Beta-defensin gene (DEFB1) polymorphisms are associated with the susceptibility to chronic respiratory diseases

Yongwei Li,Xiaodan Ran,Jinghui Chen,Lu Chen,Mengzhi Wu 한국유전학회 2016 Genes & Genomics Vol.38 No.7

In the present study, we aim to investigate the correlations between polymorphisms in the DEFB1 gene and the susceptibility to chronic respiratory diseases (CRDs). Electronic searches in multiple scientific literature databases (PubMed, EBSCO, Ovid, Springerlink, Wiley, Web of Science, Wanfang database, China National Knowledge Infrastructure database and VIP database) were made to retrieve studies on the associations between DEFB1 gene polymorphisms and CRDs. We used strict inclusion criteria in the present meta-analysis. Data analyses were performed with STATA software (version 12.0; Stata Corp, College Station, TX, USA). Of 76 initiallyretrieved articles, 11 were finally incorporated into our meta-analysis, enrolling 1343 patients with CRDs (477 with chronic obstructive pulmonary disease (COPD), 305 with asthma, 286 with cystic fibrosis (CF), 130 with ventilator- associated pneumonia (VAP), 145 with pulmonary tuberculosis, and 1261 healthy controls into our metaanalysis. Our study showed that -44 C/G (rs1800972) and 1654 G/A (rs2738047) in DEFB1 are strongly associated with the increased susceptibility to CRDs. The subgroup analysis on disease types showed that the -44 C/G (rs1800972) in DEFB1 is associated with the susceptibility to COPD, VAP and CF, and the 1654 G/A (rs2738047) associated with the susceptibility to COPD and asthma. Subgroup analyses based on ethnicity indicated that -44 C/G (rs1800972) may confer increased susceptibility to CRDs in Asians but not in Caucasians. Taken together, -44 C/G (rs1800972) and 1654 G/A (rs2738047) are strongly associated with CRD susceptibility, while associations of SNPs -52 G/A (rs1799946) and -20 G/A (rs11362) with CRDs needs further investigation.

Construction of Strontium Titanate/Binary Metal Sulfide Heterojunction Photocatalysts for Enhanced Visible-Light-Driven Photocatalytic Activity

Yongwei Yu,Qing Yang,Jiangquan Ma,Wenliang Sun,Chong Yin,Xiazhang Li,Jun Guo,Qingyan Jiang,Zhiyuan Lu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.11

A novel strontium titanate/binary metal sulfide (SrTiO3/SnCoS4) heterostructure was synthesized by a simple two-step hydrothermal method. The visible-light-driven photocatalytic performance of SrTiO3/SnCoS4 composites was evaluated in the degradation of methyl orange (MO) under visible light irradiation. The photocatalytic performance of SrTiO3/SnCoS4-5% is much higher than that of pure SrTiO3, SnCoS4, SrTiO3/SnS2 and SrTiO3/CoS2. The SrTiO3/SnCoS4 composite material with 5 wt.% of SnCoS4 showed the highest photocatalytic efficiency for MO degradation, and the degradation rate could reach 95% after 140 min irradiation time. The enhanced photocatalytic activity was ascribed to not only the improvement of visible light absorption efficiency, but also the construction of a heterostructure which make it possible to effectively separate photoexcited electrons and holes in the two-phase interface.

Bag of Visual Words Method based on PLSA and Chi-Square Model for Object Category

( Yongwei Zhao ),( Tianqiang Peng ),( Bicheng Li ),( Shengcai Ke ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.7

The problem of visual words` synonymy and ambiguity always exist in the conventional bag of visual words (BoVW) model based object category methods. Besides, the noisy visual words, so-called “visual stop-words” will degrade the semantic resolution of visual dictionary. In view of this, a novel bag of visual words method based on PLSA and chi-square model for object category is proposed. Firstly, Probabilistic Latent Semantic Analysis (PLSA) is used to analyze the semantic co-occurrence probability of visual words, infer the latent semantic topics in images, and get the latent topic distributions induced by the words. Secondly, the KL divergence is adopt to measure the semantic distance between visual words, which can get semantically related homoionym. Then, adaptive soft-assignment strategy is combined to realize the soft mapping between SIFT features and some homoionym. Finally, the chi-square model is introduced to eliminate the “visual stop-words” and reconstruct the visual vocabulary histograms. Moreover, SVM (Support Vector Machine) is applied to accomplish object classification. Experimental results indicated that the synonymy and ambiguity problems of visual words can be overcome effectively. The distinguish ability of visual semantic resolution as well as the object classification performance are substantially boosted compared with the traditional methods.

Object Classification based on Weakly Supervised E2LSH and Saliency map Weighting

( Yongwei Zhao ),( Bicheng Li ),( Xin Liu ),( Shengcai Ke ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.1

The most popular approach in object classification is based on the bag of visual-words model, which has several fundamental problems that restricting the performance of this method, such as low time efficiency, the synonym and polysemy of visual words, and the lack of spatial information between visual words. In view of this, an object classification based on weakly supervised E2LSH and saliency map weighting is proposed. Firstly, E2LSH (Exact Euclidean Locality Sensitive Hashing) is employed to generate a group of weakly randomized visual dictionary by clustering SIFT features of the training dataset, and the selecting process of hash functions is effectively supervised inspired by the random forest ideas to reduce the randomcity of E2LSH. Secondly, graph-based visual saliency (GBVS) algorithm is applied to detect the saliency map of different images and weight the visual words according to the saliency prior. Finally, saliency map weighted visual language model is carried out to accomplish object classification. Experimental results datasets of Pascal 2007 and Caltech-256 indicate that the distinguishability of objects is effectively improved and our method is superior to the state-of-the-art object classification methods.

A Modified Analysis Method for the Nonlinear Load Transfer Behaviour of Axially Loaded Piles

Jingpei Li,Yongwei Tan,Fayun Liang 대한토목학회 2012 KSCE Journal of Civil Engineering Vol.16 No.3

A modified analytical solution is proposed to calculate the load-settlement curve of axially loaded piles, which may consider the degradation of the skin friction of piles, distribution of shear strength along the pile shaft, and a combination of different stress states of the pile-soil system. The parameters for the calculation model can be obtained by means of equivalent analysis of the in-situ measured skin friction. The results of the presented approach are verified with data from the available literature. Compared with other approaches, this method can be applied to practical engineering more efficiently; therefore, it is feasible to perform nonlinear analysis for load transfer of axially loaded piles. Furthermore, it can also be used for layered soils.

Experimental Investigation of the Thermal Hydraulics in Lead Bismuth Eutectic-Helium Experimental Loop of an Accelerator-Driven System

Wenxuan Xi,Yongwei Wang,Xunfeng Li,Xiulan Huai,Jun Cai 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.5

The heat transfer characteristics between liquid lead bismuth eutectic (LBE) and helium are of great significance for the two-loop cooling system based on an accelerator-driven system(ADS). This paper presents an experimental study on the resistance characteristics and heat transfer performance in a LBE-helium experimental loop of ADS. Pressure drops in the LBE loop, the main heat transfer, and the coupled heat transfer characteristics between LBE and helium are investigated experimentally. The temperature of LBE has a significant effect on the LBE thermo-physical properties, and is therefore considered in the prediction of pressure drops. The results show that the overall heat transfer coefficient increases with the increasing helium flow rate and the decreasing inlet temperature of helium. Increasing the LBE Reynolds number and LBE inlet temperature promotes the heat transfer performance of main heat transfer and thus the overall heat transfer coefficient. The experimental results give an insight into the flow and heat transfer properties in a LBE-helium heat exchanger and are helpful for the optimization of an ADS system design.

Analysis of flow transition and separation on oscillating airfoil by pressure signature

Binbin Wei,Yongwei Gao,Long Wang,Dong Li 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1

To have a better understanding of the unsteady aerodynamic characteristics of the airfoil which play important roles in wind turbine blade design, we investigated the boundary layer transition and separation on oscillating airfoil S809 using pressure signature captured in wind tunnel testing. The developed data processing technique of "sliding window" was applied to get useful transition and separation information. Meanwhile, the hysteresis effects of oscillation frequency on transition and separation were studied. It is found that (1) the root mean square (RMS) of pressure signature can indicate the transition and separation with the dimensionless window width of `m = 0.0015; (2) the transitional attack of angle in up stroke is larger than that in down stroke at the state of the relative chord length of x/c ≥ 0.14, while the situation is opposite at the state of the relative chord length of x/c ≤ 0.14; (3) the flow separation is advanced and the reattachment is delayed with the increase of the oscillation frequency, which results in a greater hysteresis effect. The sliding window technique, whose parameters were determined in this paper, is effective for detecting boundary layer transition and separation from pressure signature.

Physics of Dynamic Stall Vortex During Pitching Oscillation of Dynamic Airfoil

Binbin Wei,Yongwei Gao,Dong Li 한국항공우주학회 2021 International Journal of Aeronautical and Space Sc Vol.22 No.6

Dynamic stall, which has a significant effect on the aerodynamic performances of dynamic airfoils, is closely related to the physics of the dynamic stall vortex (DSV). The physics of the DSV on the NACA 0012 airfoil was experimentally studied using unsteady pressure measurements with high time accuracy. The experimental Reynolds number was Re = 1.5 × 106, and the reduced frequency was k = 0.069. The propagation of the unsteady pressure field during the dynamic stall process was analyzed in detail. The motion characteristics of the DSV were examined, including its near-wall development characteristics and near-wall evolution velocity. Moreover, the frequency characteristics of the near-wall DSV were studied using wavelet analysis combined with proper orthogonal decomposition (POD) technology. In addition, the effects of the mean angle of attack (AoA) and the amplitude on the DSV motion and frequency characteristics were examined in detail. The effects of the mean AoA on the near-wall DSV strength and the propagation velocity were linear, while the effects of amplitude were nonlinear. The mean AoA and amplitude had a significant influence on the frequency of the leading-edge vortex (LEV) at the initial stage of the DSV development (x/c = 0.10–0.20). This work allows the DSV physics to be understood more deeply.

Influence of Mucor mucedo immobilized to corncob in remediation of pyrene contaminated agricultural soil

Hou Wei,Zhang Le,Xiaojun Li,Zongqiang Gong,Yongwei Yang,Zhi Li 대한환경공학회 2015 Environmental Engineering Research Vol.20 No.2

In recent years, immobilization agents were introduced into organic contaminated soil remediation and more and more materials were screened and used as the immobilizing carrier. However, effect of the decomposition of the immobilizing carrier on the bioremediation was rarely concerned. Therefore, the decomposition experiment of immobilizing carrier -corncob was carried out in the lab with the efficient degradation fungi - Mucor mucedo (MU) existing, and polycyclic aromatic hydrocarbons (PAHs) residues E4/E6 of the dissolved organic matter and microbial diversity during the decomposition process were studied. The results showed that: a) during the decomposition, the degradation of pyrene (Pyr) was mainly in the first 28 d in which the content of extractable Pyr decreased rapidly and the highest decrease was in the treatment with only MU added. b) Anslysis of E4/E6 changes showed that rich microorganisms could promote aromatization and condensation of humus. c) From the diversity index analysis it can also be seen that there is no significant difference in effects of PAHs on the uniformity of microorganisms. These results will not only be useful to have a better understanding of the bioavailability of contaminants adsorbed to biodegradable carriers in PAHs contaminated soil remediation, but also be helpful to perfect the principle of immobilized microbial technique.

Anatomical Adaptations of the Xerophilous Medicinal Plant, Capparis spinosa, to Drought Conditions

Lu Gan,Chunyu Zhang,Yongtai Yin,Zhiwei Lin,Yongwei Huang,Jun Xiang,Chunhua Fu,Maoteng Li 한국원예학회 2013 Horticulture, Environment, and Biotechnology Vol.54 No.2

Capparis spinosa is a plant that grows in dry and arid environments. As far as can be ascertained, no comprehensive studies on how the leaf, stem and root structures adapt to drought conditions have been published to date. In this paper, a study into the anatomical adaptations of the leaf, stem and root of C. spinosa to drought environments was conducted using in vitro cultured seedlings as control. The results showed that C. spinosa could change its leaf, stem, and root structures when adapting to drought conditions. The plant growing under drought conditions possessed an enlarged transit region between the stem and root where the xylem and fibro-vascular system had increased in order to enhance water absorption and storage capacity. The leaf, stem and root of C. spinosa under drought conditions were better developed than those under normal in vitro culture conditions. The leaf possessed uniform mesophyll cells and three or four layers of palisade mesophyll cells on both sides of the mature leaves. The stomata were evenly distributed across both sides of the leaf, and they remained open continually during the day throughout the summer growing period, especially those on the lower leaf surface. The xylem in the stem was extremely well developed with wide vessels and much thicker cortical layers. All these characteristics can enhance the adaptability of C. spinosa and enable it to survive in extremely dry and arid areas.