uninflamed epidermal cysts, and to assess associated factors for inflammatory change. Methods: We analyzed the biopsy-proven 1723 epidermal cysts (515 inflamed and 1208 uninflamed) at two tertiary hospitals from 2011 to 2021. Results: The proportion of inflamed epidermal cysts (IEC) and uninflamed epidermal cyst (UIEC) were 29.9 % and 70.1 %, respectively. Inflammatory change was less frequently observed on the face (25.5 %) than the other sites (32.1 %) (p=0.0046). The anatomic location with the highest rate of inflammatory change was back (40.8 %, p=0.0004). Mean duration of inflammatory change from UIEC to IEC on the face was shorter than the other sites (12.5 months vs 17.9 months, respectively, p= 0.0473). On ultrasonography, long axis of IEC (20.7mm) was generally longer than that of UIEC (15.7mm) (p=0.0218). Moreover, Inflammatory change was more frequent on the EC with punctum compared to those without punctum (35.3 % vs 30.3 %, P=0.0471). Conclusion: Based on the location, size and presence of punctum, decision on the optimal treatment strategies can be established when encountering patients with EC.

항공사진을 이용한 방포항 인근 해빈의 장기간 해안선 변화 분석

김백운 ( Baeck Oon Kim ),윤공현 ( Kong Hyun Yun ),이창경 ( Chang Kyung Lee ) 대한원격탐사학회 2013 大韓遠隔探査學會誌 Vol.29 No.5

장기간 해안선 변화 자료의 구축을 통해 해안선의 시·공간적인 변화 양상을 분석하고, 이에 근거하여 해안침식의 향후 경향을 파악하는 일은 연안관리에 매우 중요한 역할을 한다. 본 연구에서는 수치항공사진을 이용하여 방포항 인근 해안지역의 장기간(1985년 ~ 2009년) 해안선 변화 탐지를 위해 항공삼각측량, 지상기준점측량, 수치도화, 그리고 해안선 변화율을 산정하였다. 그 결과 방포해빈과 꽃지해빈의 해안선은 각각 0.2 m/yr와 최대 0.8 m/yr로 침식된 것으로 파악되었다. 또한 등고선 변화 통하여 꽃지 해빈의 북부지역에서 침식현상이 가장 뚜렷하게 나타났으며 표고 1 m 간격의 등고선은 최대 45 m 후퇴하였음을 알수 있었다. 이러한 변화는 다양하고 복합적인 요인에 의해 발생할 수 있으며 주된 요인은 1990년대 말에 설치된 해변 옹벽이 해안침식을 일으키는 주요 원인으로서 추정되고 있다. To analyze tendency of temporal and spatial change of shorelines and to estimate rate of shoreline changes using long-term shoreline change data is very important for the coastal environmental management. In this study, investigation was conducted to estimate the rate of shoreline changes using long-term shoreline change data from the year 1985 to 2009 aerial photographs. In this process aerial triangulation, GPS surveying and digital mapping was done for the estimation of changes. As the results, shorelines of Bangpo and Kkotji Beach retreated at a maximum rate of 0.2 m/yr and 0.8 m/yr, respectively. The shoreline could be changed by various factors. However, it was presumed that coastal erosion has been mainly affected by retaining wall constructed in the late 1990s.

임플란트의 collar design이 변연골과 연조직에 미치는 영향

유현상,강선녀,정창모,윤미정,허중보,전영찬 대한치과보철학회 2012 대한치과보철학회지 Vol.50 No.1

연구 목적: 임플란트 경부가 잘 설계된 경우 양호한 연조직 반응을 통해 변연골을 보존하는데 도움이 된다. 본 실험에서는 연, 경조직 경계부에 가장 가까이 위치하는 임플란트의 collar design이 변연골 변화와 연조직 반응에 미치는 영향을 동물실험을 통해 알아보고자 하였다. 연구 재료 및 방법: 2마리의 건강한 Beagle dog에 임플란트 collar design만 다른 두 종류의 임플란트(Neobiotech Co. Seoul, Korea)를 식립하였다. Collar에 bevel 을 부여한 군(Bevel 군)과 "S"자 형태를 부여한 군(Bioseal 군)으로 나누어 마리 당 7개, 군당 7개, 총 14개의 임플란트를 무작위로 식립한 후 Healing abutment를 즉시 체결하였다. 디지털 표준구내 방사선사진을 이용해 4주 간격으로 총 12주간 근원심 변연골 변화를 관찰하였고, 12주에 희생하여 조직학적 분석을 통해 협설 변연골 흡수 및 임플란트 주변 연조직 반응을 평가하였다. Mann-Whitney test를 통해 동일한 방사선 사진 촬영 시점에서 근원심 변연골 변화량 및 조직계측치를 군 간 비교하였고, Kruskal-Wallis test를 통해 방사선 사진상 근원심 변연골 변화량이 시간에 따른 차이가 있는지 군 내 분석 한 후 Duncan test를 통해 사후 검증하였다(α=.05). 결과: 방사선학적 분석 결과 각 촬영 시점에서 두 군간 근원심 변연골 변화량의 차이를 보이지 않았다(P>.05). 군 내에서 시간에 따른 근원심 변연골의 흡수량을 분석한 결과 Bevel 군에서는 시간에 따른 차이를 보이지 않았으나 (P>.05), Bioseal 군에서는 시간에 따른 차이를 보였으며, 4주및8주와 비교했을 때 12주에서 변연골의 증가를 보였다(P<.05). 조직학적 분석 결과 협설측 변연골 흡수량에서 두 군간 차이를 보이지 않았으나 (P>.05), Bevel 군에 비해 Bioseal 군에서 더 견고한 결합조직부착을 관찰할 수 있었으며, 생물학적 폭경의 값은 두 집단 간 차이를 보이지 않은 반면에 (P>.05), 접합상피부착은 Bevel 군에서 유의하게 길었고, 결합조직부착은 Bioseal 군에서 더 길게 나타났다(P<.05). 결론: Bevel 군에 비해 Bioseal 군에서 결합조직부착은 길게 형성된 반면에 접합상피부착은 더 짧게 나타났으며, 생물학적 폭경과 초기 변연골 흡수에는 차이가 없음을 알 수 있었다. 연조직 반응의 차이가 실제 기능하중 하에서 변연골 변화에 미치는 영향에 대해서 향후 연구가 필요할 것으로 생각된다. PURPOSE. The purpose of this study was to investigate the effects of implant collar design on marginal bone change and soft tissue response by an animal test. MATERIALS AND METHODS. Two types of Implant (Neobiotech Co. Seoul, Korea) that only differs in collar design were planted on two healthy Beagle dogs. The implants were divided into two groups, the first group with a beveled collar (Bevel Group) and the second group with "S" shaped collar (Bioseal group). Standardized intraoral radiographs were used to investigate the mesio-distal change of the marginal bone. Histological analysis was done to evaluate the bucco-lingual marginal bone resorption and the soft tissue response adjacent to the implant. Mann-Whitney test was done to compare the mesio-distal marginal bone change at equivalent time for taking the radiographs and the tissue measurements between the groups. RESULTS. Radiographic and histological analysis showed that there was no difference in marginal bone change between the two groups (P>.05). Histological analysis showed Bioseal group had more rigid connective tissue attachment than the Bevel group. There was no difference in biological width (P>.05). Bevel group showed significantly longer junctional epithelium attachment and Bioseal group showed longer connective tissue attachment (P<.05). CONCLUSION. For three months there were no differences in marginal bone change between the Bevel group and the Bioseal group. As for the soft tissue adjacent to the implant, Bioseal group showed longer connective tissue attachment while showing shorter junctional epithelium attachment. There were no differences in biologic width.

실험적 진폐증에서 투여약제에 따른 면역학적 병리학적 조직변화

윤임중,임현우,노영만,오상용,정장영,임영,김경아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1993 韓國의 産業醫學 Vol.32 No.2

To access the effects of some drugs such as piperazine phosphare, azathioprine and allopurinol in the experimental pneumoconiosis, 263 rats weighted 240-320 gm was divided into the control and eight experimental groups. To each group, the turbid solution mixed free silica, talc and natural coal dust of 50 mg in 0.8 ml saline were instilled intratracheally. At the begining and 5th week of experiment, piperazine phosphate(8mg/week orally), aspirin(1.5mg/day intramuscularly), azathioprine(25mg/day orally) and allopurinol(1.5mg/day orally) were administered simultaneously, while the dust turbid solution was only given to the control group. For each group the change of body weight. dry right lung weight, cellularity including total cell, macrophage, lymphocyte and neurtrophil in bronchoalveolar lavage fluid, superoxide ion, hydroxyproline, leukotriene B₄, tumor necrotsis factor, prostaglandin E₂were examined, and observed the pathological chages in lung tissue. The results were as follow : 1. The larger amount of their instilled dust and the longer observation period, the severer pathological findings were found in the lung tissue of each experimental group. 2. The body and dry right lung wight was not significantly changed in the experimental groups compared with the control group. 3. The number of total cell in bronchoalveolar lavage fluid was markedly less in the experimental group than the control one, while no significant difference was found in the percent alveolar macrophages and lymphocytes in both groups. However, the percent of neutrophiles was usually lower than in the control group. 4. The amount of superoxide ion was frequently less in the experimental group compared with the control one. 5. The amount of hydroxyproline was significantly lower in the experimental group than in the control one. 6. The amount of leukotriene B₄was usually less in the drug administered group than in the control one. 7. The amount of tumor necrotic factor was also frequently lower in each experimental group than in the control one. 8. The amount of prostaglandin E₂was usually higher in each experimental group than in the control one.

2 ㎓ 선형 위상 천이 특성을 갖는 소형 아날로그 위상천이기

오현석(Hyun-Seok Oh),최재홍(Jae-Hong Choi),정해창(Hae-Chang Jeong),허윤성(Yun-Seong Heo),염경환(Kyung-Whan Yeom) 한국전자파학회 2011 한국전자파학회논문지 Vol.22 No.1

본 논문에서는 2 ㎓ 선형 위상 천이 특성을 갖는 위상천이기를 설계 및 제작하여 보였다. 소형의 위상 천이기 구현을 위해 집중소자로 구성된 전통과 회로망(all pass network)을 기반으로 위상천이기를 구성하고, 박막 세라믹 공정을 이용하여 제작하였다. 또한, 선형의 위상 천이 특성을 얻기 위해 버랙터(varactor) 다이오드에 직렬 커패시터를 연결하여, 전압에 대한 커패시턴스를 선형화함으로써 비선형성을 개선하였다. 전통과 회로망에 나타나는 인덕터는 스파이럴 인덕터로 구현하고, 이를 다이오드 바이어스 회로에 활용하여 4 ㎜×4 ㎜ 면적을 가지는 소형 위상천이기를 구성할 수 있었다. 또한, 온-웨이퍼(on wafer)로 측정을 위해 입출력은 CPW(Coplanar Waveguide) 형상으로 구현하였으며, 제작된 위상천이기는 버랙터 조정 전압 0~5 V에 대하여, 2 ㎓에서 삽입 손실은 약 4.2~4.7 ㏈, 위상 변화량은 약 79°였으며, 예상한대로 선형 위상 천이 특성을 보였다. In this paper, we present a 2 ㎓ compact analog phase shifter with linear phase-tune characteristic. The compact phase shifter was designed base on a lumped all pass network and implemented using a ceramic substrate fabricated with thin-film technique. For a linear phase-tune characteristic, a capacitance of the varactor diode for a tuning voltage was linearized by connecting series capacitor and subsequently produced an almost linear capacitance change. The inductor and bias circuit in the all pass network was implemented using a spiral inductors for small size, which results in the size reduction to 4 ㎜×4 ㎜. In order to measure the phase shifter using the probe station, two CPW pads are included at the input and output. The fabricated phase shifter showed an insertion loss of about 4.2~4.7 ㏈ at 2 ㎓ band and a total 79° phase change for DC control voltage from 0 to 5 V, and showed linear phase-tune characteristic as expected in the design.

금산분리제도의 현황과 과제

윤창현(YUN Chang-Hyun) 한국법학원 2008 저스티스 Vol.- No.104

금산분리는 사실 해묵은 주제이고 민감한 주제이다. 은행의 사금고화로 인한 동반부실론, 감독당국의 방조론, 은행의 주요 정보가 새어나간다는 정보유출론, 그리고 피감시인이 감시인이 된다는 지위망각론 등이 이 제도의 기본에 깔린 논리라고 볼 수 있다. 그러나 모든 제도는 상황이 변화하면 수정 보완 완화 되거나 폐지되는 운명을 거치는데 이 제도도 이제 세계 경제 상황의 변화와 함께 완화를 검토할 필요가 생겼다. 그동안 금융계열사 의결권 제한제도(공정거래법)나 대기업 집단 소속 금융회사의 제조업지분 보유 한도제도(금산법) 등도 모두 금산분리 정책의 산물인바 경제력 집중억제라는 부분까지 연결되어 세계에 유례가 없는 수준의 강력한 금산분리정책이 시행되어 온 것이 사실이다. 이제 금산분리의 완화가 필요하다는 주장을 “재벌에게 은행 주자”는 논리라고 폄하하는 식의 태도는 옳지 않다. 오히려 금산분리 정책이 유지되어 온 기간 동안 우리나라에서 획기적인 금융업 발전이 이루어지지 못했다. 이제 외환위기 이후 10년이 지난 지금 자본주의의 금융화 흐름이 나타나면서 금융업의 중요성이 커지고 우리 기업이 전 세계를 무대로 활동하는 현상황에서 우리도 금융분야를 집중적으로 육성하여 신성장 동력화 시켜야 한다. 그리고 이를 이해 우선 금산분리를 완화 내지는 폐지하여 새로운 경영방식과 새로운 자본이 이 분야로 유입되도록 유도해야 한다. The principle of the separation of banking and commerce(“the principle” hereafter) is an old but sensitive issue. “The principle” has been maintained since it is based on some propositions. Those propositions include “dual bankruptcy proposition”, “impotent financial supervision proposition”, “information leakage proposition”, and “amnesia of the position proposition” The basic assumption of “the priciple” is that the bank would become a private source of funding of the chaebol firms if “the priciple” is repealed. But the systems should be reformed since the economic and political climate changes. “The principle” has had many effects on various laws and systems in Korea which include the fair trade act and financial industry restructuring act. Now reprimanding the argument that “the principle” should be weakened or repealed since it is a means to give banks to chaebol firms is not a correct way of discussing the issues. During the past years when “the principle” was maintained, Korean financial industry was not developed much. It has been 10 years since Korea experience a foreign exchange crisis and the trend of financialization appears in the capitalism. Many funds are raised and managed and the size is dramatically increasing these days. Financial industry now becomes a new growth engine. “The principle” should be changed so that new money can flow into the industry and new management system can be adopted.

반하후박탕(半夏厚朴湯) 추출물이 생쥐에 유발된 심리적 스트레스에 미치는 영향

임세현 ( Se Hyun Lim ),정현윤 ( Hyun Yun Jeong ),원호영 ( Ho Young Won ),김형우 ( Hyung Woo Kim ),최창원 ( Chang Won Choi ),정향숙 ( Hyang Sook Jeong ),김영균 ( Young Gyun Kim ),조수인 ( Su In Cho4 ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.4

Objective : Banhahubak-tang is indicated for globus hystericus, marked by a subjective sensation as if something stuffed in the throat, chest distress, cough or vomiting, greasy whitish, taut and smooth pulse. In this study, the effects of Banhahubak-Tang extract (BHTe) were tested for anti-stress action. Methods : BHTe was extracted by pure water using electronic extractor and then fed to ICR male mice (20±2g) orally with the dose of 100㎎/㎏/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : BHTe administered group showed a tendency of decreasing of serum corticosterone secretion when compared with control group, and BHTe administration also significantly up-regulated noradrenaline secretions in the dorsal cortex of brain. Lipid peroxidation of the brain tissues of mice were tested by measuring malondialdehyde, but BHTe showed no significant change. The elevated plus-maze test was designed to detect the effect of anxiolytic drugs, and BHTe administered group showed a significant increase of latency time. Conclusions : These results suggest that BHTe can effectively rid the psychological stress and it`s related diseases.

약물 중독 시 위 세척에 의한 산 - 염기 평형 및 전해질의 변화

윤형란(Hyung Ran Yun),손동현(Dong Hyun Sohn),이창범(Chang Bum Lee),이재웅(Jae Woong Lee),양석철(Suck Chul Yang),한동수(Dong Soo Han),손주현(Ju Hyun Sohn),김순길(Soon Kil Kim),김호중(Ho Jung Kim) 대한내과학회 1998 대한내과학회지 Vol.54 No.4

N/A Objectives: There is little information on the imbalance of electrolyte and acid-base metabolism associated with gastric lavage in acute drug intoxication patients. This study was aimed to analyze the acid-base and electrolyte abnormalities associated with gastric lavage in acute drug intoxication patients. Methods: We studied 24 acute drug intoxication patients who had performed gastric lavage with 10 liters of 0.9% NaC1. Electrolyte parameters and arterial blood gas analysis were carried out before and after gastric lavage. Results: After gastric lavage, acidosis was reduced in general. But there was no significant change in pH (7.34±0.02 vs. 7.38±0.15, p=NS). In acid-base balance, the mixed form of metabolic acidosis and respiratory acidosis was reduced from 7 to 2 cases, and the simple form of respiratory acidosis was reduced from 3 to 1 case. In contrast, normal form was increased from 5 to 7 cases and the simple form of metabolic acidosis was increased from 2 to 6 cases. In electrolyte parameters, serum sodium was reduced significantly (145±1.0 mEq/L vs. 141±0.8 mEq/L, p<0.01), but there was no case of significant hyponatremia (<135mEq/L). Bicarbonate level (20±1.1 mEq/L vs. 22±0.9 mEq/L, p< 0.05) and anion gap (19±1.6 mB vs. 13±1.3 mEq/L, p< 0.01) showed significant change. But, blood levels of potassium (3.6±0.1 mEq/L vs. 3.8±0.1 mEq/L, p=NS), chloride (106±0.6 mEq/L vs. 106±0.6 mEq/L, p=NS) and F'aCO2 (36±1.mmHg vs. 37±1.5 mmHg, p=NS) were no significant change before and after gastric lavage. Conclusions: Gastric lavage with 10 liters of 0.9% NaC1 in acute drug intoxication patients did not show clinically significant changes in electrolytes and acid-base balance.