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컴포넌트객체모델을 기반으로 한 지자체 도로 종합시스템의 컴포넌트 모델링과 구현 : 도로/도로시설물관리 중심으로
이동우,김진숙 우송대학교 산업연구소 2000 산업연구 Vol.2 No.1
In the paper, the components of a provincial load facility management system are modeled and implemented based on component techniques. Since it is based on component object model and its components are high-level, it is compatible with other systems in different environment and has high reusability. In addition, its components are customizable and are very flexible in various development environment. The component model for load facility management systems can be used by other provinces as a standard.
양우식,이진수,김기웅 東新大學校 1998 論文集 Vol.10 No.-
Stock(1992) had developed the figure for solving the penetration depth, tieforce of anchor and maximum bending moment of sheet-pile wall for cantilever and free earth supported anchored wall. Kim(1995) had developed figure for design of fixed earth supported anchored wall. The formula for calculating the penetration depth, tieforce of anchor and maximum bending moment of sheet-pile wall by fixed earth supported Method in case of waterfront structure, have been arranged. It have been cleared the design parameters, anchor pull ratio and penetration ratio and maximum bending moment ratio, are respectively function of independent variables which are geometrical condition and soil properties.
An outbreak of highly pathogenic H5N1 avian influenza in Korea, 2008
Kim, H.R.,Park, C.K.,Lee, Y.J.,Woo, G.H.,Lee, K.K.,Oem, J.K.,Kim, S.H.,Jean, Y.H.,Bae, Y.C.,Yoon, S.S.,Roh, I.S.,Jeong, O.M.,Kim, H.Y.,Choi, J.S.,Byun, J.W.,Song, Y.K.,Kwon, J.H.,Joo, Y.S. Elsevier Scientific Pub. Co 2010 Veterinary microbiology Vol.141 No.3
In spite of intensive surveillance programs for the control of HPAI, an outbreak of highly pathogenic avian influenza (HPAI) H5N1 in Korea in April 2008 caused serious damage to poultry farms, as did previous outbreaks in 2003/2004 and 2006/2007. Six viruses were selected from the Korean 2008 isolates for genetic analysis, and all eight gene segments from each of the influenza viruses were sequenced. A phylogenetic analysis showed that all of the viruses were of the same virus type and that the hemagglutinin (HA) gene was clustered with that of clade 2.3.2 viruses. However, the internal and neuraminidase (NA) genes were closely related to those of the clade 2.3.4 viruses (recent human and bird isolates from Southeast Asia).
Anti - Angiogenic Activity of Mouse N-/C-terminal deleted Endostatin
Kim, Young MI,Kim, Kyu Won,Kwon, Young Guen,Cho, Hee Yeong,Kim, Woo Jean,Lee, Sae Won,Choi, Eu Yul,Park, Yong Suk 생화학분자생물학회 1970 BMB Reports Vol.34 No.3
Endostatin, a proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis and the growth of several primary tumors. However, the opinions on the activity of endostatin derivatives deleted N- or C- terminal are still controversial. In this regard, we produced mouse endostatin and its derivatives in the prokaryotic system, and studied their anti-tumor activity. The [³H]-thymidine incorporation assay demonstrated that N-terminal deleted mouse endostatin, and a C- and N-terminal deleted mutant, effectively inhibited the proliferation of human umbilical vein endothelial cells (HUVECs). The biological activity of endostatin was also shown by its in vivo antiangiogenic ability on the chorioallantoic membrane (CAM) of a chick embryo. Treatment of 200 ng of mouse endostatin, or N-terminal deleted mouse endostatin, inhibited capillary formation of CAM 45 to 71%, which is comparative to a 80% effect of positive control, 1 ㎍ of retinoic acid. An in vivo mouse tumor growth assay showed that N-terminal deleted mouse endostatin, and the N-/C-terminal deleted mutant, significantly repressed the growth of B16F10 melanoma cells in mice as did the fulllength mouse endostatin. According to these results, Nand N-/C-terminal deleted mouse endostatins are the potent inhibitors of tumor growth and angiogenesis.
Blood-neural Barrier: Intercellular Communication at Glio-Vascular Interface
Kim, Jeong-Hun,Kim, Jin-Hyoung,Park, Jeong-Ae,Lee, Sae-Won,Kim, Woo-Jean,Yu, Young-Suk,Kim, Kyu-Won Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.4
The blood-neural barrier (BNB), including blood-brain barrier (BBB) and blood-retinal barrier (BRB), is an endothelial barrier constructed by an extensive network of endothelial cells, astrocytes and neurons to form functional 'neurovascular units', which has an important role in maintaining a precisely regulated microenvironment for reliable neuronal activity. Although failure of the BNB may be a precipitating event or a consequence, the breakdown of BNB is closely related with the development and progression of CNS diseases. Therefore, BNB is most essential in the regulation of microenvironment of the CNS. The BNB is a selective diffusion barrier characterized by tight junctions between endothelial cells, lack of fenestrations, and specific BNB transporters. The BNB have been shown to be astrocyte dependent, for it is formed by the CNS capillary endothelial cells, surrounded by astrocytic end-foot processes. Given the anatomical associations with endothelial cells, it could be supposed that astrocytes play a role in the development, maintenance, and breakdown of the BNB. Therefore, astrocytes-endothelial cells interaction influences the BNB in both physiological and pathological conditions. If we better understand mutual interactions between astrocytes and endothelial cells, in the near future, we could provide a critical solution to the BNB problems and create new opportunities for future success of treating CNS diseases. Here, we focused astrocyte-endothelial cell interaction in the formation and function of the BNB.
( Jin-woo Jeong ),( Cheol Park ),( Hee-jae Cha ),( Su Hyun Hong ),( Shin-hyung Park ),( Gi-young Kim ),( Woo Jean Kim ),( Cheol Hong Kim ),( Kyoung Seob Song ),( Yung Hyun Choi ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.10
Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), a major product of cyclooxygenase-2 (COX-2), plays an important role in the carcinogenesis of many solid tumors, including colorectal cancer. Because PGE<sub>2</sub> functions by signaling through PGE<sub>2</sub> receptors (EPs), which regulate tumor cell growth, invasion, and migration, there has been a growing amount of interest in the therapeutic potential of targeting EPs. In the present study, we investigated the role of EP4 on the effectiveness of cordycepin in inhibiting the migration and invasion of HCT116 human colorectal carcinoma cells. Our data indicate that cordycepin suppressed lipopolysaccharide (LPS)-enhanced cell migration and invasion through the inactivation of matrix metalloproteinase (MMP)-9 as well as the down-regulation of COX-2 expression and PGE<sub>2</sub> production. These events were shown to be associated with the inactivation of EP4 and activation of AMP-activated protein kinase (AMPK). Moreover, the EP4 antagonist AH23848 prevented LPS-induced MMP-9 expression and cell invasion in HCT116 cells. However, the AMPK inhibitor, compound C, as well as AMPK knockdown via siRNA, attenuated the cordycepin-induced inhibition of EP4 expression. Cordycepin treatment also reduced the activation of CREB. These findings indicate that cordycepin suppresses the migration and invasion of HCT116 cells through modulating EP4 expression and the AMPK-CREB signaling pathway. Therefore, cordycepin has the potential to serve as a potent anti-cancer agent in therapeutic strategies against colorectal cancer metastasis. [BMB Reports 2018; 51(10): 532-537]
김규원 ( Kim Gyu Won ),( Sae Won Lee ),( Hyun Seok Song ),( Myung Jin Son ),( You Mie Lee ),( Jeong Ae Park ),( Kwang Rok Kim ),( Chul Ho Jeong ),( Woo Jean Kim ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1
The oxygen tension during the development of vascular systems influences vessel formation through regulating angiogenesis. We studied the effect of hypoxia/reoxygenation (H/R) to explain its role in concern with astrocytes involvement in the development o