Sequential treatment from mandibulectomy to reconstruction on mandibular oral cancer – Case review I: mandibular ramus and angle lesion of primary intraosseous squamous cell carcinoma

Won-Bum LeeDae-Seok Hwang,Uk-Kyu Kim 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.2

Primary intraosseous squamous cell carcinoma (PIOSCC) is very rare type of squamous cell carcinoma (SCC) that occurs within the jaw and arises from remnants of odontogenic epithelium with no connection to the oral mucosa. This study reports two cases of PIOSCC of the mandible. Reported in this article are two cases of PIOSCC of the mandible that were treated with resection and reconstruction using a fibular free flap. The first case was a 36-year-old male patient who complained of right mandibular pain. Computed tomography (CT) and panoramic radiograph revealed a large radiolucency in the mandibular ramus area. At first, an odontogenic keratocyst was tentatively diagnosed, and an excision procedure was carried out at another clinic. A final biopsy after cyst enucleation revealed well-differentiated SCC, so we proceeded with segmental mandibulectomy and reconstruction using a fibular free flap. The second case was a 48-year-old male patient with left mandibular pain. CT and panoramic radiograph revealed irregular radiolucency in the mandibular angle area near tooth #38. At first, osteomyelitis was tentatively diagnosed, and a curettage was carried out. A later biopsy revealed well-differentiated SCC, so segmental mandibulectomy and reconstruction with a fibular free flap were secondarily performed. Our two cases have had no recurrence. The facial appearance of both patients is satisfactory, and the neo-mandibular body created using a fibular bone transfer displays adequate bony volume.

Value of Bone Scintigraphy and Single Photon Emission Computed Tomography (SPECT) in Lumbar Facet Disease and Prediction of Short-term Outcome of Ultrasound Guided Medial Branch Block with Bone SPECT

( Won Uk Koh ),( Sung Hoon Kim ),( Bo Young Hwang ),( Woo Jong Choi ),( Jun Gul Song ),( Jeong Hun Suh ),( Jeong Gill Leem ),( Jin Woo Shin ) 대한통증학회 2011 The Korean Journal of Pain Vol.24 No.2

Background: Facet joint disease plays a major role in axial low-back pain. Few diagnostic tests and imaging methods for identifying this condition exist. Single photon emission computed tomography (SPECT) is reported that it has a high sensitivity and specificity in diagnosing facet disease. We prospectively evaluated the use of bone scintigraphy with SPECT for the identification of patients with low back pain who would benefit from medial branch block. Methods: SPECT was performed on 33 patients clinically suspected of facet joint disease. After SPECT, an ultrasound guided medial branch block was performed on all patients. On 28 SPECT-positive patients, medial branch block was performed based on the SPECT findings. On 5 negative patients, medial branch block was performed based on clinical findings. For one month, we evaluated the patients using the visual analogue scale (VAS) and Oswestry disability index. SigmaStat and paired t-tests were used to analyze patient data and compare results. Results: Of the 33 patients, the ones who showed more than 50% reduction in VAS score were assigned ``responders``. SPECT positive patients showed a better response to medial branch blocks than negative patients, but no changes in the Oswestry disability index were seen. Conclusions: SPECT is a sensitive tool for the identification of facet joint disease and predicting the response to medial branch block. (Korean J Pain 2011; 24: 81-86)

Development of Prediction Equation of Diffusing Capacity of Lung for Koreans

Hwang, Yong Il,Park, Yong Bum,Yoon, Hyoung Kyu,Lim, Seong Yong,Kim, Tae-Hyung,Park, Joo Hun,Lee, Won-Yeon,Park, Seong Ju,Lee, Sei Won,Kim, Woo Jin,Kim, Ki Uk,Shin, Kyeong Cheol,Kim, Do Jin,Kim, Hui Ju The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.1

Background: The diffusing capacity of the lung is influenced by multiple factors such as age, sex, height, weight, ethnicity and smoking status. Although a prediction equation for the diffusing capacity of Korea was proposed in the mid-1980s, this equation is not used currently. The aim of this study was to develop a new prediction equation for the diffusing capacity for Koreans. Methods: Using the data of the Korean National Health and Nutrition Examination Survey, a total of 140 nonsmokers with normal chest X-rays were enrolled in this study. Results: Using linear regression analysis, a new predicting equation for diffusing capacity was developed. For men, the following new equations were developed: carbon monoxide diffusing capacity (DLco)=-10.4433-0.1434${\times}$age (year)+0.2482${\times}$heights (cm); DLco/alveolar volume (VA)=6.01507-0.02374${\times}$age (year)-0.00233${\times}$heights (cm). For women the prediction equations were described as followed: DLco=-12.8895-0.0532${\times}$age (year)+0.2145${\times}$heights (cm) and DLco/VA=7.69516-0.02219${\times}$age (year)-0.01377${\times}$heights (cm). All equations were internally validated by k-fold cross validation method. Conclusion: In this study, we developed new prediction equations for the diffusing capacity of the lungs of Koreans. A further study is needed to validate the new predicting equation for diffusing capacity.

Prevalence of Chronic Obstructive Pulmonary Disease in Korea: The Result of Forth Korean National Health and Nutrition Examination Survey

Hwang, Yong-Il,Yoo, Kwang-Ha,Sheen, Seung-Soo,Park, Joo-Hun,Kim, Sang-Ha,Yoon, Ho-Il,Lim, Sung-Chul,Lee, Shin-Yup,Park, Jae-Yong,Park, Seoung-Ju,Seo, Ki-Hyun,Kim, Ki-Uk,Lee, Sang-Yeub,Park, In-Won,Lee The Korean Academy of Tuberculosis and Respiratory 2011 Tuberculosis and Respiratory Diseases Vol.71 No.5

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of chronic morbidity and mortality throughout the world and is the only major disease that is continuing to increase in both prevalence and mortality. The second Korean National Health and Nutrition Survey revealed that the prevalence of COPD in Korean subjects aged ${\geq}45$ years was 17.2% in 2001. Further surveys on the prevalence of COPD were not available until 2007. Here, we report the prevalence of spirometrically detected COPD in Korea, using data from the fourth Korean National Health and Nutrition Survey (KNHANES IV) which was conducted in 2007~2009. Methods: Based on the Korean Statistical Office census that used nationwide stratified random sampling, 10,523 subjects aged ${\geq}40$ years underwent spirometry. Place of residence, levels of education, income, and smoking status, as well as other results from a COPD survey questionnaire were also assessed. Results: The prevalence of COPD (defined as forced expiratory volume in 1 sec/forced vital capacity <0.7 in subjects aged ${\geq}40$ years) was 12.9% (men, 18.7%; women, 7.5%). In total, 96.5% of patients with COPD had mild-to-moderate disease; only 2.5% had been diagnosed by physicians, and only 1.7% had been treated. The independent risk factors for COPD were smoking, advanced age, and male gender. Conclusion: The prevalence of COPD was 12.9% in the KNHANES IV data. Most patients with COPD were undiagnosed and untreated. Based on these results, a strategy for early COPD intervention is warranted in high risk subjects.

Association Between Persistent Treatment of Alzheimer’s Dementia and Osteoporosis Using a Common Data Model

Hwang Seonhwa,Soung Yong Gwon,Kang Seong Uk,Yu Donghan,Baek Haeran,Jang Jae-Won 대한치매학회 2023 Dementia and Neurocognitive Disorders Vol.22 No.4

Background and Purpose: As it becomes an aging society, interest in senile diseases is increasing. Alzheimer’s dementia (AD) and osteoporosis are representative senile diseases. Various studies have reported that AD and osteoporosis share many risk factors that affect each other’s incidence. This aimed to determine if active medication treatment of AD could affect the development of osteoporosis. Methods: The Health Insurance Review and Assessment Service provided data consisting of diagnosis, demographics, prescription drug, procedures, medical materials, and healthcare resources. In this study, data of all AD patients in South Korea who were registered under the national health insurance system were obtained. The cohort underwent conversion to an Observational Medical Outcomes Partnership–Common Data Model version 5 format. Results: This study included 11,355 individuals in the good persistent group and an equal number of 11,355 individuals in the poor persistent group from the National Health Claims database for AD drug treatment. In primary analysis, the risk of osteoporosis was significantly higher in the poor persistence group than in the good persistence group (hazard ratio, 1.20 [95% confidence interval, 1.09–1.32]; p<0.001). Conclusions: We found that the good persistence group treated with anti-dementia drugs for AD was associated with a significant lower risk of osteoporosis in this nationwide study. Further studies are needed to clarify the pathophysiological link in patients with two chronic diseases.

Validation of KREAM Based on In-Situ Measurements of Aviation Radiation in Commercial Flights

Hwang, Junga,Kwak, Jaeyoung,Jo, Gyeongbok,Nam, Uk-won The Korean Space Science Society 2020 Journal of astronomy and space sciences Vol.37 No.4

There has been increasing necessity of more precise prediction and measurements of aviation radiation in Korea. For our air crew and passengers' radiation safety, we develop our own radiation prediction model of KREAM. In this paper, we validate the KREAM model based on comparison with Liulin observations. During early three months of this year, we perform total 25 experiments to measure aviation radiation exposure using Liulin-6K in commercial flights. We found that KREAM's result is very well consistent with Liulin observation in general. NAIRAS shows mostly higher results than Liulin observation, while CARI-6M shows generally lower results than the observations. The percent error of KREAM compared with Liulin observation is 10.95%. In contrast, the error for NAIRAS is 43.38% and 22.03% for CARI-6M. We found that the increase of the altitude might cause sudden increase in radiation exposure, especially for the polar route. As more comprehensive and complete analysis is required to validate KREAM's reliability to use for the public service, we plan to expand these radiation measurements with Liulin and Tissue Equivalent Proportional Counter (TEPC) in the near future.

Clinical cases analysis of forearm free fasciocutaneous flaps on oral cavity defect area (초)

( Uk Kyu Kim ),( Kwang Ho Lee ),( Won Wook Song ),( Dae Seok Hwang ),( Yong Deok Kim ),( Sang Hun Shin ),( Jong Ryoul Kim ),( In Kyo Chung ) 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.2s

Preliminary Results of Tissue-Equivalent Proportional Counter (TEPC) Dosimeter for Measuring In-Situ Aviation Radiation

Uk-won Nam,Won-kee Park,Junga Hwang,Jongdae Sohn,Bongkon Moon,Sunghwan Kim 한국우주과학회 2020 Journal of Astronomy and Space Sciences Vol.37 No.4

We develop the tissue-equivalent proportional counter (TEPC) type’s space radiation dosimeter to measure in-situ aviation radiation. That was originally developed as a payload of small satellite in the low-earth orbit. This dosimeter is based on a TEPC. It is made of an A-150 tissue-equivalent plastic shell of an internal diameter of 6 cm and a thickness of 0.3 cm. TEPC is filled with pure propane at 13.9 torrs to simulate a cell diameter of 2 μm. And the associated portable and low power electronics are also implemented. The verification experiments have been performed by the calibration experiments at ground level and compared with Liulin observation at aircraft altitude during the flight between Incheon airport (ICN) and John F. Kennedy airport (JFK). We found that the TEPC dosimeter can be used as a monitor for space radiation dosimeter at aviation altitude based on the verification with Liulin observation.

Comparison of Posterior Fixation Alone and Supplementation with Posterolateral Fusion in Thoracolumbar Burst Fractures

Hwang, Jong-Uk,Hur, Jin-Woo,Lee, Jong-Won,Kwon, Ki-Young,Lee, Hyun-Koo The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.52 No.4

Objective : We compared the radiological and clinical outcomes between patients who underwent posterior fixation alone and supplemented with fusion following the onset of thoracolumbar burst fractures. In addition, we also evaluated the necessity of posterolateral fusion for patients treated with posterior pedicle screw fixation. Methods : From January 2007 to December 2009, 46 consecutive patients with thoracolumbar burst fracture were included in this study. On the basis of posterolateral fusion, we divided our patients into the non-fusion group and the fusion group. The radiological assessment was performed according to the Cobb's method, and results were obtained at immediately, 3, 6, 12 months after surgery. The clinical outcomes were evaluated using the modified Mcnab criteria at the final follow-up. Results : The demographic data and the mean follow-up period were similar between the two groups. Patients of both groups achieved satisfactory clinical outcomes. The mean loss of kyphosis correction showed that patients of both groups experienced loss of correction with no respect to whether they underwent the posterolateral fusion. There was no significant difference in the degree of loss of correction at any time points of the follow-up between the two groups. In addition, we also compared the effect of fixed levels (i.e., short versus long segment) on loss of correction between the two groups and there was no significant difference. There were no major complications postoperatively and during follow-up period. Conclusion : We suggest that posterolateral fusion may be unnecessary for patients with thoracolumbar burst fractures who underwent posterior pedicle screw fixation.

Effects of Hydrodilatation With Corticosteroid Injection and Biomechanical Properties in Patients With Adhesive Capsulitis After Breast Cancer Surgery

Chang Won Lee,In Soo Kim,Jeong-Gil Kim,Hyeoncheol Hwang,Il Young Jung,Shi-Uk Lee,Kwan-Sik Seo 대한재활의학회 2022 Annals of Rehabilitation Medicine Vol.46 No.4

Objective To compare the biomechanical properties of the glenohumeral joint capsule between adhesive capsulitis (AC) after breast cancer surgery and idiopathic AC and demonstrate the effects of hydrodilatation (HD) with corticosteroid injection for AC after breast cancer surgery.Methods Twenty-three prospective patients with AC after breast cancer surgery (BC group) and 44 retrospective patients with idiopathic AC without breast cancer (CON group) underwent HD with corticosteroid injection and home exercise training. We compared their biomechanical characteristics (capsular capacity, maximal pressure, and capsular stiffness). In the BC group, the passive range of motion (ROM) of the affected shoulder and a questionnaire (Shoulder Pain and Disability Index [SPADI]) were evaluated at baseline and 2 and 4 weeks after treatment.Results The BC group showed higher biomechanical characteristics (maximal pressure and capsular stiffness) than did the CON group. The mean maximal pressure and capsular stiffness were 519.67±120.90 mmHg and 19.69±10.58 mmHg/mL in the BC group and 424.78±104.42 mmHg and 11.55±7.77 mmHg/mL in the CON group (p=0.002 and p=0.001, respectively). And, the BC group showed significant improvements in all ROMs (abduction, flexion, and external rotation) and the SPADI pain and disability sub-scores following the treatment.Conclusion The glenohumeral joint capsular stiffness was greater in the patients with AC after breast cancer surgery than in those with idiopathic AC. HD with corticosteroid injection was effective in treating AC after breast cancer surgery.