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- 저자 : Zijiang Chen (검색결과 3 건)
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Rongling Zhang,Peng Liu,Lina Ma,Zijiang Yang,Huisu Chen,Han Xing Zhu,Huigang Xiao,Jia Li 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.2
To study the influence of different water-binder ratios on the corrosion, permeability, and freezing properties of concrete, we produced different strengths of concrete with respective water-binder ratios of 0.32, 0.38, 0.50, and 0.66. The corrosion resistance of the concrete was studied via three corrosion methods: full immersion, half immersion, and dry and wet cycles. The impermeability and frost resistance of concrete with different water-binder ratios were tested and analyzed. The test results show that the corrosion modes in order from strong to weak were dry and wet cycles, half soaking, and full soaking. The relative dynamic elasticity modulus and freeze-thaw index were used to evaluate the frost resistance of concrete based on the analysis of three indices of frost resistance. To study the internal mechanism of corrosion of concrete with different water-binder ratios, microscopic pore structure testing of the concrete was conducted using a Micromeritics AutoPore IV 9500 Series instrument. The porosimeter studies show that the smaller the water-binder ratio, the more small pores and the denser the concrete. The smaller the water-binder ratio, the higher the strength and the better the corrosion, permeability, and frost resistance.
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Influence of Ga(Al)As substrates on surface morphology and critical thickness of InGaAs quantum dots
Yi Wang,Xiang Guo,Jiemin Wei,Chen Yang,Zijiang Luo,Jihong Wang,Zhao Ding 한국물리학회 2019 Current Applied Physics Vol.19 No.4
Influence of Ga(Al)As substrates on surface morphology of InGaAs quantum dots and critical thickness of In0.5Ga0.5As film grown by molecular beam epitaxy is investigated. The In0.5Ga0.5As quantum dots are grown on (001) surfaces of GaAs and Al0.25Ga0.75 A at 450 °C, scanning tunneling microscope images show that the size of quantum dots varied slightly for 10 ML of In0.5Ga0.5As grown on GaAs and Al0.25Ga0.75As surfaces. Reflection high energy electron diffraction (RHEED) is used to monitor the growth of 4 monolayers (ML) In0.5Ga0.5As on Al0.25Ga0.75As and GaAs surfaces during deposition. The critical thickness is theoretically calculated by adding energy caused by surface roughness and heat from substrate. The calculations show that the critical thickness of In0.5Ga0.5As grown on GaAs and Al0.25Ga0.75As are 3.2 ML and 3.8 ML, respectively. The theoretical calculation agrees with the experimental results.
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A FKBP5 mutation is associated with Paget’s disease of bone and enhances osteoclastogenesis
Bingru Lu,Yulian Jiao,Yinchang Wang,Jing Dong,Muyun Wei,Bin Cui,Yafang Sun,Laicheng Wang,Bingchang Zhang,Zijiang Chen,Yueran Zhao 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Paget’s disease of bone (PDB) is a common metabolic bone disease that is characterized by aberrant focal bone remodeling, which is caused by excessive osteoclastic bone resorption followed by disorganized osteoblastic bone formation. Genetic factors are a critical determinant of PDB pathogenesis, and several susceptibility genes and loci have been reported, including SQSTM1, TNFSF11A, TNFRSF11B, VCP, OPTN, CSF1 and DCSTAMP. Herein, we report a case of Chinese familial PDB without mutations in known genes and identify a novel c.163G4C (p.Val55Leu) mutation in FKBP5 (encodes FK506-binding protein 51, FKBP51) associated with PDB using whole-exome sequencing. Mutant FKBP51 enhanced the Akt phosphorylation and kinase activity in cells. A study of osteoclast function using FKBP51V55L KI transgenic mice proved that osteoclast precursors from FKBP51V55L mice were hyperresponsive to RANKL, and osteoclasts derived from FKBP51V55L mice displayed more intensive bone resorbing activity than did FKBP51WT controls. The osteoclast-specific molecules tartrate-resistant acid phosphatase, osteoclast-associated receptor and transcription factor NFATC1 were increased in bone marrow-derived monocyte/ macrophage cells (BMMs) from FKBP51V55L mice during osteoclast differentiation. However, c-fos expression showed no significant difference in the wild-type and mutant groups. Akt phosphorylation in FKBP51V55L BMMs was elevated in response to RANKL. In contrast, IκB degradation, ERK phosphorylation and LC3II expression showed no difference in wild-type and mutant BMMs. Micro-CT analysis revealed an intensive trabecular bone resorption pattern in FKBP51V55L mice, and suspicious osteolytic bone lesions were noted in three-dimensional reconstruction of distal femurs from mutant mice. These results demonstrate that the mutant FKBP51V55L promotes osteoclastogenesis and function, which could subsequently participate in PDB development.
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