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Yangyang Zhang,Yixiao Qin,Jinpeng Gu,Qianqian Jiao,Feng Wang,Zhenshan Guo,Hao Zhang,Jianjun Wang,Chenghong Mi,Huaipeng Zheng 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.8
Unsymmetrical complex plate and shell structure is one of the common engineering structures. In practice, more redundant materials exist because of the irrationality of this kind of structure with heavy load and multiple working conditions, and the study of its topology optimization has become an engaging topic. Using the SIMP model, topological results show that one side of the main web is a hollow structure, and the other side of the auxiliary web is a truss structure. According to the topological results and considering manufacturable processing, a new structure is redesigned, the size and shape of the redesigned structure is secondary optimized, and the final structure is obtained. The method in this paper not only meets the performance requirements of the unsymmetrical complex plate and shell structures, but also realizes the topology and lightweight. The effectiveness scientific research value of the proposed method is verified by engineering examples.
Yangyang Xu,Guanghua Zhang,Zechun Kang,Yong Xu,Wangling Jiang,Shuping Zhang 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1
We investigated whether cornin, an iridoid glycoside isolated from fruits of Verbena officinalis L., regulated angiogenesis and thereby improved functional outcomes after stroke and discovered a potential mechanism. The effects of cornin on proliferation of rat artery smooth muscle cell (RASMC) and signalling was investigated in vitro. Adult male rats were subjected to 1 h of middle cerebral artery occlusion (MCAO) and reperfusion and treated with or without 25 mg/kg of cornin, starting 24 h after ischemia and reperfusion, by continuous intravenous injection daily for 14 days. Neurological functional tests were performed and cerebral Evans blue extravasation was measured. Angiogenesis and angiogenic factor expressions were measured by immunohistochemistry and Western blotting, respectively. Cornin increased the proliferation of RASMC and enhanced the expression of Wnt5a, b-catenin, cyclin D1 and angiopoietin-1 (Ang1). Cornin treatment promoted angiogenesis in the ischemic brain core and improved functional outcomes after stroke. Cornin-treated MCAO rats showed significant increase in vascularization and expression of vascular endothelial growth factor and Ang1 and phosphorylation of Tie2 and Akt compared with vehicle-treated MCAO rats. The Ang1/ Tie2 axis and Wnt/b-catenin pathways appear to mediate cornin-induced angiogenesis.