친수성기를 함유한 polysiloxane 막의 합성

윤구식 울산대학교 1987 연구논문집 Vol.18 No.2

Si-H결합에 CH₂=CH-R을 부가하는 방법을 이용하여 친수성기를 함유하는 실란단량체인(2,3-epoxypropoxy)propyldiethoxymethylsilane(EDMS)과 acetoxypropyldiethoxymethylsilane(ADMS)을 합성하였다. EDMS와 ADMS를 이용하여 poly(2,3-dihydroxypropoxy)propylmethylsiloxane과 poly(3-hydroxypropyl)methylsiloxane을 얻었다. poly(2,3-dihydroxypropoxy) propylmethylsiloxane은 42.4%의 함수율을 나타냈으며 poly(3-hydroxypropyl)methylsiloxane은 물에 용해하였다. Using the methods of addition for Si-H bond to unsaturated hydrocarbons, (2,3-epoxypropoxy)propyldiethoxymethylsilane(EDMS) and acetoxypropyldiethoxymethylsilane(ADMS) were synthesized. Poly(2,3-dihydroxypropoxy)propylmethylsiloxane and poly(3-hydroxypropy)methylsiloxane were synthesized from EDMS and ADMS, respectively. Water content of poly(2,3-dihydroxypropoxy)propylmethylsiloxane was 42.4%, and poly(3-hydroxypropyl)methylsiloxane was soluble in water.

실리콘 중합체 - 메타아크릴산 중합체의 상호침투 가교고분자의 합성 및 성질에 관한 연구

윤구식,정미라,박유미 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2

소수성 중합체인 실리콘과 수용성 중합체인 폴리메타아크릴산(PMAA)을 이용하여 친수성과 소수성을 함께 가진 양친성의 상호침투 중합체(IPN)를 합성하였다. DSC를 이용하여 합성한 중합체(IPN)의 열적 성질을 조사해 본 결과 IPN은 PMAA의 영역과 실리콘 중합체 영역의 두 상으로 분리되어 있었다. 증류수 속에서 중합체의 수팽윤도는 PMAA의 함량이 증가할수록 증가하였으며, pH에 따른 수팽윤도는 pH 4.0 < 증류수 < pH 7.2 < pH 10.7 순으로 증가하였다. 또한 용해성 파라미터 값을 달리하는 몇 가지 용매에 대한 중합체의 팽윤도를 구해본 결과 IPN내의 PMAA의 함량이 증가할수록 용해성 파라미터 값이 큰 물, 에탄올의 팽윤도 값이 커졌으며, 용해성 파라미터 값이 작은 옥탄의 평윤도는 반대의 현상을 나타내었다. 또한 부탄올의 팽윤도는 두가지 단순중합체에서는 낮았으나 IPN에서는 조금 증가하였다. The interpenetrating polymer networks(IPNs) composed of silicone polymer and poly(methacrylic acid)(PMAA) was prepared and characterized by FTIR and DSC. The IPN has the two separated phases which consist of silicone domains and PMAA domains. The sorption of water increased with increasing PMAA contents in the IPN, and at pH10.7 water was absorbed most and the second was at pH7.2. As increasing of the contents of PMAA in the IPN, the sorption of polar solvent was increased and that of nonpolar was decreased.

N-isopropylacrylamide에 기초한 공중합체의 합성과 팽윤 거동에 관한 연구

윤구식,배민애 울산대학교 2002 자연과학논문집 Vol.11 No.2

열에 민감한 poly(N-isopropylacrylamide)[poly(NIPAAm)], poly(N-isopropylacrylamide-co-acrylamide)[poly(NIPAAm-co-AAm)], poly(N-isopropylacrylamide-co-N.N-dimethylacrylamide)[poly(NIPAAm-co-DMAm)] 그리고 poly(N-isopropylacrylamide-co-N,N-diethylacrylamide)[poly(NIPAAm-co-DEAm)]을 가교제인 ethylene glycol dimethacrylate(EGDMA)와 개시제인 N,N-azobisisobutyronitrile(AIBN)을 사용하여 라디칼 중합으로 합성하였다. 공중합체의 팽윤 거동을 고분자의 친수성 및 공단량체의 조성에 따라 조사하였다. 공단량체가 더욱 친수성인 AAm과 공중합되어 있는 poly(NIPAAm-co-AAm)은 poly(NIPAAm)보다 팽윤비와 LCST가 높았으며, 단량체의 함량이 증가함에 따라 팽윤비와 LCST는 더욱 높아졌다. 반면에 단량체가 가장 소수성인 DEAm과의 공중합체 poly (NIPAAm-co-DMAm)은 팽윤비와 LCST가 가장 낮았으며, 공중합체에서 단량체 DEAm의 함량이 증가함에 따라 팽윤비와 LCST는 더욱 낮아졌다. 공중합체의 팽윤비는 공단량체의 친수성 순서와 같은 poly(NIPAAm-co-AAm)> poly(NIPAAm-co-DMAm)> poly(NIPAAm-co-DEAm)의 순이었으며, LCST 또한 같은 순서로 관찰되었다. Thermosensitive hydrogels of poly(N-isopropylacrylamide)[poly(NIPAAm)], poly(N-isopropylacrylamide-co-acrylamide)[poly(NIPAAm-co-AAm)], poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)[poly(NIPAAm-co-DMAm)] and poly(N-isopropylacrylamide-co-N,N-diethylacrylamide)[poly(NIPAAm-co-DEAm)] were prepared by free radical copolymerization with ethylene glycol dimethacrylate(EGDMA) as crosslinking agent. The swelling behavior of hydrogels was investigated as a function of hydrophilicity and composition of copolymer. The swelling ratio and LCST of poly(NIPAAm-co-AAm) were much higher than that of poly(NIPAAm), and as the AAm content increased the swelling ratio and LCST were increased. On the other hand, in the poly (NIPAAm-co-DMAm) which was prepared from NIPAAm and hydrophobic comonomer, DEAm, the swelling ratio and LCST of copolymer were decreased with increasing of DEAm content. The swelling ratio of these copolymers were poly(NIPAAm-co-AAm)> poly(NIPAAm-co-DMAm)> poly(NIPAAm-co-DEAm) in decreasing order. Also, the LCST was observed in same order.

표재성 방광 이행상피세포암에 있어서 방광내 항암제주입요법 밀 면역요법

설종구,신보현,하용원,김윤종,노안식,손성용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.2

Intravesical chemotherapy and immunotherapy will commonly eradicate residual papillary transitional cell carcinoma or carcinoma in situ(CIS) and clearly reduce the short-term incidence and rate of tumor recurrence. So I reviewed the effects and complications of different therapeutic agents(thiotepa, mitomycin-C, epirubicin, adriamycin, bacillus Cal mette-Cue'rin(BCG)) in superficial bladder cancer confirmed with histopathology, with the literatures. Bladder cancer were recurred more commonly in multiple tumors(50.6-56.3%), high grade tumors(52.6%) rather than in single(30.9%) and low grade(31.6%). And recurrence rates according to therapeutic agents were 83.3% in mitomycin-C, 71.4% in thiotepa, 50.0% in epirubicin, 46.6% in adriamycin and 32.6% in BCG. But incidence of complications were highest in BCG(50.5%). So sufficient preventive manuevers should be needed before intravesical theraphy, especially in BCG immunotherapy.

실리카 지지 백금에 있어서 일산화탄소의 흡착에 관한 연구

박상윤,윤구식,이재덕 東亞大學校附設基礎科學硏究所 1999 基礎科學硏究論文集 Vol.16 No.1

실리카 지지 백금에서 백금의 함량, 일산화탄소의 압력, 그리고 흡착온도의 변화에 따른 CO의 흡착 및 탈착거동에 대한 연구를 수행하였다. 선형결합한 일산화탄소에 의한 C-O 신축진동 적외선 흡수띠가 백금 함량이 4%인 경우 ??, 2%인 경우 ??, 1%인경우 ??, 다리 또는 다중결합한 일산화탄소 C-O신축진동 적외선 흡수띠는 ??, 계단자리 또는 모서리에 결합한 일산화탄소에 의한 C-O 신축진동 적외선 흡수띠는 ?? 나타났다. 일산화탄소의 압력을 변화시킬 때(0.2∼50torr), 위에 언급한 흡수띠들이 어느 정도 단파장 쪽으로 이동하고?? 백금 함량 4%의 흡수띠의 세기는 큰 변화가 없지만 백금 함량 1%와 2%의 경우는 커다란 변화가 있었다. 진공탈착시켰을 때 짧은 시간(1시간) 탈착시키면 흡수띠 세기는 큰 변화가 없지만 오랜 시간(12시간) 탈착시키면 그 세기는 현저하게 작아지고 백금 함량이 1%인 경우에는 흡수띠가 거의 사라졌다. 백금 함량 4% 시료에 대해 일정한 일산화탄소 압력(1.0torr)에서 흡착 온도를 변화시켰을 때 선형결합한 일산화탄소에 의한 C-O 신축진동 적외선 흡수띠가 약간 장파장으로 이동하며(?? 온도가 높아질수록 흡수띠의 나비가 점점 넓어졌다. 100℃ 이상부터 나타나는 이 흡수띠 어깨 ?? 실리카 흡수띠에 의하여 생성되는 것으로 볼 수 있다. We have investigated the infrared spectra for CO adsorbed on silica supported platinum at various CO partial pressures and various temperatures within the frequency range of ??. Due to the linear bonded CO, the ?? bands in 4 wt% Pt/SiO₂, the ?? bands in 2 wt% Pt/SiO₂, and the?? bands in 1 wt% Pt/SiO₂ were observed. Also the?? bands due to bridged or multiple bonded CO and the ?? bands due to CO adsorbed on step and edge site were observed. With increasing CO pressure all the above bands showed blue shifts and the intensities of the bands in 4 wt% Pt/SiO₂ increased a little but those in 2 wt% Pt/SiO₂ and in 1 wt% Pt/SiO₂ increased much within our experimental CO pressure range. With pumping for evacuation during 1 hour the intensities of the bands decreased a little but with pumping during 12 hour the intensities of the bands decreased much. Especially the bands in 1 wt% Pt/SiO₂. were almost disappeared. With increasing temperature of the 4 wt% Pt/SiO₂ sample at constant CO pressure(1.0torr) the linear adsorption band showed red shift ?? and the width of the band went broad. It was suggested that the newly appearing ?? shoulder of this band above 100℃ is attributed to th

3-Cyano 및 3-Carbomethoxy Chromone과 Allenylstannane과의 반응

鄭大一,宋有淨,崔舜圭,李龍均,安賢淑,윤구식 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2

t-Butyldimethylsilyl triflate 존재에서 3-Cyano 및 3-Carbomethoxy Chromone(1a,b)과 Allenylstannane(2) 과의 반응에서 Chromone의 C-2위치에 propargyl기가 도입된 유도체(3a,b)를 합성하였다. 합성한 유도체의 상대적 구조는 ¹H-NMR을 통해 분석하였으며, T.S구조의 모델을 통하여 가능한 메카니즘을 제시하였다. Reaction of 3-Cyano and 3-Carbomethoxy Chromone(1a,b) with Allenylstannane(2) in the presence of tert-butyldimethylsilyl triflate afforded the corresponding the propargylation product(3a,b) in the moderate yield. The relative stereochemistry of 3a,b are obtained on the basis of ¹H-NMR analysis. And the possible reaction mechanism are suggested by the molecular models in the transition state.

심초음파로 결정된 응급 심낭천자술의 천자부위

김성환,황성오,이강현,조준휘,강구현,문중범,이승환,윤정한,최경훈,김영식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background: The aim of this study was to determine whether the conventional subcostal approach is suitable for emergency pericardiocentesis in patients with cardiac tamponade or impending cardiac tamponade. Methods: This study was a prospective, observational study conducted at the emergency department of a tertiary hospital, Patients who had symptomatic pericardial effusion and who needed emergency pericardiocentesis in the emergency department were included in this study. We measured the epicardium-to-pericardium distance at the subcostal, parasternal, and apical area with two-dimensional echocardiography to determine the appropriate puncture site for pericardiocentesis. An epicardium-to-pericardium distance of more than 1.0 cm was considered as the primary safety factor in determining the Puncture site for pericardiocentesis. The skin-to-pericardium distance was considered as secondary safety factor. Results: Ninety-five consecutive patients(55 males and 40 females; total mean age: 53 year old) with cardiac tamponade or impending cardiac tamponade were enrolled in this study. The puncture site for pericardiocentesis, as determined by echocardiography, was the subcostal area in 43 patients(45%), the apical area in 40 patients(42%), the left parasternal area In 11 patients(12%), and the right parastemal area in one patient(1%). Pericardiocentesis failed in 2 patients(2%) with the subcostal approach and in one patient(1%) with the apical approach. The average epicardium-to-pericardium distance was 31 ±21 mm in patients with the subcostal approach and 21±8 mm in patients with other approaches. There were no differences in the amount of pericardial fluid and in the intraperical pressure among patient groups according to puncture site. There were two procedure related complications: a puncture of the right ventricle with the subcostal approach and a ventricular tachycardia with the apical approach.

실리콘을 함유한 폴리이미드 - 아미드의 합성 및 열적인 성질에 관한 연구

윤구식(Koo Sik Yoon),성용길(Yong Kiel Sung),김은식(Un Sik Kim) 한국고분자학회 1985 폴리머 Vol.9 No.5

Polydimethylsiloxane - g - poly ( γ- methyl - L - glutamate ) 의 합성과 성질에 관한 연구

윤구식(Koo Sik Yoon),성용길(Yong Kiel Sung) 한국고분자학회 1995 폴리머 Vol.19 No.2

Sequence analysis and expression of three major glycoproteins of Aujeszky’s disease virus NYJ strain in Bm5 Cells

Hyun Na Koo,Jeong Mi Oh,Jae Young Choi,Kwang Sik Lee,Jong Yul Roh,Yeon Ho Je,Byung Rae Jin,Sung Sik Yoo,Jae Su Kim,Young In Kim,In Joong Yoon,Soo Dong Woo 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.10

Aujeszky’s disease (AD), also called pseudorabies, is an infectious viral disease, caused by an alpha herpes virus and has domestic and wild pigs, as well as a wide range of domestic and wild animals, as the natural host. AD affects many countries and regions in the world, causing important economic losses, mainly due to international trade restrictions. In this study, to determine the characteristics of the Aujeszky’s disease virus (ADV), NYJ strain, which was isolated from the serum of an infected pig in 1987, we investigated the nucleotide sequence and expression of the glycoproteins gB, gC, and gD using the bBpGOZA system. We found that the glycoproteins gB, gC, and gD of NYJ consisted of 2751 bp, 1443 bp, and 1203 bp, respectively. Comparison of the NYJ with the other strains revealed nucleotide sequence identity ranging from 91.tito 99.0%. To better understand the genetic relationships between other strains, phylogenetic analyses were performed. The NYJ strain was formed a distinct branch with high bootstrap support. The expression of glycoprotein gD in insect cells was characterized by SDS-PAGE and Western blotting with an anti-ADV polyclonal antibody. Glycoprotein gD of approximately 45 kDa was detected. The results of this study have implications for both the taxonomy of ADV and vaccine development.