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Jung, Ki‐,Hye,Kang, Sun‐,Hee,Kang, Min‐,Kyoung,Kim, Soyeon,Kim, Hee‐,Kyung,Kim, Yeoun‐,Hee,Ho Lee, Gang,Shim, Gyu‐,Bo,Jung, Jae‐,Chang,Chang, Yongmin,Kim, Tae WILEY‐VCH Verlag 2015 European journal of inorganic chemistry Vol.2015 No.4
<P><B>Abstract</B></P><P>The synthesis of two bifunctional chelates, 1,4,7,10‐tetraazacyclododecane‐1,4,7‐triacetic acid (DO3A) conjugates of benzothiazoles (H<SUB>3</SUB>L<SUP>3a</SUP> and H<SUB>3</SUB>L<SUP>3b</SUP>), and the corresponding gadolinium complexes (GdL<SUP>3a</SUP> and GdL<SUP>3b</SUP>) was achieved. The intracellular and tumor‐specific nature of GdL<SUP>3a</SUP> and GdL<SUP>3b</SUP> were confirmed by magnetic resonance images of the cytosols and nuclei of various cell lines. The two complexes displayed antitumor activities with varying degrees of growth‐inhibition and total‐growth‐inhibition values depending on the types of tumor cells. They caused morphological changes in tumor cell lines at much lower concentrations of gadolinium ([Gd] ≥ 50 μ<SMALL>M</SMALL>) than their predecessors, DO3A–(<I>p</I>‐aniline benzothiazole) conjugates (H<SUB>3</SUB>L<SUP>1</SUP>), and its Gd<SUP>III</SUP> complex (GdL<SUP>1</SUP>) required concentrations that were almost four times as high ([Gd] ≥ 200 μ<SMALL>M</SMALL>).</P>
Yongmin Jung,Yunho Jung,Seongjoo Lee,Jaeseok Kim IEEE 2013 IEEE transactions on consumer electronics Vol.59 No.3
<P>This paper proposes a cyclic shift decomposition (CSD) algorithm to perform multi-way cyclic shifts with low complexity in the quasi-cyclic low-density parity-check (QCLDPC) decoder. The proposed algorithm decomposes the cyclic shift into a common cyclic shift and a private cyclic shift. Based on the proposed CSD algorithm, a low-complexity multi-way and reconfigurable cyclic shift network (CSN) for QC-LDPC codes is proposed. The proposed CSN is composed of the shared component, which performs the common cyclic shift, and the repeated component, which performs the private cyclic shift. Each component can support reconfigurability for given QCLDPC codes. By introducing the single-path shared component, only the complexity of the multi-path repeated component increases linearly as the number of multi-way paths increases. A complexity analysis of each component is also proposed. Based on the complexity analysis, the proposed CSN can perform multi-way and reconfigurable cyclic shifts with low complexity in the QC-LDPC decoder. The implementation results show that the areas of the proposed four-way CSN are 0.227 mm<SUP>2</SUP> and 0.276 mm2 for the IEEE 802.11n/ac and IEEE 802.16e QC-LDPC codes, respectively, with 130 nm CMOS technology. The area saving per each-way is from 13.8% to 86.5% compared with previously presented works.</P>
Design of Low Complexity LDPC Encoder for IEEE 802.11n WLAN Systems
Yongmin Jung,Yunho Jung,Jaeseok Kim 대한전자공학회 2008 ICEIC:International Conference on Electronics, Inf Vol.1 No.1
This paper proposes a low complexity hardware architecture of low-density parity-check (LDPC) encoder for IEEE 802.11n Wireless LAN (WLAN) systems. The proposed LDPC encoder is implemented with the two stage pipelined structure which is based on a quasi-cyclic (QC) LDPC encoding scheme with a dual diagonal matrix. To reduce the implementation complexity, the matrix multiplications are replaced by the logarithmic shift operations and the vector additions. Implementation results show that the proposed architecture reduces the required memory size by 25% and the number of the required logic gate by 20% over the wellknown Richardson’s encoding. The processing delay is also reduced by 10-23 clocks as the coding rates and the codeword block lengths.
Optical microfiber coupler for broadband single-mode operation
Jung, Yongmin,Brambilla, Gilberto,Richardson, David J. The Optical Society 2009 Optics express Vol.17 No.7
<P>We present a broadband single-mode bi-conical microfiber coupler (MFC) with a specifically designed transition region that effectively suppresses any higher-order modes present at the input fiber and provides efficient power splitting into the fundamental mode at the two output ports. As a practical example, single-mode 3-dB splitting operation over a broad spectral window (400 approximately 1700 nm) was demonstrated for a very thin taper waist approximately 1.5 microm) MFC made from conventional telecom optical fibers.</P>
Jung, Ki-Hye,Park, Ji-Ae,Kim, Jung Young,Kim, Mi Hyun,Oh, Seyoung,Kim, Hee-Kyung,Choi, Eun-Ji,Kim, Han-Jun,Do, Sun Hee,Lee, Kyo Chul,Kim, Kyeong Min,Lee, Yong Jin,Chang, Yongmin Hindawi 2018 Contrast media and molecular imaging Vol.2018 No.-
<P>Gadolinium-neutron capture therapy (Gd-NCT) is based on the nuclear capture reaction that occurs when <SUP>157</SUP>Gd is irradiated with low energy thermal neutrons to primarily produce gamma photons. Herein, we investigated the effect of neutron capture therapy (NCT) using a small molecular gadolinium complex, Gd-DO3A-benzothiazole (Gd-DO3A-BTA), which could be a good candidate for use as an NCT drug due to its ability to enter the intracellular nuclei of tumor cells. Furthermore, MRI images of Gd-DO3A-BTA showed a clear signal enhancement in the tumor, and the images also played a key role in planning NCT by providing accurate information on the <I>in vivo</I> uptake time and duration of Gd-DO3A-BTA. We injected Gd-DO3A-BTA into MDA-MB-231 breast tumor-bearing mice and irradiated the tumors with cyclotron neutrons at the maximum accumulation time (postinjection 6 h); then, we observed the size of the growing tumor for 60 days. Gd-DO3A-BTA showed good therapeutic effects of chemo-Gd-NCT for the <I>in vivo</I> tumor models. Simultaneously, the Gd-DO3A-BTA groups ([Gd-DO3A-BTA(+), NCT(+)]) showed a significant reduction in tumor size (<I>p</I> < 0.05), and the inhibitory effect on tumor growth was exhibited in the following order: [Gd-DO3A-BTA(+), NCT(+)] > [Gd-DO3A-BTA(+), NCT(−)] > [Gd-DO3A-BTA(−), NCT(+)] > [Gd-DO3A-BTA(−), NCT(−)]. On day 60, the [Gd-DO3A-BTA(+), NCT(+)] and [Gd-DO3A-BTA(−), NCT(−)] groups exhibited an approximately 4.5-fold difference in tumor size. Immunohistochemistry studies demonstrated that new combinational therapy with chemo-Gd-NCT could treat breast cancer by both the inhibition of tumor cell proliferation and induction of apoptosis-related proteins, with <I>in vivo</I> tumor monitoring by MRI.</P>
Jung, Yongmin,Lee, Sejin,Lee, Byeong Ha,Kobelke, Jens,Oh, Kyunghwan The Optical Society 2008 Optics letters Vol.33 No.24
<P>Two optical fibers with different types of air-hole imbedded structures were serially concatenated to provide novel transmission characteristics. Bending sensitive shifts of the fundamental mode cutoff in a hollow optical fiber and a hexagonal microstructured holey fiber were found to be in opposite directions, which defines a new window with flexible tuning of the center wavelength and the bandwidth of transmission by independent bending radii control of the fibers. The concatenated composite structure provided useful optical transmission window management ranging from 400 to 1700 nm along with a tunable pass bandwidth of 300-1000 nm and a sideband rejection efficiency better than 20 dB.</P>
Jung, Yongmin,Lee, Sejin,Lee, Byeong Ha,Oh, Kyunghwan Optical Society of America 2008 Optics letters Vol.33 No.24
<P>We report on an ultracompact fiber optic Mach-Zehnder interferometer (MZI) using a novel concatenated structure, single-mode-fiber (SMF)-hollow optical fiber (HOF)-SMF. An optimized air-hole size in the HOF provided two unique optical paths; the leaky waveguide modes through the central air hole and the radiation channel into the silica cladding, which enabled a compact MZI configuration with enhanced optical performances, such as high visibility, high temperature sensitivity, and wide dynamic range.</P>
Adiabatically tapered splice for selective excitation of the fundamental mode in a multimode fiber.
Jung, Yongmin,Jeong, Yoonchan,Brambilla, Gilberto,Richardson, David J Optical Society of America 2009 Optics letters Vol.34 No.15
<P>We propose a simple and effective method to selectively excite the fundamental mode of a multimode fiber by adiabatically tapering a fusion splice to a single-mode fiber. We experimentally demonstrate the method by adiabatically tapering splice (taper waist=15 microm, uniform length=40 mm) between single-mode and multimode fiber and show that it provides a successful mode conversion/connection and allows for almost perfect fundamental mode excitation in the multimode fiber. Excellent beam quality (M(2) approximately 1.08) was achieved with low loss and high environmental stability.</P>