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      • KCI등재

        Effective Low-Level Laser Therapy Including Laser Acupuncture Treatment Conditions for Non-Specific Chronic Low Back Pain: Systematic Review and Meta-Analysis

        Yeum, Hyewon,Hong, Yejin,Nam, Dongwoo Korean AcupunctureMoxibustion Medicine Society 2021 대한침구의학회지 Vol.38 No.2

        Low-level laser therapy including laser acupuncture has been widely used for non-specific chronic low back pain in primary Korean medical clinics. However, there is no critically appraised data regarding which treatment conditions are most effective. A systematic review and meta-analysis was conducted to determine effective treatment conditions using 12 databases (PubMed, Ovid, CENTRAL, KoreaMed, KMBASE, KISS, NDSL, KISTI, OASIS, CNKI, CiNII, and J-STAGE). There were 1,019 studies retrieved and 13 studies included in this review. It was determined that when the power output was ≥ 50 mW, the beam size was increased to ≥ cm<sup>2</sup>, the energy dose was increased to ≥ 4 J per point, the treatment interval was increased to ≥ 3 times a week, and the number of treatment sessions was increased to ≥ 10 treatments, these conditions appeared to increased treatment effectiveness.

      • Increased expression of aquaporin water channels in hypothyroid rat kidney

        Yeum, Chung Ho,Lee, Dae Ho,Song, Byung Cheol,Jung, Joo Young,Kim, Jineseok 제주대학교 생명과학연구소 2003 제주생명과학연구 Vol.6 No.1

        갑상선 기능저하증 환자에서의 수분 배설의 저하 및 수분 저류는 잘 알려져 있으며 항이뇨 호르몬의 비정상적인 증가, 사구체 여과율의 감소, 헨레 고리에서의 염분 재홉수의 감소등이 원인으로 생각되어 왔다. 지난 10여년 간에 이루어진 일련의 연구에서 세뇨관 상피에서의 삼투성 수분 이동은 Aquaporin(AQP) 수분 통로에 의한다는 것이 분명해졌다. 현재까지 신장에는 적어도 6개의 AQP (AQP1, AQP2, AQP3, AQP4, AQP6, AQP7) 동위단백이 발현된다고 알려져 있으며, 여러 가지 수분대사 장애를 동반하는 질환에서 이러한 AQP 단백발현의 변조가 일어난다는 사실이 밝혀졌다. 따라서 본 연구에서는 갑상선 기능 저하증과 관련된 수분저류의 기전으로 AQP 수분통로가 어떤 연관이 있는지를 알아보고자 하였다. 실험은 Sprague-Dawley(체중 200∼250g)숫쥐를 사용하며 0.04% methimazole을 음용수로 주어 8주간 유지하여 갑상선기능 저하증을 유발하여 실험하였다. 결과를 보면 실험군에서 혈청 갑상선 호르몬의 현저한 감소를 보였다. AQP 2 단백발현은 신장의 피질 수질 및 내수질에서 모두 유의한 증가를 보였다. AQP1 및 AQP 3 단백발현은 신장의 수질에서는 별 변화를 보이지 않는 반면 피질에서는 유의한 증가를 보였다. 혈청 arginine vasopressin (AVP) 의 농도는 변화를 보이지 않는 반면에 AVP, sodium fluoride, forskolin 등으로 자극한 adenylyl cyclase 활성도는 실험군의 신장에서 감약된 결과를 보였다. 이상의 결과로 AQP 1-3 단백발현의 증가가 갑상선 기능 저하증에 의한 수분저류에 적어도 일부나마 관여할 것으로 사료된다. The present study was aimed to determine the molecular mechanisms underlying the water retention associated with hypothyroidism. Male Sprague-Dawley rats (200 ~ 220g) were experimentally induced of hypothyroidism by treatment with methimazole in drinking water (0.04%) for 8 weeks. In the experimental group, serum concentrations of thyroxine and triliodothyronine were significantly decreased. The expression of AQP2 was significantly increased in the cortex, outer, medulla, and inner, medulla of the kidney. The expression of AQP1 and AQP3 was significantly increased in the cortex, though not in the medulla. The adenylyl cyclase activity provoked bv arginine vasopressin, sodium fluoride, or forskolin was blunted in the hypothyroid kidney. while plasma levels of arginine vasopressin were not significantly changed. The increased expression of AQP1-3 channels may in part be causally related with the water retention in hypothyroidism.

      • Central Pressor Mechanisms of Bradykinin in 2-Kidney, 1 Clip Goldblatt Hypertensive Rats

        Yeum, Cheol-Ho,Jun, Jae-Yeoul,Yoon, Pyung-Jin The Korean Physiological Society 1992 대한생리학회지 Vol.26 No.1

        Central cardiovascular effects of bradykinin were examined in anesthetized normotensive (NTR) and 2-kidney, 1 clip Goldblatt hypertensive rats (GHR). Bradykinin ($0.5{\sim}10nmol$) was administered into the right lateral cerebral ventricle, while blood pressure and heart rate (HR) were continuously monitored. In both NTR and GHR, intracerebroventricular bradykinin produced a dose dependent increase in mean arterial pressure (MAP) without significant changes in HR. GHR were more sensitive in the pressor response than NTR. The pressor response to bradykinin was attenuated by treatment with hexamethonium (2.5mg/kg/min, IV) or phentolamine (2mg/kg, IV) in both NTR and GHR. Reserpine treatment (2mg/kg/day, intramuscularly,2 days) did not affect the central pressor effect of bradykinin in NTR but it attenuated the pressor effect in GHR. Pretreatment with indomethacin (10mg/kg, intraperitoneally) or saralasin ($20{\mu}g$/kg/min, IV) was without effects on the pressor response to bradykinin. These results indicate that the central pressor effect of bradykinin is, at least in part, due to excitation of the autonomic nervous activity. Mechanisms other than the enhanced sympathetic nervous activity ran. not be ruled out, However. It is also suggested that the sensitivity to bradykinin is increased in the GHR.

      • Optimal Software Release Policies with Imperfect Debugging

        Yeum,Joon-Keun,Kim,Hee-Soo 동국대학교 자연과학 연구원 1999 자연과학연구 논문집 Vol.4 No.-

        This paper considers a software release policies for a software cost model with imperfect debugging by assuming that new faults are sometimes introduced when the faults originally latent in a software system are corrected and removed during the testing phase and operating phase. A software reliability model based on the NHPP is used. The optimal release polices to minimize the expected total software cost are discussed. Finally, numerical examples are shown to illustrate the results of the optimal polices.

      • SCIESCOPUSKCI등재

        A Case of Basal Cell Carcinoma Arising in Linear Porokeratosis

        Yeum, Jung Sub,Suh, Jin Chun,Shin, Dong Ju 대한피부과학회 2003 Annals of Dermatology Vol.15 No.2

        Porokeratosis are characterized by distinct clinical findings of a keratotic ridge that corresponds to the cornoid lamella on histology and has well defined potential for malignancy. We report a case of basal cell carcinoma(BCC) arising in linear porokeratosis in a 77-year-old man.

      • Effect of disperse dye on the preparation of poly(vinyl acetate)/poly(vinyl alcohol)/disperse dye composite microspheres

        Yeum, Jeong H,Park, Sung M,Kim, Jong W,Choi, Jin H,Han, Sang I,Oh, Weontae,Cheong, In W,Deng, Yulin SAGE Publications 2014 Journal of composite materials Vol.48 No.18

        <P>Microspheres of poly(vinyl acetate)/poly(vinyl alcohol)/disperse dye composite were prepared through suspension polymerization followed by the heterogeneous saponification. The effects of disperse dye on the rate of polymerization and saponification of poly(vinyl acetate) were studied. It was found that the rate of polymerization of poly(vinyl acetate) decreased when the concentration of the disperse dye increased. Also, the rates of poly(vinyl acetate) saponification decreased dramatically by the addition of disperse dye. The presence of disperse dye has almost no effect on the microsphere morphology.</P>

      • On the Best Linear Estimator of Mean Life

        Yeum,Joon Keun 동국대학교 자연과학연구소 1982 자연과학연구 논문집 Vol.2 No.-

        Failure Censored 표본으로부터 平均壽命에 대한 最良線型 推定量에 대하여 살펴봄. Let X?≤X?≤...≤X? denote the γsmallest ordered observations from a set of n independent observations on the exponential distribution. Then we can obtain the U.M.V.U.E of θ. However it is not the best linear estimator of θ.

      • 고환종양의 태반생성물질 분포에 관한 면역조직화학적 연구

        염석호,염범우,최종상 고려대학교 의과대학 1988 고려대 의대 잡지 Vol.25 No.1

        There were many efforts to find out specific tumor markers of variable tumors for the purpose of early cancer diagnosis, evaluation of cancer treatment and early detection of cancer recurrence. Now many placental hormones and proteins are believed to be produced by tumors of various origins. Among these, PAP, SPI, PAPP-A, HCS and β-HCG are included. Testicular tumors, especially in nonseminomatous germ cell tumors, are known to produce several placental products such as AFP and HCG. But there is no report specific for tumor marker of seminoma. Therefore, the author tried to evaluate presence of above 5 kinds of placental products in the tissue of testicular seminoma, teratoma, choriocarcinoma, embryonal carcinoma, yolk sac tumor, embryonal rhabdomyosarcoma and malignant lymphomaby ABC method, of immunoperoxidase stain, The results are followings: 1. All 5 cases of seminoma revealed strong positive reaction along the cell membrane to anti-PAP antisera. 2. Syncytiotrophoblast of choriocarcinoma and glandular epithelial cell in teratoma showed positive reaction to anti-SPI antisera. 3. Both seminoma and choriocarcinoma, and even embryonal rhabdomyosarcoma and malignant lymphoma disclosed positive reaction to anti-PAPP-A antisera.

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