Cone-beam computed tomographic evaluation of mandibular incisor alveolar bone changes for the intrusion arch technique: A retrospective cohort research

Lu Lin,Si Jiaping,Wang Zhikang,Chen Xiaoyan 대한치과교정학회 2024 대한치과교정학회지 Vol.54 No.2

Objective: Alveolar bone loss is a common adverse effect of intrusion treatment. Mandibular incisors are prone to dehiscence and fenestrations as they suffer from thinner alveolar bone thickness. Methods: Thirty skeletal class II patients treated with mandibular intrusion arch therapy were included in this study. Lateral cephalograms and cone-beam computed tomography images were taken before treatment (T1) and immediately after intrusion arch removal (T2) to evaluate the tooth displacement and the alveolar bone changes. Pearson’s and Spearman’s correlation was used to identify risk factors of alveolar bone loss during the intrusion treatment. Results: Deep overbite was successfully corrected (P < 0.05), accompanied by mandibular incisor proclination (P < 0.05). There were no statistically significant change in the true incisor intrusion (P > 0.05). The labial and lingual vertical alveolar bone levels showed a significant decrease (P < 0.05). The alveolar bone is thinning in the labial crestal area and lingual apical area (P < 0.05); accompanied by thickening in the labial apical area (P < 0.05). Proclined incisors, non-extraction treatment, and increased A point-nasion-B point (ANB) degree were positively correlated with alveolar bone loss. Conclusions: While the mandibular intrusion arch effectively corrected the deep overbite, it did cause some unwanted incisor labial tipping/flaring. During the intrusion treatment, the alveolar bone underwent corresponding changes, which was thinning in the labial crestal area and thickening in the labial apical area vice versa. And increased axis change of incisors, non-extraction treatment, and increased ANB were identified as risk factors for alveolar bone loss in patients with mandibular intrusion therapy.

Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury

Xue Lin,Haiyan Wang,Xiaoyan Pu 한국유전학회 2020 Genes & Genomics Vol.42 No.11

Background The acute hypoxic injury caused by the plain population entering the plateau in a short period of time hasbecome the main cause of endangering the health of the people who rush into the plateau. Objective The study aimed to identify the key genes which participate in resisting the acute hypoxic injury in SD Rats bytranscriptomic profile analysis. Methods 48 Sprague Dawley (SD) male rats were enrolled and randomly divided into four groups (0h, 24h, 48h, 72h) andhoused in hypobaric hypoxia chamber with altitude 6000m for different periods of time to make them acute hypoxic injury. The transcriptomic profile of the lung tissue of the rats was analysed by RNA second-generation sequencing combined withbioinformatics analysis. Results The results of GO and KEGG function classification analysis revealed that the differential expression genes enrichedin steroid hormone synthesis pathway especially in 48h group compared to F0 group. Further analysis revealed that FarnesylDiphosphate Farnesyl Transferase 1 (fdft1) gene encoding a rate-limiting enzyme in steroid hormone synthesis pathway wassignificant differently expressed between the groups. The expression levels of fdft1 gene were further verified by RT-PCRand Western-blot methods. Conclusions The results suggest that fdft1 gene plays an important role in responding to acute hypoxic injury by regulatingsteroid hormone biosynthesis.

Evaluation of Fe(III)EDTA and Fe(II)EDTA-NO Reduction in a NOx Scrubber Solution by Magnetic Fe3O4-Chitosan Microspheres Immobilized Microorganisms

Tianming Lin,Zuoming Zhou,Yixuan Liu,Xiaoyan Wang,Guohua Jing 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.1

A two-stage bioreduction system containingmagnetic-microsphere-immobilized denitrifying bacteria andiron-reducing bacteria was developed for the regenerationof scrubbing solutions for NOx removal. In this process, ahigher bioreduction rate and a better tolerance of inhibitionof bacteria were achieved with immobilized bacteria thanwith free bacteria. This work focused on evaluation of theeffects of the main components in the scrubbing solutionon Fe(III)EDTA (EDTA: ethylenediaminetetraacetate) andFe(II)EDTA-NO reduction, with an emphasis on masstransfer and the kinetic model of Fe(III)EDTA andFe(II)EDTA-NO reduction by immobilized bacteria. It wasfound that Fe(II)EDTA-NO had a strong inhibiting effect,but Fe(II)EDTA had no effect, on Fe(III)EDTA reduction. Fe(II)EDTA accelerated Fe(II)EDTA-NO reduction, whereasFe(III)EDTA had no effect. This showed that the use of thetwo stages of regeneration was necessary. Moreover, theeffect of internal diffusion on Fe(III)EDTA and Fe(II)EDTANOreduction could be neglected, and the rate-limiting stepwas the bioreduction process. The reduction of Fe(III)EDTAand Fe(II)EDTA-NO using immobilized bacteria wasdescribed by a first-order kinetic model. Bioreduction cantherefore be enhanced by increasing the cell density in themagnetic chitosan microspheres.

Effects of Fdft 1 gene silencing and VD3 intervention on lung injury in hypoxia-stressed rats

Pu Xiaoyan,Lin Xue,Qi Yinglian,Li Yinglian,Li Tiantian,Liu Yang,Wei Dengbang 한국유전학회 2022 Genes & Genomics Vol.44 No.10

Background: Hypoxia can induce lung injury such as pulmonary arterial hypertension and pulmonary edema. And in the rat model of hypoxia-induced lung injury, the expression of Farnesyl diphosphate farnesyl transferase 1 (Fdft 1) was highly expressed and the steroid biosynthesis pathway was activated. However, the role of Fdft 1 and steroid biosynthesis pathway in hypoxia-induced lung injury remains unclear. Objective: The study aimed to further investigate the relationship between Fdft1 and steroid biosynthesis pathway with hypoxia-induced lung injury. Methods: A rat model of lung injury was constructed by hypobaric chamber with hypoxic stress, the adenovirus interference vector was used to silence the expression of Fdft 1, and the exogenous steroid biosynthesis metabolite Vitamin D3 (VD3) was used to treat acute hypoxia-induced lung injury in rats. Results: Sh-Fdft 1 and exogenous VD3 significantly inhibited the expression of Fdft 1 and the activation of the steroid pathway in hypoxia-induced lung injury rats, which showed a synergistic effect on the steroid activation pathway. In addition, sh-Fdft 1 promoted the increase of pulmonary artery pressure and lung water content, the decrease of oxygen partial pressure and oxygen saturation, and leaded to the increase of lung cell apoptosis and the aggravation of mitochondrial damage in hypoxia-stressed rats. And VD3 could significantly improve the lung injury induced by hypoxia and sh-Fdft 1 in rats. Conclusions: Fdft 1 gene silencing can promote hypoxic-induced lung injury, and exogenous supplement of VD3 has an antagonistic effect on lung injury induced by Fdft 1 gene silencing and hypoxic in rats, suggesting that VD3 has a preventive and protective effect on the occurrence and development of hypoxia-induced lung injury.

Magnetic Resonance Image Texture Analysis of the Periaqueductal Gray Matter in Episodic Migraine Patients without T2-Visible Lesions

Zhiye Chen,Xiaoyan Chen,Mengqi Liu,Shuangfeng Liu,Shengyuan Yu,Lin Ma 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.1

Objective: The periaqueductal gray matter (PAG), a small midbrain structure, presents dysfunction in migraine. However, the precise neurological mechanism is still not well understood. Herein, the aim of this study was to investigate the texture characteristics of altered PAG in episodic migraine (EM) patients based on high resolution brain structural magnetic resonance (MR) images. Materials and Methods: The brain structural MR images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) patients using a 3T MR system. A PAG template was created using the International Consortium Brain Mapping 152 gray matter model, and the individual PAG segment was developed by applying the deformation field from the structural image segment to the PAG template. A grey level co-occurrence matrix was used to calculate the texture parameters including the angular second moment (ASM), contrast, correlation, inverse difference moment (IDM) and entropy. Results: There was a significant difference for ASM, IDM and entropy in the EM group (998.629 ± 0.162 x 10-3, 999.311 ± 0.073 x 10-3, 916.354 ± 0.947 x 10-5) compared to that found in the NC group (998.760 ± 0.110 x 10-3, 999.358 ± 0.037 x 10-3 and 841.198 ± 0.575 x 10-5) (p < 0.05). The entropy was significantly lower among the patients with CM (864.116 ± 0.571 x 10-5) than that found among patients with EM (p < 0.05). The area under the receiver operating characteristic curve was 0.776 and 0.750 for ASM and entropy in the distinction of the EM from NC groups, respectively. ASM was negatively related to disease duration (DD) and the Migraine Disability Assessment Scale (MIDAS) scores in the EM group, and entropy was positively related to DD and MIDAS in the EM group (p < 0.05). Conclusion: The present study identified altered MR image texture characteristics of the PAG in EM. The identified texture characteristics could be considered as imaging biomarkers for EM.

Simple and Sensitive Electrochemical Sandwich-type Immunosensing of Human Chorionic Gonadotropin based on b-cyclodextrin Functionalized Graphene

Linfen Xu,Ling liu,Xiaoyan Zhao,Jinyu Lin,Shaohan Xu,Jinlian He,Debin Jiang,Yong Xia The Korean Electrochemical Society 2023 Journal of electrochemical science and technology Vol.14 No.1

The effective detection of human chorionic gonadotropin (HCG) is considerably important for the clinical diagnosis of both of early pregnancy and nonpregnancy-related diseases. In this work, a simple and sensitive electrochemical sandwich-type immunosensing platform was designed by synthesizing b-cyclodextrin (CD) functionalized graphene (CD/GN) hybrid as simultaneously sensing platform and signal transducer coupled with rhodamine b (RhB) as probe. In brief, GN offers large surface area and high conductivity, while CD exhibits superior host-guest recognition capability, thus the primary antibody (Ab1) of HCG can be bound into the cavities of CD/GN to form stable Ab1/CD/GN inclusion complex; meanwhile, the secondary antibody (Ab2) and RhB can also enter into the cavities, producing RhB/Ab2/CD/GN complex. Then, by using Ab1/CD/GN as sensing platform and RhB/Ab2/CD/GN as signal transducer (in which RhB was signal probe), a simple sandwich-type immunosensor was constructed. Under the optimum parameters, the designed immunosensor exhibited a considerable low analytical detection of 1.0 pg mL^-1 and a wide linearity of 0.002 to 10.0 ng mL^-1 for HCG, revealing the developed sandwich-type electrochemical immunosensing platform offered potential real applications for the determination of HCG.

Urinary Biomarkers for the Noninvasive Detection of Gastric Cancer

Li Dehong,Yan Li,Lin Fugui,Yuan Xiumei,Yang Xingwen,Yang Xiaoyan,Wei Lianhua,Yang Yang,Lu Yan 대한위암학회 2022 Journal of gastric cancer Vol.22 No.4

Gastric cancer (GC) is associated with high morbidity and mortality rates. Thus, early diagnosis is important to improve disease prognosis. Endoscopic assessment represents the most reliable imaging method for GC diagnosis; however, it is semi-invasive and costly and heavily depends on the skills of the endoscopist, which limit its clinical applicability. Therefore, the search for new sensitive biomarkers for the early detection of GC using noninvasive sampling collection methods has attracted much attention among scientists. Urine is considered an ideal biofluid, as it is readily accessible, less complex, and relatively stable than plasma and serum. Over the years, substantial progress has been made in screening for potential urinary biomarkers for GC. This review explores the possible applications and limitations of urinary biomarkers in GC detection and diagnosis.

Urinary Biomarkers for the Noninvasive Detection of Gastric Cancer

Li, Dehong,Yan, Li,Lin, Fugui,Yuan, Xiumei,Yang, Xingwen,Yang, Xiaoyan,Wei, Lianhua,Yang, Yang,Lu, Yan The Korean Gastric Cancer Association 2022 Journal of gastric cancer Vol.22 No.-

Gastric cancer (GC) is associated with high morbidity and mortality rates. Thus, early diagnosis is important to improve disease prognosis. Endoscopic assessment represents the most reliable imaging method for GC diagnosis; however, it is semi-invasive and costly and heavily depends on the skills of the endoscopist, which limit its clinical applicability. Therefore, the search for new sensitive biomarkers for the early detection of GC using noninvasive sampling collection methods has attracted much attention among scientists. Urine is considered an ideal biofluid, as it is readily accessible, less complex, and relatively stable than plasma and serum. Over the years, substantial progress has been made in screening for potential urinary biomarkers for GC. This review explores the possible applications and limitations of urinary biomarkers in GC detection and diagnosis.

Low Stability and a Conserved N-Glycosylation Site Are Associated with Regulation of the Discoidin Domain Receptor Family by Glucose via Post-Translational N-Glycosylation

PHAN, Trong Nhat,WONG, Ee Lin,SUN, Xiaoyan,KIM, Geunwoong,JUNG, Seung Hee,YOON, Chang No,YANG, Beom-Seok Japan Society for Bioscience, Biotechnology and Ag 2013 Bioscience, biotechnology, and biochemistry Vol.77 No.9

Code Analysis and Improvement of Onion Routing Anonymous Systems

Tianbo Lu,Youwen Wang,Lingling Zhao,Yang Lin,Xiaoyan Zhang 보안공학연구지원센터 2016 International Journal of Future Generation Communi Vol.9 No.8

With the development of Internet technology, network based activities such as e-commerce, internet voting and e-government, etc. have become increasingly frequent, People are increasingly concerned about the identity of network activity, content and other private information. In order to protect user privacy in network communications, governments, companies, universities and research institutes are pushing the research and development of the onion routing systems (TOR). Tor is the most popular anonymous communication system currently, which is based on technology of the second-generation onion routing. Tor has a low latency, encrypted data transmission, secure channel, etc., which are widely used in anonymous Web browsing, instant messaging, Secure Shell Client (SSH), etc. However, the development of the onion routing systems is constrained by complicated code factors. According to this situation, this paper put forward an overall architecture of TOR code, which contains Application Needs, Code Analysis and Improvement. This paper summarizes the overall framework of tor code structure, in order to make the code structure clearer, the whole code module is divided into several sub modules, using the function call diagram and UML diagram illustrates the main function of each module and call relation between each module. This paper gives code analysis for anonymous architecture of TOR. Finally, this paper put forward the improvement of routing algorithms of TOR. Based on this paper, a method has been created which is used to understand the tor code easily. Furthermore, systematic analysis of the tor code provided in this paper aims to research the working principle and promote the further development of the onion routing.