Ultrasound-guided radiofrequency denervation and pericapsular nerve group block for chronic hip joint pain in a patient diagnosed with Duchenne muscular dystrophy

Yildiz Gokhan,Baran Muge,Sahin Saziye,Akcaboy Erkan Yavuz,Celik Seref 대한마취통증의학회 2023 Korean Journal of Anesthesiology Vol.76 No.4

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Comparison of the efficacy of genicular nerve phenol neurolysis and radiofrequency ablation for pain management in patients with knee osteoarthritis

Gokhan Yildiz,Gevher Rabia Genc Perdecioglu,Damla Yuruk,Ezgi Can,Omer Taylan Akkaya 대한통증학회 2023 The Korean Journal of Pain Vol.36 No.4

Background: Genicular nerve neurolysis with phenol and radiofrequency ablation (RFA) are two interventional techniques for treating chronic refractory knee osteoarthritis (KOA) pain. This study aimed to compare the efficacy and adverse effects of both techniques. Methods: Sixty-four patients responding to diagnostic blockade of the superior medial, superior lateral, and inferior medial genicular nerve under ultrasound guidance were randomly divided into two groups: Group P (2 mL phenol for each genicular nerve) and Group R (RFA 80°C for 60 seconds for each genicular nerve). The numeric rating scale (NRS) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used to evaluate the effectiveness of the interventions. Results: RFA and phenol neurolysis of the genicular nerves provided effective analgesia within groups at 1 week, 1 month, and 3 months compared to baseline. There was no significant difference between the groups in terms of NRS and WOMAC scores at all measurement times. At the 3rd month follow-up, 50% or more pain relief was observed in 53.1% of patients in Group P and 50% of patients in Group R. The rate of transient paresthesia was 34.4% in Group P and 6.3% in Group R, and this was significantly higher in Group P. Conclusions: Neurolysis of the genicular nerves with both RFA and phenol is effective in the management of KOA pain. Phenol may be a good alternative to RFA. Further studies are needed on issues such as dose adjustment to prevent transient paresthesia response.

Taurine relaxes human radial artery through potassium channel opening action

Kemal Gokhan Ulusoy,Erkan Kaya,Kubilay Karabacak,Melik Seyrek,İbrahim Duvan,Vedat Yildirim,Oguzhan Yildiz 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.6

The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 mM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 mM to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K+ channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 mM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride– induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance Ca2+-activated K+ channels may be involved in taurine –induced relaxation of RA.

Taurine relaxes human radial artery through potassium channel opening action

Kemal Gokhan Ulusoy,Erkan Kaya,Kubilay Karabacak,Melik Seyrek,İ,brahim Duvan,Vedat Yildirim,Oguzhan Yildiz 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K⁺ channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 µM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride–induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance Ca²⁺-activated K⁺ channels may be involved in taurine –induced relaxation of RA.

Taurine relaxes human radial artery through potassium channel opening action

Ulusoy, Kemal Gokhan,Kaya, Erkan,Karabacak, Kubilay,Seyrek, Melik,Duvan, ibrahim,Yildirim, Vedat,Yildiz, Oguzhan The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.6

The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, $30{\mu}M$) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride ($10{\mu}M$ to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the $K^+$ channel inhibitors tetraethylammonium (1 mM), glibenclamide ($10{\mu}M$) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride-induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance $Ca^{2+}$-activated $K^+$ channels may be involved in taurine -induced relaxation of RA.

Cyclic and constacyclic self-dual codes over R_k

Suat Karadeniz,Ismail Gokhan Kelebek,Bahattin Yildiz 대한수학회 2017 대한수학회보 Vol.54 No.4

In this work, we consider constacyclic and cyclic self-dual codes over the rings $R_k$. We start with theoretical existence results for constacyclic and cyclic self-dual codes of any length over $R_k$ and then construct cyclic self-dual codes over $R_1 = \F_2+u\F_2$ of even lengths from lifts of binary cyclic self-dual codes. We classify all free cyclic self-dual codes over $R_1$ of even lengths for which non-trivial such codes exist. In particular we demonstrate that our constructions provide a counter example to a claim made by Batoul et al. in \cite{Batoul} and we explain why their claim fails.

CYCLIC AND CONSTACYCLIC SELF-DUAL CODES OVER R_k

Karadeniz, Suat,Kelebek, Ismail Gokhan,Yildiz, Bahattin Korean Mathematical Society 2017 대한수학회보 Vol.54 No.4

In this work, we consider constacyclic and cyclic self-dual codes over the rings $R_k$. We start with theoretical existence results for constacyclic and cyclic self-dual codes of any length over $R_k$ and then construct cyclic self-dual codes over $R_1={\mathbb{F}}_2+u{\mathbb{F}}_2$ of even lengths from lifts of binary cyclic self-dual codes. We classify all free cyclic self-dual codes over $R_1$ of even lengths for which non-trivial such codes exist. In particular we demonstrate that our constructions provide a counter example to a claim made by Batoul et al. in [1] and we explain why their claim fails.

Comparison of the healing effects of mesazaline and Ganoderma lucidum in acetic acid-induced colitis in rats

Huseyin Ozden,Ya?ar ?ahin,Asuman Kilitci,Gokhan Karaca,Muhammed Gomec,Ahmet Yildiz,Cahit Ucar 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.1

Purpose: The etiology and pathogenesis of distal colitis (DC) are poorly understood. Activation of intestinal inflammatory response may lead to intestinal tissue necrosis. Antioxidant and anti-inflammatory agents are among the treatment options. Our study aimed to compare the protective effects of mesalazine and Ganoderma lucidum in acetic acid (AA)-induced colitis in rats. Methods: Twenty-four rats were randomly grouped as colitis, mesalazine, G. lucidum, and combined (G. lucidum + mesalazine) groups. DC was induced by intrarectal administration of AA. Statistical comparisons were done by using parameters including colonic tissue IL-1, IL-6, TNF-α, and CRP levels. Histopathologic changes of the samples of colonic tissue were scored as mucosal damage score and inflammatory score. A P-value of <0.05 was considered significant. Results: Intrarectal administration of AA leads to increased interleukin and CRP levels. High mucosal damage and inflammatory scores were noted in colitis group animals. Single mesalazine or G. lucidum treatment produced considerably decreased tissue interleukin and CRP levels. The lowest tissue interleukin and CRP levels were noted in the combined treatment group of animals. Mucosal damage and inflammatory scores were found to be significantly low in this group of animals. Conclusion: The intrarectal administration of AA results in an activation of intestinal inflammation and severe mucosal damage in colonic tissue. Single use of mesalazine and G. lucidum treatment decreases the severity of intestinal inflammatory response and mucosal damage. The healing effects of the combined treatment of mesalazine and G. lucidum seem to be more effective than that of separate use in the treatment of DC.