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- 저자 : Yanchun Xu (검색결과 4 건)
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The Frequency Estimation of Weak Signal Based on Chaotic System Fusion Technology
Yanchun Xu,Chunling Yang,Xiaodong Qu,Mengda Yang,Quan Yang 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
in this paper we use fusion technology based on Rossler chaotic oscillator and proportional differential control technology to detect the frequency of the weak signal. The dynamic character of Rossler equation is analyzed and it is immune against the white noise and the interference signal having larger frequency difference with the intrinsicfrequency of chaotic oscillator. And proportional differential control is used to regulate the system to periodic state and the method of spectrum analysis to detect the unknown frequency. The simulation result verified that the presentedmethod is effective and it is very feasible.
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Bo Li,Yanchun Xu,Jianzhang Ma 한국통합생물학회 2013 Animal cells and systems Vol.17 No.4
MHC (major histocompatibility complex)-DRB variability reflects evolutionarily relevant and adaptive processes within and between populations, and is suitable for the investigation of a wide range of questions in evolutionary ecology. Using motif-specific polymerase chain reaction (PCR), single-stranded conformation polymorphism (SSCP)analyses and direct sequencing, 15 DRB-2 alleles were identified from 43 Ussuri sika deer. Extensive sequence variation was detected at peptide-binding region (PBR) or positively selected sites (PSS) sites among DRB loci, which were proved to be maintained by positive selection. DRB-2 loci of the Ussuri sika deer were strikingly similar to those of red deer after comparing sequences. In phylogenetic analysis, DRB-2 alleles of Ussuri sika deer were not monophyletic with respect to red deer, white-tailed deer, fallow deer, and roe deer sequences. Two DRB-2 alleles of the species tended to cluster together with those of white-tailed deer or red deer with high bootstrap values,respectively. Considering that sika and red deer are closely related, and their hybridization is occasionally seen in areas of range overlap, and their mtDNAs are paraphyletic to white-tailed deer, fallow deer, and other Cervus species,we suggested that these similarities result from trans-species evolution rather than convergent evolution.
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Genetic individualization of sable (Martes zibellina L. 1758) using microsatellites
Bo Li,DanWu,Yingying Cai,Monakhov Vladimir G,Wei Zhang,Yanchun Xu 한국통합생물학회 2018 Animal cells and systems Vol.22 No.4
Genetic individualization based on non-invasive sampling is crucial for estimating the numbers of individuals in endangered mammalian populations. In sable (Martes zibellina)-poaching cases, identifying the number of animals involved is critical for determining the penalty. In addition, investigating animal numbers for wild sable populations requires genetic individualization when collecting several samples in neighboring regions. Microsatellites have been demonstrated to be reliable markers for individual identification. Thirty-three microsatellite loci derived from Mustelidae were selected to develop a genetic individualization method for sable. Three reference populations containing 54 unrelated sables were used to calculate allele number, allelic frequencies, and the polymorphic information content of each locus. The data were subsequently used to assess the validity of a combination of twelve loci for sable individualization. We defined twelve polymorphic loci that were easy to be amplified and genotyped. Four significant deviations from Hardy-Weinberg equilibrium were observed among the 12 loci in the three populations. The match probability of an individual from the reference populations with a random individual based on the 12 loci was 1.37 × 10−13. Using the combination of the twelve loci provides sufficient power to individualize sables considering the levels of microsatellite polymorphism observed. These loci were successfully applied to a case of sable poaching and provided valid evidence to determine the penalty. The genetic individualization of sable based on these loci might also be useful to investigate the numbers of animals in wild populations.
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Melatonin Attenuates Mitochondrial Damage in Aristolochic Acid-Induced Acute Kidney Injury
Sun Jian,Pan Jinjin,Liu Qinlong,Cheng Jizhong,Tang Qing,Ji Yuke,Cheng Ke,wang Rui,Liu Liang,Wang Dingyou,Wu Na,Zheng Xu,Li Junxia,Zhang Xueyan,Zhu Zhilong,Ding Yanchun,Zheng Feng,Li Jia,Zhang Ying,Yua 한국응용약물학회 2023 Biomolecules & Therapeutics(구 응용약물학회지) Vol.31 No.1
Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and is known to cause aristolochic acid nephropathy (AAN). AA-induced acute kidney injury (AKI) is a syndrome in AAN with a high morbidity that manifests mitochondrial damage as a key part of its pathological progression. Melatonin primarily serves as a mitochondria-targeted antioxidant. However, its mitochondrial protective role in AA-induced AKI is barely reported. In this study, mice were administrated 2.5 mg/kg AA to induce AKI. Melatonin reduced the increase in Upro and Scr and attenuated the necrosis and atrophy of renal proximal tubules in mice exposed to AA. Melatonin suppressed ROS generation, MDA levels and iNOS expression and increased SOD activities in vivo and in vitro. Intriguingly, the in vivo study revealed that melatonin decreased mitochondrial fragmentation in renal proximal tubular cells and increased ATP levels in kidney tissues in response to AA. In vitro, melatonin restored the mitochondrial membrane potential (MMP) in NRK-52E and HK-2 cells and led to an elevation in ATP levels. Confocal immunofluorescence data showed that puncta containing Mito-tracker and GFP-LC3A/B were reduced, thereby impeding the mitophagy of tubular epithelial cells. Furthermore, melatonin decreased LC3A/B-II expression and increased p62 expression. The apoptosis of tubular epithelial cells induced by AA was decreased. Therefore, our findings revealed that melatonin could prevent AA-induced AKI by attenuating mitochondrial damage, which may provide a potential therapeutic method for renal AA toxicity.
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