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- 저자 : Yafang Wang (검색결과 4 건)
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Design and Output Characteristic Analysis of 3-D Micron-scale Actuator
Yafang Li,Bowen Wang,Wenmei Huang 한국자기학회 2020 Journal of Magnetics Vol.25 No.1
A new type of 3-D micron-scale actuator is designed, which is mainly composed of four Galfenol rods, drive coils, base, magnetic yoke and output head. According to magnetostrictive model and structural dynamic model, the output characteristics of the actuator have been analyzed. The 3-D moving trail of the output head is controlled by the drive coils of the four rods. The actuator prototype is fabricated and experimental investigated. Good agreement is observed between the simulation and experimental results. The maximum output displacements of the X, Y and Z direction are 46 μm, 46 μm and 8.2 μm. Furthermore, when a pair of opposing rods works, the actuator has two modes of vibration under 1000 Hz. The resonant frequencies of the actuator are 522 Hz in Y direction and X direction. The results have proved that the actuator can realize varied 3-D displacement according to actual demands, and can be used in 3-D micron-scale field, such as surface mold polishing.
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Improving electrochemical performance of LiMnPO_4 by Zn doping using a facile solid state method
Yourong Wang,Yafang Chen,Siqing Cheng,Liangnian He 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.3
Olivine structure LiMnPO_4/C as cathode materials for Li-ion batteries were synthesized via a simple solidstate reaction. Improvement of the electrochemical performance of LiMnPO_4/C cathode material was realized significantly by the method of doping Zn. The obtained LiMn_(0.95)Zn_(0.05)PO_4/C electrode material was studied by the measurements of X-ray diffraction pattern, scanning electronic microscopy, electrochemical impedance spectroscopy and electrochemical performance. The results indicate that the LiMn_(0.95)Zn_(0.05)PO_4/C materials exhibit discharge specific capacity of 140.2 mA h g^(−1) at 0.02 C rate and better rate capability. These excellent results are elucidated by EIS test, which showed that there was the decrease of charge transfer resistance and faster lithium-ion diffusion in LiMnPO_4/C cathode materials after Zn doping.
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A FKBP5 mutation is associated with Paget’s disease of bone and enhances osteoclastogenesis
Bingru Lu,Yulian Jiao,Yinchang Wang,Jing Dong,Muyun Wei,Bin Cui,Yafang Sun,Laicheng Wang,Bingchang Zhang,Zijiang Chen,Yueran Zhao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Paget’s disease of bone (PDB) is a common metabolic bone disease that is characterized by aberrant focal bone remodeling, which is caused by excessive osteoclastic bone resorption followed by disorganized osteoblastic bone formation. Genetic factors are a critical determinant of PDB pathogenesis, and several susceptibility genes and loci have been reported, including SQSTM1, TNFSF11A, TNFRSF11B, VCP, OPTN, CSF1 and DCSTAMP. Herein, we report a case of Chinese familial PDB without mutations in known genes and identify a novel c.163G4C (p.Val55Leu) mutation in FKBP5 (encodes FK506-binding protein 51, FKBP51) associated with PDB using whole-exome sequencing. Mutant FKBP51 enhanced the Akt phosphorylation and kinase activity in cells. A study of osteoclast function using FKBP51V55L KI transgenic mice proved that osteoclast precursors from FKBP51V55L mice were hyperresponsive to RANKL, and osteoclasts derived from FKBP51V55L mice displayed more intensive bone resorbing activity than did FKBP51WT controls. The osteoclast-specific molecules tartrate-resistant acid phosphatase, osteoclast-associated receptor and transcription factor NFATC1 were increased in bone marrow-derived monocyte/ macrophage cells (BMMs) from FKBP51V55L mice during osteoclast differentiation. However, c-fos expression showed no significant difference in the wild-type and mutant groups. Akt phosphorylation in FKBP51V55L BMMs was elevated in response to RANKL. In contrast, IκB degradation, ERK phosphorylation and LC3II expression showed no difference in wild-type and mutant BMMs. Micro-CT analysis revealed an intensive trabecular bone resorption pattern in FKBP51V55L mice, and suspicious osteolytic bone lesions were noted in three-dimensional reconstruction of distal femurs from mutant mice. These results demonstrate that the mutant FKBP51V55L promotes osteoclastogenesis and function, which could subsequently participate in PDB development.
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Prediction of Cellulose Crystallinity in Liquid Phase Using CBM-GFP Probe
Xiaoyu Guo,Fan Yang,Huixue Liu,Yingmin Hou,Yafang Wang,Jie Sun,Xiaoyi Chen,Yanan Liu,Xianzhen Li 한국고분자학회 2019 Macromolecular Research Vol.27 No.4
Carbohydrate-binding modules (CBMs) have been developed to investigate the presence of crystalline and amorphous regions of cellulose. However, systematic and quantitative assessment of cellulose crystallinity using such non-hydrolytic fusion proteins in liquid phase has not been reported. In this work, cellulose directed CBM probes containing a green fluorescent protein (GFP) were constructed and named CG17, CG28, and CG2a. The probe binding condition was determined as incubating 30 μg/mL probes in 10 mM phosphate buffer at 30oC for 60 min. Under the optimized condition, the linear correlations between CBM probe binding capability and X-ray diffraction (XRD) crystallinity were well established. Using linear regression equations, the crystallinity of several cellulosic materials was well calculated. Amorphous component and cellulosic surface area probably had a less effect on binding capability of CG2a than that of CG17 and CG28. Therefore, crystalline-region specific probe CG2a should be an efficient tool for interpreting the crystallinity of cellulosic materials.
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