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Gong Xiaowei,Luo Huajun,Hong Liu,Wu Jun,Wu Heng,Song Chunxia,Zhao Wei,Han Yi,Dao Ya,Zhang Xia,Zhu Donglai,Luo Yiyong 한국미생물학회 2022 The journal of microbiology Vol.60 No.8
Tryptophol (TOL) is a metabolic derivative of tryptophan (Trp) and shows pleiotropic effects in humans, plants and microbes. In this study, the effect of Trp and phenylalanine (Phe) on TOL production in Saccharomyces cerevisiae was determined, and a systematic interpretation of TOL accumulation was offered by transcriptomic and metabolomic analyses. Trp significantly promoted TOL production, but the output plateaued (231.02−266.31 mg/L) at Trp concentrations ≥ 0.6 g/L. In contrast, Phe reduced the stimulatory effect of Trp, which was strongly dependent on the Phe concentration. An integrated genomic, transcriptomic, and metabolomic analysis revealed that the effect of Trp and Phe on TOL production was mainly related to the transamination and decarboxylation of the Ehrlich pathway. Additionally, other genes, including thiamine regulon genes (this), the allantoin catabolic genes dal1, dal2, dal4, and the transcriptional activator gene aro80, may play important roles. These findings were partly supported by the fact that the thi4 gene was involved in TOL production, as shown by heterologous expression analysis. To the best of our knowledge, this novel biological function of thi4 in S. cerevisiae is reported here for the first time. Overall, our findings provide insights into the mechanism of TOL production, which will contribute to TOL production using metabolic engineering strategies.
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The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese
Hongying Han,Xiaowei Xia,Huirong Zheng,Chongbang Zhao,Yanming Xu,Jiong Tao,Xianglan Wang 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.11
Objective To investigate the association between gene polymorphism of vesicular monoamine transporter type 2(VMAT2) and schizophrenia in Han Chinese population.Methods 430 patients with schizophrenia and 470 age-sex matched controls were recruited from four mental health centers. All patients were diagnosed by two psychiatrists based on the Structured Clinical Interview for DSM Disorders (SCID). The ligase detection reactions (LDR) method was used to assess the polymorphism of the two SNPs (rs363371 and rs363324) of VMAT2.Results No associations of two SNPs with schizophrenia was found. When we stratified males and females for the analysis, we found that that in the recessive model of rs363371, there was an obvious significant association between rs363371 and schizophrenia in males (OR=0.564, 95% CI=0.357–0.892, p=0.014) but not females. For the association between rs363324 and schizophrenia, no association was found in either males or females. No association was found when stratifying early-onset schizophrenia and late-onset schizophrenia.Conclusion Our findings indicate that both rs363371 and rs363324 were not associated with schizophrenia, while it seemed that the AA genotype of rs363371 plays a protective effect in male Chinese in developing schizophrenia.
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HIST1H2BN induced cell proliferation and EMT phenotype in prostate cancer via NF-κB signal pathway
Zhang Juan,Chang Yuhan,Xia Haiyan,Xu Luwei,Wei Xiaowei 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background The potential role of HIST1H2BN in prostate cancer remains unclear. Objective To evaluate the carcinogenic role of HIST1H2BN in prostate cancer. Methods The expression of HIST1H2BN in prostate cancer was analyzed using TCGA database and clinical samples. The roles and mechanisms of HIST1H2BN were investigated in DU145 and PC3 cells. Results HIST1H2BN was signifcantly upregulated in prostate cancer. HIST1H2BN knockdown inhibited cell proliferation, migration and EMT phenotype in prostate cancer cells. Downregulating HIST1H2BN diminished the expression and binding activity of NF-κB p65, then infuenced the expression of MMP2 and MMP9. Conclusion This is the frst study to elaborate a HIST1H2BN-NF-κB-EMT regulatory axis in oncogenesis, indicating that HIST1H2BN might be potential therapeutic target for prostate cancer.
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Cross-Layer Resource Allocation in Multi-interface Multi-channel Wireless Multi-hop Networks
Wei Feng,Suili Feng,Yongzhong Zhang3,Xiaowei Xia 한국전자통신연구원 2014 ETRI Journal Vol.36 No.6
In this paper, an analytical framework is proposed forthe optimization of network performance through jointcongestion control, channel allocation, rate allocation,power control, scheduling, and routing with theconsideration of fairness in multi-channel wireless multihopnetworks. More specifically, the framework modelsthe network by a generalized network utilitymaximization (NUM) problem under an elastic link datarate and power constraints. Using the dual decompositiontechnique, the NUM problem is decomposed into foursubproblems — flow control; next-hop routing; rateallocation and scheduling; power control; and channelallocation — and finally solved by a low-complexitydistributed method. Simulation results show that theproposed distributed algorithm significantly improves thenetwork throughput and energy efficiency compared withprevious algorithms.
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