기관지폐 이형성증의 임상 양상: 다기관 연구

성기혜 ( Ki Hye Sung ),김민희 ( Min Hee Kim ),김은령 ( Eun Ryoung Kim ),심재원 ( Jae Won Shim ),이정주 ( Jung Ju Lee ),임재우 ( Jae Woo Im ),진현승 ( Hyun Seung Jin ) 대한주산의학회 2009 Perinatology Vol.20 No.3

목적: 최근 극소 저출생 체중아의 생존율의 개선으로 기관지폐 이형성증(bronchopulmonary dysplasia, BPD)이 늘고 있다. 다기관 연구에 의해 전국적인 BPD의 역학, 임상 양상과 각 병원 간의 차이를 조사하여 향후 우리나라의 BPD 감소와 중증도를 줄이는 것을 목적으로 본 연구를 시행하였다. 방법: 2005년 6월부터 2007년 5월까지 건국대학교병원, 영등포 성애병원, 강북삼성병원, 중앙대학교병원, 건양대학교병원, 강릉아산병원의 신생아 집중 치료실에 입원하였던 신생아 4,476명을 대상으로 하였다. BPD의 진단 기준은 비전형적인 BPD를 포함하여 병인적인 분류를 하고 있는 Ogawa 등의 분류법을 이용하여 신생아 호흡 곤란 증후군(respiratory distress syndrome, RDS)과 전형적 또는 미만성 혼탁의 방사선 소견, 산전 감염의 유무에 따라 6가지 type으로 분류하였다. 또한 전체 신생아의 출생체중 분포와 생존율, 각 출생체중 군별 BPD의 발생률, 병태 비율, 사망률 등을 조사하고, 이 후 재택 산소요법 시행 여부와 미숙아 망막증, 괴사성 장염 등의 합병증 여부를 조사하였다. 결과: 생후 28일째 산소 치료가 필요한 신생아는 89명이었고, 이 중 Ogawa 분류법에 의한 BPD 환아는 70명(1.6%)이었으며, 특히 1,500 g 미만의 환아 237명 중 60명(25.3%)이었다. 생후 28일 이상 생존율은 98.7%이고, 사망 예는 없었으며 평균 재원 기간은 97.8±51.2일(43~405일)이었다. BPD는 900~999 g, 1,000~1,249 g의 체중 군에서 발생률이 각각 15명(21.4%)으로 가장 높았으며, 교정 36주 이후에도 산소투여가 필요한 중증 BPD의 경우 900~999 g의 체중 군에서 7명(23.3%)로 가장 높았다. Ogawa 분류법으로 BPD의 각 병태 비율로는 RDS 이후에 나타나는 I, II형이 각각 전체의 17예(24.3%), 44예(62.9%)로 대다수를 차지하였다. 이외에도 III`형은 2예(2.9%), IV형은 2예(2.9%), V형은 5예(7.1%)이었고, III형, VI형은 없었다. 재택 산소요법은 8예에서 시행되어 전체의 11.4%였으며, 이 중 BPD I형이 7예로 87.5%를 차지하였다. 미숙아 망막증은 35명(50.0%)에서 발생하였으며, 700 g 이하 신생아에서 9예(26.5%)로 가장 많았다. 또한 괴사성 장염은 3명(4.3%)이었다. 결론: 본 연구는 국내에서 처음으로 진행된 BPD의 전국적인 다기관 역학 조사로, 대상 신생아의 Ogawa 분류에 의한 BPD 유병률은 1.6% 이었고 1,500 g 미만 신생아의 25.3%이었으며, 전체 신생아의 BPD 70명 중 Ogawa 분류의 I, II형이 각각 24.3%, 62.9%로 대다수를 차지하였다. Purpose: As the neonatal intensive care advanced, the incidence of neonatal bronchopulmonary dysplasia (BPD) has increased. We conducted a multi-center investigation of the prevalence of BPD in six hospitals to investigate the epidemiology of BPD in Korea. Methods: Retrospective reviews ware performed for survival rate, prevalence of BPD of total 4,476 newborn infants who were admitted to neonatal intensive care unit in Konkuk university hospital, Sung-Ae General hospital, Kangbuk Samsung hospital, Chung-Ang university hospital, Konyang university hospital, and Gangneung Asan hospital between June, 2005 and May, 2007. By Ogawa, BPD was defined as oxygen dependency at 28 days after birth, with respiratory distress symptoms and the change of chest x-ray finding, and classified as 6 subtypes. Classic BPD was defined as oxygen dependency at 36 weeks of postmenstrual age. Results: Survival rate at 28 day after birth was 98.7%. BPD infants by Ogawa classification were 70 (1.6% of overall newborn infants), classic BPD infants were 30 (0.7%). Especially, among 237 preterm infants with birth weight less than 1,500 gram who survived to 28 days of life, 60 (25.3%) had BPD by Ogawa classification and 23 (9.7%) had classic BPD. In Ogawa classification, infants with RDS as type I and II, were 17 infants (24.3%) and 44 infants (62.9%). Home oxygen therapy was performed 8 infants (11.4%). Prevalence of retinopathy of prematurity was 35 infants (50.0%), necrotizing enterocolitis was 3 infants (4.3%), and intraventricular hemorrhage was 6 infants (8.6%). Conclusion: Prevalence of BPD infants was 1.6% of overall newborn, 25.3% of preterm infants with birth weight less than 1,500 gram. Among 70 BPD infants, BPD by Ogawa classification with history of RDS as type I and II were 24.3%, 62.9% as the majority of BPD. This study would be the first report of epidemiology of Korean BPD infants by multi-center study.

Phase and microstructure evolution during the TFA-MOD process of YBCO films

Sung-Hun Wee,Geo-Myung Shin,Gye-Won Hong,Sang-Im Yoo 한국초전도저온학회 (구 한국초전도저온공학회) 2007 한국초전도저온공학회논문지 Vol.9 No.2

Tailored radiotherapeutic strategies for disseminated uterine cervical cancer patients

Im, Jung Ho,Yoon, Hong In,Kim, Sunghoon,Nam, Eun Ji,Kim, Sang Wun,Yim, Ga Won,Keum, Ki Chang,Kim, Young Tae,Kim, Gwi Eon,Kim, Yong Bae BioMed Central 2015 Radiation oncology Vol.10 No.-

<P><B>Background</B></P><P>To investigate the role of radiotherapy (RT) in and to suggest radiotherapeutic strategies for patients presenting with disseminated cervical cancer.</P><P><B>Methods</B></P><P>We retrospectively analyzed 50 patients diagnosed as the disseminated cervical cancer with distant lymph nodal or visceral organ metastasis between September 1980 and August 2012. Patients were divided into two subgroups according to visceral organ metastasis: 35 patients diagnosed with distant lymph node metastasis only (group A) and 15 patients with visceral organ metastasis (group B). All patients received external beam RT to the pelvis (median dose 45 Gy) and high-dose rate intracavitary RT (median dose 30 Gy). Thirty-nine patients (78%) received chemotherapy.</P><P><B>Results</B></P><P>Median follow-up time was 74 months. The 5-year pelvic control rate (PCR) was 85.8%, and the progression-free survival (PFS), and overall survival (OS) rates were 28.7%, and 36.2%, respectively. The major treatment failure was systemic progression (32 patients, 64%). The 5-year PCRs in groups A and B were 87.4% and 74.7%, respectively (<I>p</I> > 0.05). Meanwhile, PFS and OS rates for group A were significantly better than those for group B (35.3% vs. 13.3%, <I>p</I> = 0.010; and 46.3% vs. 13.3%, <I>p</I> = 0.009, respectively).</P><P><B>Conclusion</B></P><P>Our data revealed considerable prognostic heterogeneity in disseminated cervical cancer. Even though a high PCR was achieved in patients treated with definitive RT, survival outcomes were dependent on progression of visceral organ metastasis. Therefore, personalized RT and chemotherapy treatment strategies according to the presence of visceral organ metastasis in disseminated cervical cancer patients may help improve clinical outcomes.</P>

LiFePO₄ Synthesis using Refined Li₃PO₄ from Wastewater in Li-Ion Battery Recycling Process

Im, Jehong,Heo, Kookjin,Kang, Sung-Won,Jeong, Hyejeong,Kim, Jaekook,Lim, Jinsub Electrochemical Society 2019 Journal of the Electrochemical Society Vol.166 No.15

<P>Increased demand for lithium resources has led to increased Li costs and supply problems and increased the importance of lithium ion battery (LIB) recycling. In this study, lithium phosphate from LIB recycling wastewater was refined in a simple process using deionized water (DI). The morphologies and compositions associated with purifying Li<SUB>3</SUB>PO<SUB>4</SUB> were investigated using X-ray diffraction, field emission-scanning electron microscopy, simultaneous thermogravimetric-differential thermal analysis, differential scanning calorimetry, pH measurement, inductively coupled plasma optical emission spectroscopy, and carbon and sulfur determinators. Simple refining with DI can increase Li<SUB>3</SUB>PO<SUB>4</SUB> purity from 94.601% to 98.867%. LiFePO<SUB>4</SUB> (LFP) was then synthesized using the purified Li<SUB>3</SUB>PO<SUB>4</SUB>; its morphology was studied and its electrochemical performance evaluated by constant current charge/discharge testing and cyclic voltammetry. The LFP cathode fabricated from purified Li<SUB>3</SUB>PO<SUB>4</SUB> exhibited improved electrochemical properties, particularly in terms of initial capacity and cycling stability.</P>

Quaternary Paleoclimatology

Im-Chul Shin,Won-Tae Kwon,Hyo-Sang Chung,Hi-Il Yi 한국기상학회 2001 Korean Journal of the Atmospheric Sciences Vol.4 No.1

Structural and electrical properties of Sr₂NaNb₄O₁₃ thin film grown by electrophoretic method using nanosheets synthesized from K(Sr₂Na)Nb₄O₁₃ compound

Im, Mir,Kweon, Sang-Hyo,Kim, Dong-Ha,Lee, Woong-Hee,Nahm, Sahn,Choi, Ji-Won,Hwang, Seong-Ju Elsevier 2017 Journal of the European Ceramic Society Vol.37 No.6

<P><B>Abstract</B></P> <P>Sr<SUB>2</SUB>NaNb<SUB>4</SUB>O<SUB>13</SUB> <SUP>−</SUP> (SNNO<SUP>−</SUP>) nanosheets were exfoliated from the K(Sr<SUB>2</SUB>Na)Nb<SUB>4</SUB>O<SUB>13</SUB> compound that was synthesized at 1200°C. The SNNO<SUP>−</SUP> nanosheets were deposited on a Pt/Ti/SiO<SUB>2</SUB>/Si substrate at room temperature by the electrophoretic method. Annealing was conducted at various temperatures to remove organic defects in the SNNO film. A crystalline SNNO phase without organic defects was formed in the film annealed at 500°C. However, a SrNb<SUB>2</SUB>O<SUB>6</SUB> secondary phase was formed in the films annealed above 600°C, probably due to the evaporation of Na<SUB>2</SUB>O. The SNNO thin film annealed at 500°C showed a dielectric constant of 74 at 1.0MHz with a dielectric loss of 2.2%. This film also exhibited a low leakage current density of 9.0×10<SUP>−8</SUP> A/cm<SUP>2</SUP> at 0.6MV/cm with a high breakdown electric field of 0.72MV/cm.</P>

Enhanced Pinning Properties of GdBa2Cu3O7-δ Films With the Gd 2O3 Nanoparticles

Won-Jae Oh,Jae-Eun Kim,Sang-Im Yoo IEEE 2017 IEEE transactions on applied superconductivity Vol.27 No.4

<P>We tried to optimize the pinning properties of GdBa<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7-δ</SUB> (GdBCO) films with the Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles. The GdBCO films with the Gd<SUB>2</SUB>O<SUB>3</SUB> contents of 0, 2, 5, 7, and 10 mol% were fabricated on CeO<SUB>2</SUB>-buffered MgO (100) substrate by pulsed laser deposition. Among these samples, 5 mol% (= 2.2 vol%) Gd<SUB>2</SUB>O<SUB>3</SUB> -doped GdBCO film exhibited the highest critical current density (J<SUB>c</SUB>) values compared with other samples at temperatures of 20 and 40 K for B//c, and it also showed the maximum pinning force density (F<SUB>p,max</SUB>) value of 119 GN/m<SUP>3</SUP> near 3.8 T at 20 K, indicating that 5 mol% Gd<SUB>2</SUB>O<SUB>3</SUB> is the optimum doping content below 40 K. However, the Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles were ineffective for flux pinning at higher temperatures (>65 K). Analysis by transmission electron microscopy for this sample revealed that the Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles of ~20 nm in diameter randomly dispersed in the GdBCO matrix. This peculiar pinning characteristics of 2.2 vol% Gd<SUB>2</SUB>O<SUB>3</SUB>-doped GdBCO film in comparison with 2.5 vol% Y<SUB>2</SUB>O<SUB>3</SUB>-doped YBCO film [P. Mele et al. 2007] are attributable to more severe degradation of Tc,zero and also to much larger particle size of Gd<SUB>2</SUB>O<SUB>3</SUB> compared with that of Y<SUB>2</SUB>O<SUB>3</SUB> nanoparticles (~8 nm).</P>

Implementation of Display Server

Sang-Won Lee,Jeong-Jin Kang,Yong-Soon Im,Sang-Yep Nam,In-Jung Park 대한전자공학회 2004 ITC-CSCC :International Technical Conference on Ci Vol.2004 No.7

Performance Improvement of Inertial Navigation System by Using Magnetometer with Vehicle Dynamic Constraints

Won, Daehee,Ahn, Jongsun,Sung, Sangkyung,Heo, Moonbeom,Im, Sung-Hyuck,Lee, Young Jae Hindawi Limited 2015 Journal of sensors Vol.2015 No.-

<P>A navigation algorithm is proposed to increase the inertial navigation performance of a ground vehicle using magnetic measurements and dynamic constraints. The navigation solutions are estimated based on inertial measurements such as acceleration and angular velocity measurements. To improve the inertial navigation performance, a three-axis magnetometer is used to provide the heading angle, and nonholonomic constraints (NHCs) are introduced to increase the correlation between the velocity and the attitude equation. The NHCs provide a velocity feedback to the attitude, which makes the navigation solution more robust. Additionally, an acceleration-based roll and pitch estimation is applied to decrease the drift when the acceleration is within certain boundaries. The magnetometer and NHCs are combined with an extended Kalman filter. An experimental test was conducted to verify the proposed method, and a comprehensive analysis of the performance in terms of the position, velocity, and attitude showed that the navigation performance could be improved by using the magnetometer and NHCs. Moreover, the proposed method could improve the estimation performance for the position, velocity, and attitude without any additional hardware except an inertial sensor and magnetometer. Therefore, this method would be effective for ground vehicles, indoor navigation, mobile robots, vehicle navigation in urban canyons, or navigation in any global navigation satellite system-denied environment.</P>

[P10-260] Chemical Compositions and Antioxidant Activity of the Colored Rice Cultivars

Sang-Won Choi,Ji-Hae Oh,Eun-Ok Kim,Sung-Soo Kim,Jung-Gyo Im,Kee-Taek Lee,Hak-Soo Suh 한국식품영양과학회 2006 한국식품영양과학회 학술대회발표집 Vol.2006 No.10