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Jing Ma,Suhe Dong,Hongtao Lu,Zhongmin Chen,Huijie Yu,Xuejun Sun,Renjun Peng,Wei Li,Sinian Wang,Qisheng Jiang,Fengsheng Li,Li Ma 한국생체재료학회 2022 생체재료학회지 Vol.26 No.2
Objective: This study aimed to reveal the protective effect of hydrogen storage nanomaterial MgH2 on radiationinduced male fertility impairment. Methods: The characterization of MgH2 were analyzed by scanning electron microscopy (SEM) and particle size analyzer. The safety of MgH2 were evaluated in vivo and in vitro. The radioprotective effect of MgH2 on the reproductive system were analyzed in mice, including sperm quality, genetic effect, spermatogenesis, and hormone secretion. ESR, flow cytometry and western blotting assay were used to reveal the underlying mechanisms. Results: MgH2 had an irregular spherical morphology and a particle size of approximately 463.2 nm, and the content of Mg reached 71.46%. MgH2 was safe and nontoxic in mice and cells. After irradiation, MgH2 treatment significantly protected testicular structure, increased sperm density, improved sperm motility, reduced deformity rates, and reduced the genetic toxicity. Particularly, the sperm motility were consistent with those in MH mice and human semen samples. Furthermore, MgH2 treatment could maintain hormone secretion and testicular spermatogenesis, especially the generation of Sertoli cells, spermatogonia and round sperm cells. In vitro, MgH2 eliminated the [·OH], suppressed the irradiation-induced increase in ROS production, and effectively alleviated the increase in MDA contents. Moreover, MgH2 significantly ameliorated apoptosis in testes and cells and reversed the G2/M phase cell cycle arrest induced by irradiation. In addition, MgH2 inhibited the activation of radiation-induced inflammation and pyroptosis. Conclusion: MgH2 improved irradiation-induced male fertility impairment by eliminating hydroxyl free radicals.
MAXIMAL INEQUALITIES AND STRONG LAW OF LARGE NUMBERS FOR AANA SEQUENCES
Xuejun, Wang,Shuhe, Hu,Xiaoqin, Li,Wenzhi, Yang Korean Mathematical Society 2011 대한수학회논문집 Vol.26 No.1
Let {$X_n$, $n{\geq}1$} be a sequence of asymptotically almost negatively associated random variables and $S_n=\sum^n_{i=1}X_i$. In the paper, we get the precise results of H$\acute{a}$jek-R$\acute{e}$nyi type inequalities for the partial sums of asymptotically almost negatively associated sequence, which generalize and improve the results of Theorem 2.4-Theorem 2.6 in Ko et al. ([4]). In addition, the large deviation of $S_n$ for sequence of asymptotically almost negatively associated random variables is studied. At last, the Marcinkiewicz type strong law of large numbers is given.
Sipeng Li,Jialing Chen,Xuanjun Zhang,Zhaoyang Ding,Xuejun Cao 한국생물공학회 2018 Biotechnology and Bioprocess Engineering Vol.23 No.1
Microbial transglutaminase (MTG) has been widely used in the food and pharmaceuticals industries. In this study, MTG was purified using affinity precipitation with an affinity polymer (PMMDN-T), which was synthesized using a pH-responsive polymer (PMMDN) coupled with L-thyroxin as an affinity ligand. Interactions between MTG and PMMDN-T were investigated using turbidimetric titration, zeta potential measurements, and low-field nuclear magnetic resonance (LF-NMR). We found different behaviors, architectures, and phase states of pH-dependent interactions between MTG and PMMDN-T interactions. Binding energetics between MTG and PMMDN-T were determined by isothermal titration calorimetry (ITC). The isoelectric point (pI) of the affinity polymer was 4.65 and was recovered with 96.7% efficiency after recycling the polymer three times. The optimal adsorption condition was 0.02 mol/L phosphate buffer (pH 6.0) with 1.0 mol/L NaCl at 30.0°C and a ligand density of 50.0 μmol/g. The maximum elution recoveries of total MTG were 98.44% (protein) with 92.19% (activity) using 0.02 mol/L pH 10.0 Gly-NaOH as the eluent.
Exponential inequalities and complete convergence for a LNQD sequence
Wang Xuejun,Hu Shuhe,Yang Wenzhi,Li Xiaoqin 한국통계학회 2010 Journal of the Korean Statistical Society Vol.39 No.4
Some exponential inequalities for a linearly negative quadrant dependent sequence are obtained. By using the exponential inequalities, we give the complete convergence and almost sure convergence for a linearly negative quadrant dependent sequence. In addition,the asymptotic behavior of the probabilities for the partial sums of a linearly negative quadrant dependent sequence is studied.
Zhiquan Wang,Jianjun Li,Xuejun Jiang,Xuejun Jiang,Neng Wang,Shimin Wang 대한의학회 2009 Journal of Korean medical science Vol.24 No.1
The effects of the antiarrhythmic drug propafenone at c-type kv1.4 channels in Xenopus laevis oocytes were studied with the two-electrode voltage-clamp techinique. Defolliculated oocytes (stage V-VI) were injected with transcribed cRNAs of ferret Kv1.4△N channels. During recording, oocytes were continuously perfused with control solution or propafenone. Propafenone decreased the currents during voltage steps. The block was voltage-, use-, and concentration- dependent manners. The block was increased with positive going potentials. The voltage dependence of block could be fitted with the sum of monoexponential and a linear function. Propafenone accelerated the inactivate of current during the voltage step. The concentration of half-maximal block (IC50) was 121 μM/L. With high, normal, and low extracellular potassium concentrations, the changes of IC50 value had no significant statistical differences. The block of propafenone was PH- dependent in high-, normal- and low- extracellular potassium concentrations. Acidification of the extracellular solution to PH 6.0 increased the IC50 values to 463 μM/L, alkalization to PH 8.0 reduced it to 58 μM/L. The results suggest that propafenone blocks the kv1.4 N channel in the open state and give some hints for an intracellular site of action.
Spatiotemporal Variations and Possible Sources of Ambient PM10 from 2003 to 2012 in Luzhou, China
Dong Ren,Youping Li,Hong Zhou,Xiaoxia Yang,Xiaoman Li,Xuejun Pan,Bin Huang 대한환경공학회 2014 Environmental Engineering Research Vol.19 No.4
Descriptive statistics methods were used to study the spatiotemporal variations and sources of ambient particulate matter (PM10) in Luzhou, China. The analyzed datasets were collected from four national air quality monitoring stations: Jiushi (S1), Xiaoshi (S2), Zhongshan (S3), Lantian (S4) over the period of 2003-2012. This city was subjected serious PM10 pollution, and the long-term annual average PM10 concentrations varied from 76 to 136 μg/m3. The maximum concentration was more than 3-fold of the annual average (40 μg/m3) issued by EPA-China for the ambient air quality. General temporal pattern was characterized by high concentrations in winter and low concentrations in summer, and general spatial gradient was in the reduction order of S2 > S4 > S3 > S1, which were both due to different particulate contributors and special meteorological conditions. The source apportionment indicated that vehicular emissions, road dusts, coal burning and chemical dusts were the major contributors of the identified PM10 pollution, and the vehicular emissions and the road wear re-suspended particles dominated the heavy PM10 pollution in recent years. Two other potential sources, agricultural and celebration activities could decrease the air quality in a short term. Finally, some corresponding suggestions and measures were provided to improve the air quality.