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      • Diffusion Characteristics of Solute in Ca-Alginate Hydrogels

        ( Xiaohong Yu ),김헌 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1

        Ca-Alginate gel beads are used in many applications as matrices for release or immobilization. Ca- Alginate beads were prepared with either external or internal calcium source. The diffusion behaviour of both beads were investigated. Diffusion characteristics of polyethyleneglycols (PEG) through Ca-alginate gel beads were studied and compared to diffusion of VB12, a small molecule. The results were compared with the theoretical effective solute diffusion coefficients in gel beads of different alginate concentrations and calcium ionic concentrations. The release experiments are operated with three different methods. Some proposed models demonstrates can provide a clear explanation of the phenomenon observed for solutes.

      • KCI등재

        Empirical Study of Dynamic Corporate Governance: New Evidence from Chinese-listed SMEs

        Lin Shao,Xiaohong Yu 한국유통과학회 2015 The Journal of Industrial Distribution & Business( Vol.6 No.4

        Purpose This study first explores – the possible dynamic relationship between ownership structure and firm performance using a panel of 4,900 Chinese-listed small- and medium-sized enterprises (SMEs) from 1999 to 2012. Research design, data, and methodology – We address this issue through a dynamic panel model using a method of moments (GMM) technique and dynamic simultaneous equations to alleviate the potential endogenous problem: unobserved heterogeneity, simultaneity, and dynamic endogeneity. Results – Under the framework of dynamic endogeneity, firm performance has a significantly positive influence on ownership, but not vice versa. Ownership and performance can be explained by their owned lagged values, respectively. Moreover, intertemporal endogeneity exists among ownership, investment, and performance through the application of system dynamic equations, which implies that the relationship among ownership structure, investment, and firm performance is dynamic by nature. Conclusions – This study also significantly contributes to a better understanding of dynamic corporate governance by providing further empirical evidence from the largest capital market in the Asian region.

      • KCI등재

        Prediction and Identification of an Acid-inducible Promoter from Lactococcus lactis ssp. cremoris MG1363

        Hongxian Yu,Wentao Xu,Yunbo Luo,Jing He,Hongtao Tian,Hui Shi,Xiaohong Mei 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.5

        Using a promoter online prediction system, the gene sequence of GroEL protein from Lactococcus lactis ssp. cremoris MG1363 was analysed and a putative promoter, designated as gro, was further studied. Under acidic conditions, gro showed preliminary promoter function by driving the expression of lacZ reporter gene in Escherichia coli DH5α. In addition, gro drove the gene expression of GroEL and green fluorescent protein. In this paper, an acid-inducible promoter was successfully identified. This promoter has a wide prospect in the field of biotechnology.

      • Mocklinter : Linting Mutual Exclusive Deadlocks with Lock Allocation Graphs

        Zhen Yu,Xiaohong Su,Tiantian Wang,Peijun Ma 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.3

        Deadlocks are serious runtime bugs and are difficult to expose, reproduce and diagnose. Once suffering from them, programs may be afflicted with increasing response time, decreasing throughputs, or even crashes. We present Mocklinter, a dynamic deadlock detection tool to capture a deadlock as soon as it happens and spit out enough information to support source-level debugging. Mocklinter tracks the synchronization state of the target program by dynamically constructing and maintaining a lock allocation graph. Mocklinter uses this graph to decide whether a deadlock is confronted or not. Mocklinter handles all types of pthread mutexes and can detect any number of deadlocks at a time. Each deadlock captured by Mocklinter can involve any number of threads. We implemented Mocklinter in Linux-3.2.0 and evaluated it with ten applications, including Dining-Philosophers, Sshfs, SQLite, OpenLDAP, MySQL and so on, whose sizes varies from 0.1K to 1021.0K in terms of LOC. The results demonstrate effectiveness against real or artificial deadlock bugs, while incurring modest performance overhead and scaling to more than one thousand of threads.

      • Empirical Study of the Dynamic Corporate Governance : New Evidence from Chinese Listed SME

        Lin Shao,Xiaohong Yu 한국유통과학회 2015 한국유통과학회 학술대회 논문집 Vol.2015 No.-

        This study explores the possible dynamic relationship between ownership and performance in a panel of 4900 Chinese listed SME over a period from 1999 to 2012. We address this issue by means of a dynamic panel model with a method of moments (GMM) through dynamic simultaneous equations to alleviate the potential endogenous problem: unobserved heterogeneity, simultaneity and dynamic endogeneity. Under the framework of dynamic endogeneity, firm performance has significantly positive influence on ownership, but not vice versa. Ownership and performance can be explained by their owned lagged value respectively. Moreover, Inter temporal endogeneity exist between ownership, investment and performance by applying system dynamic equations, which implies that the relationship among them is dynamic by nature. This study also contributes to a better understanding of dynamic corporate governance by providing further empirical evidence from the largest market in the Asian region.

      • KCI등재

        Acute Myelitis in a Patient with Vogt-Koyanagi-Harada Disease: Case Report and Review of the Literature

        Shaojuan GU,Yu Liu,Xiaohong Zi,Hao Deng 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.1

        Background Vogt-Koyanagi-Harada (VKH) disease is characterized by bilateral granulomatous uveitis with neurologic, auditory, and dermatologic manifestations. However, acute myelitis complicating VKH disease has rarely been reported. Case Report A 50-year-old Chinese Han woman presented with difficulty walking, numbness on the left side of the body, and difficulty with urination. The patient was diagnosed with incomplete VKH disease and received corticosteroid treatment prior to the neurological presentation. Acute myelitis was diagnosed based on both clinical and spinal-cord MRI findings. Conclusions Clinicians should consider acute myelitis as a rare possible neurological manifestation in VKH disease patients, and early systemic administration of corticosteroids will suppress the acute inflammatory process and prevent recurrences. This report raises the possibility that VKH disease and acute myelitis share common pathogenic pathways

      • KCI등재

        Empirical Study of Dynamic Chinese Corporate Governance Based on Chinese-listed Firms with A Panel VAR Approach

        Lin Shao,Li Zhang,Xiaohong Yu 한국유통과학회 2017 The Journal of Industrial Distribution & Business( Vol.8 No.1

        Purpose – In this article, a dynamic model like a VAR is an appropriate choice for estimating the possible interrelationship between ownership structure and firm performance as a dynamic process. Research design, data, and methodology – Data of this work are collected from Chinese stock exchange including 350 Chinese-listed firms during the period of 1999-2012. We hypothesize that this interrelationship dynamically exists between ownership structure and firm performance. To examine the correlation, a panel Vector Auto-regression (PVAR) approach generated by GMM method is utilized to test the possible dynamic relation embedded in corporate governance. Another two dynamic analysis solutions such as orthogonalized impulse-response function and variance decomposition are also used simultaneously. Results – Findings of this study indicate the evidence that dynamically endogenous relationship exists between ownership structure and firm performance. Further, there is a dynamical correlation between investment and performance. Impulse response and variance decomposition illustrate that impact of a shock to variables themselves is the main source for their variability. Conclusions – The conclusion in this study is that there is a bidirectional and inter-temporal effect between proportion of ownership and corporate performance for a long run in accordance with impulse response function. Overall, our results suggest that corporate governance in China is more market oriented.

      • KCI등재

        Sevoflurane induces neuronal apoptosis via enhancing DNMT3L expression and promoting methylation of PSD95 promoter in postoperative cognitive dysfunction

        Ling Yunzhi,Li Xiaohong,Yu Li,Sun Yiyun,Yang Dongdong,Li Zhiyi 대한독성 유전단백체 학회 2021 Molecular & cellular toxicology Vol.17 No.3

        Background Postoperative cognitive dysfunction (POCD) is a central nervous system (CNS) complication and occurs quite frequently after anesthesia, especially in elderly patients. DNA (cytosine-5)-methyltransferase 3-like (DNMT3L) is an enzymatically inactive regulatory factor that can modulate gene expression via methylation. Few studies specifically focused on the role of DNMT3L in sevoflurane-induced POCD. Objective The cognitive dysfunction was determined by Morris water maze assay. Hippocampal neuron apoptosis was measured by TdT-mediated dUTP nick-end labeling (TUNEL) assay. Neuron proliferation and apoptosis were measured by cell counting kit-8 (CCK-8) and flow cytometry assay. The expression levels of DNMT3L and postsynaptic density protein-95 (PSD95) were measured by qRT-PCR and western blot. Results The sevoflurane-induced POCD aging rat model was established for in vivo study. Suppression of DNA methylation by 5-Aza-2′-deoxycytidine (5-AZA; a widely used methylation inhibitor) reversed sevoflurane-induced cognitive dysfunction and hippocampal neuron apoptosis in rats. Moreover, sevoflurane enhanced DNMT3L expression and induced methylation of PSD95 promoter in vivo. In vitro, sevoflurane induced neuronal apoptosis and DNMT3L expression to promote PSD95 methylation. Finally, rescue experiments indicated that sevoflurane induced neuron apoptosis by increasing DNMT3L expression and promoting methylation of PDS95 in POCD. Conclusion Sevoflurane induced neuronal apoptosis by increasing DNMT3L expression and promoting methylation of PDS95 in vivo and in vitro, providing a novel therapeutic strategy for POCD.

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